Study on the Effect of Negative Pressure Occlusion Drainage Combined with Silver Ion Dressing on Inflammatory Factors (IL-6, TNF-α) and Healing Effect of Diabetic Foot Ulcer
Summary: Retrospective single-center study (n=78, Wagner 1–4 DFUs, Feb 2023–Apr 2025). Negative pressure occlusion drainage (-125 mmHg) + silver-ion dressing reduced IL-6 by 75% and TNF-α by 62% at day 30 (P<0.001), achieved 93.59% overall effectiveness, and complete healing in an average of 19.49 days. Wound area fell 81% in 30 days. Adverse events only 6.41% and mild.
Key results at a glance
- Patients: 78 (mean age 50.7 y)
- Overall effective rate: 93.59%
- Mean healing time: 19.49 ± 4.18 days
- IL-6 day 30: 16.92 → 4.16 ng/L (-75%)
- TNF-α day 30: 18.91 → 7.13 ng/L (-62%)
- Wound area reduction day 30: 81%
- Granulation tissue appearance: 6.83 days
Authors: Wang L, Gao SF, Jiang YS et al.
Journal: Frontiers in Endocrinology (2025)
DOI: 10.3389/fendo.2025.1689232
Keywords:
NPWT •
silver ion dressing •
IL-6 •
TNF-α •
diabetic foot ulcer •
wound healing