Pro-Angiogenic and Wound-Healing Potential of Bioactive Polysaccharides Extracted from Moroccan Algae Osmundea pinnatifida
Summary: Researchers investigated a bioactive polysaccharide (PSOP) extracted from the red alga Osmundea pinnatifida. Laboratory assays, chick chorioallantoic membrane (CAM) models, and rat wound models confirmed its antioxidant, pro-angiogenic, and wound healing properties. PSOP enhanced vascular growth, collagen formation, and accelerated closure, making it a promising candidate for advanced wound care therapies.
Key Highlights:
- Extraction & analysis: Structural characterization revealed PSOP’s high carbohydrate content and porous morphology, favorable for biomedical use.
- Antioxidant activity: Demonstrated strong radical scavenging and reducing power in vitro, supporting its role in reducing oxidative stress in wounds.
- Angiogenesis stimulation: Increased vascular branching by up to 250% in CAM assays.
- In vivo healing: Rats treated with PSOP hydrogel showed faster wound contraction, with complete closure by day 11.
- Mechanism: Computational docking suggested PSOP may interact with VEGF and COX-2, influencing angiogenesis and tissue repair pathways.
- Clinical potential: Findings indicate PSOP could be developed into novel, natural biomaterials for chronic or ischemic wound treatment.
Read the full article in Life (MDPI)
Keywords:
Zakaria Boujhoud,
Malek Eleroui,
Osmundea pinnatifida,
bioactive polysaccharides,
angiogenesis,
wound healing,
antioxidant activity