Effects of Oral Cholecalciferol on Chronic Wound Healing in Patients with Vitamin D Insufficiency or Deficiency
Summary: This peer-reviewed study evaluates whether correcting vitamin D insufficiency with oral cholecalciferol accelerates healing of chronic wounds. Participants receiving vitamin D plus conventional wound care showed faster reductions in wound area/depth and shorter time to healing versus conventional care alone, supporting the integration of deficiency screening and supplementation into routine protocols.
Key Highlights:
- Adults with chronic wounds and serum 25(OH)D < 30 ng/mL received short-term, high-dose cholecalciferol.
- Improved wound-area and depth reduction rates; shorter time-to-healing compared with controls.
- Findings align with holistic frameworks (e.g., TIME) where systemic factors impact local healing.
- Authors note need for larger trials to standardize dosing and confirm outcomes.
Keywords: vitamin D, cholecalciferol, chronic wounds, 25(OH)D, JMDH, Zhao