Comparative Analysis of the Therapeutic Effect of Antibiotic Bone Cement on Wagner Grade 3 or 4 Diabetic Foot Ulcer in Heel and Non-Heel Areas: A Retrospective Cohort Study
Summary: Retrospective PSM cohort (n=50) compared antibiotic bone cement (ABC) + wound surgical integrated treatment (WSIT) for Wagner 3/4 DFUs: heel (hDFU) vs non-heel (nhDFU). Post-PSM, major amputation rates were similar (12% vs 8%, p=1.0), despite hDFU’s higher baseline WBC/albumin deficits. ABC reduced WBC significantly (p<0.01), confirming infection control. Alcohol abuse/hypoalbuminemia were key risk factors (RR 1.12/1.01).
Key Highlights:
- Outcomes: Amputation 12% vs 8%; LOS ~31 days both (p>0.05).
- Infection: WBC ↓ 11.94 to 9.03 in hDFU (p=0.004).
- Risks: Alcohol RR 1.123 (p<0.05); hypoalbuminemia RR 1.010.
- Method: PSM for balance; multivariable Poisson regression.
- Authors: Yang Jian, Li Li, Wei Chen et al.
Keywords: antibiotic bone cement, Wagner 3 4, hDFU, infection control, PSM, Yang Jian, Li Li, Wei Chen