Sinapic Acid: A Natural Therapeutic for Diabetic Wound Healing
Summary: Researchers at Nagaland University have identified sinapic acid, a naturally occurring antioxidant in edible plants, as a promising oral therapeutic for accelerating wound healing in diabetic patients, particularly foot ulcers. Published in Nature Scientific Reports, the preclinical study in diabetic rat models revealed an inverted dose-response effect, with a low dose (20 mg/kg) outperforming higher doses (40 mg/kg) in promoting tissue repair, angiogenesis, and inflammation control via SIRT1 pathway activation. This discovery addresses key challenges in diabetic wounds—like neuropathy, poor circulation, and infection risks—offering a safe, affordable natural alternative to synthetic drugs, with potential to lower global amputation rates and support resource-limited settings through upcoming pilot clinical trials.
Key Highlights:
- Sinapic acid activates SIRT1 to enhance angiogenesis, reduce oxidative stress, and control inflammation, critical for stalled diabetic healing.
- Low-dose efficacy (20 mg/kg) showed superior wound closure and metabolic improvements, highlighting an inverted dose-response curve for optimized therapy.
- Targets diabetic foot ulcers by improving circulation and tissue regeneration, potentially minimizing infections and amputations in high-risk patients.
- Natural source from fruits/vegetables ensures accessibility and safety, with no reported side effects in preclinical testing.
- Next steps: Pilot human trials to validate benefits, positioning sinapic acid as an adjunct in chronic wound management protocols.
Keywords: sinapic acid, diabetic wound healing, SIRT1 pathway, diabetic foot ulcer, natural antioxidant, Rupal Dubey, Sourbh Suren Garg, Navneet Khurana