Next-Generation Wound Care: Guiding the Body to Heal Itself
Summary:** National Taiwan University researchers review multimodal strategies combining physical cues (electricity, light, mechanical forces, pH control) and chemical signals (therapeutic gases like H2S) to mimic natural skin regeneration, accelerating healing in chronic wounds like diabetic ulcers. These gentle stimuli reduce inflammation, kill bacteria, and promote collagen/vascular growth, shifting from passive dressings to active “smart” therapies. Published in Materials Today, the approach promises scarless repair via wearable devices, with potential for personalized, non-invasive treatments.
Key Highlights:
- Multimodal: Electricity guides migration; light (photothermal) kills bacteria/collagen formation; H2S regulates inflammation/angiogenesis.
- Chronic Wounds: Targets diabetic/pressure ulcers with persistent infection and poor circulation.
- Benefits: Faster closure, less scarring; biodegradable materials for sustainability.
- Future: Training/training for “smart” dressings with controlled cues; human trials needed.
- Lead: Prof. Zong-Hong Lin: “A revolution from passive to active healing.”
Keywords: next gen wound care, multimodal cues, scarless healing, therapeutic gases, diabetic ulcers