The Use of Adipose-Derived Stem Cells for the Treatment of Complex Postoperative Enterocutaneous Fistulas: A Preliminary Case Series Study
Summary: This prospective case series (n=6) evaluated autologous ADSC injection for complex postoperative enterocutaneous fistulas unresponsive to conservative management. 67% achieved complete closure (4-12 weeks), with >80% output reduction in another; no AEs. ADSCs promoted angiogenesis and reduced inflammation via VEGF/TGF-β, improving albumin (from 2.8 to 3.6 g/dL) and CRP. Suggests ADSC as minimally invasive option for hostile abdomens.
Key Highlights:
- Outcomes: 67% complete closure; 17% partial; 17% failure (surgery).
- Biomarkers: Albumin +0.8 g/dL; CRP ↓ to 1.1 mg/dL (p<0.05).
- Method: 5-10M ADSCs injected under US; 12-week follow-up with CT/MRI.
- Safety: No infections; GMP-processed cells.
- Authors: Pietro Fransvea, Valeria Fico, Gilda Pepe et al.
Keywords: ADSC, enterocutaneous fistulas, postoperative wounds, closure rates, VEGF, Pietro Fransvea, Valeria Fico, Gilda Pepe