Human Keratin Matrix in Addition to Standard of Care Accelerates Healing of Venous Ulcers: A Case Series
Summary: This case series evaluated human keratin matrix (HKM) + standard of care (SOC) and vascular interventions for 16 venous leg ulcers (VLUs; 7 very large >200 cm², 9 smaller <35 cm²). Very large VLUs reduced 71% in 10 weeks (50% in 4 applications); smaller ones 50% in 3 weeks, with 89% complete healing in ~6.5 weeks (4.5 applications). HKM promoted granulation and epithelialization, demonstrating efficacy for chronic VLUs.
Key Highlights:
- Large VLUs: 71% reduction; mean 4 applications over 10 weeks.
- Small VLUs: 89% healed; 50% reduction in 3 weeks.
- Method: Weekly HKM post-debridement + compression; size categorization.
- Safety: No AEs; vascular interventions as needed.
- Implications: HKM accelerates VLU healing, even large ones; RCT needed.
Keywords: human keratin matrix, venous ulcers, case series, healing acceleration, large VLUs