Biodegradable Temporising Matrix in Diabetic Foot Ulcer Management
Summary:** This review evaluates biodegradable temporising matrix (BTM)—a 3D scaffold of medical-grade bovine collagen—for wound bed preparation in diabetic foot ulcers (DFUs), where vascular disease delays healing. BTM facilitates granulation in 60-80% of cases within 2-4 weeks, supporting skin grafting or closure, with 90% graft take rates. As adjunct to debridement/offloading, it reduces infection risks and amputation in 70% of Wagner III-IV DFUs, though challenges include cost and infection in ischemic wounds.
Key Highlights:
- BTM Structure: 98% type I collagen scaffold promotes fibroblast migration and vascularization.
- DFU Application: Ordered in 4-6 weeks post-debridement; 60-80% granulation; 90% graft success.
- Evidence: 70% limb salvage in advanced DFUs; reduced hospital stays vs. standard care.
- Challenges: Contraindicated in active infection; cost $500-1000 per application.
- Implications: Ideal for refractory DFUs; future with growth factors for enhanced regeneration.
Keywords: biodegradable matrix, diabetic foot ulcer, BTM, granulation, limb salvage