Glutaraldehyde-Induced Porcine Model Mimics Human Chronic Wounds
Summary: Researchers developed a porcine chronic wound model using topical glutaraldehyde that faithfully recreates human DFU hallmarks: persistent inflammation, biofilm formation, impaired angiogenesis, and stalled re-epithelialization. Unlike traditional excisional models that heal rapidly, these wounds remain open >8 weeks without intervention. The model enables reliable preclinical testing of advanced therapies (cell therapies, bioengineered skin, growth factors) with direct translational relevance, potentially slashing failure rates in human trials.
Key Highlights:
- Model: Topical glutaraldehyde on full-thickness porcine wounds.
- Features: Biofilm, excess inflammation, impaired healing >8 weeks.
- Advantage: Closest mimic of human DFU to date.
- Impact: Faster, more predictive testing of DFU therapies.
- Authors: Not specified in alert (Trends in Biotechnology).
Keywords: porcine model, chronic wound, glutaraldehyde, DFU model, biofilm, preclinical