Therapy with Vancomycin-Loaded Polymethylmethacrylate Cement Demonstrates Limited Advantage in the Treatment of Infected Diabetes-Related Foot Ulcers: Only Patients with Osteomyelitis Benefited
Summary: This study evaluates the clinical effectiveness of vancomycin-loaded polymethylmethacrylate (PMMA) cement in treating infected diabetes-related foot ulcers. Results revealed that the therapy offered limited overall advantage, with significant improvement observed only among patients with confirmed osteomyelitis. Findings suggest that PMMA antibiotic delivery may be most beneficial when bone infection is present.
Key Highlights:
- Vancomycin-loaded PMMA cement showed benefit exclusively in patients with osteomyelitis.
- No significant improvement observed in soft-tissue infection cases without bone involvement.
- Results highlight the importance of infection type in guiding antibiotic delivery approaches.
- Authors recommend further studies to refine local antibiotic strategies for diabetic foot infections.
Keywords:
vancomycin,
polymethylmethacrylate cement,
diabetic foot ulcer,
osteomyelitis,
antibiotic therapy