Optimization of Processing Parameters for Autologous Platelet Gel for Diabetic Foot Ulcer
Summary: This study optimizes RAPID Biodynamic Haematogel—a point-of-care autologous platelet gel—for DFU wound healing, identifying centrifugation (1500g, 5 min) for 80% platelet yield and growth factor retention. In 20 DFU patients, gel application post-debridement accelerated granulation 50% vs controls, with 60% closure at 4 weeks. The parameters ensure reproducibility, positioning it as a cost-effective adjunct for chronic ulcers in low-resource clinics.
Key Highlights:
- Optimization: 1500g/5 min yields 80% platelets; retains PDGF/VEGF.
- Trial: 20 DFU patients; 50% faster granulation; 60% closure at 4 weeks.
- Point-of-Care: 30-min preparation; no lab needed.
- Safety: No AEs; biocompatible for diabetics.
- Authors: Preti M, Barone M, Cavallo S et al.
Keywords: autologous platelet gel, diabetic foot ulcer, RAPID Haematogel, centrifugation, growth factors, Preti M, Barone M, Cavallo S