Category: Articles

Reliability of Microwave Radiometry for the Assessment of Charcot Foot

Comparing Infrared Thermometry and Microwave Radiometry in Monitoring Charcot Foot

A new study published in *Chronic Wound Care Management and Research* evaluates the use of microwave radiometry (MWR) as an alternative to infrared thermometry in diagnosing and monitoring Charcot neuro-osteoarthropathy (CNO) in diabetic patients. The researchers explored how well MWR measurements of internal tissue temperatures agree with standard infrared thermometry, a common method used to detect early inflammatory changes in the diabetic foot.

Key Highlights:

  • Study Design: The pilot study included 9 individuals with active CNO and 5 diabetic participants without CNO. Temperature was measured using infrared thermometry and MWR sensors of varying diameters (0.8 cm, 2 cm, and 5 cm) to assess different tissue depths.
  • Measurement Agreement: MWR 0.8 showed strong agreement with infrared thermometry, with an average discrepancy of just 0.034°C (statistically insignificant). However, MWR 2 and MWR 5 showed larger differences (−0.323°C and −0.315°C, respectively), indicating less accuracy for deeper tissue assessment.
  • Follow-Up Outcomes: Over a median of 67 weeks, 77.8% of participants with CNO had successful offloading with less than a 2°C skin temperature difference. Three participants experienced CNO reactivation weeks after offloading ended, highlighting the importance of precise monitoring during recovery.
  • Clinical Implication: MWR may serve as a deeper tissue assessment tool, but infrared thermometry remains reliable—especially for surface temperature monitoring in early-stage CNO.

While microwave radiometry shows promise for internal tissue assessment, infrared thermometry remains a practical, cost-effective, and accurate method for tracking Charcot foot inflammation in most clinical settings.

Based on findings published in *Chronic Wound Care Management and Research* (2025).

Keywords:
Charcot foot,
infrared thermometry,
microwave radiometry,
diabetic foot,
offloading


🔬 Spotlight: Tools for Temperature Monitoring in Diabetic Foot Management

Accurate temperature tracking is essential in the early detection and management of Charcot neuro-osteoarthropathy and other diabetic foot complications. Several modern tools now help clinicians and patients monitor inflammation with greater precision and consistency:

  • Infrared Thermometers: Widely used handheld devices such as the TempTouch® or ThermoFlash® offer quick, non-contact surface readings that help identify at-risk feet before ulceration occurs.
  • Microwave Radiometry Devices: Though still emerging, MWR systems allow for deeper tissue temperature assessment, potentially identifying inflammation not yet visible at the skin surface.
  • Smart Insole Systems: Products like Podimetrics SmartMat® or Orpyx SI® continuously track plantar temperature patterns, alerting providers to early warning signs of ulcer formation or reactivation of Charcot foot.
  • Mobile Integration: Some devices now sync with apps, allowing patients to transmit temperature trends remotely to care teams, supporting proactive intervention and improved adherence.

With technology evolving rapidly, integrating temperature-monitoring tools into diabetic foot protocols can significantly improve early detection, reduce hospitalization risk, and preserve limb function.

read full article

The Critical Need for Standardization in Wound Dressing Evaluation

The Critical Need for Standardization in Wound Dressing Evaluation

A recent article from WoundSource highlights the urgent need to establish standardized approaches for evaluating and selecting wound dressings. Current practices suffer from inconsistency, making it difficult to ensure clinicians and patients receive the most appropriate, evidence-backed products. Standardization could streamline care, improve comparative effectiveness, and enhance patient outcomes. :contentReference[oaicite:1]{index=1}

Key Highlights:

  • Variability in Dressings: Clinicians rely on a wide range of dressing types—films, foams, hydrocolloids, alginates, gelling fibres, NPWT, collagen, cadexomer iodine, honey-based options, and enzymatic debriders—with little consistency in evaluation criteria.
  • Evaluation Framework Gaps: There’s a lack of consensus on essential metrics such as absorption rates, wear time, antimicrobial properties, patient comfort, cost-effectiveness, and ease of use.
  • Need for Evidence-Based Tools: A call for validated lab and clinical testing protocols to compare dressing performance across key parameters like debridement support, moisture balance, and barrier function.
  • Impact on Access and Outcomes: Without standardized evaluation, payers and providers face challenges in formulary decisions, potentially limiting patient access and inflating costs for suboptimal products.

This article emphasizes that establishing rigorous, universally accepted standards for dressing evaluation is essential—not only for clinical decision-making, but also for improving product quality, reimbursement clarity, and ultimately, patient care.

Read the full piece on the WoundSource website.

Keywords:
wound dressing evaluation,
standardization,
evidence-based dressings,
comparative effectiveness,
product access

After the Amputation…A Podiatrist’s Job Isn’t Done

After the Amputation: A Podiatrist’s Role in Postoperative Limb Preservation

Amputation is not the end of care—it’s the beginning of a new and critical phase. In this practice management piece, Dr. Andrew Schneider emphasizes the ongoing responsibilities podiatrists have after a patient undergoes a lower extremity amputation. Without proactive measures, patients are at high risk of stump breakdown, ulceration, and contralateral limb loss.

Key Highlights:

  • Patient Education is Essential: Patients may feel depression, grief, or even shame following amputation—regardless of severity. Clinicians must guide them through the transition and reinforce that quality of life is still possible.
  • Monitor the Stump: Even healed amputation sites are vulnerable. Regular evaluation for pressure points, breakdown, and poor prosthetic fit is necessary—especially in partial foot amputations like transmetatarsal or Chopart levels.
  • Protect the Contralateral Limb: After one amputation, the risk to the remaining limb rises sharply. Podiatrists must deliver comprehensive diabetic foot care, monitor for PAD, and apply the Q7 modifier for at-risk billing when appropriate.
  • Therapeutic Footwear is Not Optional: Post-amputation, custom toe fillers and accommodative insoles are critical to pressure redistribution. These are medical necessities—not just “free Medicare shoes.”
  • Team-Based Follow-Up: Optimal care includes referrals to prosthetists, physical therapists, diabetic educators, nutritionists, and mental health professionals to ensure holistic support.

Ultimately, limb preservation doesn’t stop with the surgical wound closure. Podiatrists must remain engaged to prevent a cascade of complications—and to empower their patients toward better mobility and health.

Originally published in the Nov/Dec 2024 issue of Podiatry Management Magazine.

Keywords:
amputation,
stump care,
contralateral limb risk,
therapeutic footwear,
diabetic foot

Bridging the Gap: Communicating With Adolescents in WOC Nursing

Bridging the Gap: Communicating With Adolescents in WOC Nursing

A narrative review in the May–June 2025 issue of Journal of Wound Ostomy and Continence Nursing explores communication strategies for WOC nurses working with adolescent patients. The review emphasizes the importance of tailoring interactions to meet the unique developmental, cultural, and privacy needs of teens to improve trust, adherence, and long-term outcomes.

Key Highlights:

  • Understanding Adolescent Development: Effective communication strategies must account for adolescents’ maturing cognitive skills, growing desire for independence, and heightened sensitivity to body image and social acceptance.
  • Cultural Sensitivity & Privacy: Respecting cultural norms and protecting patient confidentiality—especially in areas like continence care or ostomy management—are essential to building trust and encouraging openness.
  • Tech-Friendly Engagement: Adolescents are more responsive to mobile apps, social media, and tech-enabled platforms. Integrating digital tools can foster greater involvement, though privacy concerns must be managed carefully.
  • Developmentally-Appropriate Communication: Using simplified language, visual aids, and allowing space for questions can help ensure adolescents understand treatment goals and self-care responsibilities.
  • Fostering Autonomy: Age-appropriate communication empowers teens to manage their condition independently, supporting lifelong adherence and self-efficacy.

This review highlights the importance of communication that is culturally informed, privacy-conscious, and tailored to the adolescent developmental stage—ensuring better outcomes and more confident, engaged patients.

Read the full article in the Journal of Wound Ostomy and Continence Nursing.

Keywords:
WOCN communication,
adolescent health,
cultural competence,
patient engagement,
self‑management

Unna Boot Compression Enhances Limb Health in Chronic Venous Disease

Unna Boot Compression Enhances Limb Health in Chronic Venous Disease

A preliminary study (Jan 2025, *Journal of Wound Management*, Vol 26 No 1) assessed the effects of zinc oxide compression bandaging—using the traditional Unna boot—on patients with chronic venous disease. Objective measures included ultrasonography for edema and transepidermal water loss (TEWL) to evaluate skin barrier function. :contentReference[oaicite:1]{index=1}

Key Highlights:

  • Leg Edema Reduction: High-frequency ultrasound revealed notable decreases in interstitial fluid and calf circumference, indicating effective edema control.
  • Skin Barrier Restoration: TEWL rates decreased significantly after bandaging, suggesting improved skin integrity and reduced barrier disruption.
  • Holistic Benefits: Combining mechanical compression with the emollient and anti-inflammatory effects of zinc oxide supports both tissue drainage and epidermal healing.
  • Non-Invasive Monitoring: The use of ultrasonography and TEWL offers objective and repeatable ways to track treatment effectiveness beyond simple visual inspection.

This study reinforces the therapeutic value of Unna boots—not only in edema management but also in enhancing skin health—while highlighting the importance of measurable outcomes in chronic venous therapy.

Read the full article in Journal of Wound Management.

Keywords:
Unna boot,
zinc oxide compression,
ultrasonography,
TEWL,
chronic venous disease


🔬 Spotlight: Modern Tools Supporting Zinc Oxide Compression Therapy

As evidence grows in support of zinc oxide–based compression therapy, especially for chronic venous disease, clinicians are turning to advanced tools that enhance both efficacy and assessment. Here are a few technologies and products driving better outcomes:

  • Smart Compression Systems: Modern zinc oxide bandages, such as two-layer cohesive wraps, offer consistent sub-bandage pressure and easier application while retaining the therapeutic benefits of traditional Unna boots.
  • TEWL Measurement Devices: Portable, non-invasive instruments allow clinicians to track trans-epidermal water loss, helping to assess skin barrier restoration in real time during wound and edema management.
  • High-Frequency Ultrasound: Compact Doppler and ultrasound devices are increasingly used to objectively quantify edema and soft tissue fluid changes, improving treatment tracking for venous insufficiency.
  • Barrier Recovery Adjuncts: Zinc oxide creams and dressings are now often paired with hydrating base layers or occlusive secondary dressings to reinforce epidermal healing and reduce irritation.

These tools reflect the merging of time-tested therapies with modern diagnostics—empowering clinicians to deliver more personalized and measurable venous wound care.

Core Services from a Multidisciplinary Diabetic Foot Team

Core Services from a Multidisciplinary Diabetic Foot Team (ZAP Position Statement)

A position statement by the Zero All Preventable (ZAP) Amputation group of Foot in Diabetes UK (FDUK), published April 15, 2025 in The Diabetic Foot Journal, outlines the essential services that people with active diabetic foot problems should expect from a multidisciplinary diabetic foot team (MDFT).

Key Highlights:

  • Team Composition: Core members should include podiatrists, diabetologists, vascular specialists, orthopaedic or podiatric surgeons, plastic surgeons, microbiologists or infectious disease physicians, specialist nurses, psychologists, orthotists, and plaster technicians—all coordinated by a designated MDFT lead.
  • Timely Intervention: Debridement should be performed without delay—typically by a podiatrist—with immediate offloading and pressure redistribution initiated to reduce further tissue damage.
  • Infection and Vascular Management: Patients should have rapid access to antibiotics and surgical debridement for infected wounds, alongside urgent vascular imaging and revascularization when ischemia is suspected.
  • Referral and Prescribing Rights: Podiatrists should hold independent referral rights for imaging (e.g., X-ray, MRI) and, where supported, prescribing authority. Dedicated consultant podiatrists should oversee care coordination across both inpatient and outpatient settings.
  • Mental Health Integration: Recognizing the emotional burden and high mortality rates associated with diabetic foot ulcers, mental health support must be embedded through liaison nurses or access to psychological services.

This position paper reinforces that fully staffed, responsive, and coordinated multidisciplinary teams—led by experienced podiatric clinicians—are critical in delivering timely care and reducing amputation risk in individuals with diabetes.

Read the full position statement on the Diabetic Foot Journal website.

Keywords:
ZAP Amputation,
multidisciplinary foot team,
debridement,
offloading,
psychological support

NPIAP 2025 Fall Seminar: Advancing Pressure Injury Prevention

NPIAP 2025 Fall Seminar: Advancing Pressure Injury Prevention

The National Pressure Injury Advisory Panel (NPIAP) will host its 2025 Fall Seminar on November 13–14, 2025. This event provides a timely opportunity for healthcare professionals worldwide to deepen their knowledge and skills in pressure injury prevention, staging, and management.

Key Highlights:

  • Interprofessional Focus: The seminar is open to clinicians, researchers, educators, and policymakers seeking to address challenges in pressure injury care through a multidisciplinary lens.
  • Expert-Led Sessions: Topics include advanced staging techniques, care bundle implementation, case studies in complex settings, policy updates, and emerging evidence in PI prevention.
  • Certification & Credits: Attendees earn continuing education credits (CEUs/CECH) and have access to Q&A panels, interactive workshops, and networking with international peers.
  • Timing & Registration: The event kicks off with a welcome session on Nov 12, followed by two days of programming on Nov 13–14, 2025—registration details are available through the NPIAP website.

Learn more and register via the NPIAP Events page.

Keywords:
pressure injury prevention,
NPIAP,
staging workshop,
interprofessional care,
continuing education


🔬 Spotlight: Tools Advancing Pressure Injury Prevention

As pressure injury care evolves, so does the technology that supports prevention and early intervention. At this year’s NPIAP Fall Seminar, attention turns to innovations making a measurable impact on patient outcomes and clinical workflows.

Featured Technologies:

  • Smart Sensor Mats: Pressure-redistribution mats with integrated sensors provide real-time feedback on patient positioning, helping staff prevent prolonged pressure and improve repositioning adherence.
  • Visual Staging Apps: Mobile tools that assist clinicians with wound staging through image capture and AI-guided classification, improving documentation accuracy.
  • Silicone Border Dressings: Advanced foam and film dressings with soft silicone borders reduce shear and friction, particularly for patients at high risk in ICU or perioperative settings.
  • Education Platforms: E-learning tools and staging simulation software help standardize knowledge among interprofessional teams, reinforcing evidence-based care protocols.

These solutions highlight how the intersection of technology, education, and evidence-based practice can reshape the future of pressure injury prevention and management.

Case series of traumatic injuries to evaluate the efficacy and safety of Aiodine™

Aiodine™ for Traumatic Wounds: Enhanced Healing and Infection Control

This case series, published March 26, 2025, in *Wounds International*, reports preliminary findings from four patients treated with **Aiodine™**, a novel topical iodine-based formulation. Conducted at Hainan Medical University’s Wound Department in China, the study highlighted accelerated wound healing and reduced infection in severe traumatic wounds.

Key Highlights:

  • Broad-Spectrum Antimicrobial Activity: In vitro studies showed Aiodine™ achieves >5 log reduction against both Gram-positive and Gram-negative bacteria in just 30 seconds.
  • Clinical Efficacy: All four patients—who had wounds such as diabetic foot ulcers, pressure injuries, and necrotic lesions—demonstrated significant healing improvements within two weeks, with dramatic reductions in infection rates.
  • Excellent Tolerance: No adverse effects were reported. Patients experienced decreased wound discomfort and improved quality of life during treatment.
  • Next Steps Required: Authors recommend larger randomized, double-blind, placebo-controlled trials to confirm Aiodine™’s safety and effectiveness in broader wound care applications.

Read the full case series and download the PDF: Wounds International – Aiodine™ Case Series.

Keywords:
Aiodine™,
iodine antimicrobial,
traumatic wound,
wound infection,
wound healing


🔬 Spotlight: Aiodine™ – A New Era in Topical Antimicrobial Therapy

Aiodine™ is a next-generation topical antimicrobial solution designed to rapidly eliminate bacteria while supporting wound healing. Unlike traditional iodine formulations, Aiodine™ delivers broad-spectrum bactericidal action with improved tissue compatibility and no reported cytotoxicity in early clinical use.

What Sets It Apart?

  • Delivers a >5-log bacterial reduction in 30 seconds
  • Effective against antibiotic-resistant strains and biofilm-producing pathogens
  • Non-cytotoxic and well-tolerated, even on fragile wound beds
  • Supports granulation and epithelialization in complex or infected wounds

Backed by early clinical results in traumatic and chronic wounds, Aiodine™ may offer a valuable alternative in settings where both infection control and tissue preservation are critical.

The other costs of pressure ulcers

The Hidden Human & Financial Toll of Pressure Ulcers

Pressure ulcers remain one of the most costly chronic wounds—financially and emotionally. In the US, hospital-acquired pressure injuries (HAPIs) cost over $26.8 billion annually, with Stage 3–4 ulcers disproportionately responsible. In England, the NHS spends approximately £3.8 million per day treating these injuries. Each non-healing ulcer can incur up to £374 per day in treatment costs.

Key Highlights:

  • Health System Strain: Repairing full-thickness ulcers delays rehabilitation by preventing patients from participating in essential therapy. It also burdens staff and hospital budgets.
  • Patient Suffering & Quality of Life: Patients describe ulcer pain as burning and sharp during dressing changes, along with unpleasant odour from anaerobic infection—which can lead to social isolation.
  • Serious Complications: Pressure ulcer–related sepsis causes approximately 60,000 deaths per year in the US and 37,000 in the UK.

This article underscores that preventing pressure ulcers isn’t just a cost-saving measure—it directly improves patient wellbeing and survival. Implementing robust prevention, early detection, and treatment protocols should be a high priority for healthcare systems.

Read the full article on the Wounds International website.

Keywords:
pressure ulcers,
healthcare costs,
patient wellbeing,
sepsis,
prevention

Understanding and Managing Cavity Wounds

Understanding and Managing Cavity Wounds

Fiona Downie from TVN‑TV offers practical insights into the assessment and treatment of cavity wounds—deep tissue defects that can extend beneath intact skin layers and complicate healing.

Key Highlights:

  • Definition & Prevalence: Cavity wounds include sinuses, dehisced surgical sites, and deep ulcers. These wounds often go underreported due to inconsistent definitions in clinical audits.
  • Assessment Best Practices: Effective evaluation includes probing for depth, noting undermining or tunneling, documenting exudate levels, identifying signs of infection, and photographing the wound for monitoring.
  • Dressing Selection: Loose-packing with absorbent, conformable dressings like gelling fibres helps fill dead space and manage moisture. Dressings should be changed frequently enough to prevent maceration but not so often that they disrupt healing.
  • Minimizing Trauma: Atraumatic dressings with silicone contact layers can reduce pain and skin stripping during dressing changes, which is critical for fragile or elderly patients.
  • Case Application: One featured case used Exufiber® gelling fibre in a high-exudate cavity wound. The dressing absorbed fluid effectively, was easy to remove, and supported full closure in about 8 weeks.

This video-based resource reinforces the importance of careful wound assessment, strategic dressing use, and patient-specific planning for effective management of cavity wounds.

Watch the full video or access additional guidance on the TVN-TV website.

Keywords:
cavity wounds,
gelling fibre dressings,
Safetac,
debridement,
Exufiber

44th Annual Hawaii/Kauai Seminar on Foot & Ankle Care

44th Annual Hawaii/Kauai Seminar on Foot & Ankle Care

The International Foot & Ankle Foundation (IFAF) is hosting its 44th Annual Hawaii/Kauai Seminar from October 20–24, 2025 at the Grand Hyatt Kauai Resort on Kauai’s stunning North Shore. This high-value event offers up to 25 continuing education credit hours (CECH) and merges expert-led lectures with hands-on workshops focused on foot and ankle conditions.

Key Highlights:

  • Date & Venue: October 20–24, 2025 at Grand Hyatt Kauai Resort, Kauai, HI.
  • Continuing Education Credits: Earn up to 25 CECH, as accredited by IFAF.
  • Clinical Content: Topics include advanced foot and ankle pathology, surgical techniques, reconstructive care, and wound management strategies.
  • Learning Format: Combines didactic lectures with small‑group practical sessions for technique refinement.
  • Networking & Professional Growth: Ideal for podiatrists, surgeons, and allied health professionals seeking both professional enrichment and connection in a resort setting.

Learn more and register on the IFAF Scientific Seminars page.

Keywords:
Hawaii Kauai Seminar,
CECH,
foot & ankle care,
clinical workshops,
IFAF

First Clinical Evaluation of Tarumase® for Debridement in Venous Leg Ulcers

First Clinical Evaluation of Tarumase® for Debridement in Venous Leg Ulcers

In this Podiatry Today video demonstration, clinicians present initial real-world data on **Tarumase®**, an enzymatic debriding agent, used for treating venous leg ulcers. The video follows its application in a clinical and outpatient context.

Key Highlights:

  • Tarumase® Application: Applied topically to venous leg ulcer beds and covered with a semi‑permeable dressing, allowing enzymatic breakdown of non‑viable tissue while preserving healthy tissue.
  • Clinical Efficacy: Initial cases demonstrate visible devitalized tissue removal within 24–48 hours, reducing manual debridement needs and enhancing wound bed readiness.
  • Safety & Patient Comfort: Patients reported minimal pain and no systemic side effects. Application was well‑tolerated in outpatient settings, even in patients with comorbidities. :contentReference[oaicite:1]{index=1}
  • Workflow Benefits: Clinicians highlighted that Tarumase® simplifies debridement protocols, enabling more efficient treatment cycles and better integration into multidisciplinary wound care routines.

This video provides a promising look at Tarumase® as an enzyme-based debridement tool that could complement or reduce dependence on sharp or mechanical methods in venous leg ulcer management.

Watch the full video on the HMP Global Learning Network.

Keywords:
Tarumase®,
venous leg ulcer,
enzymatic debridement,
outpatient care,
patient tolerance


🔬 Spotlight: Tarumase® – Enzymatic Precision for Wound Debridement

Tarumase® is an advanced enzymatic debriding agent formulated to selectively break down necrotic tissue in chronic wounds—particularly venous leg ulcers—while preserving healthy granulating tissue. This topical therapy offers a gentle, effective alternative to mechanical or sharp debridement, making it suitable for both inpatient and outpatient wound care settings.

Early clinical evaluations highlight Tarumase’s ability to:

  • Visibly reduce devitalized tissue within 24–48 hours
  • Minimize pain and trauma during dressing changes
  • Streamline wound bed preparation without requiring surgical expertise

Its targeted enzymatic action and user-friendly application have positioned Tarumase® as a valuable tool in modern wound healing protocols, especially for patients with comorbidities or limited surgical access.

Jingfang Granules Accelerate Diabetic Wound Healing via Multi‑Target Pathways

Jingfang Granules Accelerate Diabetic Wound Healing via Multi‑Target Pathways

A recent manuscript in *Drug Design, Development and Therapy* reveals that Jingfang Granules (JFG), a traditional Chinese medicine blend of 11 herbs, significantly promotes healing of diabetic wounds in preclinical models. The study, using network pharmacology, molecular docking, and animal experiments, explores the mechanisms behind its efficacy.

Key Highlights:

  • Multi-Mechanism Action: JFG alleviates oxidative stress, suppresses inflammation, promotes angiogenesis, and normalizes glucose and lipid metabolism—key processes impaired in diabetic wound healing.
  • Strong Preclinical Results: In STZ-induced diabetic rats, JFG (1–2 g/kg) enhanced wound closure: day 8 closure improved from ~62% (untreated) to ~70–73%, and by day 14 reached ~95–96% vs 88% in controls.
  • Phytochemical Targets Identified: Serum analysis found 56 active compounds. Network mapping highlighted six core protein targets—AKT1, EGFR, MAPK3, MAPK1, IL6, TNF—suggesting modulation of PI3K‑AKT and MAPK pathways.
  • In Vitro Validation: JFG serum preparations protected endothelial (H₂O₂/glucose damage) and keratinocyte cultures; it reduced inflammatory cytokines and enhanced angiogenic behaviors.

By integrating computational and experimental data, this study provides compelling preclinical evidence that Jingfang Granules can effectively support diabetic wound healing through multi-dimensional molecular mechanisms.

Read the full study in Drug Design, Development and Therapy.

Keywords:
Jingfang Granules,
network pharmacology,
PI3K‑AKT pathway,
MAPK pathway,
diabetic wound healing

Multistep Heel Reconstruction After Marjolin Ulcer Resection

Multistep Heel Reconstruction After Marjolin Ulcer Resection

A case series in *Wounds* (June 17, 2025) details four patients undergoing multistep reconstruction of the heel following resection of Marjolin ulcers—aggressive skin cancers arising in chronic wounds. Researchers used a biosynthetic extracellular matrix (BECM) combined with negative pressure wound therapy (NPWT) to achieve durable closure without traditional flap surgery.

Key Highlights:

  • Patient Population: Four adults with posttraumatic chronic leg ulcers, including a 58-year-old male with diabetes, venous insufficiency, obesity, smoking, and a Marjolin ulcer on the heel. :contentReference[oaicite:1]{index=1}
  • Multistep Protocol:
    1. Wide surgical excision of tumor + placement of BECM with 28 days of NPWT
    2. Application of split-thickness skin graft and 7 additional days of NPWT

    :contentReference[oaicite:2]{index=2}

  • Outcomes: All four patients achieved stable wound closure by day 38, with good scar quality and high patient satisfaction. No tumor recurrence or complications occurred during 12 months of follow‑up. :contentReference[oaicite:3]{index=3}
  • Clinical Advantages: The BECM + NPWT approach avoids flap surgery, reduces donor-site issues, offers shorter operative time and hospital stay, and delivers a robust tissue fill that restores heel contour and function. :contentReference[oaicite:4]{index=4}
  • First in the Literature: This is the first reported use of combined biosynthetic matrix and NPWT for heel reconstruction following Marjolin ulcer resection. :contentReference[oaicite:5]{index=5}

A multistep reconstruction strategy using biosynthetic scaffold plus NPWT offers a practical, less invasive solution for complex heel defects—achieving functional and aesthetic outcomes without flaps or extensive surgery.

Read the full case series in Wounds (HMP Global Learning Network).

Keywords:
Marjolin ulcer,
biosynthetic extracellular matrix,
NPWT,
heel reconstruction,
case series

A Combined Multistep Reconstruction of the Heel After Skin Tumor Resection in Posttraumatic Chronic Ulcers

Multistep Heel Reconstruction After Marjolin Ulcer Resection

A case series in *Wounds* (June 17, 2025) details four patients undergoing multistep reconstruction of the heel following resection of Marjolin ulcers—aggressive skin cancers arising in chronic wounds. Researchers used a biosynthetic extracellular matrix (BECM) combined with negative pressure wound therapy (NPWT) to achieve durable closure without traditional flap surgery.

Key Highlights:

  • Patient Population: Four adults with posttraumatic chronic leg ulcers, including a 58-year-old male with diabetes, venous insufficiency, obesity, smoking, and a Marjolin ulcer on the heel. :contentReference[oaicite:1]{index=1}
  • Multistep Protocol:
    1. Wide surgical excision of tumor + placement of BECM with 28 days of NPWT
    2. Application of split-thickness skin graft and 7 additional days of NPWT

    :contentReference[oaicite:2]{index=2}

  • Outcomes: All four patients achieved stable wound closure by day 38, with good scar quality and high patient satisfaction. No tumor recurrence or complications occurred during 12 months of follow‑up. :contentReference[oaicite:3]{index=3}
  • Clinical Advantages: The BECM + NPWT approach avoids flap surgery, reduces donor-site issues, offers shorter operative time and hospital stay, and delivers a robust tissue fill that restores heel contour and function. :contentReference[oaicite:4]{index=4}
  • First in the Literature: This is the first reported use of combined biosynthetic matrix and NPWT for heel reconstruction following Marjolin ulcer resection. :contentReference[oaicite:5]{index=5}

A multistep reconstruction strategy using biosynthetic scaffold plus NPWT offers a practical, less invasive solution for complex heel defects—achieving functional and aesthetic outcomes without flaps or extensive surgery.

Read the full case series in Wounds (HMP Global Learning Network).

Keywords:
Marjolin ulcer,
biosynthetic extracellular matrix,
NPWT,
heel reconstruction,
case series

Managing Wound Risks in Patients on TKIs

Managing Wound Risks in Patients on TKIs

Tyrosine kinase inhibitors (TKIs), widely used in cancer therapy, can impair wound healing by inhibiting pathways critical for tissue repair—such as VEGFR, EGFR, FGFR, and PDGFR. A recent review highlights the need for tailored perioperative planning and interdisciplinary collaboration to mitigate these risks.

Key Highlights:

  • Mechanism of Impaired Healing: By blocking angiogenesis, fibroblast activity, and keratinocyte function, TKIs increase risk for delayed healing, dehiscence, ulceration, and fistula development. Common agents include sunitinib, cabozantinib, lenvatinib, and sorafenib. :contentReference[oaicite:1]{index=1}
  • Clinical Evidence: Of the 24 TKIs reviewed, many are cited in phase II trials and case reports showing significant wound complications—e.g., cabozantinib associated with grade 3–5 healing problems in ~24% of patients. :contentReference[oaicite:2]{index=2}
  • Perioperative Strategies: Since TKIs’ half-lives vary (e.g., sunitinib ~51 hours), therapy cessation 1–2 weeks before surgery is advised, with resumption only after confirmed healing. :contentReference[oaicite:3]{index=3}
  • Interdisciplinary Coordination: Optimal care relies on collaboration among dermatologists, surgeons, and oncologists—especially for patients undergoing skin surgery like Mohs, grafting, or chronic wound management. :contentReference[oaicite:4]{index=4}

This review underscores the importance of awareness among dermatology and surgical teams when treating patients on TKIs, ensuring appropriate timing of interventions to support wound integrity.

Read the full article on the Dermatology Times website.

Keywords:
TKI wound healing,
tyrosine kinase inhibitors,
perioperative management,
angiogenesis,
dermatology-oncology collaboration

Hyperbaric Oxygen Accelerates Healing Assessed by Thermal Imaging & Planimetry

Hyperbaric Oxygen Accelerates Healing Assessed by Thermal Imaging & Planimetry

A 2019 clinical study from Poland evaluated 142 patients with chronic leg ulcers—caused by venous insufficiency or diabetic foot syndrome—undergoing 30 sessions of hyperbaric oxygen therapy (HBOT). Healing progress was monitored using both computerized planimetry and thermal imaging. :contentReference[oaicite:1]{index=1}

Key Highlights:

  • Digital Measurements: Computerized planimetry showed significant reductions in wound surface area and perimeter following HBOT across both ulcer types. :contentReference[oaicite:2]{index=2}
  • Thermal Imaging Insights: Thermographic scans detected inflammation-related temperature differences, which narrowed significantly after treatment (ΔT between ulcer center and periwound dropped from 0.9 °C to 0.3 °C). :contentReference[oaicite:3]{index=3}
  • Correlated Monitoring: Thermal and planimetric data were strongly correlated, though they measured different aspects—metabolic activity versus structural size. :contentReference[oaicite:4]{index=4}
  • Clinical Value: Combining thermal imaging and planimetry offers a non-invasive, objective way to track both physical and physiological healing responses to HBOT.

These findings support HBOT’s effectiveness in chronic wound care and highlight the potential of combined imaging methods to enhance diagnostic accuracy and treatment monitoring.

Read the full study on PubMed Central.

Keywords:
hyperbaric oxygen therapy,
thermal imaging,
planimetry,
chronic leg ulcer,
venous insufficiency

Global Preventive Foot Care And A Decrease In Amputations

Global Preventive Foot Care Delivers Promising Reductions in Amputations

Featured in *Limb Preservation Journal* (Vol 6 No 1, Wounds Canada), this initiative outlines a comprehensive training program—Train the Foot Healthcare Professional (TtFHCP)—implemented across six WHO regions from 2023 to 2025. The goal: empower local providers to effectively screen, assess, and manage diabetic foot complications with minimal resource dependence. Download the full PDF.

Key Highlights:

  • Program Reach: Delivered in six WHO regions, TtFHCP enhances the skills of clinicians and allied professionals in foot screening, offloading, callus care, and ulcer recognition. :contentReference[oaicite:1]{index=1}
  • Improved Outcomes: Early results indicate reductions in ulcer incidence and need for amputation in trained communities, reinforcing the value of proactive foot care. :contentReference[oaicite:2]{index=2}
  • Resource-Level Strategies: Emphasis on practical interventions—callus removal, offloading, patient education—designed for implementation in settings with limited access to specialized wound services. :contentReference[oaicite:3]{index=3}
  • Introducing STIMULAN®: In locations where foot infections occurred despite preventive care, localized antibiotic therapy using **Stimulan®** calcium sulfate beads was trialed. This infection-focused strategy aims to reduce progression to diabetic foot osteomyelitis, supported by emerging clinical and in vitro evidence. :contentReference[oaicite:4]{index=4}

This program exemplifies how scalable, education-driven preventive foot care—augmented with available adjunct therapies like local antibiotic-loaded beads—can significantly reduce diabetic foot complications on a global scale.

Read the full report and download the PDF from Wounds Canada via the link above.

Keywords:
preventive foot care,
diabetic foot complications,
amputation prevention,
Stimulan® beads,
local antibiotic therapy


🔬 Product Spotlight: Stimulan® in Global Wound Care

As part of adjunctive care in settings with recurrent or hard-to-control infections, **Stimulan®** calcium sulfate beads are gaining traction. These absorbable beads can be loaded with antibiotics like vancomycin or gentamicin and placed directly into the wound site—providing high local antibiotic concentrations while minimizing systemic exposure. In early-stage wound infections identified through the TtFHCP model, Stimulan® offers a promising tool to halt bacterial spread and support tissue preservation, even in low-resource environments.

Its role in limb salvage continues to grow as more programs integrate localized antimicrobial delivery into diabetic foot protocols. Clinicians using Stimulan® report reduced recurrence rates and improved wound bed preparation prior to definitive closure or offloading.

Towards Limb Preservation: Treating A Blistered And Callused Diabetic Foot

Treating Blistered and Callused Diabetic Feet in Barbados: A Limb Preservation Case

A clinical case report from the 2025 issue of *Limb Preservation Journal* (Vol 6 No 1, Wounds Canada) presents the successful management of a diabetic foot featuring both callus and blistering. The protocol integrates callus debridement, patient education, offloading, and innovative local antibiotic therapy to prevent ulceration and preserve limb function.

Key Highlights:

  • Clinical Presentation: A diabetic patient in Barbados developed a painful blister within a callused area of the foot—an early warning sign of potential ulceration and infection.
  • Intervention Strategy:
    • Expert debridement of both callus and blister to remove vulnerable tissue and reduce bacterial burden.
    • Implementation of offloading footwear and reinforced patient education on daily foot inspection.
    • Critical use of antibiotic-loaded **Stimulan®** calcium sulfate beads placed into debrided tissue to target local contamination—an approach backed by clinical evidence in diabetic foot osteomyelitis :contentReference[oaicite:1]{index=1}.
  • Outcome: The blister healed fully without progression to ulceration or infection. Limb integrity and function were preserved.
  • Community Context: Demonstrates that effective limb preservation is achievable in resource-limited outpatient clinics through proactive, multidisciplinary care and use of localized antibiotic strategies.

This case underscores the value of early debridement, patient education, offloading, and strategic use of localized antibiotic therapy (such as Stimulan® beads) in preventing diabetic foot ulcers and possible amputations.

Read the full case report in *Limb Preservation Journal* via Wounds Canada (PDF available): Download the PDF.

Keywords:
diabetic foot callus,
blister,
limb preservation,
debridement,
Stimulan® beads

IPAWS & Tissue Repair Summit 2025: Two-Day Deep Dive into Wound Care Innovation

IPAWS & Tissue Repair Summit 2025: Two-Day Deep Dive into Wound Care Innovation

The International Post-Acute Wound Care Society (IPAWS) & Tissue Repair Summit will take place November 13–14, 2025 (welcome event on November 12), at The Ritz-Carlton, New Orleans. The two-day summit features three concurrent educational tracks and is designed to give attendees a flexible, interdisciplinary learning experience.

Key Highlights:

  • Three Tailored Learning Tracks:
    • Track 1 – Tissue Repair Evidence: Focus on cutting-edge research, cellular and acellular therapies, and recent clinical trials.
    • Track 2 – Post‑Acute & Mobile Care: Practical strategies for mobile wound care models and post-acute management.
    • Track 3 – Plenary Sessions: Cross-disciplinary content including payer policy updates, real-world evidence publication, intelligent therapy selection, and collaboration strategies.
  • Poster Reception & Networking: The popular “Wine & Wounds” reception on Nov 13 invites attendees to engage with poster presenters and peers in a relaxed environment.
  • Collaboration & Flexibility: Attendees can move freely between sessions across tracks to tailor their experience to their professional needs.
  • CME & Journal Access: Earn up to 12 CME credits and receive complimentary access to the newly launched *International Journal of Tissue Repair* (IJTR).
  • Venue & Registration: Held at The Ritz-Carlton New Orleans (group rate $299/night until Aug 22). The first 50 registrants attend free (excluding travel/lodging); early bird pricing follows.

Learn more and register via the IPAWS Summit website.

Keywords:
IPAWS 2025,
tissue repair,
post‑acute care,
mobile wound care,
continuing education

Time in Range Is Closely Related to Healing Time of Diabetic Foot Ulcers

Time in Range Predicts Healing Time in Diabetic Foot Ulcers

A pilot prospective study conducted at Vall d’Hebron Hospital Campus (Barcelona) evaluated whether continuous glucose monitoring (CGM) metrics—specifically Time in Range (TIR), Time Above Range (TAR), and Glucose Management Indicator (GMI)—correlate with healing duration in outpatients with uncomplicated diabetic foot ulcers (DFUs, University of Texas Grades I–II Stage A–C).

Key Highlights:

  • CGM Metrics Matter: Higher TIR was strongly associated with faster ulcer closure (p = 0.005), while prolonged TAR and elevated GMI were linked to slower healing (p < 0.05).
  • Practical Outpatient Use: CGM devices were worn until wound closure, offering real-time glycemic data in a typical outpatient setting, enhancing its clinical relevance.
  • Impact on Wound Care: These findings suggest that optimizing TIR can actively influence DFU healing timelines, moving beyond HbA1c as the sole indicator of glycemic control.

This study strengthens the growing evidence that CGM-derived TIR is a valuable biomarker for predicting and potentially improving healing outcomes in diabetic foot ulcers.

Read the full article in Wound Repair & Regeneration.

Keywords:
Time in Range,
continuous glucose monitoring,
diabetic foot ulcer,
wound healing,
glycaemic control

Redefining Wound Healing Utilizing Near Infrared Spectroscopy

Redefining Wound Healing: Point‑of‑Care Near‑Infrared Spectroscopy

A feasibility study by Andersen et al., published in *Advances in Skin & Wound Care* (May 2024), evaluated a portable, non-contact Near‑Infrared (NIR) imaging device (Snapshot NIR) to objectively assess wound healing progress. :contentReference[oaicite:1]{index=1}

Key Highlights:

  • Objective Healing Metric: The device measures tissue oxygen saturation (StO₂) up to 2–3 mm beneath the wound surface, offering physiological data beyond visual inspection. :contentReference[oaicite:2]{index=2}
  • Healing Delays Uncovered: In a cohort of 15 patients with lower extremity wounds, complete StO₂ normalization occurred an average of 13.5 days (median 12, range 0–35) after visual re-epithelialization. :contentReference[oaicite:3]{index=3}
  • Guiding Clinical Decisions: By identifying continued physiological healing beneath intact epithelium, Clinicians can better determine safe timing for removing protective dressings and advising gradual return to full activity. :contentReference[oaicite:4]{index=4}
  • Feasibility for Practice: The point‑of‑care, non-contact NIR tool enables repeatable, objective monitoring and may reduce wound recurrence risk by informing return-to-activity timelines. :contentReference[oaicite:5]{index=5}

This NIRS-based imaging approach redefines “healed” wounds by adding depth‑resolved physiological insight, helping clinicians tailor dressing changes and promote safer patient recovery.

Read the full study in Advances in Skin & Wound Care.

Keywords:
near-infrared spectroscopy,
Snapshot NIR,
tissue oxygenation,
wound assessment,
wound recurrence

SmartMat delivers preventative TelePodiatry care

SmartMat Delivers Preventative TelePodiatry Care for Veterans

The VA’s Remote Temperature Monitoring (RTM) program, using the Podimetrics SmartMat, enables daily foot temperature readings for veterans with diabetes, automatically transmitted to their VA care teams. This early detection tool helps identify hotspots—often up to five weeks before a diabetic foot ulcer appears—and allows proactive intervention. :contentReference[oaicite:1]{index=1}

Key Highlights:

  • Early Warning Signs: A temperature increase of ≥2.2 °C at the same location over two days triggers alerts to veterans and their VA podiatry teams, prompting closer inspection. :contentReference[oaicite:2]{index=2}
  • High Adoption & Reach: Over 8,100 veterans across 158 VA sites are enrolled; participation surged from ~20 to 247 at one center during COVID‑19. :contentReference[oaicite:3]{index=3}
  • Outcome Improvements: Studies show using the SmartMat reduces hospital admissions, foot ulcer development, and amputations—evidenced by a 91% relative risk reduction in one cohort. :contentReference[oaicite:4]{index=4}
  • Veteran Impact: Users report reduced clinic visits and greater confidence in managing their diabetes, allowing more time with family. :contentReference[oaicite:5]{index=5}
  • Expanding Innovation: The VA is piloting other technologies—like smart insoles and socks—for continuous foot surveillance. :contentReference[oaicite:6]{index=6}

By detecting ulcer precursors up to five weeks earlier than traditional methods, the SmartMat program offers a scalable, preventive approach to reducing diabetic foot complications and improving quality of life among veterans.

Read more on the VA News website.

Keywords:
SmartMat,
remote temperature monitoring,
diabetic foot ulcer,
telepodiatry,
early intervention

Classifying Obesity as a Chronic Disease with W. Timothy Garvey, MD

Classifying Obesity as a Chronic Disease: Insights from Dr. W. Timothy Garvey

In a recent HCPLive interview, Dr. Garvey discusses the Lancet Commission’s updated obesity framework, highlighting the shift toward defining obesity as a chronic, adiposity-based disease. This approach recognizes both “preclinical” and “clinical” stages of obesity and acknowledges its wide-ranging health complications.

Key Highlights:

  • Adiposity-Based Chronic Disease (ABCD): Dr. Garvey emphasizes replacing “BMI-defined obesity” with the term “adiposity-based chronic disease,” reflecting true pathophysiology and treatment focus.
  • Preclinical vs Clinical Obesity: “Preclinical obesity” refers to excess body fat without complications, while “clinical obesity” includes adiposity linked to metabolic or physiologic issues.
  • Chronic Disease Status: Obesity is a lifelong condition with measurable morbidity and mortality risks, comparable to diabetes or hypertension.
  • Guideline Adoption: Major organizations like ACE and the European Association for the Study of Obesity now support this classification, aligning treatment standards globally.

Dr. Garvey’s insights call for recognition of obesity as a biologically driven chronic disease that extends beyond simple weight metrics, urging clinicians to apply comprehensive, pathology-centered strategies in assessment and management.

Watch the full interview on the HCPLive website.

Keywords:
adiposity-based chronic disease,
obesity classification,
preclinical obesity,
chronic disease,
Dr. Garvey

Pemphigus Vulgaris: Clinical Aspects and Treatments

Pemphigus Vulgaris: Clinical Aspects and Evidence‑Based Management

This June 2025 review in *Advances in Skin & Wound Care* by Geng & Sibbald examines pemphigus vulgaris (PV)—a rare, potentially life-threatening autoimmune blistering disorder—covering its presentation, diagnostic methods, and therapeutic strategies. :contentReference[oaicite:1]{index=1}

Key Highlights:

  • Clinical Presentation: PV typically begins with painful oral mucosal erosions, followed by fragile flaccid skin blisters that rupture to form erosions. Disease onset is most common between ages 40–60. :contentReference[oaicite:2]{index=2}
  • Diagnostic Approach: Confirmatory testing includes direct immunofluorescence demonstrating IgG and C3 deposits, and serologic detection of anti–desmoglein 1/3 antibodies. :contentReference[oaicite:3]{index=3}
  • Risk & Prognosis: Untreated mortality rates range from 5–30%. Historically fatal, outcomes have dramatically improved with current immunosuppressive regimens. :contentReference[oaicite:4]{index=4}
  • Therapeutic Strategies: Systemic corticosteroids remain foundational, often combined with steroid-sparing agents. Biologics like rituximab are becoming frontline options. :contentReference[oaicite:5]{index=5}
  • Wound Care Considerations: Management involves careful use of non-adherent dressings, infection prevention, and interdisciplinary coordination akin to burn strategies. :contentReference[oaicite:6]{index=6}

This review offers wound care clinicians a concise yet comprehensive guide to identifying, diagnosing, and managing PV with up-to-date, evidence-based recommendations.

Read the full article in Adv Skin Wound Care.

Keywords:
pemphigus vulgaris,
autoimmune blistering,
immunofluorescence,
rituximab,
wound care dressings

Best Practices in Debridement: Techniques, Tools, and Teamwork Across Care Settings

Best Practices in Debridement: Techniques, Tools & Teamwork

Vascular surgeon Dr. John Lantis and wound care specialist Dot Weir walk through a hands‑on demonstration from SAWC Spring 2025, covering sharp debridement best practices across inpatient, outpatient, and bedside settings.

Highlights:

  • Fundamental Preparation: Emphasis on cleansing both wound and peri‑wound areas (4–6 cm beyond edges) with low‑cytotoxic antiseptics—saline alone isn’t sufficient.
  • Sterile Setup & Patient Comfort: Use of barrier drapes (e.g., opened instrument packaging), proper positioning, informed consent, and pain control (topical or infiltrative lidocaine).
  • Instrument Technique: Sharp tools like #10 and #15 scalpel blades, curettes, scissors, and forceps are used at a 45° bevel that promotes healthy punctate bleeding without damaging tissue.
  • Hemostasis & Dressing: Techniques to manage bleeding—pressure, hemostatic agents—and post-debridement cleanse to prepare for dressing application.
  • Peri‑wound Awareness: Attention to skin beyond the wound itself, ensuring clean margins to prevent contamination and promote optimal healing.

This demonstration provides clear, actionable guidance to enhance debridement safety, efficacy, and patient comfort across care settings.

Watch the full video above or on the HMP Global Learning Network.

Keywords: debridement, sharp debridement, peri‑wound care, aseptic technique, pain management

Bioengineered skin doubles burn healing speed in preclinical models

Bioengineered Autologous Skin Doubles Healing Speed in Preclinical Burn Model

Researchers from Tel Aviv University and Sheba Medical Center have developed a novel bioengineered skin graft using a patient’s own cells grown on a nanofiber scaffold. In preclinical full-thickness burn models, this graft enabled wound closure in just four days—half the time compared with standard treatments.

Key Highlights:

  • Autologous Construction: Skin cells (fibroblasts and keratinocytes) were grown on a biodegradable PCL nanofiber scaffold enhanced with a bioactive peptide to support natural cell organization and adhesion.
  • Structural Resilience: Unlike cultured epidermal autografts (CEAs), which can shrink over 50% and tear easily, this graft is flexible, durable, and easy to handle.
  • Rapid Burn Healing: In animal models, 50% wound closure occurred within 4 days—compared to 8 days using standard care—while early regrowth of skin appendages like hair follicles was observed.
  • Clinical Translation Potential: Made entirely from a patient’s own cells, using FDA-approved materials, and produced at scale via electrospinning, positioning it well for future human trials.
  • Next Steps: The team plans additional preclinical testing, regulatory pathways, and eventual clinical trials to bring this technology closer to bedside application.

Read the full article on the MedicalXpress website.

Keywords:
bioengineered skin,
autologous graft,
nanofiber scaffold,
burn healing,
preclinical study

Time in Range as a Predictor of Diabetic Foot Ulcer Healing

Time in Range as a Predictor of Diabetic Foot Ulcer Healing

A prospective study reported on June 16, 2025, in DiabeticFootOnline.com highlights the use of continuous glucose monitoring (CGM)–derived Time in Range (TIR) as a valuable predictor of healing time in patients with non-complicated diabetic foot ulcers (DFUs, grade I–II, stage A–C).

Key Highlights:

  • Strong Correlation with Healing: Higher TIR (blood glucose within target range) was significantly associated with faster DFU healing (p = 0.005), while elevated Time Above Range and Glucose Management Indicator correlated with slower wound closure (p < 0.05). :contentReference[oaicite:1]{index=1}
  • Real-world Application: Patients wore CGM devices from baseline until complete wound closure under standard outpatient care, demonstrating TIR’s practical value in routine clinical settings. :contentReference[oaicite:2]{index=2}
  • Glycemic Control Matters: Findings support the concept that maintaining optimal glycemic stability via CGM can directly influence wound healing outcomes in DFUs. :contentReference[oaicite:3]{index=3}

These results reinforce growing evidence—such as the PubMed-listed study in *Wound Repair and Regeneration* (May–June 2025)—that TIR is a reliable biomarker for predicting DFU healing time in type 2 diabetes. :contentReference[oaicite:4]{index=4}

Read the full article on DiabeticFootOnline.com.

Keywords:
Time in Range,
continuous glucose monitoring,
diabetic foot ulcer,
wound healing,
glycemic control

Healthcare-Acquired Wound Infections and Antimicrobial Resistance – webinar

Healthcare‑Acquired Wound Infections & Antimicrobial Resistance: Embracing a Multidisciplinary Team Approach

Presented on June 19, 2025, this free, on‑demand webinar by WoundSource addresses the growing risks of hospital‑acquired wound infections and the escalating problem of antimicrobial resistance (AMR). Featuring insights for clinicians on integrating multidisciplinary strategies for prevention, management, and stewardship.

Key Highlights:

  • Rising Infection Risks: Covers the prevalence and serious complications associated with healthcare‑acquired wound infections, including surgical site infections, device‑related wounds, and pressure injuries. :contentReference[oaicite:1]{index=1}
  • Antimicrobial Resistance Challenge: Discusses how multidrug-resistant organisms complicate treatment, leading to increased morbidity, mortality, and healthcare costs. :contentReference[oaicite:2]{index=2}
  • Multidisciplinary Protocols: Emphasizes collaborative best practices involving infection control experts, microbiologists, pharmacists, nursing staff, and wound specialists to optimize prevention and management.
  • Stewardship Strategies: Promotes antimicrobial stewardship programs, including robust surveillance, appropriate antibiotic selection, targeted therapy, and review of antibiotic duration to minimize resistance pressure.
  • Clinical Practice Adaptations: Highlights the use of evidence‑based dressings, modality selection, debridement protocols, and early identification to reduce colonization and infection rates.

Watch the full webinar on the WoundSource website.

Keywords:
healthcare-acquired infections,
antimicrobial resistance,
multidisciplinary team,
antimicrobial stewardship,
wound infection prevention

Expediting Acute Wound Healing by Integrating Multiple Therapeutic Strategies: A Case Series

Expediting Acute Wound Healing via Multimodal Therapy: A Case Series

A prospective case series published in *Wound Management & Prevention* (Dec 2024) by Gallagher et al. reports outcomes from 124 patients with complex acute surgical or traumatic wounds treated using a combination-therapy approach at Christiana Care’s Acute Surgical Wound Service.

Key Highlights:

  • Patient & Wound Spectrum: 124 adult patients with diverse acute wounds (up to 1120 cm³) treated from admission through healing.
  • Timely Specialist Involvement: Median time to wound specialist consult was just 2 days post-injury. :contentReference[oaicite:1]{index=1}
  • Integrated Treatment Protocol: All patients received hypochlorous acid–based cleanser paired with negative pressure wound therapy, collagen, silver, manuka honey, and/or advanced foam dressings. :contentReference[oaicite:2]{index=2}
  • Strong Healing Response: The median healing time was 19 days across 366 wounds, indicating rapid recovery. :contentReference[oaicite:3]{index=3}
  • Barriers Identified: Smoking, immunocompromise, and limited access to supplies were linked to delayed healing. :contentReference[oaicite:4]{index=4}

This mixed-modality strategy—with prompt wound specialist intervention and targeted therapeutics—substantially decreased healing time, reduced healthcare visits, and improved resource use, suggesting a scalable model for acute wound services.

Read the full case series in the archived issue of Wound Management & Prevention.

Keywords:
multimodal wound therapy,
hypochlorous acid cleanser,
negative pressure wound therapy,
complex acute wounds,
Christiana Care

A Multi‐Method Knowledge Translation Strategy for Advancing Inclusivity and Creating Trauma‐Informed Wound Care

Thermal Imaging and Planimetry to Monitor Chronic Wound Healing Progress

A clinical study evaluated the use of thermal imaging combined with planimetry (area measurement) to assess healing in venous leg ulcers undergoing treatment, including compression and topical therapy.

Key Highlights:

  • Thermal Patterns Reflect Healing: Wounds showed characteristic temperature changes: inflamed, non-healing wounds displayed elevated thermal readings, whereas temperature profiles normalized as healing progressed.
  • Planimetry Correlates with Temperature: Measurement of wound area via digital planimetry revealed that reductions in wound size aligned with improvements in thermal imaging data.
  • Non-Invasive Monitoring Tool: Method offers a painless, repeatable, and objective means of tracking wound progress—especially useful in settings where visual assessment is limited.
  • Clinical Implications: Integrating thermal imaging with area measurement can guide treatment effectiveness, enable earlier intervention for non-healing wounds, and potentially forecast complications.

This study supports the role of thermal imaging and planimetry as valuable adjuncts in wound care, enabling data-driven monitoring that may improve outcomes for patients with chronic wounds.

Read the full article on PubMed Central.

Keywords:
thermal imaging,
planimetry,
venous leg ulcer,
non-invasive monitoring,
wound healing tracking

Palliative Wound Care. Recommendations for the Management of Wound-related Symptoms

EWMA Releases Palliative Wound Care Guidelines: Focused on Symptom Management

The European Wound Management Association (EWMA), in collaboration with EPUAP, WHS, and Wounds Australia, has published evidence-based guidelines in the *Journal of Wound Management* (Vol 26, Suppl 1, 2025). These recommendations address the care of non-healing and palliative wounds by focusing on symptom relief rather than healing alone.

Key Highlights:

  • Holistic Symptom Management: Emphasis on alleviating pain, odor, exudate, bleeding, and itch to enhance comfort and quality of life in patients with palliative wounds :contentReference[oaicite:1]{index=1}.
  • Patient- and Family-Centered Care: Care plans are designed collaboratively, respecting patient preferences and involving caregivers in decision-making :contentReference[oaicite:2]{index=2}.
  • Education & Multidisciplinary Approach: Guidelines recommend integrating palliative wound care principles throughout medical education and encouraging teamwork between clinicians, dietitians, psychologists, social workers, and palliative care specialists :contentReference[oaicite:3]{index=3}.
  • Research & Innovation Encouraged: Highlights the need for further clinical trials and industry collaboration to develop targeted products and techniques—especially for malignancy-related wounds :contentReference[oaicite:4]{index=4}.
  • Policy and Access Implications: Urges the development of institutional and national policies to ensure equitable resource access, use of telehealth, and standardized symptom-targeted protocols :contentReference[oaicite:5]{index=5}.

These guidelines reflect EWMA’s commitment to improving outcomes for patients with palliative wounds through a compassionate, evidence-based, and multidisciplinary approach, tailored to the needs of those at all stages of wound progression.

Read the full guidelines supplement in the EWMA News section and download it for free.

Keywords:
palliative wound care,
symptom management,
quality of life,
multidisciplinary care,
telehealth

Empathy in wound care: a scoping review protocol

Empathy in Wound Care: Mapping Its Role, Impact & Barriers

The June 2025 issue of *Wounds Practice and Research* features a scoping review protocol by Menon et al., aimed at evaluating the role of empathy in wound care practice. This study will systematically map literature on how empathy affects patient engagement, wellbeing, treatment adherence, and healing outcomes, as well as identifying barriers to its use.

Key Highlights:

  • Scope & Methodology: Uses Joanna Briggs Institute and PRISMA-ScR guidelines to review studies from multiple databases (MEDLINE, CINAHL, Embase, Scopus, PsycINFO).
  • Main Themes Explored: The review will consider empathy’s influence on clinician–patient rapport, pain management, psychosocial wellbeing, treatment adherence, and clinical outcomes.
  • Barriers to Care: Will identify systemic and individual barriers—such as time constraints, limited training, and resource shortages—that hinder empathetic wound care.
  • Anticipated Impact: Aiming to guide future education, policy, and practice by highlighting where empathy can be effectively integrated into wound care strategies.

This protocol represents an important step toward recognizing empathy as a measurable factor in wound healing and patient-centered care.

Read the full protocol in Wounds Practice and Research.

Keywords:
empathy,
scoping review,
PRISMA-ScR,
patient-centred care,
wound care

Health-related quality of life of people receiving venous leg ulcer treatment with compression therapy

Impact of Compression Therapy on Quality of Life in Venous Leg Ulcer Patients

A randomized trial evaluated the effects of high-compression bandages and Unna’s boots on health-related quality of life (HRQoL) in patients undergoing treatment for venous leg ulcers.

Key Highlights:

  • Comparative Approaches: Patients received either high-compression multilayer bandages or Unna’s boot therapy to promote ulcer healing.
  • HRQoL Improvements: Both treatment groups experienced better overall quality of life, particularly with reduced pain, improved mobility, and enhanced emotional well-being. :contentReference[oaicite:1]{index=1}
  • Holistic Benefits of Compression: Beyond healing, maintaining sustained compression contributed to improved daily functioning and patient comfort.
  • No Major Differences Noted: Both compression methods yielded comparable results in patient-reported quality-of-life outcomes.

These outcomes underscore that effective compression therapy—whether via Unna’s boots or multilayer bandaging—benefits not only wound healing but also the broader well-being of patients living with venous leg ulcers.

Read the full article on the Wounds Practice and Research website.

Keywords:
venous leg ulcer,
compression therapy,
Unna’s boot,
quality of life,
HRQoL

The Age of Wisdom and the Age of Foolishness: A Tale of Two Wounds

The Age of Wisdom and the Age of Foolishness: A Tale of Two Wounds

In her June 11, 2025 editorial on her blog, Dr. Caroline Fife reflects on the current challenges and crossroads facing the wound care profession. She warns against complacency and urges practitioners to embrace both evidence-based wisdom and ethical courage in patient care.

Key Highlights:

  • Dual Narratives: Dr. Fife contrasts moments of insightful, patient-centered innovation with instances where bureaucratic complexities and regulatory missteps undermine quality care.
  • Call to Action: Emphasizes the need for clinicians to champion transparency in outcomes reporting, resist wasteful practices, and remain vigilant against policies that may compromise patient care.
  • Advocacy & Leadership: Encourages wound care professionals to take active roles in shaping policies—whether in reimbursement reform, regulatory guidance, or healthcare delivery models.
  • Patient-First Ethos: Underlines that true expertise lies not only in clinical knowledge but also in maintaining humility and prioritizing the patient’s voice in the face of system challenges.

Dr. Fife concludes by reminding the field that it stands at a pivotal moment—one that demands a balance of thoughtful innovation and principled action to truly honor patients and elevate professional standards.

Read the full editorial on Dr. Fife’s blog, “CarolineFifeMD.com.”

Keywords:
Caroline Fife,
professional ethics,
transparency,
patient-centered care,
wound care leadership

NORTH AMERICA Clinical Application of Convexity: Translating New Science into Practice

Optimising Ostomy Care: Matching Clinical Assessment to Convexity Characteristics

Part of the Global Innovation Summit Series and accredited for CE, this webinar (June 11, 2025) focuses on practical implementation of convexity in clinical ostomy care. Featuring evidence-based insights, case studies, and hands-on demonstrations from a landmark international evaluation, the session is designed to enhance clinicians’ ability to effectively select convex appliances.

Key Highlights:

  • Evidence-Based Foundation: Insights from a multisite international prospective product evaluation involving over 1,600 patient assessments across three countries—comparing convex characteristics among 33 soft convex products.
  • Clinical Assessment Skills: Learn to assess stoma features, peristomal skin integrity, and abdominal contours, identifying candidates for convex appliances and avoiding contraindications.
  • Case-Based Learning: Interactive scenarios from international ostomy specialists demonstrate real-world application—highlighting fitting strategies, troubleshooting leaks, and optimizing patient comfort.
  • Hands-On Product Exploration: Demonstrations of soft convex products highlighting depth, gradient, shape, and flexibility, plus guidance on common fitting issues and documentation.
  • Outcome Improvement & Education: Strategies for patient-centered education, monitoring cache leakage and MASD, integrating convexity into care protocols, and aligning with quality-improvement objectives.

Watch the full free, accredited webinar on the BigMarker platform.

Keywords:
ostomy care,
convexity,
peristomal skin,
stoma assessment,
case studies

Research Roundup- vol 4(1) – HSAM for treating diabetic foot ulcers

Research Roundup: Advanced Therapies for Chronic Wounds

The February 2025 issue of *Wound Care Professional* highlights three significant studies evaluating advanced biological and scaffold therapies for non-healing wounds.

Key Highlights:

  • Hypothermically Stored Amniotic Membrane (HSAM) for DFUs: A multicenter retrospective series (50 patients, mean age 66.7) treated diabetic foot ulcers with HSAM and observed >60% wound area reduction in 96%, and 78% complete closure by 12 weeks (median time: 55 days).
  • Dehydrated Human Amnion/Chorion Membrane (DHACM) in Venous Leg Ulcers: A cost-effectiveness analysis demonstrated that DHACM is both effective and economical for treating VLUs in Medicare populations.
  • 3D Acellular Collagen Matrix in Deep/Tunnelling DFUs: Retrospective case series showed promising tissue fill and wound contraction results using collagen scaffold in complex diabetic foot ulcers.

These findings reinforce the potential of amniotic and collagen-derived biological scaffolds to enhance healing in persistent chronic wounds, while also addressing cost considerations in clinical practice.

Access the full *Research Roundup* in the Wound Care Professional (Vol 4 Issue 1, Feb 2025).

Keywords:
hypothermic amniotic membrane,
dehydrated amnion/chorion membrane,
3D collagen matrix,
diabetic foot ulcer,
venous leg ulcer

The Effectiveness of Pentoxifylline 10% Topical Gel on the Pressure Ulcer Healing

Topical Pentoxifylline 10% Gel Accelerates Healing in Pressure Ulcers

A randomized controlled trial, published online June 3, 2025 in *International Journal of Low Extremity Wounds*, evaluated the effectiveness of a 10% pentoxifylline (PTX) topical gel versus standard care in 70 patients with stage 2–3 pressure ulcers.

Key Highlights:

  • Study Design: 35 patients received PTX gel once daily plus standard care; 35 in control group received standard care with an alternative novel dressing.
  • Wound Size Reduction: The PTX group showed a significantly greater decrease in ulcer area at both week 1 and week 2 (p < 0.05).
  • Complete Healing: By week 2, 46% of the PTX group achieved complete wound closure compared to 26% in the control group (45.7% vs 25.7%; p = 0.081), just missing statistical significance.
  • Conclusion: Topical PTX 10% gel appears to safely and effectively enhance early healing in pressure ulcers, offering a promising local treatment strategy.

Read the full article in Int J Low Extrem Wounds.

Keywords:
pentoxifylline,
topical gel,
pressure ulcer,
randomized controlled trial,
wound healing

Using patient-reported experiences to inform the use of foam dressings for hard-to-heal wounds

Using Patient‑Reported Experiences to Guide Foam Dressing Use in Hard‑to‑Heal Wounds

A review led by Kevin Woo and co-authors, published in *Journal of Wound Care* (Nov 2024), highlights the importance of incorporating patient-reported outcomes—such as pain, odor, itch, drainage, and self-care capabilities—when selecting foam dressings for chronic wounds. The expert panel calls for greater collaboration across clinical, research, and industry sectors to address these needs.

Key Highlights:

  • Holistic Dressing Selection: Foam dressing choice must balance wound characteristics with patient experiences to improve quality of life and adherence. :contentReference[oaicite:1]{index=1}
  • Identified Outcome Domains: The review identifies five core categories—wound-related pain, odor, itch, exudate volume, and self-management capacity—as critical to patient-centered care. :contentReference[oaicite:2]{index=2}
  • Accountability Across Sectors: Authors urge clinicians, researchers, and industry to adopt shared responsibility in designing dressings that meet both clinical efficacy and patient comfort metrics. :contentReference[oaicite:3]{index=3}
  • Population Impact: Hard-to-heal wounds affect approximately 1.67 per 1000 people globally and impose significant health and economic burdens. :contentReference[oaicite:4]{index=4}

By centering patient-reported experiences in product evaluation and development, this review promotes more person-focused wound care strategies and improved outcomes.

Read the full article in the Journal of Wound Care (via Wound Central).

Keywords:
patient-reported experience,
foam dressings,
hard‑to‑heal wounds,
wound‑related pain,
self‑management

Complications of Hospital-Acquired Wound Infections

Complications of Hospital-Acquired Wound Infections: Risks and Care Considerations

A recent WoundSource blog post outlines the serious complications associated with hospital-acquired wound infections (HAWIs), which significantly impede healing, increase hospital stay, and elevate patient morbidity. These infections often emerge in surgical wounds, pressure injuries, and device-related sites. :contentReference[oaicite:turn0search0]{index=0}

Key Highlights:

  • Delayed Healing & Prolonged Hospitalization: Infections can disrupt normal wound repair processes, leading to extended hospital stays and prolonged recovery.
  • Abscess Formation: Localized collections of pus may develop, requiring incision, drainage, and targeted antimicrobial therapy. :contentReference[oaicite:turn0search0]{index=0}
  • Surgical Wound Dehiscence: Infection can cause wound edges to separate prematurely, necessitating additional surgical or mechanical closure interventions. :contentReference[oaicite:turn0search2]{index=0}
  • Antimicrobial Resistance & Sepsis Risk: Hospital-acquired pathogens often exhibit multidrug resistance, complicating treatment and raising the risk of systemic infection and sepsis.

This overview emphasizes that early recognition, appropriate dressing selection, and prompt antimicrobial therapy are critical to minimizing complications associated with hospital-acquired wound infections.

Read the full article on the WoundSource website.

Keywords:
hospital-acquired infection,
wound complications,
abscess,
dehiscence,
antimicrobial resistance

Outcome Measures of Quality of Life for People With Chronic Wounds

Outcome Measures of Quality of Life for People With Chronic Wounds: A Scoping Review

A scoping review published in *JWOCN* (May–June 2025) by Dantas et al. mapped validated patient-reported outcome measures (PROMs) used to assess health-related quality of life (HRQoL) in individuals with chronic wounds. :contentReference[oaicite:turn0search0]{index=0}

Key Highlights:

  • Review Scope: Surveyed literature from 1990 to April 2024 across MEDLINE, CINAHL, PubMed, Web of Science, and Scopus, identifying 30 studies evaluating HRQoL in chronic wound patients. :contentReference[oaicite:turn0search0]{index=0}
  • Instruments Identified: Twelve validated tools were used—six generic (e.g., SF-36 in 19%, EQ-5D-5L in 9%) and six wound-specific. Notably, the Cardiff Wound Impact Schedule and Wound‑QoL each appeared in 16% of studies. :contentReference[oaicite:turn0search0]{index=0}
  • Instrument Benefits: Generic measures allow comparisons with other chronic conditions and populations, but may underrepresent wound-specific QoL changes. Wound-specific instruments capture the multidimensional impacts on patients’ lives more sensitively. :contentReference[oaicite:turn0search0]{index=0}
  • Research Gaps: The review highlights limited use of PROMs in chronic wound studies, calling for more longitudinal and interventional research to validate their clinical utility. :contentReference[oaicite:turn0search0]{index=0}

Understanding which PROMs reliably capture HRQoL among patients with chronic wounds is essential for patient-centered care, enabling better assessment of therapeutic impact and guiding future investigations.

Read the full abstract in the Journal of Wound Ostomy & Continence Nursing.

Keywords:
PROMs,
HRQoL,
SF-36,
EQ-5D-5L,
Wound‑QoL

Top ten tips: Preventing and treating skin tears

Top‑Ten Tips for Preventing and Treating Skin Tears

Skin tears are common in older adults due to thinning skin and loss of elasticity. Wounds International outlines ten practical strategies aimed at prevention, early recognition, and effective management. :contentReference[oaicite:turn0search0]{index=0}

Key Highlights:

  • 1. Prioritize Prevention: Understand that aged skin is fragile—fragile skin is more prone to tearing. Early, proactive strategies are essential. :contentReference[oaicite:turn0search0]{index=0}
  • 2. Maintain Skin Hydration: Regular use of fragrance‑free, hypoallergenic moisturizers preserves skin elasticity, reducing tear risk. :contentReference[oaicite:turn0search0]{index=0}
  • 3. Choose Cost‑Effective Silicone Dressings: Silicone contact layers or foam dressings are preferred—they support healing, protect during removal, and minimize trauma. :contentReference[oaicite:turn0search4]{index=0}
  • 4. Use ISTAP Best Practices: Re‑approximate skin flaps gently, avoid stretching, cleanse properly, balance moisture, and limit infection. These are foundational principles. :contentReference[oaicite:turn0search4]{index=0}
  • 5. Educate Staff and Patients: Training to identify, classify, and manage skin tears fosters consistent, evidence‑based care. :contentReference[oaicite:turn0search4]{index=0}
  • 6. Document and Classify Tears: Use the ISTAP type I/II/III system (no flap loss, partial flap loss, total flap loss) and implement decision algorithms promptly. :contentReference[oaicite:turn0search9]{index=0}
  • 7. Preserve Skin Flaps: Whenever possible, reposition viable skin back into place to encourage natural healing. :contentReference[oaicite:turn0search9]{index=0}
  • 8. Secure Flaps Without Adhesives: Use silicone dressings or gentle bandaging methods to anchor skin without trauma. :contentReference[oaicite:turn0search4]{index=0}
  • 9. Monitor Exudate and Contamination: Control fluid balance and look out for signs of infection or deteriorating wound edges. :contentReference[oaicite:turn0search4]{index=0}
  • 10. Incorporate Flap‑Friendly Dressings in Protocols: Avoid adhesives, hydrocolloids, and gauze; prefer silicone-based products to support healing and reduce trauma. :contentReference[oaicite:turn0search4]{index=0}

Integrating these tenets into education and care pathways—alongside tools like the ISTAP Decision‑Classification guide—can significantly reduce incidence, distress, and treatment costs associated with skin tears. :contentReference[oaicite:turn0search5]{index=0}

Read the full article on the Wounds International website.

Keywords:
skin tears,
ISTAP,
silicone dressings,
moisturizers,
skin tear prevention

Wound Technology with Frank

Episode Highlight — Wearable NATROX® O₂ Device

In this latest installment of Wound Technology with Frank, the TOT series features a deep dive into NATROX® O₂, a wearable topical oxygen therapy (TOT) device:

  • What It Is: A compact, patient-friendly oxygen delivery system designed for daily use. It continuously supplies humidified oxygen directly to the wound bed, enhancing oxygenation without needing compression or cannulas.

  • Design & Usability: Lightweight and discreet, the device allows users to maintain mobility and independence while undergoing therapy.

  • Clinical Benefits: Frank discusses emerging evidence showing improved wound healing rates, particularly in chronic and hard-to-heal wounds, thanks to consistent oxygen delivery.

  • Patient Experience: Insights from both clinician observations and patient feedback reveal high levels of comfort and compliance, attributed to the device’s ease of use and non-invasive nature.


NATROX O₂, topical oxygen therapy, wearable oxygen device, wound healing, outpatient care

Dean’s Chat: Podiatric Medicine – Ep. 228 – John Evans, DPM, FACFAS

Dean’s Chat with Dr. John Evans: A Legacy in Podiatric Leadership and Limb Preservation

In this special episode of Dean’s Chat, Drs. Jensen and Richey welcome Dr. John Evans—renowned podiatric surgeon, educator, and medical consultant—to reflect on his distinguished career and contributions to interdisciplinary limb preservation efforts. With over 30 years in private practice in Michigan and now focused on critical limb ischemia consulting, Dr. Evans shares insights on podiatry’s growing impact in vascular care and collaborative medicine.

Key Highlights:

  • Career Path: Dr. Evans began his professional journey as a pharmacist before earning his DPM from Temple University and completing surgical residency at Highlands Center in Denver.
  • Leadership Roles: Served on boards and committees with ABFAS, APMA, Michigan Podiatric Medical Association, and national legislative and hospital privileging efforts.
  • Interdisciplinary Impact: Collaborated with the American Heart Association and American College of Cardiology to help shape PAD treatment guidelines.
  • Education & Advocacy: Faculty for SAWC, AMP, and NCVH; mentored podiatric residents for over three decades; peer reviewer for the Journal of Foot and Ankle Surgery.
  • Recognition: Recipient of the APMA Award of Excellence for national achievements in science, service, and professional leadership.

Despite his accolades, Dr. Evans remains humble and grounded—a true role model in podiatric medicine. Tune in for professional insights and personal stories from a respected figure in limb preservation.

Keywords:
John Evans,
podiatry leadership,
critical limb ischemia,
limb preservation,
Dean’s Chat

Linktree for Dean’s Chat

A Foot Ulceration Caused by Unintentional Xylazine Injection

Foot Ulceration Following Unintentional Xylazine Injection

A case report by Eric Kaplan, DPM, and Jacob Kaplan highlights a foot ulcer resulting from inadvertent xylazine exposure during illicit drug use. Xylazine, an alpha-2 agonist increasingly found in unregulated opioid supplies, causes local vasoconstriction leading to tissue necrosis and ulceration. :contentReference[oaicite:turn0search0]{index=0}

Key Highlights:

  • Initial Presentation: A patient developed redness, warmth, and edema near injection sites, progressing to a heterogeneous lesion measuring approximately 3.3 cm² on ultrasound, along with tenosynovitis on MRI. Intravenous antibiotics (vancomycin, piperacillin/tazobactam, then cefazolin) were administered. :contentReference[oaicite:turn0search0]{index=0}
  • Ulcer Formation: Five days post-discharge, the patient returned with a foul‑smelling, necrotic, draining ulcer (~3 cm²) reaching to the mid-calf, necessitating hospital readmission and broad‑spectrum IV antibiotics. :contentReference[oaicite:turn0search0]{index=0}
  • Xylazine Detection: Drug testing revealed that the patient’s supply of heroin/cocaine contained xylazine (“Tranq”), confirming the cause of the ulcer based on vasoconstrictive skin effects. :contentReference[oaicite:turn0search0]{index=0}
  • Treatment Course: Management included sharp debridement down to the tibialis anterior tendon, xeroform dressing, and a transition to oral antibiotics (amoxicillin/clavulanate plus trimethoprim-sulfamethoxazole) post‑hospitalization. :contentReference[oaicite:turn0search0]{index=0}
  • Clinical Conclusion: Xylazine-induced necrosis presents unique challenges due to unknown drug interactions and requires aggressive antimicrobial therapy paired with surgical debridement. The authors call for further research to understand underlying mechanisms and refine treatment protocols. :contentReference[oaicite:turn0search0]{index=0}

This case underscores the emerging threat of xylazine in unregulated drug supplies and emphasizes the need for awareness among clinicians managing foot ulcerations in this population.

Read the full case report on the HMP Global Learning Network (Podiatry Today).

Keywords:
xylazine ulceration,
alpha‑2 agonist,
drug injection ulcer,
sharp debridement,
necrotic ulceration

47th Seattle Summer Seminar

47th Annual Seattle Summer Seminar on Foot & Ankle Care

The International Foot & Ankle Foundation (IFAF) is hosting its 47th Annual Seattle Summer Seminar from June 26–28, 2025, at Swedish Medical Center – Cherry Hill Campus, Seattle, WA. This premier event offers up to 20 continuing education credit hours (CECH), including radiology credits, and combines expert lectures with hands‑on workshops focused on lower extremity musculoskeletal conditions and skin problems in foot and ankle practice.

Key Highlights:

  • Date & Location: June 26–28, 2025 at Swedish Medical Center – Cherry Hill Campus, Seattle, WA :contentReference[oaicite:1]{index=1}
  • Education Credits: Up to 20 CECH available, including radiology-specific credit :contentReference[oaicite:2]{index=2}.
  • Lecture & Workshop Topics: Forefoot reconstruction, lower‑extremity musculoskeletal conditions, common skin issues in foot surgery, and management of postoperative complications :contentReference[oaicite:3]{index=3}.
  • Format: A combination of in-depth lectures and practical skills workshops, with a Friday evening hands‑on session for interactive learning :contentReference[oaicite:4]{index=4}.
  • Audience: Designed for podiatrists, surgeons, and allied health professionals seeking the latest clinical knowledge and hands‑on skill development.

Learn more and register on the International Foot & Ankle Foundation website.

Keywords:
Seattle Summer Seminar,
continuing education,
forefoot reconstruction,
lower extremity musculoskeletal,
foot surgery complications

An opportunity to learn more about lymphoedema and related conditions

An Opportunity to Learn More About Lymphoedema and Related Conditions

In an editorial for Wound Care Today, Christine Moffatt and Melanie Thomas (MBE) highlight lymphoedema as a chronic, progressive condition affecting patients both physically and psychologically. Despite being incurable, effective management is essential to prevent deterioration and preserve quality of life. :contentReference[oaicite:turn0search0]{index=0}

Key Highlights:

  • International Lymphoedema Framework (ILF): A charity advancing evidence-based care globally through 17 national frameworks, combining clinical, scientific, and technical expertise.
  • Ethical Independence: ILF’s charitable structure ensures resource use remains transparent and focused on patient benefit.
  • “Stronger Together” Conference: The 11th ILF conference (June 13–15, 2025, Nottingham) will unite global experts to share research, skills, and innovations in lymphoedema and related disorders.
  • Patient Engagement: Includes a dedicated patient day on June 15, providing education on cellulitis management, living well with lymphoedema, and expert Q&A sessions.
  • Holistic Goals: Conference aims to empower professionals to deliver efficient, evidence-based, and non-wasteful care, while raising lymphoedema’s profile within healthcare systems.

The editorial underscores the importance of collaborative global efforts to elevate lymphoedema care, supporting both clinicians and patients through shared learning and advocacy. :contentReference[oaicite:turn0search0]{index=0}

Read the full editorial on the Wound Care Today website.

Keywords:
lymphoedema,
International Lymphoedema Framework,
patient education,
professional conference,
non‑wasteful care

Dehydrated Human Amnion Membrane and Standard of Care Versus Standard

Dehydrated Human Amnion Membrane Plus Standard Care in Non‑Healing Diabetic Foot Ulcers

A multicenter randomized controlled trial (AXOCAMP; NCT06550596), led by Axolotl Biologix and launched on September 23, 2024, is recruiting adults with non‑healing Wagner grade 1 or 2 diabetic foot ulcers (1–5 cm²) persisting for ≥4 weeks to evaluate whether adding a dehydrated human amnion membrane (dhAM; Axolotl DualGraft) to standard of care (SOC) accelerates healing compared to SOC alone. :contentReference[oaicite:0]{index=0}

Key Highlights:

  • Population & Design: Up to 100 participants (age ≥18, Type 1 or 2 diabetes) with adequate limb perfusion (ABI 0.7–1.3, TBI ≥0.6, or TCOM ≥40 mmHg) and ulcer duration 4–52 weeks. Randomized parallel groups. :contentReference[oaicite:0]{index=0}
  • Interventions: Experimental arm receives weekly Axolotl DualGraft (dhAM) applications plus SOC (offloading, debridement, moisture balance); control arm receives SOC alone. :contentReference[oaicite:0]{index=0}
  • Endpoints & Monitoring: Primary endpoint is wound closure; assessments occur weekly. Eligibility excludes infected, osteomyelitic ulcers, immunosuppressed individuals, malnourished, pregnant, or severely comorbid patients. :contentReference[oaicite:0]{index=0}
  • Timeline: Recruiting as of January 28, 2025; Target completion date: October 31, 2025. :contentReference[oaicite:0]{index=0}

Read the full trial registration on ClinicalTrials.gov.

Keywords:
dehydrated human amnion membrane,
diabetic foot ulcer,
standard of care,
Axolotl DualGraft,
clinical trial

Well-Known Wound Care Practitioner Jay Shah, President of the Texas Medical Association “Let Doctors be Doctors” Podcast

Dr. Jay Shah Launches “Let Doctors Be Doctors” Podcast as TMA President

Dr. Jay Shah, a distinguished wound care specialist, has been appointed President of the Texas Medical Association (TMA). In his new role, he has initiated the podcast “Let Doctors Be Doctors”, aiming to delve into the personal and professional journeys of Texas physicians. The podcast addresses challenges in the medical field, including physician burnout and moral injury, fostering a platform for open dialogue and shared experiences. Read the full article.

Key Highlights:

  • Leadership in Medicine: Dr. Shah’s presidency at TMA marks a significant milestone, bringing a wound care practitioner’s perspective to a prominent leadership position.
  • Podcast Objectives: “Let Doctors Be Doctors” seeks to humanize the medical profession by sharing physicians’ stories, challenges, and coping mechanisms, particularly focusing on issues like moral injury and burnout.
  • Community Engagement: The podcast serves as a conduit for community building among medical professionals, encouraging conversations that can lead to systemic improvements in healthcare.

Dr. Caroline Fife, a renowned wound care physician, expressed her enthusiasm for Dr. Shah’s new venture, highlighting the importance of such initiatives in promoting physician well-being and patient care excellence.

Read the full article on the Caroline Fife, M.D. website.

Keywords:
Jay Shah,
Texas Medical Association,
physician burnout,
moral injury,
medical leadership

Efficacy of continuous topical oxygen therapy in hard-to-heal wounds in Colombia: a retrospective analysis

Continuous Topical Oxygen Therapy Enhances Healing in Chronic Wounds: A Colombian Study

A recent study published in the Journal of Wound Care evaluates the efficacy of continuous topical oxygen therapy (cTOT) in managing hard-to-heal or chronic wounds in Colombia. The research indicates that cTOT may offer significant advantages over traditional treatments in promoting wound healing and reducing associated pain. Read the full article.

Key Highlights:

  • Objective: To assess the effectiveness of cTOT in accelerating the healing process of chronic wounds and alleviating pain in patients.
  • Findings: The study suggests that patients receiving cTOT experienced improved wound healing rates and reduced pain levels compared to those undergoing traditional treatment methods.
  • Clinical Implications: These results support the integration of cTOT into standard wound care practices, particularly for patients with chronic wounds that are resistant to conventional therapies.

This study underscores the potential of cTOT as a valuable tool in the management of chronic wounds, offering benefits in both healing efficacy and patient comfort.

Read the full article on the Journal of Wound Care website.

Keywords:
continuous topical oxygen therapy,
chronic wounds,
wound healing,
pain management,
Colombia wound care

Cost effectiveness of topical wound oxygen therapy for chronic diabetic foot ulcers

Topical Wound Oxygen Therapy Proven Cost-Effective for Chronic Diabetic Foot Ulcers

A recent study published in the Journal of Diabetes and Its Complications evaluates the cost-effectiveness of Topical Wound Oxygen (TWO2) therapy for chronic diabetic foot ulcers (DFUs). Utilizing a Markov model over a two-year horizon, the research assesses both economic and clinical outcomes associated with TWO2 therapy compared to standard care. Read the full article.

Key Highlights:

  • Economic Benefits: The study indicates that, at a weekly cost of £650 for up to 12 weeks, TWO2 therapy results in a £5,038 reduction in total diabetic foot care costs over two years per patient compared to standard care.
  • Improved Health Outcomes: Patients receiving TWO2 therapy experienced an increase of 0.07 quality-adjusted life years (QALYs) over the two-year period.
  • High Probability of Cost-Effectiveness: Probabilistic sensitivity analysis reveals an 81% likelihood that TWO2 therapy is cost-effective at a willingness-to-pay threshold of £25,000 per QALY.
  • Clinical Efficacy: The model’s clinical inputs are derived from a multinational randomized controlled trial demonstrating superior healing rates with TWO2 therapy.
  • Global Health Implications: Given the substantial burden of DFUs worldwide, the adoption of cost-effective treatments like TWO2 therapy could significantly reduce healthcare expenditures and improve patient quality of life.

This study underscores the potential of TWO2 therapy not only to enhance clinical outcomes for patients with chronic DFUs but also to provide significant cost savings for healthcare systems.

Read the full article on the Advanced Oxygen Therapy Inc. website.

Keywords:
Topical Wound Oxygen Therapy,
diabetic foot ulcers,
cost-effectiveness,
quality-adjusted life years,
health economics

PREVENTION AND MANAGEMENT OF PERIWOUND SKIN COMPLICATIONS

ISTAP Best Practice Recommendations for Prevention and Management of Periwound Skin Complications

The International Skin Tear Advisory Panel (ISTAP) has published comprehensive guidelines to enhance the prevention and management of periwound skin complications. These recommendations emphasize the significance of periwound skin health in promoting effective wound healing and reducing associated complications. Read the full document.

Key Highlights:

  • Definition of Periwound: The periwound is identified as the area surrounding a wound that may be affected by wound-related factors and/or underlying pathology.
  • Risks of Periwound Damage: Complications such as maceration, skin stripping, and medical adhesive-related skin injury (MARSI) can delay healing, increase infection risk, and elevate treatment costs.
  • Assessment Protocols: Regular evaluation of the periwound area should be integrated into wound assessments, focusing on skin integrity, moisture levels, and signs of infection or inflammation.
  • Management Strategies: Effective approaches include managing exudate to prevent moisture-associated skin damage (MASD), using appropriate dressings, and employing gentle cleansing techniques with pH-balanced solutions.
  • Infection Control: Implementing antimicrobial stewardship principles is crucial to prevent and manage infections without contributing to antimicrobial resistance.
  • Education and Training: Ongoing education for healthcare professionals and caregivers is essential to ensure best practices in periwound care are understood and applied consistently.

These guidelines serve as a valuable resource for clinicians aiming to improve patient outcomes through diligent periwound care.

Read the full document on the Wounds International website.

Keywords:
periwound skin care,
moisture-associated skin damage,
medical adhesive-related skin injury,
wound assessment,
antimicrobial stewardship

Diagnosis And Treatment Of Periwound Dermatitis

Comprehensive Strategies for Managing Periwound Dermatitis in Chronic Wounds

Periwound dermatitis, an inflammatory condition affecting the skin surrounding chronic wounds, poses significant challenges to effective wound healing. Characterized by symptoms such as redness, itching, and discomfort, this condition often arises from factors like excessive wound exudate and irritants from dressings. Read the full article.

Key Highlights:

  • Understanding Periwound Dermatitis: This condition is commonly a form of contact dermatitis, either allergic or irritant, frequently resulting from exposure to wound exudate or components of wound dressings. It is often classified under moisture-associated skin damage (MASD).
  • Risk Factors: Factors contributing to periwound dermatitis include advanced age, comorbidities like venous insufficiency, nutritional deficiencies, and a history of skin disorders. These elements can compromise skin integrity, making it more susceptible to inflammation and damage.
  • Clinical Assessment: Regular evaluation of the periwound area is crucial. Clinicians should look for signs such as erythema, increased skin temperature, and patient-reported symptoms like itching or burning sensations. It’s important to note that skin changes may present differently across various skin tones.
  • Management Strategies: Effective management involves:
    • Removal of Irritants: Identifying and eliminating the causative agents, such as switching to hypoallergenic dressings or using normal saline instead of potential irritant cleansers.
    • Skin Protection: Applying barrier creams like zinc paste or petrolatum to shield the skin from further irritation.
    • Exudate Management: Utilizing appropriate absorbent dressings to control excessive wound exudate, thereby reducing moisture-related skin damage.
    • Pharmacological Interventions: In cases of significant inflammation, topical corticosteroids or antihistamines may be prescribed to alleviate symptoms.
  • Patient Education: Educating patients on proper wound care practices, including gentle cleansing techniques and the importance of adhering to treatment plans, is vital for preventing recurrence and promoting healing.

Addressing periwound dermatitis requires a multifaceted approach that combines careful assessment, targeted interventions, and patient involvement to enhance healing outcomes and improve quality of life.

Read the full article on the The Wound Pros website.

Keywords:
periwound dermatitis,
moisture-associated skin damage,
contact dermatitis,
wound exudate management,
skin barrier protection

How to Care for Periwound Skin

Periwound Skin: Understanding and Managing the Skin Surrounding Wounds

Proper care of the periwound skin—the area extending approximately 1.5 inches from the wound edge—is essential for effective wound healing. This delicate skin is susceptible to damage from moisture, adhesives, and infection, which can impede the healing process. Read the full article.

Key Highlights:

  • Moisture-Associated Skin Damage (MASD): Excessive wound exudate can lead to maceration, causing redness, irritation, and pain in the periwound area. Managing moisture levels is crucial to prevent skin breakdown.
  • Medical Adhesive-Related Skin Injury (MARSI): Improper application or removal of wound dressings can strip the skin, leading to MARSI. Over 25% of post-surgical patients experience MARSI in the periwound region.
  • Signs of Periwound Complications: Indicators include induration (hardening), erythema (redness), swelling, bruising, red streaks emanating from the wound, fever, or general malaise.
  • Prevention Strategies:
    • Gently clean the periwound area during each dressing change.
    • Use barrier creams like petroleum jelly to protect against moisture.
    • Minimize dressing changes to those recommended by healthcare providers.
    • Carefully remove adhesives by pressing down on the skin beneath to reduce trauma.
    • Regularly assess the periwound area for any changes or signs of damage.
  • Treatment Approaches: Addressing periwound skin damage involves preventing further injury and promoting healing. This may include repositioning bandages, using barrier creams, and consulting healthcare providers for tailored care plans.

Maintaining the integrity of the periwound skin is vital for optimal wound healing. Incorporating periwound care into the overall wound management plan can enhance patient outcomes and reduce complications.

Read the full article on the Verywell Health website.

Keywords:
periwound skin,
moisture-associated skin damage,
medical adhesive-related skin injury,
wound healing,
barrier creams

The Clinical Utility of Autofluorescence Imaging for Bacterial Detection in Wounds: A Systematic Review

Autofluorescence Imaging Enhances Detection of Bacterial Burden in Wounds

A recent study published in Advances in Wound Care investigates the clinical utility of autofluorescence imaging for identifying significant bacterial loads in chronic wounds. The research demonstrates that fluorescence-guided wound care can improve the detection of bacterial burden, leading to more targeted and effective treatment strategies. Read the full article.

Key Highlights:

  • Enhanced Bacterial Detection: Autofluorescence imaging enables clinicians to visualize bacterial presence in wounds by emitting fluorescence signals, allowing for more accurate identification of infection-prone areas.
  • Improved Treatment Outcomes: Utilizing fluorescence-guided assessments can lead to more precise debridement and antimicrobial interventions, potentially accelerating wound healing and reducing complications.
  • Non-Invasive Technique: This imaging method offers a non-invasive approach to assess bacterial burden, minimizing patient discomfort and the need for invasive sampling procedures.
  • Clinical Implications: Incorporating autofluorescence imaging into routine wound assessments may enhance clinical decision-making, optimize treatment plans, and improve overall patient outcomes.

This study underscores the potential of autofluorescence imaging as a valuable tool in the management of chronic wounds, offering a more accurate and patient-friendly method for detecting bacterial infections.

Read the full article on the PubMed Central website.

Keywords:
autofluorescence imaging,
bacterial burden,
chronic wounds,
fluorescence-guided wound care,
non-invasive diagnostics

Enzymatic Debridement Is More Effective than Autolytic for Severe Wounds

Enzymatic Debridement Outperforms Autolytic Methods in Treating Severe Wounds

A recent systematic review published in Dermatology Times highlights the superior efficacy of enzymatic debridement over autolytic methods for managing severe chronic wounds. The analysis encompassed five studies involving 236 patients with conditions such as diabetic foot ulcers, pressure ulcers, venous leg ulcers, and post-traumatic burn wounds. Read the full article.

Key Highlights:

  • Accelerated Wound Healing: Enzymatic debridement achieved a 65% reduction in wound size, compared to 50% with autolytic methods, indicating a statistically significant improvement in healing rates.
  • Enhanced Tissue Regeneration: Patients treated with enzymatic agents exhibited higher rates of granulation tissue formation and epithelialization, leading to quicker wound closure.
  • Higher Complete Healing Rates: Approximately 65% of patients undergoing enzymatic debridement experienced complete healing, versus 50% in the autolytic group.
  • Safety Profile: Both methods were well tolerated, with mild irritation being the most common adverse effect reported in the enzymatic debridement group.
  • Clinical Recommendations: While autolytic debridement remains suitable for non-severe wounds due to its non-invasive nature, enzymatic debridement is recommended for severe wounds requiring faster and more effective tissue removal.

This review underscores the importance of selecting appropriate debridement techniques based on wound severity to optimize healing outcomes and patient care.

Read the full article on the Dermatology Times website.

Keywords:
enzymatic debridement,
autolytic debridement,
chronic wounds,
wound healing,
collagenase

Comments to OMB with Recommendations for Deregulation

Alliance Advocates for Deregulation to Enhance Wound Care Access and Efficiency

On May 12, 2025, the Alliance of Wound Care Stakeholders submitted comprehensive comments to the Office of Management and Budget (OMB), responding to a federal request for feedback on opportunities for deregulation. The Alliance’s recommendations aim to streamline regulatory processes, reduce administrative burdens, and improve patient access to essential wound care treatments. Read the full article.

Key Highlights:

  • Opposition to FDA Reclassification: The Alliance urges the withdrawal of the FDA’s proposed rule to reclassify certain antimicrobial wound dressings, citing concerns over reduced product availability and potential negative impacts on patient care.
  • Prior Authorization Reforms: Recommendations include simplifying prior authorization processes to alleviate delays and administrative burdens for both providers and patients.
  • Medicare Therapeutic Shoe Program Adjustments: The Alliance suggests reducing complexities within this program to enhance access for diabetic patients requiring therapeutic footwear.
  • Payment Provision Corrections: Calls for rectifying problematic payment structures for Cellular and/or Tissue-based Products (CTPs) within the Hospital Outpatient Prospective Payment System to ensure fair reimbursement.
  • Emphasis on Real-World Evidence (RWE): Advocates for the expanded adoption of RWE in coverage determinations and updates to the Coverage with Evidence Development framework.
  • Administrative Simplification: Proposes reforms to the National Correct Coding Initiative, audit procedures, and data reporting processes to eliminate duplicative or overly complex requirements.

These targeted recommendations reflect the Alliance’s commitment to fostering a regulatory environment that supports efficient, patient-centered wound care practices.

Read the full article on the Alliance of Wound Care Stakeholders website.

Keywords:
wound care regulation,
prior authorization,
therapeutic shoe program,
real-world evidence,
Medicare payment policy

Why Do We Publish?

Editorial Insight: Exploring the Motivations Behind Medical Publishing

In the May 2025 editorial of Wounds, Editor-in-Chief Dr. John C. Lantis II delves into the multifaceted reasons why clinicians and researchers choose to publish their work. While the altruistic aim of sharing knowledge to benefit patient care is often cited, Dr. Lantis acknowledges that various other motivations drive the publication process. Read the full article.

Key Highlights:

  • Product Support: A prevalent reason for publication is to endorse the use of specific products in treating common diseases, a trend amplified by recent governmental regulations. This has led to increased literature on managing pressure injuries, atypical wounds, and post-surgical complications.
  • Academic Advancement: The “publish or perish” culture in academia motivates individuals at all career stages to contribute to scientific literature. Notably, even high school students have been recognized for their research contributions, highlighting the broad spectrum of academic involvement.
  • Clinical Protocol Development: Publishing can stem from the desire to share effective care algorithms developed through clinical experience, offering valuable insights into successful treatment protocols.
  • Understanding Negative Outcomes: Documenting studies with unfavorable results is crucial, as they provide insights into disease progression and inform future research directions, especially in areas like critical limb ischemia and venous leg disease.
  • Industry Collaboration: Collaborations between clinicians and industry partners can yield comprehensive consensus documents, combining practical experience with in-depth knowledge of therapeutic mechanisms.

Dr. Lantis emphasizes the importance of transparency regarding one’s motivations for publishing. Recognizing and understanding these drivers can enhance the integrity and impact of scientific contributions.

Read the full editorial on the HMP Global Learning Network website.

Keywords:
medical publishing,
academic advancement,
clinical research,
product support,
industry collaboration

TWC Is Evolving to the Wound Care Business Navigator

Today’s Wound Clinic Evolves into Wound Care Business Navigator

After 18 years of serving the wound care community, Today’s Wound Clinic (TWC) is transitioning into the Wound Care Business Navigator (WCBN), a dynamic digital platform designed to meet the evolving needs of modern wound care professionals. This change reflects the growing demand for comprehensive, real-time resources that address the complexities of reimbursement, compliance, and operational efficiency in wound care practice. Read the full article.

Key Highlights:

  • Purpose-Driven Transition: WCBN is designed to provide clinicians with immediate access to expert insights, regulatory updates, and practical tools to navigate the complexities of wound care business operations.
  • Interactive and Adaptive Platform: Unlike traditional publications, WCBN offers a continuously updated, interactive experience that evolves alongside industry changes, ensuring users have the most current information at their fingertips.
  • Comprehensive Resource Hub: The platform aims to centralize critical information, addressing common challenges such as fragmented knowledge, revenue leakage, compliance risks, and operational inefficiencies.
  • Expert Leadership: Dr. Caroline E. Fife, who has been instrumental in TWC’s success, continues to contribute her expertise, ensuring that WCBN maintains the high standards and relevance that readers have come to expect.

This strategic evolution signifies a commitment to empowering wound care professionals with the resources needed to optimize patient care and practice management in a rapidly changing healthcare landscape.

Read the full article on the HMP Global Learning Network website.

Keywords:
Wound Care Business Navigator,
Today’s Wound Clinic,
wound care reimbursement,
practice management,
regulatory compliance

What you need to know about transparent film dressings

Understanding Transparent Film Dressings: Applications and Best Practices

Transparent film dressings are thin, adhesive-coated polyurethane sheets designed to provide a moist healing environment, promote autolytic debridement, and protect wounds from mechanical trauma and bacterial invasion. Their flexibility allows them to conform to various body contours, making them suitable for wounds in challenging locations like elbows and heels. The transparency of these dressings enables easy visualization of the wound bed without removal, facilitating ongoing assessment. Read the full article.

Key Highlights:

  • Moist Healing Environment: These dressings maintain a moist environment conducive to wound healing and support autolytic debridement by allowing the body’s own enzymes to break down necrotic tissue.
  • Barrier Protection: They are waterproof and impermeable to bacteria and contaminants, yet permeable to moisture vapor and gases, facilitating gas exchange while protecting the wound.
  • Versatile Applications: Ideal for partial-thickness wounds with minimal drainage, protection of intact skin (e.g., over bony prominences), securing IV catheters, and as secondary dressings over other wound care products.
  • Application Considerations: Proper application involves ensuring the skin is clean and dry, applying a moisture barrier to the periwound area, and avoiding stretching the dressing during placement to prevent tension that could lead to skin damage.
  • Precautions: Not recommended for wounds with moderate to heavy exudate, third-degree burns, suspected or active infections, or in patients with fragile skin, as removal may cause skin stripping or tears.

Transparent film dressings are a valuable tool in wound care management, offering protection and promoting healing in suitable wound types. Proper selection and application are crucial to maximize their benefits and minimize potential complications.

Read the full article on the Wound Care Advisor website.

Keywords:
transparent film dressings,
autolytic debridement,
wound healing,
moist wound environment,
periwound skin protection

Jingfang Granules for Diabetic Wound Healing

Jingfang Granules Show Promise in Accelerating Diabetic Wound Healing

A recent study published in Drug Design, Development and Therapy investigates the therapeutic potential of Jingfang Granules (JFG), a traditional Chinese medicine formulation, in promoting diabetic wound healing. Utilizing a combination of network pharmacology and experimental validation, the research aims to elucidate the mechanisms by which JFG may enhance wound repair in diabetic conditions. Read the full article.

Key Highlights:

  • Multi-Component Analysis: Network pharmacology identified multiple active compounds within JFG that target key proteins involved in wound healing processes, including inflammation modulation and tissue regeneration.
  • Pathway Enrichment: The analysis revealed that JFG influences several critical signaling pathways, such as the PI3K-Akt and MAPK pathways, which are integral to cell proliferation and angiogenesis.
  • Experimental Validation: In vivo experiments demonstrated that JFG treatment significantly accelerated wound closure in diabetic rat models, corroborating the computational predictions.
  • Anti-Inflammatory Effects: JFG administration resulted in reduced expression of pro-inflammatory cytokines, suggesting its role in mitigating chronic inflammation associated with diabetic wounds.

This integrative study underscores the potential of Jingfang Granules as a complementary therapeutic approach for enhancing diabetic wound healing, warranting further clinical investigations.

Read the full article on the Dove Medical Press website.

Keywords:
Jingfang Granules,
diabetic wound healing,
network pharmacology,
traditional Chinese medicine,
PI3K-Akt pathway

Use of a Novel Silicone-Acrylic Drape With Negative Pressure Wound Therapy in Four Patients With Periwound Skin Breakdown

Innovative Silicone-Acrylic Drape Enhances NPWT Outcomes in Patients with Periwound Skin Breakdown

A recent case series published in Wounds journal explores the use of a novel silicone-acrylic hybrid drape (HA-drape) in conjunction with negative pressure wound therapy (NPWT) to address periwound skin breakdown. The study involved four patients who developed mild to moderate periwound skin irritation during standard NPWT. Transitioning to the HA-drape aimed to minimize skin damage while maintaining effective wound sealing. Read the full article.

Key Highlights:

  • Enhanced Patient Comfort: All patients reported decreased pain during dressing removal after switching to the HA-drape, attributed to its gentler adhesion properties.
  • Improved Periwound Skin Integrity: Significant improvement in periwound skin condition was observed after the first dressing change using the HA-drape.
  • Effective Seal Maintenance: The HA-drape maintained a reliable negative pressure seal throughout treatment, comparable to traditional drapes.
  • Repositionable Design: The hybrid drape allowed for repositioning during application, facilitating better fit and reducing the need for ancillary sealing products.

This study suggests that the silicone-acrylic hybrid drape may offer a beneficial alternative for patients experiencing periwound skin complications during NPWT, enhancing comfort and potentially improving healing outcomes.

Read the full article on the HMP Global Learning Network website.

Keywords:
negative pressure wound therapy,
silicone-acrylic drape,
periwound skin breakdown,
wound healing,
medical adhesive-related skin injury

Wound dressings made of drug-releasing polymers

Electrospun Polymer Mats for Controlled Drug Delivery in Wound Care

Researchers at the Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences (IFJ PAN) have developed electrospun polymer mats embedded with the antibacterial agent metronidazole, aiming to enhance wound healing through localized and controlled drug release. :contentReference[oaicite:2]{index=2}:contentReference[oaicite:3]{index=3}

Key Highlights:

  • Electrospinning Technique: Utilizing electrospinning, a method that creates fine polymer fibers through an electrostatic field, the team produced mats capable of delivering drugs directly to wound sites.
  • Controlled Drug Release: The mats are designed to release metronidazole gradually over several hours, ensuring sustained antibacterial action while minimizing systemic exposure.
  • Structural Design: Two types of fiber structures were developed: homogeneous fibers and core-shell fibers, the latter using a coaxial needle to encapsulate the drug within a protective polymer shell.
  • Optimal Fiber Dimensions: Studies determined that fiber diameters between 0.7 and 1.3 micrometers provide an adequate surface area for effective drug absorption and release.
  • Storage Considerations: The mats can be stored for up to one month before application, after which the metronidazole may begin to crystallize, potentially affecting efficacy.

This innovative approach to wound care highlights the potential of electrospun polymer mats in delivering targeted therapy, reducing the risk of systemic side effects, and improving patient outcomes. The researchers suggest that this method could be adapted to carry other therapeutic agents, broadening its applicability in medical treatments. :contentReference[oaicite:18]{index=18}:contentReference[oaicite:19]{index=19}

Read the full article on the EurekAlert! website.

Keywords:
electrospinning,
polymer mats,
metronidazole,
wound healing,
controlled drug release

Embracing the Pain: What Stoicism, Residency, and Running Teach Us About Resilience

Sole Purpose 61: Embracing the Pain—Lessons in Resilience from Stoicism, Residency, and Running

In the latest installment of the Sole Purpose series, Dr. Santiago delves into the intertwined themes of physical and mental endurance, drawing parallels between the rigors of medical residency, the discipline of long-distance running, and the philosophical tenets of Stoicism. :contentReference[oaicite:2]{index=2}:contentReference[oaicite:3]{index=3}

Key Highlights:

  • Stoic Philosophy in Medicine: Dr. Santiago explores how Stoic principles—such as embracing discomfort, focusing on what can be controlled, and maintaining equanimity—can serve as valuable tools for medical professionals facing the challenges of residency and clinical practice.
  • Running as a Metaphor: The article draws comparisons between the perseverance required in long-distance running and the resilience needed in the medical field, emphasizing the importance of mental fortitude and consistent effort.
  • Personal Narratives: Through candid reflections, Dr. Santiago shares personal experiences of navigating the physical and emotional demands of medical training, highlighting the growth that emerges from confronting and embracing pain.

This piece offers a compelling perspective on the cultivation of resilience, suggesting that the challenges faced in both medicine and athletics can be opportunities for personal development when approached with a Stoic mindset.:contentReference[oaicite:12]{index=12}

Read the full article on the PRESENT Podiatry website.

Keywords:
Stoicism,
medical residency,
running,
resilience,
Dr. Santiago

Candidate Biomarkers for Hard-to-Heal Wounds Revealed by …

Preventive Care for Individuals with Deep Pressure Ulcers in Sweden: A Mobile Team Approach

A recent study published in Health Science Reports details the implementation and outcomes of a mobile pressure ulcer (PU) team in Sweden, aimed at enhancing preventive care for individuals with deep pressure ulcers. :contentReference[oaicite:2]{index=2} This initiative represents a shift towards more proactive and patient-centered wound care management.:contentReference[oaicite:5]{index=5}

Key Highlights:

  • Mobile PU Team Establishment: The Swedish healthcare system introduced a mobile PU team to deliver and monitor preventive interventions and advanced wound care treatments both at patients’ homes and outpatient clinics.
  • Comprehensive Care Delivery: The team focused on individualized care plans, incorporating risk assessment, patient education, and tailored treatment strategies to address the specific needs of each patient.
  • Improved Patient Outcomes: The mobile team’s approach led to enhanced healing rates, reduced incidence of new pressure ulcers, and increased patient satisfaction due to the convenience and personalized nature of the care provided.

This study underscores the effectiveness of mobile healthcare teams in managing complex wound care needs, particularly for patients with limited mobility or access to traditional healthcare facilities. By bringing specialized care directly to patients, the Swedish model demonstrates a promising strategy for improving outcomes in pressure ulcer prevention and treatment.:contentReference[oaicite:16]{index=16}

Read the full article on the Health Science Reports website.

Keywords:
pressure ulcers,
mobile healthcare teams,
wound care management,
preventive care,
Sweden healthcare

ACFAP 2025 Pediatric Foot & Ankle Seminar: Advancing Clinical Excellence

ACFAP 2025 Pediatric Foot & Ankle Seminar: Advancing Clinical Excellence

The American College of Foot & Ankle Pediatrics (ACFAP) is hosting its 2025 Pediatric Foot & Ankle Seminar from September 18–20, 2025, at the Holiday Inn in Estes Park, Colorado, adjacent to the scenic Rocky Mountain National Park. This Continuing Medical Education (CME) event will feature leading authorities on pediatric foot and ankle conditions, covering topics such as pediatric history and physical examination, flatfoot, equinus, sports medicine, surgery, and rotational conditions. :contentReference[oaicite:4]{index=4}:contentReference[oaicite:5]{index=5}

Key Highlights:

  • Comprehensive Curriculum: Attendees will engage in sessions that delve into developing effective protocols for treating pediatric patients, evaluating surgical versus non-surgical options for common pediatric foot and ankle pathologies, and improving patient outcomes for conditions like flatfeet, juvenile hallux valgus (HAV), and equinus.
  • Networking Opportunities: The seminar will commence with an outing to Rocky Mountain National Park on Thursday, September 18, providing a unique opportunity for attendees to connect with peers in a relaxed setting.
  • Accreditation: This CME activity is designed to enhance the knowledge and skills of healthcare professionals specializing in pediatric foot and ankle care.

Registration Details:

  • Non-Members: $674
  • 2025 ACFAP Members: $424
  • Residents: $275
  • Students: $250

No commercial interest has provided financial support for this continuing education activity. :contentReference[oaicite:22]{index=22}:contentReference[oaicite:23]{index=23}

For more information and to register, visit the ACFAP Events page.

Keywords:
ACFAP,
pediatric foot and ankle,
continuing medical education,
flatfoot,
equinus,
juvenile hallux valgus

The Human Body Is Designed to Walk: Insights from Linda Rusiecki, DPT

The Human Body Is Designed to Walk: Insights from Linda Rusiecki, DPT

In her article, “The Human Body Is Designed to Walk: It Thrives When It Walks”, Linda Rusiecki, DPT, Inpatient Rehabilitation Educator at Corewell Health, emphasizes the fundamental role of walking in human health and the importance of mobility aids in supporting this function. She underscores that walking is not only essential for physical well-being but also for psychological and emotional health.

Key Highlights:

  • Evolutionary Perspective: Rusiecki discusses how the human body has evolved to walk upright, making walking a natural and necessary activity for maintaining health.
  • Health Benefits: Regular walking contributes to improved cardiovascular health, enhanced mood, better balance, and increased independence, especially in older adults.
  • Role of Mobility Aids: For individuals facing mobility challenges, appropriate aids such as walkers, canes, or prosthetics can facilitate walking, thereby promoting autonomy and quality of life.
  • Rehabilitation Focus: In rehabilitation settings, encouraging walking with or without aids is a primary goal to restore function and prevent complications associated with immobility.

Rusiecki’s insights highlight the intrinsic link between walking and overall health, advocating for the use of mobility aids as tools to enhance movement and independence. Her perspective serves as a reminder of the importance of maintaining mobility throughout all stages of life.

Read the full article on the Medical Tech Outlook website.

Keywords:
walking,
mobility aids,
rehabilitation,
Linda Rusiecki,
Corewell Health

Diabetic Foot Ulcers

Overview of Diabetic Foot Ulcers: Causes, Diagnosis, and Management

This detailed summary, adapted from a comprehensive article on Medscape, outlines the essential aspects of diabetic foot ulcers (DFUs), including risk factors, clinical presentation, diagnostic workup, and treatment approaches. Diabetic foot ulcers are a major complication of diabetes and contribute significantly to patient morbidity and healthcare costs.

Key Highlights:

  • Causes and Risk Factors: DFUs are commonly caused by peripheral neuropathy (loss of protective sensation), peripheral arterial disease (reduced blood flow), and structural foot deformities. These factors together increase the likelihood of ulcer formation and delay healing.
  • Clinical Presentation: DFUs typically present as open sores, especially on weight-bearing areas of the foot. Redness, swelling, discharge, and odor may indicate infection. Notably, pain is often absent due to neuropathy.
  • Diagnosis: Evaluation includes physical and neurological exams, vascular assessments (e.g., ABI), imaging (X-ray or MRI), and lab tests to detect infection or bone involvement.
  • Treatment: Effective care involves offloading pressure, regular wound debridement, appropriate dressings, infection management, tight glycemic control, and in some cases, surgery or revascularization. Multidisciplinary care is often required.
  • Prognosis: Up to 20% of DFUs may lead to lower-limb amputation. Recurrence is common, so prevention through foot care education and ongoing monitoring is critical.

With early detection and a coordinated treatment plan, many diabetic foot ulcers can be healed and serious complications avoided. Healthcare providers should remain vigilant for early signs in diabetic patients and implement evidence-based strategies to improve outcomes.

Read the full article on the Medscape website.

Keywords:
diabetic foot ulcers,
wound care,
debridement,
peripheral neuropathy,
offloading

Columbia VA podiatrist recognized for diabetes-related amputation research

Columbia VA Podiatrist Recognized for Research on Emotional Impact of Diabetic Amputations

Dr. Brandon Brooks, a podiatrist at the Columbia VA Health Care System, received first place honors at the 10th Annual Conference of the American Society of Podiatric Surgeons for his innovative research on the psychological burden of diabetes-related amputations. His study introduces the concept of DREADD—Diabetes-Related Extremity Amputation Depression & Distress—to better understand the emotional trauma experienced by patients undergoing even minor amputations.

Key Highlights:

  • DREADD Framework: Dr. Brooks coined the acronym to emphasize that minor, non-traumatic amputations—such as toe removal—can lead to serious emotional consequences, including depression, anxiety, and treatment noncompliance.
  • Impact on Patient Behavior: The study found that approximately 90% of patients reported increased emotional distress after minor amputations, which contributed to poorer disease management, such as missed appointments and medication lapses.
  • Call for Integrated Care: Dr. Brooks advocates for integrating behavioral health into limb preservation teams and utilizing tools like the PHQ-9 to screen for depressive symptoms during podiatric care.

This research adds an important dimension to limb preservation, stressing that successful outcomes require attention not only to physical recovery but also to emotional well-being. Dr. Brooks collaborated on the study with his brother, Dr. Bradley Brooks, a board-certified psychiatrist, highlighting the value of interdisciplinary teamwork in advancing diabetic foot care.

Read the full article on the VA News website.

Keywords:
diabetes-related amputations,
psychological distress,
limb preservation,
Brandon Brooks,
Bradley Brooks

Paediatric skin health and wound healing study day

Upcoming Event: Paediatric Skin Health and Wound Healing Study Day

The Society of Tissue Viability is hosting a comprehensive virtual study day on paediatric skin health and wound healing, scheduled for June 17, 2025, from 9:30 AM to 4:00 PM. This free event is designed for healthcare professionals involved in paediatric care, including children’s nurses, paediatric specialist nurses, tissue viability nurses, allied health professionals, GPs, and nursing students. :contentReference[oaicite:3]{index=3}:contentReference[oaicite:4]{index=4}

Key Highlights:

  • Patient and Family Perspectives: Aarron and Jacqueline Higgins will share their experiences of managing a child’s chronic wound, providing valuable insights into the challenges faced by families. :contentReference[oaicite:7]{index=7}
  • Holistic Wound Assessment: Rachel Allaway, Tissue Viability Clinical Nurse Specialist at Great Ormond Street Hospital, will discuss comprehensive approaches to wound assessment in children. :contentReference[oaicite:10]{index=10}
  • Managing Hypergranulation: Jansy Williams, Lead Paediatric Tissue Viability Specialist at Alder Hey Children’s NHS Foundation Trust, will present problem-solving strategies for hypergranulation in paediatric wounds. :contentReference[oaicite:13]{index=13}
  • Nutrition’s Role in Healing: Natalie Yerlett, Interim Head of Dietetics at Great Ormond Street Hospital, will explore the impact of nutrition on wound healing processes. :contentReference[oaicite:16]{index=16}
  • Antimicrobial Stewardship: Claire Gardiner, Paediatric Tissue Viability CNS at the Royal Hospital for Children in Glasgow, will address responsible antimicrobial use in paediatric wound care. :contentReference[oaicite:19]{index=19}
  • Pressure Ulcer Prevention: Judith Kay and Sophie Whitecroft from Great Ormond Street Hospital will discuss the importance of seating, posture, and equipment selection in preventing and managing pressure ulcers in children. :contentReference[oaicite:22]{index=22}

This study day offers up to five hours of participatory learning, contributing to NMC revalidation requirements. Attendees will also benefit from industry presentations by organizations such as Flen Health, Pressure Care Management, Mediq, and Medstrom, providing insights into the latest products and innovations in paediatric wound care. :contentReference[oaicite:25]{index=25}:contentReference[oaicite:26]{index=26}

For more information and to register, visit the Society of Tissue Viability website.

Keywords:
paediatric wound care,
skin health,
hypergranulation,
nutrition and wound healing,
antimicrobial stewardship,
pressure ulcer prevention

A Review of the Current Trends in Chronic Wound and Scar Management

Current Trends in Chronic Wound and Scar Management: A Comprehensive Review

A recent review published in Wound Management & Prevention by Drs. Chantalle Crous, Judey Pretorius, and Anél Petzer offers a detailed examination of contemporary approaches to managing chronic wounds and pathological scars. The article underscores the complexity of these conditions and the necessity for multifaceted treatment strategies. :contentReference[oaicite:5]{index=5}

Key Highlights:

  • Multiphase Healing Process: The review outlines the four overlapping phases of wound healing—hemostasis, inflammation, proliferation, and remodeling—and discusses how disruptions in these phases can lead to chronic wounds.
  • Scar Formation Challenges: It emphasizes that while scar tissue is a natural part of healing, excessive or pathological scarring can cause significant physical and psychological distress, highlighting the need for effective management strategies.
  • Emerging Therapies: The authors discuss various treatment modalities, including advanced dressings, growth factor therapies, and stem cell applications, noting that while these show promise, further research is needed to establish their efficacy and safety.

The review concludes that despite the availability of numerous treatment options, there is no universally accepted gold standard for managing chronic wounds and scars. The authors advocate for continued research into the molecular mechanisms of wound healing and scarring to develop more effective and targeted therapies.:contentReference[oaicite:16]{index=16}

Read the full article on the HMP Global Learning Network website.

Keywords:
chronic wounds,
scar management,
wound healing,
Chantalle Crous,
Judey Pretorius,
Anél Petzer

Latest Advances in the World of NPWT

Upcoming Webinar: Latest Advances in NPWT and Algorithmic Wound Management

On Wednesday, June 11, 2025, at 1:00 PM ET, HMP Global will host a webinar titled “Latest Advances in the World of NPWT: Defining an Algorithmic Framework for Wound Management Throughout the Transition of Care”. This 60-minute session, sponsored by Solventum, aims to equip healthcare professionals with the latest insights into negative pressure wound therapy (NPWT) and its application across various care settings. :contentReference[oaicite:5]{index=5}

Key Highlights:

  • Algorithmic Decision-Making: Attendees will learn streamlined strategies to select appropriate NPWT options, facilitating patient transitions across the continuum of care.
  • Practical Application Tips: The session will provide guidance on wound characteristics and recommendations for utilizing NPWT technologies, including the 3M™ V.A.C.® Peel and Place system.
  • Evidence-Based Insights: The webinar will highlight published data supporting the efficiency and cost-effectiveness of Solventum’s NPWT solutions.

This educational event is designed for clinicians seeking to enhance their wound management practices through evidence-based NPWT applications. The session will conclude with a Q&A segment to encourage interactive discussion and address participant queries.:contentReference[oaicite:16]{index=16}

Register for the webinar on the HMP Global website.

Keywords:
NPWT,
wound management,
Solventum,
Ralph J. Napolitano

Storied Careers: A Chat with Podiatric Surgeon Prof. David Armstrong

Storied Careers: A Conversation with Prof. David Armstrong on Diabetic Limb Preservation

In a recent interview featured on Diabetic Foot Online, Professor David G. Armstrong of the Keck School of Medicine at USC reflects on his journey in podiatric surgery and his mission to prevent diabetic foot amputations. As a leading figure in limb preservation, Dr. Armstrong discusses the evolution of his career, the importance of interdisciplinary collaboration, and his vision for the future of diabetic foot care.:contentReference[oaicite:4]{index=4}

Key Highlights:

  • Early Inspiration: Growing up with his father, renowned podiatrist Leo N. Armstrong, David was inspired by the immediate impact podiatric care could have on patients. This early exposure laid the foundation for his commitment to the field.
  • Team-Based Approach: Dr. Armstrong emphasizes the “toe and flow” philosophy, advocating for a collaborative approach that combines podiatric and vascular expertise to enhance patient outcomes in limb preservation.
  • Educational Influence: His training at the California College of Podiatric Medicine instilled a culture of interdisciplinarity, shaping his perspective on the importance of teamwork in medical practice.

Dr. Armstrong’s dedication to advancing diabetic foot care is evident through his extensive research, including over 600 peer-reviewed articles, and his leadership roles, such as founding the Southwestern Academic Limb Salvage Alliance (SALSA). His work continues to inspire a new generation of clinicians committed to reducing preventable amputations and improving patient quality of life.:contentReference[oaicite:15]{index=15}

Read the full interview on the Diabetic Foot Online website.

Keywords:
David Armstrong,
diabetic foot care,
limb preservation,
SALSA,
Keck School of Medicine

Detecting invisible wounds: Study could change how wound closure is defined

Study Reveals ‘Invisible Wounds’ in Diabetic Foot Ulcers: Rethinking Wound Closure Criteria

A recent study by the National Institutes of Health (NIH) Diabetic Foot Consortium, led by researchers at the University of Pittsburgh, has uncovered that diabetic foot ulcers (DFUs) appearing healed may still possess compromised skin barriers, making them prone to reopening. Published in Diabetes Care, the study suggests that the current FDA definition of wound closure may not adequately reflect true healing. :contentReference[oaicite:4]{index=4}:contentReference[oaicite:5]{index=5}

Key Highlights:

  • Functional vs. Visual Healing: The study found that wounds meeting the FDA’s closure criteria—complete skin coverage without discharge for two weeks—might still have defective barrier functions, leading to potential re-injury. :contentReference[oaicite:8]{index=8}
  • Transepidermal Water Loss (TEWL) as an Indicator: Researchers utilized a handheld device to measure TEWL, discovering that higher TEWL readings in closed wounds correlated with a greater likelihood of ulcer recurrence. :contentReference[oaicite:11]{index=11}
  • Study Findings: Among 368 participants with recently healed DFUs, 22% experienced wound reopening within 16 weeks. Wounds with TEWL values exceeding 30 were approximately 2.7 times more likely to reopen compared to those with lower readings. :contentReference[oaicite:14]{index=14}

These findings highlight the importance of assessing not just the visual appearance of wound closure but also the functional integrity of the skin barrier. Incorporating TEWL measurements into standard wound assessment protocols could enhance the prediction of wound recurrence and inform more effective treatment strategies. :contentReference[oaicite:17]{index=17}:contentReference[oaicite:18]{index=18}

Read the full article on the Medical Xpress website.

Keywords:
diabetic foot ulcers,
wound closure,
TEWL,
Chandan Sen,
Gayle Gordillo,
Sashwati Roy

Advances in Burn Wound Management

Advances in Burn Wound Management: Innovative Strategies for Healing and Infection Control

A recent literature review published in Wounds explores the latest developments in burn wound management, emphasizing innovative strategies that enhance healing and infection control. The article provides a comprehensive overview of burn wound causes, classifications, and treatments, discussing the healing phases, potential infections, and complexities associated with conventional treatments. It also highlights advanced techniques that have proven effective in reducing hospital stays and making treatment more cost-effective.

Key Highlights:

  • Advanced Therapies: The review discusses the use of adipose tissue-derived stem cells (ADSCs), bone marrow-derived stem cells (BMSCs), and umbilical cord-derived stem cells (UDSCs) in promoting burn wound healing.
  • Innovative Materials: The application of acellular fish skin (AFS) and extracellular matrix (ECM) components are highlighted as effective in supporting tissue regeneration and reducing inflammation.
  • Modern Techniques: The utilization of negative pressure wound therapy (NPWT) and platelet-derived growth factor (PDGF) are examined for their roles in enhancing wound healing and minimizing infection risks.

These advancements in burn wound management represent significant progress in the field, offering new avenues for treatment that prioritize patient outcomes and cost-effectiveness. By integrating these innovative strategies into clinical practice, healthcare providers can improve healing times, reduce complications, and enhance the overall quality of care for burn patients.

Read the full article on the HMP Global Learning Network website.

Keywords:
burn wound management,
stem cell therapy,
negative pressure wound therapy

NPIAP Hosts 2024 Clinical and Research Symposium in San Diego

NPIAP Hosts 2024 Clinical and Research Symposium in San Diego

The National Pressure Injury Advisory Panel (NPIAP) held its 2024 Clinical and Research Symposium from February 15–16 in San Diego, California. This annual event brought together clinicians, researchers, and industry professionals dedicated to the prevention and treatment of pressure injuries. The symposium served as a hub for sharing the latest science, evidence-based practices, and policy updates in pressure injury care.

Key Highlights:

  • Evidence-Based Practice Focus: Sessions highlighted the latest research in pressure injury etiology, staging, and prevention strategies. Emphasis was placed on the integration of new technologies and updated clinical guidelines into practice.
  • Multidisciplinary Collaboration: The symposium fostered interdisciplinary dialogue among nurses, physicians, physical therapists, researchers, and product developers. This collaboration helps bridge gaps between clinical innovation and bedside application.
  • Policy and Education Updates: Attendees received updates on CMS policies affecting pressure injury documentation and reimbursement, as well as NPIAP’s current initiatives related to public education, guideline dissemination, and global partnerships.

NPIAP’s annual symposium continues to serve as a cornerstone event for professionals working to reduce the prevalence and severity of pressure injuries. With a strong focus on clinical excellence, research translation, and interdisciplinary teamwork, the organization remains a leader in pressure injury education and advocacy.

Learn more about the event and future programming on the NPIAP website.

Keywords:
NPIAP,
pressure injuries,
wound prevention

Recent Policy and Regulatory Insights from the Alliance of Wound Care Stakeholders

Alliance of Wound Care Stakeholders Drives Policy Progress in 2024

In a recent blog post on the HMP Global Learning Network, Marcia I. Nusgart, RPh, Executive Director of the Alliance of Wound Care Stakeholders, highlighted the organization’s major regulatory and policy accomplishments throughout 2024. These initiatives have advanced equitable reimbursement, clarified billing practices, and protected patient access to vital wound care treatments.

Key Highlights:

  • National Payment Rate for Autologous Blood-Derived Products: The Alliance successfully advocated for CMS to establish a standardized national payment rate under HCPCS code G0465 for platelet-rich plasma (PRP) and similar autologous blood-derived therapies used in chronic wound care. This helps eliminate inconsistent payment practices among Medicare Administrative Contractors (MACs).
  • Billing Clarity for Skin Substitutes: The Alliance worked with CMS to clarify that application of skin substitutes in physician office settings can be billed using standard CPT codes, even when the products are provided at no cost. This clarification ensures continued patient access to these critical therapies.
  • Revisions to Draft LCDs: The Alliance played a leading role in revising several Local Coverage Determinations (LCDs) involving skin substitutes. Their comments ensured coverage policies remained evidence-based and clinically sound, protecting patient access and aligning guidelines with real-world practice.

Through its active engagement with CMS and MACs, the Alliance of Wound Care Stakeholders continues to shape policy that supports quality care and fair reimbursement. Its ongoing advocacy helps wound care professionals deliver timely, effective treatments while minimizing administrative and financial obstacles.

Read the full article on the HMP Global Learning Network website.

Keywords:
wound care policy,
CMS reimbursement,
skin substitutes,
Marcia Nusgart

Therapeutic Wound and Skin Cleansing: Clinical Evidence and Recommendations

Therapeutic Wound and Skin Cleansing: Clinical Evidence and Recommendations

The International Wound Infection Institute (IWII) has released a comprehensive consensus document titled Therapeutic Wound and Skin Cleansing: Clinical Evidence and Recommendations. This publication aims to redefine wound cleansing as a critical, evidence-based component of wound care, moving beyond traditional, ritualistic practices. It emphasizes the importance of targeted cleansing strategies to prevent infection and promote optimal healing outcomes.

Key Highlights:

  • Holistic Cleansing Approach: The document underscores the necessity of cleansing not just the wound bed, but also the wound edge, periwound, and surrounding skin. This comprehensive approach ensures the removal of contaminants and supports the overall healing process.
  • Evidence-Based Practices: Utilizing a systematic literature review and expert consensus, the guidelines provide clear recommendations on cleansing techniques, solutions, and equipment. This ensures that practices are grounded in the latest clinical evidence.
  • Decision-Support Tools: The publication offers practical tools and step-by-step guidance to assist healthcare professionals, caregivers, and patients in performing effective wound cleansing tailored to individual needs.

This consensus document serves as a vital resource for clinicians and caregivers, advocating for the allocation of appropriate time and resources to wound cleansing practices. By adopting these evidence-based recommendations, healthcare providers can enhance patient outcomes, reduce infection rates, and contribute to more efficient wound management strategies.

Read the full consensus document on the Wounds International website.

Keywords:
wound cleansing,
skin cleansing,
IWII,
Terry Swanson,
Emily Haesler,
Karen Ousey

Use of hypothermically stored amniotic membrane on diabetic foot ulcers

Hypothermically Stored Amniotic Membrane Shows Promise in Diabetic Foot Ulcer Healing

A multicenter retrospective case series published in Wound Care Professional evaluated the effectiveness of hypothermically stored amniotic membrane (HSAM) in the treatment of diabetic foot ulcers (DFUs). Conducted across several U.S. wound care centers, the study followed 50 patients over a 12-week period to assess healing outcomes, wound size reduction, and frequency of treatment applications.

Key Highlights:

  • Patient Profile: The average patient age was 66.7 years, with 68% male participants. Most wounds (88%) had been present for less than six months at the time of initial evaluation.
  • Wound Area Reduction: Between initial presentation and the first HSAM application, wound area decreased by an average of 68.3%, indicating substantial early progress under standard care alone.
  • Wound Closure Outcomes: By week 12, 78% of DFUs had completely closed. The median time to full closure was 55 days, with an average of 5.5 HSAM applications per patient, spaced approximately 7.5 days apart.

These findings suggest that HSAM, when added to standard DFU care, may accelerate wound healing, potentially reducing the risk of complications and lowering long-term treatment costs. The high closure rate within 12 weeks is especially notable in a population with typically slow-to-heal wounds. This study adds to the growing body of evidence supporting the role of biologically active grafts in managing complex diabetic wounds.

Read the full article on the Wound Care Professional website.

Keywords:
HSAM,
diabetic foot ulcers,
wound healing,
Anna Sanchez,
Alan Hartstein,
Hisham Ashry,
Maryam Raza

International Surgical Wound Complications Advisory Panel

Global Guideline for Post-Operative Incision Care: A New Standard for Surgical Wound Management

In January 2025, the International Surgical Wound Complications Advisory Panel (ISWCAP) released a groundbreaking global guideline focused exclusively on post-operative incision care. Published as a supplement in the Journal of Wound Care, this consensus document addresses the critical need for standardized practices in managing closed surgical incisions, distinguishing them from chronic wounds and those healing by secondary intention. The guideline serves as a living document, intended to evolve with emerging evidence and clinical insights.

Key Highlights:

  • Individualized Treatment Plans: The guideline emphasizes the necessity of tailoring surgical wound treatment plans to individual patient needs, considering factors such as comorbidities, surgical procedure type, and risk of complications.
  • Comprehensive Risk Assessment: It provides a framework for assessing risk factors associated with surgical wound complications, including patient-related factors (e.g., diabetes, obesity), surgical factors (e.g., duration of surgery, type of incision), and postoperative care considerations.
  • Evidence-Based Dressing Selection: The guideline offers recommendations on selecting appropriate dressings based on wound characteristics, aiming to promote optimal healing environments and reduce the risk of infection.

The ISWCAP’s global guideline represents a significant advancement in postoperative care, providing clinicians with a structured approach to incision management. By focusing on individualized care plans, thorough risk assessment, and evidence-based interventions, the guideline aims to improve patient outcomes, reduce the incidence of surgical wound complications, and standardize care practices across various healthcare settings. As a living document, it will continue to incorporate new research findings and clinical experiences, ensuring its relevance and applicability in the ever-evolving field of surgical wound care.

Read the full guideline on the Journal of Wound Care website.

Keywords:
postoperative incision care,
surgical wound management,
ISWCAP,
Kylie Sandy-Hodgetts,
Sara Carvalhal,
Melissa Rochon,
Gulnaz Tariq

Jean-Martin Charcot: 200 years after his birth, still a paragon in the diabetic foot

Addressing the Complexities of Chronic Wound Management: Insights from Wound Practice and Research

Chronic wounds represent a significant and growing challenge in healthcare, characterized by their prolonged healing times and the multifaceted factors influencing their progression. In the article “The complexities of managing an ever-growing problem of chronic wounds” by Peta Tehan and Zlatko Kopecki, published in Wound Practice and Research, the authors delve into the intricate nature of chronic wound management and the pressing need for comprehensive strategies to address this issue.

Key Highlights:

  • Multifactorial Nature of Chronic Wounds: Chronic wounds often result from a combination of factors, including underlying health conditions, infection, and inadequate wound care practices. The article emphasizes the importance of understanding these contributing elements to develop effective treatment plans.
  • Importance of Multidisciplinary Approaches: Effective management of chronic wounds requires collaboration among various healthcare professionals, including physicians, nurses, and specialists. The authors advocate for integrated care models that facilitate communication and coordinated interventions.
  • Need for Continued Research and Education: The article highlights gaps in current knowledge and the necessity for ongoing research to inform evidence-based practices. Additionally, it underscores the role of education in equipping healthcare providers with the skills needed to manage complex wound cases effectively.

The complexities inherent in chronic wound management demand a comprehensive and informed approach. By acknowledging the multifaceted nature of these wounds and fostering multidisciplinary collaboration, healthcare systems can enhance patient outcomes and reduce the burden of chronic wounds. Continued research and education are pivotal in advancing wound care practices and addressing this persistent healthcare challenge.

Read the full article on the Journal of Wound Care website.

Keywords:
chronic wounds,
wound management,
multidisciplinary care,
Peta Tehan,
Zlatko Kopecki

The complexities of managing an ever-growing problem of chronic wounds

Addressing the Complexities of Chronic Wound Management: Insights from Wound Practice and Research

Chronic wounds represent a significant and growing challenge in healthcare, characterized by their prolonged healing times and the multifaceted factors influencing their progression. In the article “The complexities of managing an ever-growing problem of chronic wounds” by Peta Tehan and Zlatko Kopecki, published in Wound Practice and Research, the authors delve into the intricate nature of chronic wound management and the pressing need for comprehensive strategies to address this issue. :contentReference[oaicite:5]{index=5}

Key Highlights:

  • Multifactorial Nature of Chronic Wounds: Chronic wounds often result from a combination of factors, including underlying health conditions, infection, and inadequate wound care practices. The article emphasizes the importance of understanding these contributing elements to develop effective treatment plans.
  • Importance of Multidisciplinary Approaches: Effective management of chronic wounds requires collaboration among various healthcare professionals, including physicians, nurses, and specialists. The authors advocate for integrated care models that facilitate communication and coordinated interventions.
  • Need for Continued Research and Education: The article highlights gaps in current knowledge and the necessity for ongoing research to inform evidence-based practices. Additionally, it underscores the role of education in equipping healthcare providers with the skills needed to manage complex wound cases effectively.

The complexities inherent in chronic wound management demand a comprehensive and informed approach. By acknowledging the multifaceted nature of these wounds and fostering multidisciplinary collaboration, healthcare systems can enhance patient outcomes and reduce the burden of chronic wounds. Continued research and education are pivotal in advancing wound care practices and addressing this persistent healthcare challenge.

Read the full article on the Wound Practice and Research website.

Keywords:
chronic wounds,
wound management,
multidisciplinary care,
Peta Tehan,
Zlatko Kopecki

Integral Debridement in the Postoperative Setting: An Expert’s Perspective

Integral Debridement in the Postoperative Setting: An Expert’s Perspective

In a recent article published by WoundSource, Dr. Abigail E. Chaffin, MD, FACS, CWSP, MAPWCA, explores the application of integral debridement in postoperative wound care. This advanced approach involves the synergistic use of multiple debridement techniques to optimize wound healing, particularly in complex postoperative wounds. :contentReference[oaicite:5]{index=5}

Key Highlights:

  • Comprehensive Debridement Strategy: Integral debridement combines mechanical, chemical, biological, and novel methods to enhance the effectiveness of wound bed preparation. This approach tailors debridement techniques to individual patient needs and clinician expertise. :contentReference[oaicite:10]{index=10}
  • Application in Complex Wounds: Postoperative wounds, including those resulting from trauma, surgical dehiscence, and inflammatory conditions, present unique challenges such as residual necrotic tissue and microbial colonization. Integral debridement addresses these issues by employing techniques like sharp excisional debridement, ultrasonic debridement, and negative pressure wound therapy with instillation and dwell (NPWTi-d). :contentReference[oaicite:15]{index=15}
  • Adjunctive Therapies: The use of pure hypochlorous acid (pHA) wound irrigation and highly charged fiber dressings (e.g., UrgoClean Ag) extends the benefits of debridement between sessions, aiding in slough removal and microbial management. :contentReference[oaicite:18]{index=18}

Dr. Chaffin reports that incorporating integral debridement into her practice has led to notable improvements in wound healing outcomes, including decreased pain and increased patient comfort. By consistently addressing microbial burden and optimizing wound bed preparation, these advanced strategies enhance healing trajectories for complex wounds. :contentReference[oaicite:23]{index=23}

Read the full article on the WoundSource website.

Keywords:
integral debridement,
postoperative wound care,
Abigail E. Chaffin

Human keratin matrix in addition to standard of care accelerates healing of venous ulcers: a case series

Human Keratin Matrix Accelerates Healing of Venous Leg Ulcers: A Case Series

A recent case series published in the Journal of Wound Care explores the efficacy of a novel human keratin matrix (HKM) in conjunction with standard of care (SoC) for treating venous leg ulcers (VLUs). Conducted by Dr. George Koullias and Dr. Allison N. Ramey-Ward, the study assesses the healing outcomes of VLUs treated with HKM alongside indicated vascular interventions and conventional wound care practices.

Key Highlights:

  • Significant Reduction in Wound Size: Very large VLUs (>200 cm²) exhibited an average size reduction of 71% within 10 weeks, achieving a 50% reduction within four HKM applications. :contentReference[oaicite:7]{index=7}
  • Rapid Healing in Smaller Ulcers: Smaller VLUs (<35 cm²) reduced by 50% in size within the first three weeks of treatment, with 88.9% achieving complete healing after an average of 4.5 HKM applications over 6.5 weeks. :contentReference[oaicite:10]{index=10}
  • Enhanced Healing Rates: The integration of HKM with SoC demonstrated accelerated healing compared to SoC alone, suggesting HKM’s potential to improve outcomes in hard-to-heal VLUs.

The study underscores the potential of human keratin matrices as a valuable adjunct in the management of chronic VLUs, offering promising results in both large and small ulcerations. By facilitating faster wound closure, HKM may contribute to improved patient quality of life and reduced healthcare burdens associated with prolonged wound care.

Read the full article on the Journal of Wound Care website.

Keywords:
human keratin matrix,
venous leg ulcers,
wound healing,
George Koullias,
Allison N Ramey-Ward

CuraMedical: Innovating Hemostatic Solutions in Surgical Care

CuraMedical: Innovating Hemostatic Solutions in Surgical Care

Founded in 1998 and headquartered in Assendelft, Netherlands, CuraMedical B.V. is a privately held medical device company specializing in the development, manufacturing, and marketing of hemostatic agents. With a commitment to quality and innovation, CuraMedical has established itself as a trusted provider of surgical solutions, distributing products to over 50 countries worldwide. :contentReference[oaicite:4]{index=4}

Key Highlights:

  • Comprehensive Hemostatic Product Line: CuraMedical offers a range of absorbable and non-absorbable hemostatic products, including CuraSpon®, CuraCel®, CuraTamp®, and CuraWax®. :contentReference[oaicite:7]{index=7}
  • Global Reach and Compliance: The company’s products are distributed in over 50 countries, adhering to international standards such as ISO 13485 and the EU Medical Device Directive. :contentReference[oaicite:10]{index=10}
  • Commitment to Quality and Innovation: CuraMedical employs leading-edge technology and maintains rigorous quality control processes to ensure reliable product performance. :contentReference[oaicite:13]{index=13}

CuraMedical’s dedication to advancing surgical care through innovative hemostatic solutions underscores its role as a key player in the global medical device industry. By focusing on quality, compliance, and customer satisfaction, the company continues to contribute significantly to improved surgical outcomes and patient care worldwide.

Learn more about the company on the CuraMedical website.

Keywords:
CuraMedical,
hemostatic agents,
surgical care

Observational Study of Venous Leg Ulcer Treated With a Native Collagen-Alginate Dressing …

Collagen-Alginate Dressing Enhances Healing and Quality of Life in Venous Leg Ulcer Patients

An observational study published in Wound Management & Prevention evaluated the efficacy and safety of a native bovine collagen-alginate dressing (Cutimed® Epiona®) in treating non-healing venous leg ulcers (VLUs). Conducted at the Northwell Health System Comprehensive Wound Care Healing Center and Hyperbarics in New York, the study involved 60 patients over a four-week period. The research aimed to assess wound area reduction, pain management, and improvements in wound-related quality of life (QoL).:contentReference[oaicite:7]{index=7}

Key Highlights:

  • Significant Wound Area Reduction: The mean wound area decreased from 17.8 ± 11.2 cm² to 11.4 ± 9.0 cm², with four patients achieving complete wound closure within the study period. :contentReference[oaicite:10]{index=10}
  • Improved Pain Management: Patients reported decreased wound pain after two weeks of treatment, accompanied by a reduction in analgesic intake. :contentReference[oaicite:13]{index=13}
  • Enhanced Quality of Life: Assessments using the Wound-QoL-17 questionnaire indicated significant improvements in patients’ wound-related QoL, correlating with the observed wound area reduction. :contentReference[oaicite:16]{index=16}

The study concluded that the collagen-alginate dressing is a safe and effective adjunct to standard wound care practices, promoting healing and improving patient outcomes in cases of hard-to-heal VLUs. Healthcare professionals rated the dressing’s performance as “very good” or “good,” and patients reported high levels of comfort during use. :contentReference[oaicite:21]{index=21}

Read the full article on the Wound Management & Prevention website.

Keywords:
venous leg ulcer,
collagen-alginate dressing,
wound healing,
Alisha Oropallo,
Amit S. Rao,
Sally Kaplan,
Farisha Baksh,
Christina Del Pin

Improving Patient Outcomes With Integral Debridement

Improving Patient Outcomes With Integral Debridement

The May 2025 edition of WoundSource’s Practice Accelerator spotlights “Integral Debridement,” an advanced, evidence-based approach to wound bed preparation. This strategy combines multiple debridement modalities—such as sharp, enzymatic, mechanical, and antimicrobial techniques—tailored to the wound’s characteristics, patient comorbidities, and care setting. The goal is to enhance healing outcomes, particularly in complex or chronic wounds.

Key Highlights:

  • Multimodal Synergy: Integral debridement leverages a combination of methods—including conservative sharp debridement, hypochlorous acid cleansing, and silver-impregnated dressings—to effectively remove necrotic tissue and biofilm, fostering a conducive environment for healing. :contentReference[oaicite:9]{index=9}
  • Continuity Across Care Settings: This approach ensures consistent wound management throughout various care environments, from inpatient to home care, by employing tools like UrgoClean Ag dressings and Vashe® hypochlorous acid soaks that maintain debridement effects between clinical visits.
  • Patient-Centered Customization: Integral debridement emphasizes individualized care plans, considering factors such as wound type, patient pain tolerance, and overall health to select the most appropriate combination of debridement techniques.

By adopting integral debridement, clinicians can address the multifaceted barriers to wound healing more effectively, leading to improved patient outcomes, reduced infection rates, and enhanced quality of life for those with complex wounds.

Read the full article on the WoundSource website.

Keywords:
integral debridement,
wound bed preparation,
chronic wound management

Global Leaders Unite in Shijiazhuang China to Combat Diabetes and Prevent Amputation

Global Leaders Unite in Shijiazhuang to Combat Diabetes and Prevent Amputation

The 11th Shijiazhuang International Diabetes Conference, held on May 16, 2025, at The Second Hospital of Shijiazhuang in China, brought together over 1,000 clinicians, scientists, and policy leaders from around the world. The event focused on urgent challenges and innovative solutions in diabetes care, emphasizing prevention, technology, and limb preservation. :contentReference[oaicite:5]{index=5}

Key Highlights:

  • Keynote Address by Prof. David G. Armstrong: Distinguished Professor of Surgery and Neurological Surgery at the University of Southern California and Founding President of the American Limb Preservation Society, Prof. Armstrong delivered a keynote titled “The Diabetic Foot and Wound Healing: Looking Back to Look Forward,” discussing the evolution of global diabetic foot care and future prevention strategies. :contentReference[oaicite:8]{index=8}
  • International Collaboration: Speakers from various countries shared insights, including Prof. Marg McGill (Australia) on national foot care models, Prof. Vanessa Nube (Australia) on equitable foot care delivery, Prof. Carlo Fornaini (Italy) on laser therapy in oral health for diabetics, Prof. Dirk Hochlenert (Germany) on chronic disease management programs, and Dr. Peter Lin (Canada) on microplastics’ impact on peripheral artery disease. :contentReference[oaicite:11]{index=11}
  • China’s Leadership in Diabetic Research: The conference highlighted China’s advancements in diabetic kidney disease, digital health, biomechanics, stem cell therapies, and comprehensive foot ulcer and vascular care. :contentReference[oaicite:14]{index=14}

This conference underscored the importance of global collaboration in combating diabetes and preventing amputations. By sharing knowledge and strategies, healthcare professionals aim to reduce preventable complications and improve patient outcomes worldwide.

Read the full article on the Diabetic Foot Online website.

Keywords:
diabetes conference,
limb preservation,
global health collaboration

Blisters and Bullous Disease: Is It Infection or Inflammation?

Blisters and Bullous Disease: Infection or Autoimmune?

A recent article in Advances in Skin & Wound Care explores the diagnostic challenges of distinguishing between infectious and autoimmune blistering skin conditions. The piece emphasizes the importance of accurate diagnosis, as treatment strategies differ significantly between bacterial infections like impetigo and autoimmune diseases such as pemphigus vulgaris. :contentReference[oaicite:5]{index=5}

Key Highlights:

  • Infectious Blisters: Impetigo, a common superficial bacterial infection, can present with bullous or nonbullous lesions. Bullous impetigo is typically caused by toxin-producing Staphylococcus aureus and manifests as deeper, larger blisters. :contentReference[oaicite:8]{index=8}
  • Autoimmune Blisters: Pemphigus vulgaris (PV) is a severe autoimmune blistering disease characterized by fragile, flaccid blisters that often begin in the oral mucosa. Early diagnosis and treatment with high-dose corticosteroids and immunosuppressants are crucial to reduce mortality rates. :contentReference[oaicite:11]{index=11}
  • Diagnostic Approach: Differentiating between infectious and autoimmune causes involves clinical assessment, histological examination, and immunofluorescent studies to detect specific autoantibodies. :contentReference[oaicite:14]{index=14}

Understanding the underlying cause of blistering skin conditions is essential for effective management. Clinicians should maintain a high index of suspicion and utilize appropriate diagnostic tools to distinguish between infectious and autoimmune etiologies.

Read the full article on the Advances in Skin & Wound Care website.

Keywords:
blisters,
pemphigus vulgaris,
impetigo

Health Care Costs and Clinical Outcomes of Necrotizing Soft Tissue Infections

Skin-Sparing Surgery Reduces Costs and Improves Outcomes in Necrotizing Soft Tissue Infections

A recent study published in Wounds evaluates the effectiveness of skin-sparing surgery (SSS) in managing necrotizing soft tissue infections (NSTIs). Conducted at a regional burn and wound center, the research highlights how SSS can lead to better clinical outcomes and lower healthcare costs for patients suffering from these severe infections. :contentReference[oaicite:2]{index=2}

Key Highlights:

  • Improved Clinical Outcomes: Patients undergoing SSS experienced reduced mortality rates and shorter hospital stays compared to traditional surgical approaches.
  • Cost-Effective Treatment: The SSS approach was associated with decreased healthcare costs, making it a financially viable option for managing NSTIs.
  • Preservation of Healthy Tissue: SSS focuses on removing necrotic tissue while preserving viable skin, facilitating better wound healing and potentially reducing the need for complex reconstructive procedures.

This study underscores the potential of skin-sparing surgery as a beneficial strategy in the treatment of necrotizing soft tissue infections, offering both clinical and economic advantages.

Read the full article on the Wounds website.

Keywords:
necrotizing soft tissue infection,
skin-sparing surgery,
wound care costs

American College of Clinical Wound Specialists

Introducing the American College of Clinical Wound Specialists (ACCWS)

The American College of Clinical Wound Specialists (ACCWS) is a multidisciplinary organization dedicated to advancing wound care through education, certification, and professional collaboration. By uniting certified wound care professionals, ACCWS fosters a community committed to delivering evidence-based care and advocating for the recognition of wound care specialists.

Key Highlights:

  • Educational Initiatives: ACCWS offers both on-site and conference-based educational programs, with plans to introduce online courses, ensuring accessible, high-quality wound care education for all members.
  • Advocacy and Certification: The organization supports professionals holding certifications such as CWS®, CWSP®, and WCC®, promoting their recognition and validity in clinical practice and reimbursement policies.
  • Leadership and Governance: The ACCWS Board of Directors comprises esteemed professionals, including Chairwoman Tracy Winkley, MPT, CWS, CLT, FACCWS, DAPWCA; Immediate Past Chair Jean Archer, DPM, FACPM, FACCWS, FASPS, CWS; Chair Elect Lonnie Lassiter, MD, MBA; Treasurer Louis Thibodeaux, MD, FACS; Secretary Emily Greenstein, MD; and Education Chair Kelly McFee, DNP, FNP-C, FACCWS.

Through its commitment to education, certification, and advocacy, ACCWS plays a pivotal role in enhancing the standards of wound care, supporting clinicians in their professional growth, and ultimately improving patient outcomes.

Learn more about the organization on the ACCWS website.

Keywords:
ACCWS,
wound care education,
wound care certification

Contact Dermatitis to Common Wound Care Products Exacerbates Chronic Ulcers

Contact Dermatitis from Common Wound Care Products May Worsen Chronic Ulcers

A recent study highlighted by HCPLive reveals that contact dermatitis triggered by standard wound care products may significantly impede the healing of chronic ulcers. Conducted at the Wound Healing Institute of Southeast Wisconsin, the study emphasizes the overlooked impact of allergic reactions in patients with non-healing wounds.

Key Highlights:

  • Widespread Sensitivities: 15 out of 16 patients with chronic ulcers tested positive for contact dermatitis in patch tests using commonly applied wound care products.
  • Delayed Healing: Allergic reactions to these products can worsen chronic ulcers and interfere with effective treatment.
  • Diagnostic Implications: The study calls for broader awareness and improved diagnostic testing to identify contact dermatitis in chronic wound care patients.

This research underscores the importance of considering allergic reactions as a complicating factor in chronic ulcer management, urging clinicians to incorporate allergy assessments into routine wound evaluations.

Read the full article on the HCPLive website.

Keywords:
contact dermatitis,
chronic ulcers,
wound care products

Legs Matter Campaign

Legs Matter: Elevating Awareness for Lower Limb and Foot Health

The Legs Matter campaign is a UK-wide initiative dedicated to raising awareness about lower leg and foot conditions, emphasizing the importance of early diagnosis and effective treatment. Established in 2018, this coalition comprises eight healthcare charities and not-for-profit organizations, including the Society of Tissue Viability, Accelerate, The British Lymphology Society, The Royal College of Podiatry, Foot in Diabetes UK, Leg Ulcer Forum, Lindsay Leg Club Foundation, and the Society of Vascular Nurses [source].

Key Objectives:

  • Increase Awareness: Educate the public and healthcare professionals about the significance of leg and foot health.
  • Promote Early Intervention: Encourage prompt diagnosis and treatment to prevent complications.
  • Provide Resources: Offer evidence-based information and support for patients and clinicians.

Annual Awareness Week: Each year, Legs Matter hosts an Awareness Week to spotlight the importance of leg and foot health. The 2025 event is scheduled for 9–13 June, focusing on the power of speaking up about experiences in lower limb care [source].

Get Involved: Healthcare professionals and community members can participate by accessing free action packs, which include posters, flyers, and patient leaflets to promote the campaign locally [source].

Learn more about the campaign and access resources on the Legs Matter website.

Keywords:
Legs Matter campaign,
Lower limb health awareness,
Society of Tissue Viability,
Legs Matter Awareness Week

Webinar: Diabetic Foot Ulcer Charting the Depths With Intact Fish Skin

Diabetic Foot Ulcer: Charting the Depths With Intact Fish Skin

Join us for an insightful webinar exploring the early management of diabetic foot ulcers (DFUs) using intact fish skin grafts. This session delves into the genesis and application of this innovative treatment, offering a comprehensive overview of its role in wound care.

Webinar Details:

  • Date: Tuesday, June 10, 2025
  • Time: 12:00 PM EDT
  • Presenter: John Lantis, II MD, FACS

Dr. Lantis will share his expertise on the utilization of intact fish skin grafts in managing DFUs, discussing clinical experiences and outcomes. Attendees will gain valuable insights into this emerging therapy and its potential benefits in wound healing.

Register for the webinar on the Podiatry.com website.

Keywords:
Diabetic foot ulcer,
Intact fish skin graft,
John Lantis,
DFU management

AI in Wound Assessment: Transforming Chronic Wound Care

AI in Wound Assessment: Transforming Chronic Wound Care

Artificial intelligence (AI) is revolutionizing wound care by transforming how clinicians assess and manage chronic wounds. By automating measurements, enhancing diagnostic precision, and enabling remote monitoring, AI-powered tools address the shortcomings of traditional manual assessments, which are often subjective, time-consuming, and variable. From smartphone-based imaging to deep learning algorithms, AI delivers data-driven insights that improve treatment planning and patient outcomes for conditions like diabetic ulcers, pressure injuries, and venous leg ulcers. This article delves into AI’s impact on wound assessment, offering wound care professionals a glimpse into a technology poised to redefine clinical practice.

The Need for AI in Wound Assessment

Chronic wounds affect over 6 million Americans, costing healthcare systems billions annually. Accurate assessment is crucial to guide treatments, prevent infections, and accelerate healing. Yet, traditional methods—ruler measurements, visual inspections—rely on clinician experience, leading to inconsistencies. AI overcomes these barriers with standardized, objective analysis. Tools like Healthy.io’s Minuteful for Wound use smartphone cameras with calibration markers to capture high-resolution images, instantly measuring wound dimensions and classifying tissue types (granulation, necrotic, epithelialization). Such automation saves time, reduces errors, and allows clinicians to focus on patient care rather than documentation.

Key Highlights:

  • Automated Precision: AI systems like eKare’s inSight measure wound size and tissue composition with 94% accuracy, outperforming manual methods. Deep learning models, such as U-Net, segment wound areas precisely, ensuring reliable data for clinical decisions.
  • Advanced Diagnostics: AI tools, including Spectral AI’s DeepView SnapShot, predict healing potential and identify infection risks early. These capabilities enable proactive interventions, improving outcomes for complex wounds.
  • Telemedicine Integration: AI apps facilitate remote monitoring, allowing patients to upload wound images for real-time clinician review. This enhances access for rural or bedbound patients, reducing hospital visits.
  • Future Potential: AI could integrate with wearables and predictive analytics to forecast complications like amputations. Research continues to address challenges like limited datasets and tissue segmentation accuracy.

Clinical and Economic Benefits

AI’s precision in wound assessment drives significant clinical and economic advantages. By detecting subtle changes in wound characteristics—such as early signs of infection or delayed healing—AI supports tailored treatments, from selecting optimal dressings to initiating therapies like negative pressure wound therapy. Early intervention reduces infection rates and hospital readmissions, critical given chronic wounds’ $20–$30 billion annual U.S. cost. AI’s telemedicine capabilities also empower patients, improving adherence and satisfaction. For clinicians, AI tools integrate into workflows, enhancing documentation for reimbursement and freeing time for patient interaction. A 2024 review notes AI’s potential to standardize care across settings, from hospitals to home care.

Challenges to Overcome

Despite its promise, AI in wound assessment faces obstacles. Limited public datasets hinder model training, especially for complex tissues like necrotic areas, which vary in appearance. Regulatory approval, such as FDA clearance, is essential for credibility, but not all apps meet these standards. Clinicians must balance AI insights with clinical judgment to account for patient-specific factors, avoiding over-reliance. The PMC review emphasizes the need for robust clinical validation and diverse datasets to ensure AI tools perform reliably across populations, particularly for underrepresented groups.

The Road Ahead

AI’s future in wound assessment is brimming with possibility. Integration with wearables could enable real-time wound monitoring, while predictive analytics might forecast complications weeks in advance. Imagine smart bandages that alert clinicians to infection risks or AI models that personalize treatment plans based on genetic and environmental factors. As research advances, collaboration between developers, clinicians, and regulators will be key to overcoming current limitations. For wound care professionals, adopting AI tools now means staying at the forefront of innovation, delivering precise, patient-centered care that transforms lives.

AI in wound assessment is more than a technological leap—it’s a new era in chronic wound care. By automating assessments, enhancing diagnostics, and bridging access gaps, AI empowers clinicians to achieve better outcomes. Wound care professionals are urged to explore these tools, stay updated on advancements, and integrate AI into their practice to elevate care standards.

Keywords:
AI wound assessment,
Wound care,
Chronic wounds,
Deep learning,
Telemedicine

NORTH AMERICA Clinical Application of Convexity

Global Summit on Ostomy Care: Optimizing Outcomes with Convexity

The Global Innovation Summit Series hosts a free, accredited webinar on optimizing ostomy care through clinical assessment and convexity selection. This event equips wound care professionals with evidence-based strategies for better patient outcomes.

Key Highlights:

  • Clinical Assessment: Learn to evaluate peristomal skin and stoma to select optimal convex barriers.
  • Convexity Selection: Explore evidence-based approaches to match convexity characteristics to patient needs.
  • Interactive Learning: Engage in case studies and Q&A with leading ostomy care experts.
  • Practical Skills: Gain techniques to reduce complications like leaks and skin issues.

This summit offers wound care professionals actionable insights to enhance ostomy management.

Register for the event at the Global Innovation Summit Series.

Keywords:
Ostomy care,
Convexity,
Peristomal skin,
Wound care,
Clinical assessment

OxyGenesys Dissolved Oxygen Dressing

OxyGenesys Dissolved Oxygen Dressing: Clinical Trial Insights

A ClinicalTrials.gov study tested the OxyGenesys Dissolved Oxygen Dressing in abdominoplasty patients to assess its wound healing potential. While inconclusive, the trial offers valuable insights into oxygen therapy for wound care professionals.

Key Highlights:

  • Study Design: Patients received OxyGenesys on one side and Tegaderm on the other, serving as their own controls.
  • Findings: No significant healing benefits were observed, with data collection incomplete due to inconclusive results.
  • Oxygen Therapy: OxyGenesys aimed to enhance chronic wound recovery through continuous oxygen delivery.
  • Clinical Relevance: The trial highlights challenges in validating oxygen-based wound treatments, guiding future research.

This study informs clinicians’ approach to oxygen therapy in wound care innovation.

Learn more about the trial on the ClinicalTrials.gov study page.

Keywords:
Oxygen therapy,
OxyGenesys,
Wound healing,
Topical oxygen,
Chronic wounds

SigmoidOxy – Mobile System for Diabetic foot ulcer Detection

MolecuLightDX: Revolutionizing Wound Care with Fluorescence Imaging

A new MolecuLight video demonstrates the MolecuLightDX, an FDA-cleared device using fluorescence imaging to detect bacteria in wounds, enhancing clinical outcomes. It supports real-time assessment and targeted treatment for wound care professionals.

Key Highlights:

  • Bacterial Detection: Visualizes bacteria at or below the skin surface, aiding precise wound assessment.
  • FDA-Cleared: Clinically validated for reliability in detecting bacterial presence in various wound types.
  • Clinical Applications: Guides debridement and treatment, reducing infection risks and improving healing.
  • User-Friendly: Portable, non-invasive, and integrates seamlessly into clinical workflows.

The MolecuLightDX empowers clinicians to optimize wound management with cutting-edge technology.

Learn more about the product on the MolecuLightDX product sheet.

Keywords:
Fluorescence imaging,
MolecuLightDX,
Wound assessment,
Bacterial detection,
Wound care technology

Dr. Lisa Gould: Combining Classical Guitar & Wound Care

Dr. Lisa Gould: Blending Classical Guitar with Wound Care Expertise

A recent Wound Healing Society feature highlights Dr. Lisa Gould, a plastic surgeon who combines her wound care expertise with classical guitar performance. Practicing at South Shore Hospital, she brings discipline from music to clinical precision.

Key Highlights:

  • Wound Care Leadership: Dr. Gould, a Wound Healing Society leader, advances research and treatment for complex wounds.
  • Classical Guitar: She performs at events like the Rhode Island Philharmonic’s Amica Rush Hour Series.
  • Clinical Role: As a plastic surgeon at South Shore Hospital, she specializes in difficult wound problems.
  • Multidisciplinary Approach: Her musical discipline enhances focus and empathy in patient care.

Dr. Gould’s unique blend of music and medicine inspires wound care professionals to embrace diverse passions.

Read the full article on the Caroline Fife, MD website.

Keywords:
Wound care expert,
Classical guitar,
Plastic surgery,
Wound Healing Society,
Lisa Gould

St. Louis Wound & Vascular Symposium Saturday 21st June 2025

St. Louis Wound & Vascular Symposium 2025

The St. Louis Wound & Vascular Symposium, set for June 21, 2025, at the Hilton St. Louis Frontenac, offers wound care professionals 7 CME hours. This one-day event features expert-led sessions on vascular surgery, complex wound management, and innovative treatments.

Key Highlights:

  • CME Credits: Earn 7 CME hours through advanced wound and vascular care sessions.
  • Expert Topics: Explore vascular surgery, complex cases, and new treatments with leading specialists.
  • Audience: Designed for clinicians, nurses, and specialists in vascular surgery, dermatology, podiatry, and plastic surgery.
  • Networking: Connect with peers to enhance clinical practice and share insights.

This symposium is an essential opportunity for wound care professionals to advance their expertise.

Register for the event on the St. Louis Wound & Vascular Symposium website.

Keywords:
Wound care symposium,
CME event,
Vascular surgery,
Complex wound management,
St. Louis symposium

Comparative Assessment of Negative Pressure Wound Therapy …

Comparative Assessment of Negative Pressure Wound Therapy Systems

A recent study in the Journal of Wound, Ostomy and Continence Nursing compares various Negative Pressure Wound Therapy (NPWT) systems, evaluating their efficacy, usability, and patient outcomes. The research provides insights to guide clinicians in selecting optimal NPWT devices for wound management.

Key Highlights:

  • Efficacy Comparison: The study assesses NPWT systems based on healing rates, infection control, and exudate management across different wound types.
  • Usability Factors: Device portability, ease of application, and patient comfort are critical in determining clinical suitability.
  • Patient Outcomes: Systems with advanced features, like adjustable pressure settings, showed improved patient satisfaction and faster healing.
  • Clinical Recommendations: The findings advocate for tailored NPWT selection based on wound characteristics and patient needs.

This research is a valuable resource for wound care professionals seeking to optimize NPWT use in clinical practice.

Read the full article on the Journal of Wound, Ostomy and Continence Nursing website.

Keywords:
Negative pressure wound therapy,
NPWT systems,
Wound healing,
Patient outcomes,
Sarah Johnston

Advanced Wound Care Summit USA 2025: Uniting Industry Leaders

Advanced Wound Care Summit USA 2025: Uniting Industry Leaders

The Advanced Wound Care Summit USA, scheduled for July 15-16, 2025, in Boston, is a premier industry-led forum bringing together wound care experts to drive innovation and collaboration. This event focuses on strategic partnerships, cutting-edge research, and overcoming key challenges in wound care product development.

Key Highlights:

  • Innovative Solutions: Explore novel clinical trial designs and next-generation diagnostic tools to advance wound care technologies.
  • Reimbursement Challenges: Address barriers to skin substitute product adoption through improved reimbursement models.
  • Networking Opportunities: Connect with C-level executives, R&D directors, and investors to foster partnerships and growth.
  • Expert Insights: Hear from leading figures like Dr. Thomas Serena and Dr. David G. Armstrong on biomaterials, personalized medicine, and regulatory strategies.

This summit is a must-attend for wound care professionals seeking to shape the future of patient care through innovation and collaboration.

Learn more and register at the Advanced Wound Care Summit USA website.

Keywords:
Wound care innovation,
Clinical trials,
Reimbursement models,
Personalized medicine,
Thomas Serena,
David G. Armstrong

Healing Rate and Time to Closure of Venous Leg Ulcers

Venous Leg Ulcers: Healing Rates and Time to Closure

A recent study in the Advances in Skin & Wound Care journal examines healing rates and time to closure for venous leg ulcers (VLUs), providing insights into effective treatment strategies. The research highlights factors influencing healing outcomes and optimal management approaches.

Key Highlights:

  • Healing Rate Factors: Compression therapy and wound bed preparation significantly improve healing rates for VLUs.
  • Time to Closure: The study identifies patient-specific factors, such as comorbidities and adherence, that affect the duration of VLU healing.
  • Treatment Protocols: Standardized protocols, including advanced dressings and regular monitoring, are critical for faster closure.
  • Clinical Implications: The findings support tailored interventions to enhance outcomes and reduce recurrence in VLU management.

This study offers valuable guidance for clinicians aiming to optimize venous leg ulcer treatment and improve patient quality of life.

Read the full article on the Advances in Skin & Wound Care website.

Keywords:
Venous leg ulcers,
Healing rates,
Compression therapy,
Wound management,
Laura Bolton

If I Were Queen I Would Fix These Six Stupid Things in Wound Care

Common Missteps in Wound Care: Insights for Better Practice

In a recent blog post, Caroline Fife, MD, critiques common mistakes in wound care, highlighting practices that hinder effective treatment. Drawing from her expertise, the article emphasizes evidence-based approaches to improve patient outcomes and avoid outdated or ineffective methods.

Key Highlights:

  • Avoiding Outdated Treatments: The post debunks reliance on non-evidence-based practices, such as inappropriate dressing choices, that can delay healing.
  • Proper Wound Assessment: Accurate diagnosis of wound type and underlying causes is critical to selecting effective treatments.
  • Patient Education: Educating patients on wound care protocols enhances compliance and supports better healing outcomes.
  • Evidence-Based Focus: Clinicians are urged to stay updated on research to avoid common pitfalls and adopt best practices.

This article is a valuable resource for wound care professionals seeking to refine their approach and improve patient care.

Read the full article on Caroline Fife, MD’s website.

Keywords:
Wound care mistakes,
Evidence-based practice,
Wound assessment,
Patient education,
Caroline Fife

Reframing Diabetes Treatment as Diabetes Prevention

Reframing Diabetes Treatment: A Shift Toward Prevention

A recent article from Podiatry Today advocates for a proactive approach to diabetes management, emphasizing prevention over reactive treatment. By focusing on early intervention and lifestyle changes, healthcare providers can reduce complications, including diabetic foot ulcers, and improve patient outcomes.

Key Highlights:

  • Preventive Focus: Early education and lifestyle modifications, such as diet and exercise, are critical to preventing diabetes progression and related complications.
  • Foot Health Emphasis: Regular podiatric assessments can identify risks early, reducing the incidence of ulcers and amputations in diabetic patients.
  • Patient Empowerment: Encouraging patient engagement through education and self-care practices fosters better long-term health outcomes.
  • Interdisciplinary Approach: Collaboration between podiatrists, endocrinologists, and primary care providers is essential for comprehensive diabetes prevention strategies.

This perspective shift offers clinicians actionable insights to prioritize prevention in diabetes care, particularly for foot-related complications.

Read the full article on the HMP Global Learning Network website.

Keywords:
Diabetes prevention,
Diabetic foot ulcers,
Podiatric care,
Patient education,
Preventive healthcare,
Robert G. Smith

Negative Pressure Wound Therapy With Instillation

Negative Pressure Wound Therapy with Instillation: Enhancing Wound Healing

A recent study in the Journal of Wound, Ostomy and Continence Nursing explores the efficacy of Negative Pressure Wound Therapy with Instillation (NPWTi), highlighting its role in improving wound healing outcomes. The research emphasizes the combination of negative pressure and periodic instillation of solutions to manage complex wounds effectively.

Key Highlights:

  • Enhanced Wound Cleaning: NPWTi delivers cleansing solutions to the wound bed, reducing bioburden and promoting a cleaner healing environment.
  • Improved Healing Rates: The study reports faster wound closure and reduced infection rates compared to standard NPWT in specific wound types.
  • Clinical Applications: NPWTi is particularly beneficial for chronic, infected, or high-exudate wounds, offering a targeted approach to complex cases.
  • Evidence-Based Practice: The findings support integrating NPWTi into wound care protocols, with recommendations for tailored solution selection and treatment schedules.

This study provides valuable insights for clinicians seeking advanced wound management techniques to optimize patient outcomes.

Read the full article on the Journal of Wound, Ostomy and Continence Nursing website.

Keywords:
Negative pressure wound therapy,
NPWTi,
Wound healing,
Chronic wounds,
Infection management

Recommendations for the management of wound-related symptoms

Palliative Wound Care: Managing Symptoms to Enhance Quality of Life

The European Wound Management Association (EWMA) has published comprehensive guidelines focusing on the management of wound-related symptoms in palliative care settings. Recognizing that not all wounds are healable, the document emphasizes a patient-centered approach aimed at alleviating distressing symptoms and improving the quality of life for individuals with life-limiting conditions.

Key Highlights:

  • Symptom Management Focus: The guidelines prioritize the control of pain, odor, exudate, bleeding, and itching over wound healing, acknowledging the unique challenges in palliative wound care.
  • Holistic Care Approach: Emphasis is placed on interdisciplinary collaboration, involving dietitians, psychologists, social workers, and palliative care specialists to address the complex needs of patients.
  • Patient and Family Involvement: Care plans are encouraged to be developed in partnership with patients and their families, ensuring that treatment aligns with their preferences and goals.
  • Education and Research: The document advocates for the inclusion of palliative wound care principles in medical curricula and calls for further research to develop and validate new symptom management interventions.

These recommendations serve as a valuable resource for healthcare professionals, educators, policymakers, and industry stakeholders committed to enhancing palliative wound care practices.

Read the full article on the Journal of Wound Management website.

Keywords:
Palliative wound care,
Symptom management,
Quality of life,
EWMA,
Interdisciplinary care

a pharmacist’s role in managing diabetes and foot ulcers

Stepping Up: A Pharmacist’s Role in Managing Diabetes and Foot Ulcers

The South African Pharmaceutical Journal highlights the critical role pharmacists play in the management of diabetes and associated complications, such as foot ulcers. The article emphasizes the importance of pharmacists in early detection, patient education, and interdisciplinary collaboration to prevent and manage diabetic foot ulcers (DFUs).

Key Highlights:

  • Early Detection: Pharmacists are often the first point of contact and can identify early signs of foot complications, facilitating prompt referrals.
  • Patient Education: Through counseling, pharmacists can educate patients on foot care practices, glycemic control, and the importance of regular check-ups.
  • Interdisciplinary Collaboration: Working alongside healthcare providers, pharmacists contribute to comprehensive care plans, ensuring optimal patient outcomes.
  • Medication Management: Pharmacists play a pivotal role in managing medications, monitoring for side effects, and ensuring adherence to treatment regimens.

The article underscores the evolving role of pharmacists from traditional dispensers to integral members of the healthcare team, particularly in chronic disease management and complication prevention.

Read the full article on the South African Pharmaceutical Journal website.

Keywords:
Pharmacist role in diabetes,
Diabetic foot ulcers,
Patient education in diabetes,
Interdisciplinary care

Telemedicine for wound management

Telemedicine for Wound Management: Enhancing Care Through Remote Monitoring

In the article “Telemedicine for Wound Management,” published in the International Journal of Lower Extremity Wounds, the authors explore the integration of telemedicine into wound care practices. The study highlights how remote monitoring and consultations can improve patient outcomes, especially for those in underserved or remote areas.

Key Highlights:

  • Improved Access to Care: Telemedicine bridges the gap for patients who have limited access to specialized wound care facilities, ensuring timely interventions.
  • Cost-Effectiveness: Remote consultations can reduce the need for frequent in-person visits, leading to cost savings for both healthcare systems and patients.
  • Enhanced Patient Engagement: Patients become more involved in their care through regular virtual check-ins, leading to better adherence to treatment plans.
  • Clinical Outcomes: The study notes comparable healing rates between telemedicine-managed wounds and those managed through traditional in-person care.

The authors conclude that telemedicine is a viable adjunct to traditional wound care, offering a flexible and effective approach to managing chronic wounds.

Read the full article on the PubMed Central website.

Keywords:
Telemedicine wound care,
Remote patient monitoring,
Chronic wound management,
Digital health in wound care

A young Black scientist discovered a pivotal leprosy treatment …

Alice Ball: The Trailblazing Chemist Behind a Breakthrough Leprosy Treatment

In the early 20th century, Alice Augusta Ball, a pioneering African American chemist, developed a groundbreaking treatment for leprosy (Hansen’s disease) that significantly improved patient outcomes. Her innovative work involved creating an injectable, water-soluble form of chaulmoogra oil, which had previously been used with limited success due to its poor absorption. Ball’s method, later known as the “Ball Method,” became the most effective treatment for leprosy until the development of sulfonamide drugs in the 1940s.

Despite her monumental contribution, Ball’s achievements were initially overshadowed. After her untimely death at the age of 24, her colleague, Arthur L. Dean, continued her work and published findings without crediting her, leading to the method being erroneously named after him. It wasn’t until years later that Ball’s role was rightfully acknowledged, thanks in part to the efforts of scholars and historians who brought her story to light.

Ball’s legacy has since been honored in various ways, including the declaration of Alice Augusta Ball Day in Hawaii and the installation of a sculpture at the University of Hawaiʻi. Her story serves as a powerful reminder of the importance of recognizing the contributions of all scientists, regardless of gender or race.

Read the full article on the Wound Care Advisor website.

Keywords:
Alice Augusta Ball,
Leprosy treatment history,
Chaulmoogra oil,
Ball Method,
Women in science,
African American scientists

Macrophage-Derived Extracellular Vesicles: A Novel Therapeutic Alternative for Diabetic Wound

Macrophage-Derived Extracellular Vesicles: A Novel Therapeutic Alternative for Diabetic Wound Healing

A recent study published in the International Journal of Nanomedicine explores the potential of macrophage-derived extracellular vesicles (MDEVs) as a therapeutic approach for diabetic wound healing. The research highlights how MDEVs, as natural nanocarriers, can modulate inflammation and promote tissue regeneration, offering a promising alternative to traditional cell-based therapies.

Key Highlights:

  • Immunomodulatory Effects: MDEVs can influence macrophage polarization, shifting the balance towards anti-inflammatory phenotypes, which is crucial in chronic wound environments.
  • Enhanced Angiogenesis: The vesicles carry bioactive molecules that stimulate new blood vessel formation, aiding in tissue repair.
  • Reduced Fibrosis: By modulating the wound healing process, MDEVs help in minimizing scar tissue formation.
  • Safety and Efficacy: As acellular therapies, MDEVs reduce risks associated with cell-based treatments, such as immune rejection and tumorigenicity.

The study suggests that MDEVs could be integrated into existing wound care protocols, potentially improving outcomes for patients with diabetic ulcers.

Read the full article on the Dove Medical Press website.

Keywords:
Macrophage-derived extracellular vesicles,
Diabetic wound healing,
Nanomedicine,
Immunomodulation,
Angiogenesis

Optimizing Diabetic Foot Ulcer Care: Four Steps to Save Limbs Worldwide

Optimizing Diabetic Foot Ulcer Care: Four Steps to Save Limbs Worldwide

Keck Medicine of USC outlines a comprehensive, four-step approach to diabetic foot ulcer (DFU) management, aiming to reduce the global incidence of lower-limb amputations. This strategy emphasizes early detection, interdisciplinary care, and patient empowerment to enhance outcomes for individuals with diabetes.

1. Establishing a “Hot Foot Line”: A dedicated hotline facilitates rapid triage of patients presenting with diabetic foot infections or ischemia, ensuring immediate assessment by a specialized limb-salvage team. This prompt intervention can significantly decrease the risk of major amputations.

2. Developing Wound-Healing Clinics: Specialized outpatient clinics focus on active tissue loss, employing advanced modalities such as total contact casting, vascular diagnostics, and surgical debridement. These clinics aim to expedite healing and reduce hospitalization rates.

3. Establishing Remission Clinics: Post-healing, remission clinics work to prevent ulcer recurrence through patient education, biomechanical evaluations, and preventive interventions. Tools like pressure-relieving footwear and thermal monitoring devices are utilized to maintain ulcer-free periods.

4. Implementing Screening Clinics: Annual foot screenings assess risk factors like neuropathy and peripheral artery disease. Early identification allows for timely referrals to appropriate care pathways, including remission or wound-healing clinics, thereby preventing the progression to limb-threatening conditions.

This model has demonstrated success at Keck Medicine of USC and is adaptable to various healthcare settings globally. By integrating these steps, healthcare systems can proactively manage chronic conditions, ultimately saving limbs and improving quality of life for patients with diabetes.

Read the full article on the Keck Medicine of USC website.

Keywords:
Diabetic foot ulcers,
Foot ulcer care,
Limb salvage,
Amputation prevention,
Keck Medicine of USC,
David G. Armstrong

Canceled Plans, New Purpose – A Journey to Podiatry School

Sole Purpose 59: Canceled Plans, New Purpose – A Journey to Podiatry School

In the latest installment of the Sole Purpose series, Dr. Santiago shares her inspiring journey to podiatry school, detailing how unexpected life changes led her to discover a new calling in podiatric medicine. Originally set on a different career path, unforeseen circumstances prompted her to reevaluate her goals and ultimately find purpose in helping others through foot and ankle care.

Dr. Santiago candidly discusses the challenges she faced, including the cancellation of her initial plans, and how these obstacles became opportunities for growth and redirection. She emphasizes the importance of resilience and adaptability, qualities that not only guided her through personal transitions but also serve her well in the demanding field of podiatry.

Included in the article is the personal statement she submitted with her podiatry school application, offering readers a glimpse into the motivations and experiences that shaped her decision to pursue this profession. Her story serves as a testament to the idea that setbacks can lead to new beginnings, and that finding one’s true purpose often involves embracing change.

Read the full article on the Podiatry.com website.

Keywords:
Dr. Santiago,
Sole Purpose series,
Journey to podiatry school,
Career change to podiatry,
Personal statement for podiatry school

FDA Clears NEXA™ NPWT System for Home Use

FDA Clears NEXA™ NPWT System for Home Use — A Major Advancement in Portable Wound Therapy

Advanced Oxygen Therapy Inc. (AOTI) has announced that its NEXA™ Negative Pressure Wound Therapy (NPWT) system has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for use in the home care setting. This expanded indication allows patients to receive the same advanced level of wound care outside of institutional environments, a breakthrough that could improve healing rates and reduce hospital readmissions for chronic and acute wounds.

The clearance (K241515), issued in August 2024, followed rigorous evaluation including a human factors study that confirmed the system’s safety and effectiveness when used by patients or caregivers at home. NEXA is now FDA-cleared for use across acute, extended, and home care environments, aligning with its previous CE Mark approval and international adoption.

“Bringing advanced wound care into the home is the future of healing,” said Dr. Mike Griffiths, CEO of AOTI. “With NEXA, we’re combining the ease and affordability of disposable NPWT with the performance and reliability clinicians expect from traditional systems.”

Key features of the NEXA™ NPWT System:

  • Portable and discreet: Lightweight design with a convenient shoulder bag and quiet operation for patient comfort and mobility.
  • Extended use: Each unit can be used for up to 56 days, with a rechargeable battery and replaceable dressing kits.
  • Innovative fluid management: 120ml pouch-style canister and hydrodynamic pump that functions even with minor leaks.
  • Visual-only alerts: Eliminates disruptive audio alarms while maintaining safety.
  • Cost-effective care: Low daily cost and reduced need for frequent dressing changes may help healthcare systems save significantly.

Designed to support the healing of a wide range of wound types — including diabetic foot ulcers, venous leg ulcers, pressure injuries, and surgical wounds — NEXA aims to bring hospital-grade therapy to the patient’s doorstep.

Read the full press release on the AOTI website.

Keywords:
NEXA NPWT,
Negative Pressure Wound Therapy,
AOTI,
FDA 510(k) clearance,
Home wound care,
Portable NPWT,
Chronic wound healing

Platelet‑rich plasma‑derived exosomes accelerate the healing …

Platelet-Rich Plasma Exosomes: A Novel Approach to Diabetic Foot Ulcer Healing

Diabetic foot ulcers (DFUs) are a significant complication of diabetes, often leading to prolonged healing times and increased risk of infection. Recent research has explored innovative therapies to enhance the healing process. One such study investigates the role of platelet-rich plasma-derived exosomes (PRP-Exos) in promoting wound healing through macrophage polarization.

Understanding PRP-Exos and Macrophage Polarization

Platelet-rich plasma (PRP) is known for its regenerative properties, containing growth factors that aid tissue repair. Exosomes derived from PRP (PRP-Exos) are nano-sized vesicles that carry proteins and genetic material, influencing cell behavior. Macrophages, a type of immune cell, play a pivotal role in wound healing. They exist in two primary phenotypes:

  • M1 Macrophages: Pro-inflammatory, involved in initial defense mechanisms.
  • M2 Macrophages: Anti-inflammatory, promoting tissue repair and regeneration.

The transition from M1 to M2 macrophages is crucial for effective wound healing. The study by He et al. examines how PRP-Exos influence this polarization, thereby accelerating the healing of DFUs.

Key Findings

  • Enhanced Healing: Application of PRP-Exos to diabetic wounds in mice resulted in faster wound closure compared to controls.
  • Macrophage Polarization: PRP-Exos promoted the shift of macrophages from the M1 to the M2 phenotype, reducing inflammation and supporting tissue regeneration.
  • Collagen Deposition: Treated wounds showed increased collagen deposition, indicating improved structural integrity of the healing tissue.

Clinical Implications

The findings suggest that PRP-Exos could be a promising therapeutic avenue for enhancing DFU healing. By modulating the immune response and promoting tissue repair mechanisms, PRP-Exos offer a targeted approach to address the challenges associated with chronic diabetic wounds.

Read the full article here.

Adapted from: “Platelet-rich plasma-derived exosomes accelerate the healing of diabetic foot ulcers by promoting macrophage polarization toward the M2 phenotype” by Ling He et al., published in Clinical and Experimental Medicine, May 2025. Available under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Improving Physical, Physiological, and Psychological Health Outcomes

Holistic Approaches to Diabetic Foot Ulcer Management: Integrating Physical, Physiological, and Psychological Care

In a recent publication in Clinical, Cosmetic and Investigational Dermatology, researchers Prashanth Vas and Nachiappan Chockalingam emphasize the necessity of a comprehensive approach to managing diabetic foot ulcers (DFUs). Their study highlights the intertwined nature of physical, physiological, and psychological factors in patient outcomes.

Key Insights:

  • Physical Health: Effective wound care and offloading techniques are crucial for ulcer healing and preventing complications.
  • Physiological Factors: Proper glycemic control and vascular health play significant roles in the healing process.
  • Psychological Well-being: Addressing mental health aspects, such as depression and anxiety, can improve patient adherence to treatment and overall quality of life.

The authors advocate for integrated care models that encompass these three dimensions, aiming to enhance healing rates and reduce the risk of amputation.

Read the full article on the Diabetic Foot Online website.

Keywords:
Diabetic foot ulcers,
Holistic care,
Psychological well-being,
Prashanth Vas,
Nachiappan Chockalingam

Analysis of Bias Criteria Checklist for Wound Care Registries & EHRs

US Wound Registry Releases White Paper on Evaluating Real-World Data in Wound Care

The U.S. Wound Registry (USWR) has published a comprehensive white paper titled “Analysis of Bias Criteria Checklist for Wound Care Registries & EHRs,” aimed at improving the quality and reliability of wound care research derived from real-world data. This document offers a practical tool for identifying bias in observational studies using electronic health records (EHRs), a crucial step in refining clinical decision-making and treatment evaluation.

Key Highlights:

  • Wound Care Burden: Chronic wounds affect 8.2 million Medicare patients and cost the healthcare system an estimated $96.8 billion annually.
  • Real-World Evidence Gap: Many patients with multiple comorbidities are excluded from randomized controlled trials, making real-world data vital to understanding actual treatment outcomes.
  • The ABC Checklist: The Analysis of Bias Criteria (ABC) checklist—modeled after the STROBE Statement—offers a structured approach for assessing observational wound care studies derived from EHRs.
  • USWR’s Role: Founded in 2005, USWR is a CMS-approved Qualified Clinical Data Registry (QCDR), focused on measuring, reporting, and improving quality of care in wound and podiatric medicine.

The white paper is especially timely as CMS increasingly emphasizes quality measures and value-based care in wound management. It provides clinicians, researchers, and policymakers with a framework to critically appraise registry-based data in ways that align with both scientific rigor and practical application.

Read the full white paper on the US Wound Registry website.

Keywords:
US Wound Registry,
EHR data,
Bias criteria checklist,
Real-world evidence,
Chronic wounds,
QCDR,
STROBE Statement

Prostacyclin (PGI2) Pathway to Enhance Wound Healing in Diabetic Foot Ulcers

Clinical Trial Spotlight: Evaluating RGN-137 for Diabetic Foot Ulcers

Study Title: A Study to Evaluate the Safety and Efficacy of RGN-137 in Subjects With Diabetic Foot Ulcers (DFUs)

ClinicalTrials.gov Identifier: NCT05099367

Study Overview: This Phase 2, randomized, double-blind, placebo-controlled trial aims to assess the safety and efficacy of RGN-137, a topical gel formulation of thymosin beta 4, in promoting the healing of diabetic foot ulcers.

Key Details:

  • Intervention: Participants will receive either RGN-137 topical gel or a placebo, applied to the ulcer site.
  • Primary Outcome Measure: Proportion of subjects achieving complete ulcer closure within a specified timeframe.
  • Secondary Outcome Measures: Time to complete ulcer closure, incidence of ulcer recurrence, and assessment of safety and tolerability.

Eligibility Criteria:

  • Adults aged 18 years and older with Type 2 Diabetes Mellitus.
  • Presence of a diabetic foot ulcer of a specified size and duration.
  • Exclusion of ulcers with active infection or exposure of bone, tendon, or joint capsule.

Study Status: As of the latest update, the trial is actively recruiting participants across multiple sites in the United States.

For more information or to participate, please visit the ClinicalTrials.gov page.

Keywords:
RGN-137,
Thymosin beta 4,
Diabetic foot ulcers,
Clinical trial,
Topical therapy

Does Wound Repair of Traumatic Lacerations After the “Golden Period” Increase Poor Wound Outcomes?

Reevaluating the ‘Golden Period’ in Traumatic Laceration Repair

Traditionally, the “golden period” for primary closure of traumatic lacerations has been considered to be within 6 to 8 hours post-injury, based on early 20th-century animal studies. However, recent insights suggest that this timeframe may be more flexible than previously thought.

Key Insights:

  • Extended Closure Window: Emerging evidence indicates that clean lacerations, especially on the face, may be safely closed up to 24 hours after injury in healthy individuals.
  • Factors Influencing Closure Decisions: The decision to close a wound beyond the traditional window should consider the wound’s cleanliness, location, and the patient’s overall health status.
  • Individualized Assessment: Rather than adhering strictly to a fixed timeframe, clinicians are encouraged to assess each wound individually, balancing the risks of infection against the benefits of primary closure.

This evolving perspective underscores the importance of personalized clinical judgment in wound management, moving beyond rigid time constraints to optimize patient outcomes.

Read the full article on the Clinical Advisor website.

Keywords:
Traumatic lacerations,
Golden period,
Wound closure timing,
Infection risk,
Clinical judgment

The Importance of Research in Podiatric Medicine and Surgery

The Importance of Research in Podiatric Medicine and Surgery

In this insightful presentation, Dr. Windy E. Cole, Director of Wound Care Research at Kent State University College of Podiatric Medicine, emphasizes the pivotal role of podiatrists in advancing research, particularly in diabetic foot care. Drawing from her personal journey from general podiatry to specialized wound care, Dr. Cole advocates for a proactive approach to evidence generation within the field.

Key Highlights:

  • Inquisitive Mindset: Dr. Cole underscores that initiating research begins with curiosity and the desire to answer clinical questions encountered in practice.
  • Leadership in Diabetic Foot Care: As experts in diabetic foot management, podiatrists are uniquely positioned to lead research efforts that shape best practices.
  • Call to Action: Encourages podiatric professionals to actively participate in research to contribute to the advancement of evidence-based medicine.

Watch the full video on the HMP Global Learning Network.

Keywords:
Windy E. Cole,
Podiatric research,
Diabetic foot care,
Wound care research,
Evidence-based medicine

FDA approves shock wave device for treatment of diabetic foot ulcers

FDA Approves dermaPACE® Shock Wave Device for Diabetic Foot Ulcers

On December 28, 2017, the U.S. Food and Drug Administration (FDA) approved the marketing of the dermaPACE® System, developed by Sanuwave Health, Inc., marking it as the first shock wave device authorized for treating diabetic foot ulcers (DFUs) in the United States. This non-invasive, extracorporeal shock wave therapy (ESWT) device delivers acoustic energy pulses to mechanically stimulate chronic wounds, promoting healing in conjunction with standard diabetic ulcer care.

Key Details:

  • Indication: Treatment of chronic, full-thickness diabetic foot ulcers extending through the epidermis, dermis, tendon, or capsule, without bone exposure, and with wound areas ≤16 cm².
  • Patient Criteria: Adults aged 22 years and older with DFUs persisting for more than 30 days.
  • Clinical Evidence: Approval was based on two multicenter, randomized, double-blind studies involving 336 patients. Results showed a 44% wound closure rate at 24 weeks for patients treated with dermaPACE®, compared to 30% in the control group receiving sham therapy.
  • Regulatory Pathway: The device was reviewed under the FDA’s de novo premarket review pathway, establishing a new regulatory classification for similar devices.

Read the full article on the Wound Care Advisor website.

Keywords:
dermaPACE,
Shock wave therapy,
Diabetic foot ulcers,
Sanuwave Health,
FDA approval

Mesenchymal Stem Cell-Derived Exosomes Hold Promise in the Treatment of Diabetic Foot Ulcers

Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Avenue for Diabetic Foot Ulcers

Recent research highlights the potential of mesenchymal stem cell (MSC)-derived exosomes as a novel treatment for diabetic foot ulcers (DFUs). These nano-sized vesicles, secreted by MSCs, are rich in bioactive molecules that can modulate various aspects of the wound healing process.

Key Mechanisms:

  • Anti-inflammatory Effects: MSC-derived exosomes can reduce inflammation by modulating immune cell responses, thereby creating a conducive environment for healing.
  • Promotion of Angiogenesis: They stimulate the formation of new blood vessels, ensuring adequate oxygen and nutrient supply to the wound site.
  • Enhancement of Cell Proliferation and Migration: Exosomes encourage the proliferation and migration of skin cells, essential for tissue regeneration.
  • Extracellular Matrix Remodeling: They aid in the remodeling of the extracellular matrix, providing structural support for new tissue formation.

These multifaceted actions position MSC-derived exosomes as a promising cell-free therapeutic strategy for DFUs, potentially overcoming limitations associated with direct stem cell therapies.

Read the full article on the Dove Medical Press website.

Keywords:
Mesenchymal stem cells,
Exosomes,
Diabetic foot ulcers,
Regenerative medicine,
Cell-free therapy

Millions of people with diabetic foot ulcers could benefit from new research discovery

Insulin and Metformin Synergy May Accelerate Diabetic Foot Ulcer Healing

Researchers from Michigan State University and South Shore Hospital have uncovered a potential synergistic effect between two common diabetes medications—insulin and metformin—that may enhance the healing of diabetic foot ulcers (DFUs). Their study, published in ACS Pharmacology and Translational Science, analyzed wound exudate from patients with DFUs and discovered the presence of metformin in the wound fluid of those taking the drug orally. Notably, patients concurrently using insulin injections exhibited significantly higher levels of metformin at the wound site.

Key Findings:

  • Metformin was detected in the wound exudate of patients taking the drug orally.
  • Patients using both insulin and metformin had increased concentrations of metformin at the wound site.
  • This interaction suggests a previously unrecognized synergy between insulin and metformin in promoting wound healing.

These findings could have immediate implications for clinicians treating chronic wounds and for developers of advanced wound dressings. The study was funded by the National Institute of Diabetes and Digestive and Kidney Diseases.

Read the full article on the EurekAlert! website.

Keywords:
Diabetic foot ulcers,
Insulin,
Metformin,
Wound healing,
Morteza Mahmoudi,
Lisa Gould

How Effective Is Bromelain-based Debridement (BBD) in Diabetic Foot Ulcers?

How Effective Is Bromelain-based Debridement (BBD) in Diabetic Foot Ulcers?

At the Symposium on Advanced Wound Care (SAWC) Spring, a poster presented by Brian McCurdy highlighted the potential benefits of bromelain-based debridement (BBD) for diabetic foot ulcers (DFUs). The post-hoc analysis involved 19 patients, with 12 receiving BBD 5% and 7 receiving a gel vehicle control. Treatments were administered daily for up to 10 sessions over two weeks, followed by weekly assessments for 12 weeks.

Key Findings:

  • Complete Debridement: Achieved in 58% of BBD patients compared to 14% in the control group within the two-week treatment period.
  • Granulation Tissue Formation: ≥75% granulation observed in a higher proportion of BBD-treated wounds, indicating enhanced wound bed preparation.
  • Wound Closure: Defined as complete epithelialization without drainage or dressing use for two weeks, was more frequently attained in the BBD group.

While the subgroup analysis was not powered to detect statistically significant differences, the results suggest that BBD may offer advantages over traditional gel vehicle debridement in promoting wound healing in DFUs.

Read the full article on the HMP Global Learning Network website.

Keywords:
Bromelain-based debridement,
Diabetic foot ulcers,
Wound healing,
Enzymatic debridement,
Brian McCurdy

Case series of traumatic injuries to evaluate the efficacy and …

Case Series: Evaluating Aiodine™ for Severe Traumatic Wounds

A recent case series published in Wounds International explores the preliminary outcomes of using Aiodine™, a novel topical iodine-based formulation, in the management of severe traumatic wounds. Conducted at the Wound Department of the First Affiliated Hospital of Hainan Medical University in Haikou, China, the study involved four patients presenting with various types of severe wounds.

Key Findings:

  • Significant improvements in wound healing were observed within two weeks or less.
  • Substantial reductions in infection rates were noted across all cases.
  • No adverse effects related to Aiodine™ application were reported.

These findings suggest that Aiodine™ may serve as a promising therapeutic agent in wound care. However, the authors emphasize the need for further validation through larger, randomized, double-blind, placebo-controlled clinical trials to confirm these preliminary outcomes.

Read the full article on the Wounds International website.

Keywords:
Aiodine,
Iodine-based formulations,
Traumatic wound management,
Infection control,
Cheng Shaowen,
Yao Jiangling,
Fu Sheng,
Patrick Fernandez,
Shabbir Moochhala

A conversation about diabetes foot care (video)

The Wound Healing Process

This educational video provides a comprehensive overview of the wound healing process, detailing the physiological stages from hemostasis to tissue remodeling. It’s an excellent resource for healthcare professionals and students seeking to understand the intricacies of wound repair mechanisms.

Keywords:

Innovative Therapeutic Strategies for Managing DFUs

Call for Submissions: Innovative Therapeutic Strategies for Managing Diabetic Foot Ulcers

Frontiers in Medicine is currently accepting submissions for its ongoing research topic, “Innovative Therapeutic Strategies for Managing Diabetic Foot Ulcers and Mitigating Associated Complications.” This initiative aims to spotlight cutting-edge clinical and translational research in the prevention, diagnosis, and treatment of diabetic foot ulcers (DFUs) and related conditions.

The editors are seeking contributions in the following areas:

  • Novel pharmacological and regenerative therapies, including cell-based and platelet-rich plasma approaches
  • Biomaterials, hydrogels, and advanced wound dressings that promote healing
  • Machine learning and AI-driven tools for DFU diagnosis and care planning
  • Studies on microbial spectra and antibiotic resistance in diabetic foot infections
  • Real-world implementation of wearable and remote monitoring technologies

This cross-disciplinary topic is open to original research, systematic reviews, clinical trials, case reports, and perspectives from experts in podiatry, wound care, infectious disease, endocrinology, and rehabilitation.

The editorial team includes Andrés González-Cortés (Mexico), Gianluca Sapino (Italy), and Katarzyna T. Targonska (Poland). Researchers interested in contributing can find full submission details and deadlines on the Frontiers website.

Submissions are peer-reviewed and published on a rolling basis. Early contributions will shape the future direction of diabetic foot care research globally.

Keywords:
Call for submissions,
Diabetic foot ulcers,
Innovative therapies,
Machine learning in healthcare,
Cell therapy,
Andrés González-Cortés,
Gianluca Sapino,
Katarzyna T. Targonska

The Wound Reporting in Animal and Human Preclinical Studies

WRAHPS: New Guidelines Aim to Standardize Preclinical Wound Research

In an effort to enhance the quality and reproducibility of preclinical wound healing studies, a consortium of experts has introduced the Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) guidelines. Published in the January-February 2025 issue of Wound Repair and Regeneration, these guidelines provide comprehensive checklists and reporting templates for commonly used animal and human ex vivo wound models.

Key Highlights:

  • Standardization of Reporting: WRAHPS offers detailed checklists to ensure consistent documentation of experimental conditions, facilitating transparency and comparability across studies.
  • Enhancing Translational Research: By addressing the variability in preclinical models and methodologies, the guidelines aim to bridge the gap between laboratory findings and clinical applications.
  • Comprehensive Coverage: The guidelines encompass various aspects of preclinical studies, including animal species selection, wound induction methods, assessment techniques, and data analysis protocols.

The development of WRAHPS involved collaboration among researchers from institutions such as the University of Miami, University of Pennsylvania, The Ohio State University, and the University of Illinois Chicago. The initiative underscores the importance of meticulous reporting in advancing wound care research and ultimately improving patient outcomes.

Read the full article on the PubMed Central website.

Keywords:
Preclinical wound models,
WRAHPS guidelines,
Standardized reporting,
Translational research,
Animal models in wound healing,
Human ex vivo models

The complexities of managing an ever-growing problem of chronic wounds

The Complexities of Managing an Ever-Growing Problem of Chronic Wounds

In the latest issue of Wound Practice and Research, editors Peta Tehan and Zlatko Kopecki delve into the multifaceted challenges of chronic wound management in Australia. The issue underscores the increasing prevalence of chronic wounds and the necessity for a comprehensive, multidisciplinary approach to address this growing healthcare concern.

Key highlights include:

  • Redefining Research Priorities: A consensus study by Finlayson et al. identifies critical areas for chronic wound research, emphasizing pain management, venous leg ulcer compression therapy, and pressure injury management. Notably, diabetic foot ulcers and pressure injury care emerged as top priorities among experts for prevention and management strategies.
  • Patient-Centric Approaches: A scoping review by Pennisi et al. advocates for integrating patients into chronic disease management frameworks to prevent venous leg ulcer recurrence. The study calls for a shift in language and focus, promoting community integration and multidisciplinary collaboration.
  • Early Detection and Intervention: Research by O’Connor et al. highlights the prevalence and risk factors of chronic lower limb oedema in older populations, stressing the importance of early detection to initiate timely interventions. Additionally, a case study by Astrada demonstrates the utility of ultrasonography in identifying subcutaneous scarring post-healing of infected diabetic foot ulcers, facilitating appropriate management strategies.
  • Innovative Treatment Modalities: Kruschwitz and Probst present a retrospective analysis on managing exudate in pressure injuries using multipurpose dressings, resulting in significant wound area reduction. Furthermore, Hulsdunk and Haesler discuss evidence supporting low-level laser therapy for venous leg ulcer healing.

This comprehensive issue serves as a valuable resource for clinicians and researchers, offering insights into current challenges and advancements in chronic wound care.

Read the full article on the Wound Practice and Research website.

Keywords:
Chronic wounds,
Venous leg ulcers,
Pressure injuries,
Diabetic foot ulcers,
Compression therapy,
Low-level laser therapy,
Multidisciplinary care,
Patient-centered care,
Ultrasonography,
Oedema management

Challenging historic practice in leg and foot care

Challenging Historic Practice in Leg and Foot Care: Ensuring Compression is the Default Therapy for Lower Leg Wounds

The Society of Tissue Viability, in collaboration with the Legs Matter coalition, is hosting a free full-day educational session on June 10, 2025, aimed at transforming the approach to lower limb wound care. The event focuses on advocating for compression therapy as the default treatment for various lower leg wounds, moving beyond its traditional association with venous leg ulcers.

Despite the well-documented benefits of compression therapy, its application remains inconsistent due to entrenched practices and a lack of comprehensive education. This study day seeks to address these gaps by presenting evidence-based strategies and challenging outdated methodologies that hinder optimal patient care.

Key topics include:

  • Utilizing compression in lower limb trauma management within plastic surgery settings – Stephanie Brown, Clinical Practitioner, Royal Stoke Hospital
  • Applying compression therapy in cases of combined arterial and venous insufficiency – Annie Clothier, Vascular Clinical Nurse Specialist, Aneurin Bevan University Health Board
  • Implementing compression for patients with diabetic foot ulceration – Jayne Robbie, Senior Lecturer in Diabetes Care and Specialist Podiatrist, Birmingham City University and University Hospitals Birmingham NHS Trust
  • Personalizing compression therapy to meet individual patient needs – Kate Williams, Associate Director of Wound Care, Accelerate CIC
  • Living better with lymphoedema – Matt Hazledine, Founder of Lymph United

This event is tailored for healthcare professionals involved in lower limb wound care, including community nurses, podiatrists, tissue viability specialists, vascular and plastic surgery practitioners, dermatology and lymphoedema services, and general practitioners.

Read the full article and register for the event on the Society of Tissue Viability website.

Keywords:
Compression therapy,
Lower leg wounds,
Venous leg ulcers,
Diabetic foot ulceration,
Lymphoedema,
Society of Tissue Viability,
Legs Matter coalition

Tell Me Your Story – The Undaunted Spirit of Patients with Chronic Wounds

Tell Me Your Story – The Undaunted Spirit of Patients with Chronic Wounds

In a heartfelt blog post, Dr. Caroline Fife shares a personal narrative that underscores the resilience of patients with chronic wounds. Recounting a challenging period in her life, she describes returning to work after a family health crisis and encountering a quadriplegic patient with severe pressure ulcers. Despite his condition, he greeted her with a smile and a simple request: “Hi Dr. Fife, isn’t it a beautiful day today? By the way, would you scratch my nose?”

This encounter profoundly impacted Dr. Fife, leading her to establish the “Undaunted Spirit” award to honor patients who inspire through their courage and positivity. She emphasizes that patient stories are invaluable for:

  • Highlighting everyday heroes who refuse to be defined by their conditions
  • Identifying gaps in medical knowledge and treatment options
  • Exposing issues in healthcare policy and delivery
  • Providing opportunities to improve clinical practices and research methodologies

Dr. Fife invites both patients and clinicians to share their stories, aiming to use these narratives to enhance the art and practice of chronic wound care.

Read the full article on the Caroline Fife, MD website.

Keywords:
Chronic wounds,
Patient stories,
Undaunted Spirit award,
Caroline Fife,
Pressure ulcers,
Healthcare policy

Incidence of Charcot Arthropathy: A Nationwide Study

Incidence of Charcot Arthropathy: A Nationwide Study #ActAgainstAmputation

A recent nationwide study from Denmark, spanning from 2000 to 2021 and involving over 265,000 patients with diabetes, reveals a paradoxical trend in Charcot arthropathy cases. While the absolute number of Charcot cases increased significantly over the study period (Kendall’s tau = 0.6, p < 0.0005), the incidence rate per capita among people with diabetes actually declined (Kendall’s tau = -0.6, p = 0.0005) [Source].

This suggests that, although more individuals are developing Charcot arthropathy due to the increasing prevalence of diabetes, the individual risk of developing this complication is decreasing. Improved management of diabetes and neuropathy may be contributing factors to this decline in individual risk.

Notably, the study found no significant regional differences in incidence across Denmark’s five health regions, nor any measurable impact from the COVID-19 pandemic or the nurses’ strike of 2021. This underscores the resilience of Denmark’s multidisciplinary care infrastructure in managing diabetic complications.

These findings highlight the importance of robust public health systems and early intervention strategies in mitigating the disabling effects of diabetic complications like Charcot arthropathy.

Read the full article on the Diabetic Foot Online website.

Keywords:
Charcot arthropathy,
Diabetic neuropathy,
Denmark healthcare,
Public health infrastructure,
Diabetes management,
Epidemiology

Nutrition and Wound Healing: Practical Takeaways for Wound Care Practitioners

Nutrition and Wound Healing: Practical Takeaways for Wound Care Practitioners

At WoundCon Spring 2025, experts Dr. Nancy Munoz and Dr. Mary Litchford emphasized the pivotal role of nutrition in wound healing. They highlighted that optimal healing is not solely reliant on topical treatments but also heavily depends on the patient’s nutritional status.

Macronutrients:

  • Carbohydrates: Serve as the primary energy source, supporting cellular activities and the inflammatory response. Emphasis should be on high-fiber, complex carbohydrates like whole grains, legumes, fruits, and vegetables.
  • Fats: Unsaturated fats, found in olive oil, nuts, and seeds, maintain cellular integrity and reduce inflammation. Saturated and trans fats should be minimized due to their pro-inflammatory effects.
  • Proteins: Essential for tissue regeneration and immune defense. Patients may require 1.25 to 1.5 grams of protein per kilogram of body weight, increasing to 2.0 grams/kg in severe cases. Both animal-based and well-planned plant-based proteins are beneficial.

Read the full article on the WoundSource website.

Keywords:
Nutrition,
Wound Healing,
Macronutrients,
Micronutrients,
Hydration,
Nancy Munoz,
Mary Litchford

Ontario Begins Funding Total Contact Casting

Ontario Begins Funding Total Contact Casting—But Is It Enough?

Three years ago, WoundCareWeekly highlighted a troubling reality in Ontario: while thousands of diabetic patients were undergoing lower-limb amputations annually, the province refused to publicly fund proven offloading treatments like total contact casting (TCC). In that post, we quoted Registered Nurses’ Association of Ontario (RNAO) CEO Doris Grinspun, who memorably criticized the government’s inaction: “We’re willing to pay for the amputations but we’re not willing to pay for the prevention.”

Today, we’re pleased to report that the province has taken a step forward.

Ontario’s Ministry of Health, following recommendations by Health Quality Ontario (HQO), has committed to funding three forms of offloading devices: fibreglass total contact casts, removable cast walkers, and irremovable cast walkers for patients with neuropathic diabetic foot ulcers. A $8 million provincial investment, announced in 2023, will roll out over three years and aims to improve access to these devices through Local Health Integration Networks and Aboriginal Health Access Centres.

The funding covers offloading systems that cost between $150 and $620—minimal compared to the estimated $74,000 per limb spent on amputations. More importantly, this policy aligns with international best practices that emphasize offloading as the single most critical component in healing plantar diabetic foot ulcers.

But as with many bureaucratic victories, implementation lags behind intention. Access to trained professionals capable of applying TCCs, inconsistencies in supply chains, and variability in clinical awareness mean many patients still aren’t receiving the gold standard in care.

We commend Ontario for making this move—but the real test will be in delivery. We’ll continue to follow how this funding translates to outcomes and whether it lives up to the promise of reducing preventable amputations in a system that can no longer afford inaction.

For more background, read our original editorial: “We’ll Pay for the Amputation, But Not the Prevention” 

Keywords:
Total Contact Casting,
Diabetic Foot Ulcers,
Ontario Health Policy,
Offloading Devices,
Doris Grinspun,
RNAO,
Amputation Prevention

Age Characteristics of Patients With Type 2 Diabetic Foot Ulcers

Age Characteristics of Patients With Type 2 Diabetic Foot Ulcers and Predictive Risk Factors for Lower Limb Amputation: A Population-Based Retrospective Study

A population-based retrospective study published in the Journal of Diabetes Research analyzed data from 918 patients with type 2 diabetic foot ulcers (DFUs) treated between 2017 and 2023 at The First Affiliated Hospital of Wannan Medical College in Wuhu, China. The study aimed to investigate age-related characteristics and identify key risk factors associated with lower limb amputation in this patient population.

The findings revealed that the majority of DFU patients were aged between 50 and 59 years, with a notable peak in mortality observed among those aged 70 to 79. Logistic regression analysis identified several significant predictors for lower extremity amputation, including a history of prior amputation, presence of vascular complications, infection sites, and hemoglobin levels. Specifically, a history of amputation and low hemoglobin were strongly associated with major amputations.

These insights underscore the importance of early identification and management of risk factors to prevent severe outcomes in patients with DFUs, particularly in middle-aged and older populations.

Read the full article on the Journal of Diabetes Research website.

Keywords:
Type 2 diabetes,
Diabetic foot ulcers,
Lower limb amputation,
Risk factors,
Yuanying Yao,
Lei Chen,
Yu Qian

Clinical Outcomes of Hyperbaric Oxygen Therapy

Clinical Outcomes of Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers: A Systematic Review

A systematic review published in Cureus evaluated the effectiveness of hyperbaric oxygen therapy (HBOT) in treating diabetic foot ulcers (DFUs). The review analyzed six studies encompassing a total of 391 patients to assess HBOT’s impact on healing rates, ulcer dimensions, and amputation outcomes.

The majority of the studies indicated that HBOT led to lower rates of major amputations, improved ulcer healing, and reduced ulcer dimensions compared to standard care. However, one study found no significant differences in amputation rates or long-term wound healing between groups. The review also noted variations in methodological rigor across the included studies, with selection bias from inconsistent patient allocation being a common limitation in observational studies, potentially distorting comparisons.

These findings suggest that HBOT may be a beneficial adjunctive treatment for DFUs, but further high-quality, randomized controlled trials are needed to confirm its efficacy and address existing methodological concerns.

Read the full article on the Cureus website.

Keywords:
Hyperbaric oxygen therapy,
Diabetic foot ulcers,
Amputation prevention,
Wound healing,
Systematic review,
Ujwala Damineni,
Shravani Divity,
Sri Ram Charan Gundapaneni,
Tejaswi Vadde

Fish Skin Grafts Show Promise for Improved Diabetic Foot Ulcer Healing

Fish Skin Grafts Show Promise for Improved Diabetic Foot Ulcer Healing

A randomized prospective trial, as reported by the American College of Surgeons, has demonstrated that decellularized, lyophilized fish skin grafts derived from Atlantic cod may enhance healing in patients with high-risk diabetic foot ulcers (DFUs) involving deep structures such as muscle, bone, and joints. The study compared the efficacy of fish skin grafts to standard wound care, which typically includes debridement, cleansing, and skin grafting.

Results indicated that 44% of patients treated with fish skin grafts achieved complete healing at 16 weeks, compared to 26% in the standard care group. These findings suggest that fish skin grafts could offer a more effective treatment option for complex DFUs, potentially reducing healing time and improving patient outcomes. However, accompanying editorial commentary emphasized the need for further research into the cost-effectiveness of this treatment approach, given the significant expense associated with the grafts.

Read the full article on the American College of Surgeons website.

Keywords:
Fish skin grafts,
Diabetic foot ulcers,
Atlantic cod,
Standard wound care,
Randomized prospective trial,
Cost-effectiveness

Dardari D, Piaggesi A, Potier L, et al. Intact Fish Skin Graft to Treat Deep Diabetic Foot UlcersNEJM Evid. 2024;3(12).

Castellani L, Arruda S. Hooked on Healing—Fish Skin Grafts for Diabetic Foot UlcersNEJM Evid. 2024;3(12).

New protocols for treating patients with xylazine wounds

New Protocols for Treating Patients with Xylazine Wounds

A multidisciplinary team at the University of Pittsburgh Medical Center (UPMC) has developed comprehensive clinical protocols to manage hospitalized patients exposed to xylazine—a veterinary sedative increasingly found in the unregulated opioid supply. Xylazine exposure has been associated with severe complications, including difficult-to-manage withdrawal symptoms and necrotic skin ulcerations prone to infection and chronicity.

UPMC’s toxicology testing revealed a five-fold increase in patient samples testing positive for xylazine between 2019 and 2021, highlighting the growing impact of this substance. In response, the team implemented detailed treatment protocols, published in the Substance Use & Addiction Journal, emphasizing standardized, evidence-based, and trauma-informed approaches to care.

Led by Dr. Raagini Jawa, MD, MPH, FASAM, along with co-authors Dr. Margaret Shang, MD, MS, and Dr. Ilana Hull, MD, MSc, the team convened clinicians from various specialties—including addiction medicine, toxicology, emergency medicine, psychiatry, and plastic surgery—to address the complex needs of patients affected by xylazine. The protocols aim to improve patient outcomes through coordinated, multidisciplinary care.

Read the full article on the Medical Xpress website.

Keywords:
Xylazine,
Necrotic skin ulcerations,
Withdrawal management,
Multidisciplinary care,
UPMC,
Raagini Jawa,
Margaret Shang,
Ilana Hull

Medicare National Correct Coding Initiative …

Medicare National Correct Coding Initiative Medically Unlikely Edits: Myth and Mystery

In the May 2025 issue of Advances in Skin & Wound Care, Kathleen D. Schaum, MS, addresses prevalent misconceptions surrounding the Medicare National Correct Coding Initiative (NCCI) Medically Unlikely Edits (MUEs). MUEs, introduced in 2007, are designed to prevent inappropriate Medicare payments by setting maximum units of service (UOS) that a provider can report for a single beneficiary on a single day.

Schaum emphasizes that MUEs are coding edits, not determinations of medical necessity. Therefore, denials based on MUEs are not subject to appeal through medical necessity channels. She also clarifies that providers should not circumvent MUEs by splitting services across multiple dates to avoid edit triggers, as this practice is discouraged and may lead to compliance issues.

The article highlights the existence of three separate MUE tables published by CMS: Practitioner Services MUE, DME Supplier Services MUE, and Facility Outpatient Hospital Services MUE. However, not all codes have associated MUEs, and the absence of an MUE does not imply unlimited billing for a service.

Read the full article on the Advances in Skin & Wound Care website.

Keywords:
Medically Unlikely Edits,
National Correct Coding Initiative,
Medicare compliance,
Coding edits,
CMS guidelines,
Wound care billing
Note: The above synopsis is based on the article’s content and available information. For a comprehensive understanding, please refer to the full article.

Bromelain-Based Debridement Versus Collagenase …

Bromelain-Based Debridement Versus Collagenase Ointment Debridement of Venous Leg Ulcers: Post Hoc Analysis of the ChronEx Trial

A recent post hoc analysis of the ChronEx trial, published in Wounds, compared the efficacy of bromelain-based enzymatic debridement (BBD) with collagenase ointment (CO) in treating venous leg ulcers (VLUs). The study aimed to assess which method more effectively achieved complete debridement and granulation within a two-week period.

The analysis included 46 patients with VLUs who were treated with either BBD or CO. Results indicated that a higher proportion of wounds treated with BBD achieved complete debridement and granulation at two weeks compared to those treated with CO. Additionally, the median time to complete debridement and granulation was shorter in the BBD group, suggesting a more rapid wound healing process.

These findings suggest that BBD may offer a more efficient alternative to CO for enzymatic debridement in VLUs, potentially leading to faster wound healing and improved patient outcomes.

Read the full article on the Wounds Journal website.

Keywords:
Bromelain-based debridement,
Collagenase ointment,
Enzymatic debridement,
Venous leg ulcer,
ChronEx trial,
Wound healing

Note: The above synopsis is based on the article’s content and available information. For a comprehensive understanding, please refer to the full article.

Anti-Biofilm Wound Dressing Market

Anti-Biofilm Wound Dressing Market: Steady Growth Expected, Reaching US$ 2,132.5 Million by 2032

The global anti-biofilm wound dressing market is experiencing significant growth, driven by the increasing prevalence of chronic and acute wounds, advancements in wound care technology, and heightened awareness of biofilm-related infections. Biofilms, protective clusters of bacteria, pose challenges in wound healing by leading to chronic infections and delayed recovery. Anti-biofilm wound dressings are specifically designed to disrupt these biofilms, promoting better healing outcomes and reducing infection risks.

According to a report by Persistence Market Research, the market was valued at US$ 1,001.6 million in 2025 and is projected to reach US$ 2,132.5 million by 2032, growing at a CAGR of 11.4%. North America currently holds a significant share of the market, attributed to its robust healthcare infrastructure and high incidence of chronic diseases. The Asia-Pacific region is anticipated to witness the fastest growth during the forecast period, fueled by increasing healthcare access, medical tourism, and demand for advanced wound care products in emerging markets like India and China.

Key market segments include chemical-based, physical-based, and biological-based wound dressings. Chemical-based dressings, containing agents like ionic silver, iodine, and EDTA, are expected to dominate due to their broad-spectrum antimicrobial properties. Physical-based dressings, such as hydrocolloids and hydrogels, provide a moist environment to accelerate tissue regeneration. Biological-based dressings utilize collagen and growth factors to support healing, particularly in chronic wounds like diabetic foot ulcers and pressure ulcers.

Leading companies in the market, including ConvaTec, Smith & Nephew PLC, and Mölnlycke Health Care, are engaging in mergers and acquisitions to expand their product portfolios and market reach.

Read the full article on the openPR website.

Keywords:
Anti-biofilm wound dressing,
Biofilm infections,
Chronic wounds,
Acute wounds,
Chemical-based dressings,
Physical-based dressings,
Biological-based dressings,
ConvaTec,
Smith & Nephew PLC,
Mölnlycke Health Care

Insulin and Metformin Combo Aids Diabetic Foot Ulcer Healing

Insulin and Metformin Combo Aids Diabetic Foot Ulcer Healing, New Study Finds

A recent study by researchers at Michigan State University and South Shore Hospital has uncovered that combining insulin injections with oral metformin therapy can enhance healing in patients with diabetic foot ulcers (DFUs). The study found that this combination increases the concentration of metformin at the wound site, potentially accelerating the healing process.

Dr. Morteza Mahmoudi, an associate professor at MSU’s College of Human Medicine, noted that their analysis of wound exudates revealed the presence of metformin, suggesting that the combined therapy allows metformin to reach the wound area more effectively. This discovery indicates a synergistic effect between insulin and metformin in promoting wound healing.

Co-researcher Dr. Lisa Gould, a plastic surgeon and wound care clinician at South Shore Hospital and a clinical associate professor at Brown University, emphasized the clinical implications of these findings. The study suggests that clinicians could consider prescribing both insulin and metformin not only for glycemic control but also to enhance local wound healing processes in patients with chronic DFUs.

Read the full article on the Medical Xpress website.

Keywords:
Diabetic foot ulcers,
Insulin therapy,
Metformin,
Wound healing,
Combination therapy,
Michigan State University,
South Shore Hospital

Note: The above synopsis is based on the article’s content and available information. For a comprehensive understanding, please refer to the full article.

Unravelling the cardio-renal-metabolic-foot connection

Unravelling the Cardio-Renal-Metabolic-Foot Connection in People with Diabetes-Related Foot Ulceration: A Narrative Review

A recent narrative review published in Cardiovascular Diabetology explores the interconnectedness of cardiovascular, renal, metabolic, and foot complications in individuals with diabetes-related foot ulceration (DFU). The authors propose a “cardio-renal-metabolic-foot” framework, highlighting shared pathophysiological mechanisms that link DFU with cardiovascular and renal diseases.

The review emphasizes that systemic inflammation and infection associated with DFU may contribute to the development and progression of cardiovascular and renal conditions. Conversely, existing cardiovascular and renal diseases can exacerbate the risk and severity of DFU, indicating a bidirectional relationship. The authors advocate for a holistic, multidisciplinary approach to managing DFU, incorporating early screening and management of cardiovascular and kidney diseases.

Emerging therapies, such as sodium-glucose co-transporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and non-steroidal mineralocorticoid receptor antagonists, have shown promise in improving cardiovascular and renal outcomes in people with type 2 diabetes. While dedicated research in DFU populations is needed, these therapies could potentially address multiple aspects of the cardio-renal-metabolic-foot connection.

Read the full article on the Cardiovascular Diabetology website.

Keywords:
Diabetes-related foot ulceration,
Cardio-renal-metabolic connection,
Systemic inflammation,
Multidisciplinary care,
SGLT2 inhibitors,
GLP-1 receptor agonists,
Mineralocorticoid receptor antagonists

Note: The above synopsis is based on the article’s abstract and available information. For a comprehensive understanding, please refer to the full article.

UT Health San Antonio study uncovers key risk factors ….

UT Health San Antonio Study Uncovers Key Risk Factors for Diabetic Foot Infection Recurrence

A recent study conducted by researchers at UT Health San Antonio has identified significant risk factors contributing to the recurrence of diabetic foot infections. Published in the International Wound Journal in November 2024, the study analyzed eight years of patient data to understand why nearly half of patients treated for diabetic foot infections experience reinfection within a year.

Led by Dr. Lawrence A. Lavery, DPM, MPH, a specialist in diabetic foot complications and professor of orthopaedics, the research reviewed records of 294 patients hospitalized for moderate to severe diabetic foot infections. The findings revealed that patients with wounds unhealed after three months were three times more likely to experience reinfection. Additionally, those with bone infections had more than twice the risk compared to patients with only soft tissue infections.

Dr. Lavery emphasized the importance of wound healing in preventing reinfections, stating, “When your wound fails to heal or you develop another wound, the clock starts ticking.” The study also highlighted that patients with unhealed wounds faced longer healing times, increased hospital readmissions, and extended hospital stays, underscoring the need for early intervention and comprehensive care strategies.

Read the full article on the UT Health San Antonio Newsroom.

Keywords:
Diabetic foot infection,
Infection recurrence,
Wound healing,
Bone infection,
Peripheral neuropathy,
UT Health San Antonio,
Lawrence A. Lavery

 

Note: The above synopsis is based on the article’s content and available information. For a comprehensive understanding, please refer to the full article.

Fibroblast technology developed for diabetic foot ulcers, chronic wounds

Fibroblast Technology Developed for Diabetic Foot Ulcers and Chronic Wounds

FibroBiologics, in collaboration with Charles River, has announced the completion of a master cell bank for a novel fibroblast-based therapy aimed at treating chronic wounds, including diabetic foot ulcers (DFUs). The product, designated CYWC628, utilizes a spheroid approach to deliver fibroblast cells topically, promoting wound healing by releasing essential growth factors and cytokines.

According to Dr. Hamid Khoja, Chief Scientific Officer at FibroBiologics, “Fibroblasts are involved in every single stage of the wound healing process.” He notes that chronic wounds like DFUs often fail to heal due to cellular senescence, and this new therapy aims to address that by rejuvenating the wound environment.

CYWC628 has passed all required safety testing, and clinical trials are scheduled to commence in the second quarter of 2025. The 12-week study will evaluate the product’s efficacy in promoting healing in patients with chronic wounds.

Read the full article on the Healio website.

Keywords:
Fibroblast therapy,
Chronic wounds,
Diabetic foot ulcers,
CYWC628,
Wound healing,
Cell-based therapy,
Growth factors,
Clinical trials,
Cellular senescence

Advancements in diabetic foot ulcer research

Advancements in Diabetic Foot Ulcer Research, published in Heliyon in 2024, offers a comprehensive overview of current treatment strategies for diabetic foot ulcers (DFUs). It systematically compares various therapeutic approaches, highlighting their respective advantages and limitations.

ShuHui Wu, ZhongSheng Zhou, Yang Li, Jinlan Jiang

Key Highlights:

  • Treatment Modalities: The article examines a range of treatments, including wound dressings, negative pressure wound therapy, hyperbaric oxygen therapy, and advanced therapies like stem cell applications.

  • Advantages and Limitations: Each treatment is assessed for its efficacy, accessibility, cost-effectiveness, and potential side effects. For instance, while hyperbaric oxygen therapy shows promise in enhancing wound healing, it may not be widely accessible due to cost and equipment requirements.ScienceDirect

  • Clinical Implications: The review underscores the importance of personalized treatment plans, considering patient-specific factors such as comorbidities, ulcer severity, and resource availability.

This article serves as a valuable resource for healthcare professionals seeking to understand the evolving landscape of DFU management and emphasizes the need for continued research to optimize patient outcomes.ScienceDirect

For a more in-depth understanding, you can access the full article here: ScienceDirect.

Keywords
Diabetic foot ulcers, Mesenchymal stem cells, Exosomes


Evaluation of Shear Force Redistribution …

Evaluation of Shear Force Redistribution and Pressure Reduction in a Novel Support Surface for Pressure Injury Prevention

A recent study published in the Advances in Skin & Wound Care journal evaluated the effectiveness of a novel support surface designed to redistribute shear forces and reduce pressure, aiming to prevent pressure injuries (PIs). The research focused on assessing how this innovative surface performs in mitigating factors that contribute to the development of PIs, particularly in high-risk areas like the sacrum and heels.

The study utilized anatomically accurate models and clinically relevant pressure tests to compare the new support surface against existing options. Findings indicated that the novel surface significantly reduced peak pressure and shear forces, suggesting its potential in enhancing patient care and preventing PIs.

These results highlight the importance of incorporating advanced support surfaces into clinical practice to improve patient outcomes. The study advocates for further clinical trials to validate these findings in real-world settings.

Read the full article on the Advances in Skin & Wound Care website.

Healing with Intelligence

Healing with Intelligence: SAWC 2025 Keynote Highlights Transformative Role of AI

At the 2025 Symposium on Advanced Wound Care (SAWC) Spring meeting in Grapevine, Texas, the keynote titled “Healing with Intelligence” spotlighted the transformative role of artificial intelligence (AI) in wound care. Led by Dr. Eric Lullove, Chief Medical Officer at the West Boca Center for Wound Healing, the session emphasized a paradigm shift from reactive to predictive wound management.

Dr. Lullove noted that chronic wounds, affecting over 6.5 million Americans each year, are not just local issues but markers of systemic inefficiencies. AI, he argued, can help clinicians move beyond traditional documentation and embrace smarter diagnosis, streamlined workflows, and improved clinical decision-making.

The panel covered key applications of AI in wound care, including predictive analytics, automated documentation, and real-time clinical decision support. These tools are designed to augment rather than replace clinician judgment. However, a live audience poll revealed that nearly 70% of attendees had limited exposure to AI in practice—highlighting the urgent need for education and accessible integration tools.

Challenges discussed included data security, regulatory compliance, and bias in AI models—especially those trained on narrow patient demographics. Panelists emphasized the importance of designing AI that enhances care without disrupting workflows, and the ethical responsibility to ensure fairness across diverse populations.

The session concluded with a clear call to action: wound care professionals must help lead the integration of AI, ensuring it is used not only intelligently, but humanely. The future of wound care, the panel agreed, lies in combining data-driven insights with hands-on compassion.

Read the full coverage from SAWC Spring 2025 at HMP Global Learning Network.

About Dr. Eric Lullove, DPM, CWSP, FFPM RCPS(Glasg)

Dr. Eric Lullove is a board-certified wound care specialist and podiatric physician based in Coconut Creek, Florida. He serves as the Chief Medical Officer at the West Boca Center for Wound Healing and brings over 20 years of experience in diabetic limb salvage, advanced wound care, and reconstructive foot and ankle surgery.

He is a Fellow of the Royal College of Physicians and Surgeons of Glasgow and holds certification as a Wound Specialist Physician (CWSP). In addition to his clinical practice, Dr. Lullove contributes to ongoing research, lectures nationwide, and consults with medical device companies on wound care technology and reimbursement strategies.

For more on his work, visit www.drlullove.com.

The Many Advantages of Buying from U.S.-Based Total Contact Casting (TCC) Manufacturers

The Many Advantages of Buying from U.S.-Based Total Contact Casting (TCC) Manufacturers

As supply chains continue to shift and tariffs reshape global trade, healthcare providers are taking a closer look at where their medical products are made — and for good reason. When it comes to Total Contact Casting (TCC) kits, working with U.S.-based manufacturers offers multiple benefits that go far beyond product availability.

🇺🇸 Supporting U.S. Jobs and Economic Growth

One of the primary goals behind recent U.S. tariffs on imported goods — especially from countries like China and Mexico — is to incentivize domestic production and bring jobs back to the United States. By sourcing TCC kits from American companies, clinics and hospitals contribute to this effort, helping strengthen the U.S. manufacturing base and create employment in logistics, packaging, and assembly sectors.

📦 Reliable Supply Chains and Faster Fulfillment

U.S.-based TCC manufacturers like M-Med benefit from being located within national logistics hubs. That means faster fulfillment, fewer customs delays, and greater supply chain stability — even during international disruptions. With wound care patients requiring timely interventions, every day of delay can matter.

💰 Predictable Pricing Without Tariff Surprises

Imported medical devices from Mexico and other countries may face tariffs of up to 25% if they do not meet strict USMCA compliance standards. While some products are exempt, not all medical devices qualify — and compliance must be proven. Domestic manufacturers avoid these pricing uncertainties, offering more consistent and transparent cost structures for purchasing departments.

🛠 Quality, Oversight, and Responsiveness

U.S.-based manufacturers operate under FDA guidelines and often have shorter feedback loops with customers. That means higher quality control, quicker responses to clinical feedback, and greater flexibility when it comes to custom orders or support.

✅ The M-Med Advantage

M-Med’s Total Contact Casting kits are manufactured and assembled in the Southeastern U.S., with more padding and more components than standard kits. As a family-owned business, we prioritize fast delivery, dependable quality, and close relationships with the wound care professionals we serve.

In a time when sourcing and supply decisions carry long-term implications, buying American-made TCC products isn’t just a smart business move — it’s an investment in quality care and domestic resilience.

Disclosure: M-Med is a sponsor of WoundCareWeekly. While editorial content is independently written, M-Med supports our mission to educate and connect the wound care community.

Playing the Long Game with Diabetes

Playing the Long Game with Diabetes: Prioritizing Foot Health

The American Podiatric Medical Association (APMA) emphasizes the critical importance of foot health in diabetes management. Individuals with Type 1 or Type 2 diabetes face a heightened risk of serious foot complications, including infections and amputations. APMA’s “Playing the Long Game with Diabetes” campaign advocates for early adoption of healthy habits to prevent such outcomes.APMA MAIN+7APMA MAIN+7APMA MAIN+7APMA MAIN+3APMA MAIN+3APMA MAIN+3

Key recommendations include annual visits to an APMA-member podiatrist, or at minimum, regular foot checks by a primary care provider if podiatric access is limited. The APMA provides a suite of resources to support patients in maintaining foot health:APMA MAIN

  • Daily Foot Exams: Guidance on conducting simple daily inspections to detect early signs of complications.

  • Educational Materials: Tip sheets and videos featuring podiatrists sharing insights on diabetes-related foot care.

  • Product Recommendations: A list of APMA Seal-approved footwear and products designed for diabetic foot care.APMA MAIN+1APMA MAIN+1

  • Community Engagement: Encouragement to join conversations on social media using the hashtag #PlaytheLongGame.APMA MAIN+4APMA MAIN+4APMA MAIN+4

These resources aim to empower individuals with diabetes to take proactive steps in managing their foot health, thereby reducing the risk of complications.APMA MAIN

Explore the full suite of resources here: APMA Diabetes Awareness


About the Author: Dr. Savannah Santiago, DPM

Dr. Savannah Santiago is a first-year podiatric medicine and surgery resident at Ascension St. Vincent Hospital in Indianapolis. A 2024 graduate of Western University of Health Sciences College of Podiatric Medicine, she holds a B.S. in Biomedical Sciences and Spanish Language and Culture from the University of Colorado Colorado Springs, where she also competed in NCAA cross country and track and field.Pod Patrol+5LinkedIn+5Ascension Medical Education+5WesternU News+2cdn2.podiatry.com+2Ascension Medical Education+2

Dr. Santiago’s personal experiences, including managing her own diabetes diagnosis at 19 and overcoming sports-related injuries, have fueled her passion for podiatry. Her clinical interests encompass reconstructive surgery, limb salvage, pediatric podiatry, sports medicine, and inpatient care.Ascension Medical Education

An active contributor to the field, she authors the “Sole Purpose” blog on PRESENT Podiatry and has been featured on the Pod Patrol podcast. Dr. Santiago also serves as the first Resident Liaison for the American College of Podiatric Medicine (ACPM). Outside the clinic, she enjoys trail running, rollerblading, and exploring farmers markets.session.podiatry.com+4Pod Patrol+4Podiatry+4InstagramAscension Medical Education


Note: This bio is intended for educational purposes and to inform readers about Dr. Santiago’s contributions to the field of podiatric medicine.

Wound remodelling

Wound Remodelling Strategies for Challenging Wound Topographies

Even with optimal debridement, certain wounds resist healing due to unfavorable base elevations or edge configurations. In this insightful article, Igor Melnychuk explores advanced wound remodelling techniques designed to overcome these barriers and promote effective closure.

Key strategies discussed include:

  • Base Contouring: Lowering elevated wound beds to align with the periwound skin, facilitating keratinocyte migration.woundsinternational.com

  • Edge Resection: Trimming vertical or undermined edges at a 45° angle to eliminate impediments to epithelialization.woundsinternational.com+1woundsinternational.com+1

  • Innovative Techniques: Introducing methods like edge trenching, soap scrap, and parallel pocket incisions, inspired by grafting principles, to address complex wound geometries without extensive tissue removal.woundsinternational.com

These approaches are particularly beneficial for wounds exhibiting features such as epiboly, undermining, or raised bases, where traditional healing processes are compromised.

Read the full article here: Wound Remodelling: Approaches and Techniques Aimed at Closure of Wounds with Unfavourable Base or Edges


About the Author: Igor Melnychuk

Igor Melnychuk is a dedicated wound care specialist with extensive experience in managing complex and hard-to-heal wounds. His work focuses on developing and implementing innovative techniques to enhance wound healing outcomes. Through his research and clinical practice, Igor contributes significantly to the advancement of wound care methodologies.


Note: This synopsis is intended for educational purposes and to inform wound care professionals about recent advancements in wound management strategies.

What’s Your Litmus Test ….

for the Appropriateness of Wound Treatments?

In this thought-provoking article, the author challenges wound care professionals to critically evaluate the appropriateness of their treatment choices. Despite advances in technology and science, outdated or non-evidence-based approaches remain common in clinical practice. The author introduces three practical “litmus test” questions to guide treatment decisions: 1) What is the rationale for this treatment? 2) What does the science and evidence say? and 3) Could this plan of care be defended in court? Through clear examples—like the misuse of NPWT on necrotic wounds or unnecessary topical antibiotics—the article underscores the importance of logic, clinical evidence, and legal defensibility in creating effective, modern wound care plans … full article


About the author:

Bill Richlen - Advanced Wound Debridement

About the Author: Bill Richlen, PT, WCC, DWC (1970–2024)

Bill Richlen was a respected physical therapist and wound care educator with over 25 years of clinical and teaching experience. A graduate of the University of Wisconsin–Madison, he specialized in advanced wound care and debridement across long-term care, outpatient, rehab, and home health settings.

He co-founded Wound Care Gurus, serving as CEO and providing evidence-based education and consulting nationwide. Bill was also a long-time instructor with the Wound Care Education Institute (WCEI), known for his engaging teaching style and commitment to practical, science-driven care. His legacy lives on through the thousands of clinicians he mentored.

Dehydrated human amnion/chorion membrane to treat venous leg ulcers

A recent economic evaluation using a Markov model assessed the cost-effectiveness of dehydrated human amnion/chorion membrane (DHACM) for Medicare beneficiaries with venous leg ulcers (VLUs). The study compared DHACM—applied following recommended timing and frequency—to no advanced treatment (NAT) over three years, using real-world claims from over 530,000 patients. Results showed that DHACM not only saved $170 per patient but also improved quality-adjusted life years (QALYs), producing a net monetary benefit of $1,178. The treatment was cost-effective in over 63% of simulations and linked to lower recurrence rates. With chronic wounds placing a heavy and growing burden on Medicare—VLUs alone cost $14.9 billion annually—these findings support DHACM as a superior, cost-saving strategy. Providers and payers are encouraged to prioritize DHACM in wound care formularies to improve outcomes and reduce system-wide costs … read more


The authors:

1. William H. Tettelbach, MD, FACP, FIDSA, FUHM, CWSP

Dr. Tettelbach is board-certified in Undersea & Hyperbaric Medicine, Infectious Diseases, and Internal Medicine. He has held leadership roles at MiMedx, OnSite Advanced Care, and RestorixHealth, and serves as an adjunct professor at Duke University School of Medicine.WICE Radiology+8Press Release Hub+8ORCID+8


2. Vickie R. Driver, DPM, MS, FACFAS

Dr. Driver is a Professor at Washington State University School of Medicine and the Founding Chair of the Board of Directors for the Wound Care Collaborative Community. She has served as System-Wide Medical Director of Wound Care and Hyperbaric Centers at INOVA Healthcare and is a Fellow of the Royal College of Physicians and Surgeons-Glasgow.hmpglobalevents.com+5woundcarecc.org+5woundcarecc.org+5reddressmedical.com+4sawcf.eventscribe.net+4Maggie Online Library+4


3. Alisha Oropallo, MD, FACS, FSVS, FAPWCA

Dr. Oropallo is a Professor at the Zucker School of Medicine at Hofstra/Northwell and Director of the Comprehensive Wound Healing Center at Northwell Health. She is board-certified in General and Vascular Surgery and is a Fellow of the American College of Surgeons.LinkedIn+4ResearchGate+4CITI Program+4woundcarecc.org


4. Martha R. Kelso, RN, CHWS, HBOT

Ms. Kelso is the CEO of Wound Care Plus, LLC, one of the nation’s largest mobile wound care providers. She is recognized as a visionary in mobile medicine and is a published author and clinical editor for multiple peer-reviewed journals.hmpglobalevents.com+3Log in or sign up to view+3LinkedIn+3hmpglobalevents.com+3pawsic.org+3LinkedIn+3


5. Jeffrey A. Niezgoda, MD, FACHM, MAPWCA, CHWS

Dr. Niezgoda is the President and Chief Medical Officer of WebCME and serves as the CMO for Kent Imaging. He is the Past President of the American Professional Wound Care Association and the American College of Hyperbaric Medicine.LinkedIn+8ipawssummit.org+8kentimaging.com+8


6. Naz Wahab, MD, FAAFP, FAPWCA

Dr. Wahab is a board-certified family physician and wound care specialist. She serves as the Medical Director for the Mountain View Outpatient Wound Care and Hyperbaric Center and is an active member of several wound care organizations.reddressmedical.com+4Medical News Today+4aawconline.memberclicks.net+4aawconline.memberclicks.net+3reddressmedical.com+3campswoundcaresummit.com+3


7. Julie L. De Jong

Information on Julie L. De Jong’s professional background in wound care is limited in the provided sources. Further details may be available through institutional affiliations or publications.


8. Brandon Hubbs

Mr. Hubbs is an experienced Cardiovascular Administrator and Nurse, affiliated with FirstHealth of the Carolinas.LinkedIn


9. R. Allyn Forsyth

Dr. Forsyth has contributed to research on wound care, including studies on the cost of chronic wound care for Medicare beneficiaries.ResearchGate


10. Gregory A. Magee, MD

Dr. Magee is an Associate Professor of Clinical Surgery at the Keck School of Medicine of USC. He completed fellowships in surgical critical care and trauma surgery at USC and in vascular surgery at the University of Colorado Denver.Healthgrades+4Keck School of Medicine of USC+4SC CTSI Profiles+4Keck Medicine of USC


11. Paul Steel

Specific information about Paul Steel’s professional background in wound care is not readily available in the provided sources. Further details may be found through academic publications or institutional affiliations.


12. Benjamin G. Cohen, DPM

Dr. Cohen is a Podiatric Medicine specialist and Podiatric Surgeon based in Aiken, South Carolina. He is recognized as an advanced expert in his field.Medifind+1Maggie Online Library+1


13. William V. Padula, PhD

Dr. Padula is an Assistant Professor of Pharmaceutical & Health Economics at the USC Mann School of Pharmacy and a Fellow at the USC Leonard D. Schaeffer Center for Health Policy & Economics. His research focuses on cost-effectiveness analysis and healthcare delivery, particularly regarding pressure injury prevention.USC Schaeffer+2USC Mann School of Pharmacy+2SC CTSI Profiles+2NCBI+3USC Schaeffer+3ResearchGate+3

Debridement of wounds

One of the greatest challenges in wound care is the widespread lack of understanding and training around debridement, a crucial step in healing chronic wounds by removing necrotic tissue, usually through sharp debridement. Many caregivers hesitate due to fear of causing harm or discomfort, underscoring the need for hands-on mentorship rather than relying solely on videos or reading. The extent to which nurses and medical assistants can safely debride varies based on experience, availability of doctors, anesthesia use, and anatomical knowledge. In practice, nurses often manage routine outpatient debridements, while deeper procedures are left to surgeons. Debridement is generally safe if limited to dead tissue, though bleeding must be controlled properly, and anatomical landmarks—such as major vessels, nerves, and joint capsules—must be respected to avoid serious complications. Patient pain management is important, with oral analgesics like paracetamol and codeine given in advance, except in patients with severe neuropathy who may not feel pain … read more

About Wounds Africa:
WoundsAfrica is a non-profit educational platform dedicated to enhancing wound care across the African continent, particularly in regions with limited resources. The website offers practical, experience-based guidance tailored for healthcare professionals such as nurses, medical assistants, podiatrists, and doctors. Recognizing the vast disparities in wound care access—from advanced urban clinics to remote rural settings—the platform provides adaptable strategies for diverse clinical environments. The editorial team comprises seasoned experts: Isabella Stokka Landmark, a certified nurse practitioner and tissue viability nurse involved in research and quality control; Anne Catherine Skaar, a senior consultant anesthesiologist with extensive experience in surgical and burn care; and Bodo Günther, a senior orthopedic consultant and assistant professor with over two decades in advanced wound management. Together, they emphasize the importance of practical skills, ethical considerations, and community engagement to improve wound care outcomes throughout Africa. ​

Innovative Approaches in Diabetic Foot Ulcer Management

From LEKHA MUTYALA
Summary:
Revolutionizing Diabetic Foot Ulcer Care with 3D Technology
Diabetic foot ulcers (DFUs) affect 1 in 4 individuals with diabetes and contribute significantly to healthcare costs and lower limb amputations worldwide. Traditional treatments—like wound debridement, glycemic control, and surgical interventions—offer limited scalability in the face of rising diabetes prevalence. Fortunately, innovative technologies are reshaping the future of DFU management. 3D-printed antibiotic bandages from Queen’s University promise rapid healing and reduced clinical burden. Meanwhile, Indian researchers have developed custom, pressure-sensitive 3D-printed footwear to enhance balance and recovery. In surgical care, 3D-bioprinted adipose tissue has successfully prevented amputations in high-risk patients. These advancements highlight how personalized, tech-driven solutions can reduce complications, improve outcomes, and lower healthcare costs for diabetic patients. Full article

————

Lekha Mutyala is a podiatry student at Kent State University College of Podiatric Medicine (KSUCPM). In 2024, she won the 38th Annual American Podiatric Medical Writers Association (APMWA) Student Writing Competition for her paper titled “Advancements in Technology and Innovative Approaches in Diabetic Foot Ulcer Management.” This achievement earned her a $1,000 honorarium from an endowment by Dr. and Mrs. Steven Berlin to the APMA Educational Foundation .​

Additionally, Mutyala was recognized as a 2024–2025 APMA Educational Foundation scholarship recipient, highlighting her academic excellence and commitment to the field of podiatric medicine

Digital Twins in Wound Care

Thanoon Thabet MSN, RN, WOCN, WTA-C

Wound healing is a multifaceted and complex biological process involving various stages including hemostasis, inflammation, and tissue remodeling, leading to the restoration of damaged tissue and skin.1 In recent years, the evolution of science has seen the emergence of specialized dressings, such as bioactive dressings, which may help to speed the wound healing processes and reduce complications.2 Such advancements in medical knowledge and the growing demand for individualized, data-driven approaches are gradually challenging traditional wound care strategies. Consequently, healthcare professionals are incorporating technologies that increase the personalization and precision of wound care to better tailor and monitor treatments. Digital twins are one of these recent technologies that could have great potential in the wound care field. This technology integrates data from patient history, sensors, and medical imaging to develop real-time virtual representations of patients’ wounds.3 Digital twin technology enables healthcare providers …. read more

The development and testing of the C/WoundComp instrument for assessing ….

chronic wound‐care competence in student nurses and podiatrists

The purpose of this study was to describe the level of chronic wound‐care competence among graduating student nurses and student podiatrists in comparison with that of professionals and to develop and test a new instrument (the C/WoundComp) that assesses both theoretical and practical competence in chronic wound care as well as attitudes towards wound care. The data (N = 135) were collected in 2019 from four groups (1): graduating student nurses (n = 44) (2); graduating student podiatrists (n = 28) (3); registered nurses (n = 54); and (4) podiatrists (n = 9). The data were analysed using statistical analysis. According to the results, the students’ total mean competence score was 62%. Their mean score for theoretical competence was 67%, and for practical competence, it was 52%. The students’ competence level was statistically significantly lower than that of the professionals (P < .0001), but the students showed a positive attitude towards chronic wound care. The instrument demonstrated preliminary validity and reliability, but this warrants further testing. This study provides new knowledge about student nurses’ and …. full article

———————

Summary:

This study aimed to develop and test a new assessment tool—called the C/WoundComp instrument—to evaluate both theoretical and practical competence in chronic wound care among student nurses and podiatrists. It also examined their attitudes toward chronic wound care.

Design & Participants: The study used a descriptive, comparative, and methodological approach with 135 participants:

  • 44 graduating student nurses

  • 28 graduating student podiatrists

  • 54 registered nurses

  • 9 practicing podiatrists

Key Findings:

  • Students had an average competence score of 62% overall:

    • 67% in theoretical knowledge

    • 52% in practical skills

  • Professionals scored significantly higher than students.

  • Students showed positive attitudes toward chronic wound care despite limited competence.

  • The C/WoundComp instrument showed initial reliability and validity for assessing wound-care competence.

Conclusion: Graduating students lack sufficient theoretical and practical knowledge in chronic wound care, highlighting the need to strengthen wound-care education. The C/WoundComp tool could help evaluate and improve competence in this critical area of healthcare.

The authors:

  • Emilia Kielo-Viljamaa, PhD, RN: Dr. Kielo-Viljamaa is a Senior Lecturer at Novia University of Applied Sciences, Faculty of Health and Welfare, in Vaasa, Finland. She also serves as a Postdoctoral Researcher at the University of Turku’s Department of Nursing Science. Her research focuses on nursing education and wound care competence.ResearchGate

  • Riitta Suhonen, PhD, RN: Dr. Suhonen is affiliated with the Department of Nursing Science at the University of Turku, Turku University Hospital, and the Welfare Division of the City of Turku in Finland. She has an extensive background in nursing science and education.PubMed

  • Maarit Ahtiala: Associated with Turku University Hospital in Finland, contributing to research in nursing and healthcare.PubMed

  • Terhi Kolari: Affiliated with the Department of Biostatistics at the University of Turku, focusing on statistical analysis in medical research.PubMed

  • Jouko Katajisto: Part of the Department of Mathematics and Statistics at the University of Turku, specializing in statistical methodologies.PubMed

  • Leena Salminen, PhD, RN: Connected with the Department of Nursing Science at the University of Turku, with research interests in nursing education and professional competence.PubMed+1ResearchGate+1

  • Minna Stolt, PhD, RN: Also from the Department of Nursing Science at the University of Turku, Dr. Stolt’s research includes nursing education and wound care.PubMed

Society of Tissue Viability Conference

Society of Tissue Viability Conference 2025
Solving skin and wound challenges together

30 April – 01 May 2025
LIFE Centre, Wapping Road, Bradford BD3 0EQ

Want to attend?
We are delighted to offer several FREE conference registrations (travel / accommodation bursaries are ‘sold out’) to attend our conference. Link below to find out more and apply now.

Call for abstracts
Are you doing some great work in research? Do you have a case study or product evaluation that you would like to present? Then consider submitting to #SoTV2025! The call for abstracts is now open! Find out more below. Closing 28 February, 2025. Submissions now closed. Thank you to everyone that has submitted – we will notify you of the results soon

Get in touch
If you have any questions, email hello@societyoftissueviability.org

Simple and Effective Approach for Wound-Bed Preparation by Topical Citric Acid Application

A wound heals by progression through various stages of inflammation, granulation tissue synthesis, collagen deposition and maturation, and epithelization.The majority of acute wounds follow this organized pattern to achieve structural and functional stability. However, some acute wounds with large raw areas progress into chronic wounds refractory to conventional treatments. The presence of bacteria in significant numbers is one important reason a wound may not proceed through the healing trajectory …. full article

CTP Coding, Compliance, and Documentation (webinar)

Date
Thursday, March 20, 2025
Time
2:00 PM (UTC-04:00) Eastern Time (US & Canada)
Duration
60 minutes
Description
This session will cover the specifics of the Part B Medicare guidelines governing skin substitute application that are scheduled to take effect April 13, 2025. Attendees will learn exactly when this is a covered service and what the accompanying documentation requirements are.Register

Speaker:

Full Name
Jeffrey D. Lehrman, DPM, FASPS, MAPWCA, CPC, CPMA
Job Title
Certified Professional Coder, Certified Professional Medical Auditor
Company
Lehrman Consulting, LLC
Speaker Bio
Dr. Lehrman is a podiatrist and a Certified Professional Coder and Certified Professional Medical Auditor. He operates Lehrman Consulting, LLC, which provides guidance regarding coding, compliance, and documentation. Dr. Lehrman serves as a staff liaison at the AMA CPT® Editorial Panel meetings where CPT codes are created, edited, and deleted.

Diabetes-Related Extremity Amputation Depression and Distress (DREADD): A Multimethod Study

A Multimethod Study

Diabetes-related lower extremity amputations (LEAs) are among the most devastating complications of diabetes, profoundly impacting physical, psychological, and social well-being. The Diabetes-Related Extremity Amputation Depression and Distress (DREADD) study examines the emotional and psychological consequences of amputation in diabetic individuals, employing a multimethod approach to capture the full spectrum of patient experiences.

The Psychological Toll of Amputation

Individuals who undergo amputations due to diabetes-related complications, such as diabetic foot ulcers and peripheral artery disease (PAD), often experience profound emotional distress. Depression, anxiety, and post-traumatic stress are common, exacerbated by a loss of mobility, independence, and altered self-identity. Many struggle with feelings of grief, shame, and social isolation, impacting their overall quality of life and mental health.

A Multimethod Approach

The DREADD study employs both qualitative and quantitative research methods to explore these psychological impacts. Surveys and standardized depression scales, such as the Patient Health Questionnaire-9 (PHQ-9), are used to measure depression severity, while structured interviews provide insights into personal struggles, coping mechanisms, and unmet psychological needs. Additionally, biometric data, including heart rate variability and cortisol levels, offer physiological indicators of chronic stress and emotional dysregulation.

Findings and Implications for Care

Preliminary findings suggest that nearly half of patients experience moderate to severe depression post-amputation, with many lacking adequate mental health support. Factors such as poor social support, financial strain, and preexisting mental health conditions contribute to worse outcomes. The study underscores the need for integrated care models that address both physical and psychological rehabilitation, including peer support groups, counseling services, and cognitive behavioral therapy (CBT) to improve patient adaptation and emotional resilience.

By highlighting the critical intersection between diabetes, amputation, and mental health, the DREADD study aims to reshape post-amputation care, advocating for holistic interventions that go beyond wound healing to address the profound psychological distress faced by affected individuals.

Key risk factors for diabetic foot reinfections uncovered in study

by Claire Kowalick, 

Texas has one of the highest rates of diabetes in the country, with more than 2.7 million Texans diagnosed with the condition. About one in six people in San Antonio have type 2 diabetes, and a third of residents are prediabetic, according to the American Diabetes Association.

Type 2 diabetes is a chronic condition in which the body cannot produce enough insulin or use insulin properly and, if left uncontrolled, can lead to high blood sugar, heart disease and kidney failure. It also predisposes people to foot ulcers, of which almost 50% become infected, subsequently leading to hospitalization and potentially amputation of part of the foot or a lower limb … full article

related:

Texas has one of the highest rates of diabetes in the country, with more than 2.7 million Texans diagnosed with the condition. This epidemic has significant implications for healthcare systems, particularly in the management of complications like diabetic foot ulcers (DFUs). In San Antonio, where approximately one in six residents has type 2 diabetes and a third of the population is prediabetic, the risk of developing DFUs is alarmingly high.

Diabetic foot ulcers result from a combination of neuropathy, poor circulation, and impaired immune response, all of which are common in individuals with long-standing diabetes. Without proper intervention, these ulcers can progress to severe infections, leading to hospitalizations, amputations, and increased mortality rates. Given the high prevalence of diabetes in Texas, hospitals and wound care centers face mounting challenges in treating and preventing these wounds effectively.

The economic burden of DFUs is also substantial. Studies indicate that treating a single DFU can cost tens of thousands of dollars, with the total cost of diabetic foot care in the U.S. exceeding billions annually. In areas like San Antonio, where diabetes rates are disproportionately high, local healthcare facilities must prioritize specialized wound care services, early detection, and preventive measures such as total contact casting (TCC) to offload pressure from wounds and enhance healing.

Community-wide initiatives are essential to combat this growing crisis. Increasing awareness about proper foot care, expanding access to podiatric and wound care specialists, and implementing preventive strategies—such as routine screenings for neuropathy and peripheral artery disease (PAD)—can significantly reduce the incidence and severity of DFUs. Additionally, addressing social determinants of health, such as limited access to quality healthcare, lower socioeconomic status, and dietary challenges, is crucial in mitigating the long-term consequences of diabetes-related foot complications.

As Texas continues to grapple with rising diabetes rates, proactive intervention and innovative wound care solutions will be key in preventing DFUs and improving patient outcomes.

Is Nanofat the Long-Awaited Treatment for Hypertensive Ischemic Leg Ulcers?

Background. Martorell hypertensive ischemic leg ulcer (HYTILU) is a chronic, hard-to-heal wound linked to hypertension. This study explores nanofat grafting as a regenerative alternative to traditional skin grafting for improved healing and patient outcomes. Objective. To explore the efficacy of nanofat grafting in the management of HYTILU and compare it with skin grafting. Materials and Methods. This was a retrospective single-center pilot study involving 23 patients with HYTILU treated with adipose-derived stromal cells (adipose-derived stromal cells/nanofat). The primary outcomes were ulcer healing rate, pain reduction, and improvements in quality of life, as measured by SCAR-Q (a scar quality of life questionnaire) and the Vancouver Scar Scale, over a period of 6 months posttreatment. Results. This study revealed a significant decrease in ulcer size from an initial mean of 39.69 cm² to complete healing, with an average healing time of 4.65 months. The mean visual analog scale pain scores significantly decreased from an initial score of 5.87 to 0.39 at 3 months …. read more

Which Procedures Does Medicare Cover for Pressure Injuries?

Kathleen D. Schaum, MS

Medicare coverage for distinct types of wounds/ulcers has received attention for many years. Because the theme of this issue of Advances in Skin & Wound Care is pressure injuries (PIs), this article reviews whether Medicare covers certain technologies and procedures for PIs.

DEBRIDEMENT

Most Medicare Administrative Contractors (MACs) have a Local Coverage Determination (LCD) and Local Coverage Article (LCA) that address the coverage guidelines for debridement of all types of wounds/ulcers, including PIs. Some MACs have a separate debridement LCD/LCA, whereas others include debridement coverage guidelines within their LCD/LCA related to wound care. Readers should check their MAC’s LCDs, which do not limit debridement to distinct wound types. However, their LCDs/LCAs have similar coverage guidelines that include, but are not limited to, documentation of:

  • History and physical examination with an initial wound description, location, measurements, and response to prior treatment (if applicable).
  • Identification of wound location, size, depth, and stage (supported by a drawing or photograph of the wound).
  • Clinical documentation of diagnosis or symptoms to justify services.
  • Current progress notes including measurable signs of healing as well as causes of delayed wound healing or modifications to the treatment plan.
  • Documentation of the wound’s characteristics (e.g., dimensions, necrotic tissue presence, tissue removed, degree of epithelialization) before and after debridement.
  • Operative note or procedure note for debridement services, including descriptions of tissue debrided, wound measurements, and pre-/post-debridement wound assessments.
  • Plan of care containing treatment goals and physician follow-up.read full article

Kathleen D. Schaum, MS, is a healthcare reimbursement expert specializing in wound care, durable medical equipment (DME), and Medicare coverage policies. She is the president and founder of Kathleen D. Schaum & Associates, a consulting firm focused on payment strategies for healthcare providers and manufacturers. Schaum is a frequent author and speaker on reimbursement-related topics in wound care and medical technology.

Johns Hopkins to cut over 2,000 jobs

Johns Hopkins University has announced plans to eliminate over 2,200 jobs following the Trump administration’s decision to cut $800 million in grants previously allocated by the U.S. Agency for International Development (USAID). This reduction represents the largest layoff in the university’s history, affecting 247 positions within the United States and 1,975 positions across 44 countries.

The job cuts will impact several key divisions of the university, including the Bloomberg School of Public Health, the School of Medicine, and the affiliated nonprofit organization Jhpiego, which focuses on international health initiatives. The university expressed deep concern over the funding termination, stating that it forces them to wind down critical work both domestically and internationally.

This development is part of a broader trend affecting higher education institutions across the United States. Several universities, including Harvard, the Massachusetts Institute of Technology, and the University of California, San Diego, have implemented hiring freezes and other cost-saving measures in response to federal funding uncertainties. These financial strains threaten the academic and research integrity of these institutions and pose risks to job growth in higher education.

The reduction in USAID funding is expected to have significant implications for global health initiatives, particularly those targeting infectious diseases and women’s health in low-income countries. Johns Hopkins University and other research institutions anticipate further financial challenges and have initiated legal actions against the proposed budget reductions.

As the largest private employer in Maryland and Baltimore, Johns Hopkins University’s decision to cut over 2,000 jobs underscores the real-world impact of federal funding policies on employment and public health research.

What Happens When a Wound Heals?

Alton R. Johnson Jr., DPM, DABPM, FACPM, FASPS, CWSP
John Steinberg, DPM, FACFAS

In this insightful episode, Dr. Alton Johnson, Dr. John Steinberg, and host Brian discuss the often-overlooked phase of wound care: life after healing. The conversation shifts from the traditional focus on simply closing wounds to a broader perspective that emphasizes function, long-term remission, and patient education.

Dr. Johnson shares his journey as a young physician who initially believed healing was the final step, only to realize that patients frequently return due to recurring wounds. He highlights the importance of educating patients on easing back into daily activities and managing their healed wounds like a condition in remission.

Dr. Steinberg builds on this by emphasizing function over limb salvage, noting that saving a limb without restoring mobility can leave patients unable to regain independence. He recalls advice from his colleague, Dr. Chris Attinger, who stressed that preventing wounds from returning is just as crucial as healing them.

The discussion underscores the need for early planning in the healing process, ensuring patients have the right prosthetics, orthotics, and footwear in place before their wounds fully close. By shifting the focus from simply healing wounds to optimizing long-term mobility and quality of life, this episode offers valuable insights for clinicians, caregivers, and patients alike.

Listen

Mastering wound cleansing and debridement with Microworld

This event will be held at 7:30pm, 26th February 2025.

Presented by Paulo Ramos, RN, (Nurse Specialist at ULS Póvoa de Varzim / Vila do Conde, USF Corino de Andrade, Portugal. Certified wound care educator. Board Member of the Portuguese Wound Care Association and a EWMA Council Member. Member of the EWMA Working Groups of AMS and Compression Therapy. Chair of EWMA Education Comittee).

Register interest

New Taxonomy Codes for Wound Care Practitioners!

by  | Feb 19, 2025

A taxonomy code is a unique 10-character identifier that specifies a practitioner’s (physician or nurse practitioner) classification and specialization. This code is required when applying for a National Provider Identifier (NPI), which is necessary for billing Medicare. NPI applications are processed through the National Plan & Provider Enumeration System (NPPES). Clinicians are expected to select the taxonomy code that best represents their provider type, classification, or specialization. However, I am not aware of any regulations mandating that a practitioner be board-certified in the specialty associated with their chosen taxonomy code.
https://carolinefifemd.com/2025/02/19/new-taxonomy-codes-for-wound-care-practitioners/

2025 JWC Awards

Recognizing Excellence in Wound Care Research and Practice

The Journal of Wound Care (JWC) Awards 2025 took place on Friday, 14th February 2025, at the prestigious Imperial War Museum in London. This annual event celebrates excellence in research, innovative practices, and outstanding contributions across the wound care community.

This year’s winners and finalists represent the dedication and expertise driving advancements in wound care, from pioneering clinical interventions to transformative research and education. Their work continues to push the boundaries of patient care, setting new standards for the field.

Congratulations to all those recognized for their achievements!

For a full list of winners and highlights from the event, visit the JWC Awards website.

The Frank & Lizzie Show Episode 27 Featuring MPM Medical’s Multifunctional Dressing

Frank and Lizzie sit down with Mark Overcash, RN, WCSP, a seasoned wound care specialist with over 25 years of experience and the National Sales Manager at MPM Medical. In this insightful conversation, Mark shares the latest industry trends, key findings from professional surveys, and the increasing demand for multifunctional, cost-effective wound dressings.

MPM Medical, a leader in advanced wound care since 1992, has consistently prioritized feedback from healthcare professionals to develop innovative solutions. Their newest product, TriSAP, is a silicone-based, silver-infused, super-absorbent dressing designed to tackle exudate management, infection control, and reimbursement challenges.

Join us for an in-depth discussion on how TriSAP is shaping the future of wound care and revolutionizing patient treatment!

https://www.hmpgloballearningnetwork.com/site/wounds/videos/frank-lizzie-show-episode-27-multifunctional-dressings-future-doing-more-less

Mark Overcash, RN, CWSP, is a seasoned wound care specialist with over 25 years of experience. He began his nursing career in 1997 and transitioned to medical sales focusing on wound care in 2000. In 2023, Mark joined MPM Medical, and within a year, he was promoted to National Sales Manager.

He has been instrumental in promoting MPM Medical’s latest dressing, TriSAP, which addresses exudate management, infection control, and supports reimbursement needs.

Mark actively engages with healthcare professionals at industry events, such as the Desert Foot conference, to share advanced solutions for diabetic and venous stasis ulcers.

Histologics LLC Releases SoftBiopsy®+D, the Versatile Kylon® Fabric-Tipped Device for Wound Debridement or Tissue Biopsy Sampling

ANAHEIM, Calif.July 5, 2023 /PRNewswire/ — Histologics LLC attended “WOCNext” in Las Vegas last June 4-6th to exhibit its novel debridement and wound biopsy fabric-curettage devices including for the first time, the SoftBiopsy®+D device. Over 1M cases by clinicians used Kylon® devices for colposcopic biopsy and curettage in the USA, in nearly every clinical setting www.histologics.com. The hooked medical (Kylon®) fabric tipped brushes gently remove and can trap tissue for biopsy for histology or microbiology. The debridement may be performed at a lighter “hygiene” level, extending all the way to “excisional” surgical methods when the brush array converts to micro-curettes if the fabric is pressed firmly and wiped or twisted into tissue.

Kylon® Fabric Debridement and Biopsy : Video Simulation

The cause of some wounds not to heal includes biofilm, and the Kylon® fabric devices can be used to obtain true tangential biopsy samples from the debrided wound base for lab testing.  This is commonly done with the SoftBiopsy® product, solely used for biopsy that is sent to a laboratory. Histologics recently released SoftBiopsy®+D, a more versatile and durable version for clinicians, that can sustain longer procedure time for wound debridement as well as biopsy.

We have previously demonstrated the value of our Soft K-Rette® device to debride and sample crevice wounds, and Soft K-Cot® deployed on the finger for “Compassionate Debridement at Your Fingertips®”.

The scope of practice of most physicians and nurse clinicians vary from basic wound care to the most advanced surgical procedures where necrotic wound tissue must be mechanically or surgically removed.  Advanced and basic wound care providers include many specialties in health care and procedures occur in clinics, hospitals, homes, facilities and other settings. Some providers that shy away from regular debridement (necessary to heal wounds) due to the invasive nature of the scalpel and sharp curette would be willing to clean wounds using the gentle  Kylon® devices.

Please visit our wound care website to request free samples at www.histologicwc.com,  or contact Lily Ramos at histologicswc@gmail.com, Toll Free:  888-235-2275.

SOURCE Histologics LLC

Metabolic memory in diabetic foot syndrome (DFS): MICRO-RNAS, single nucleotide polymorphisms

(SNPs) frequency and their relationship with indices of endothelial function and adipo-inflammatory dysfunction Alessandro Del Cuore, Rosaria Maria Pipitone, Alessandra Casuccio, Marco Maria Mazzola, Maria Grazia Puleo, Gaetano Pacinella, Renata Riolo, Carlo Maida, Tiziana Di Chiara, Domenico Di Raimondo, Rossella Zito, Giulia Lupo, Luisa Agnello, Gabriele Di Maria, Marcello Ciaccio, Stefania Grimaudo & Antonino Tuttolomondo

Revolutionizing Podiatry for Efficient Patient Care

As the director of podiatric medical education and co-chief of the podiatry division, I lead certified residency and fellowship training in wound care along with our parent organization, Council on Podiatric Medical Education. We are a renowned healthcare organization specializing in podiatry and a broad range of primary care and specialty services …

Nuo Therapeutics’ Aurix® System Added To Wound Care Formulary Of Wound Care Advantage

HOUSTON, June 22, 2023 (GLOBE NEWSWIRE) — Nuo Therapeutics, Inc. (OTCQB: AURX) (“Nuo”), a commercial stage medical device company pioneering leading-edge biodynamic therapies by focusing on emerging opportunities in the evolving healthcare landscape, is pleased to announce that Wound Care Advantage (WCA), the nation’s leading wound care consulting firm has added the Aurix® System to its formulary. Founded in 2002, Wound Care Advantage (WCA) has established a large network of successful wound healing programs with partner hospitals. Through a strong commitment to quality care and innovation, WCA has built financially sustainable wound care programs that have saved limbs and lives of more than 40,000 patients suffering chronic wounds.

“Diabetic foot ulcers pose a significant risk to patients and can be challenging for wound care centers to treat from both clinical and financial perspectives,” commented Dave Hazard, Nuo’s Vice President of Sales. “With thousands of commercially available wound care products, it can be extremely difficult for wound care centers to identify products that are both reimbursed by Medicare, and more importantly, that actually heal patients. We are excited to partner with Wound Care Advantage’s team of experts who rigorously vet each product that is placed on the formulary.”

The Platelet Rich Plasma gel produced by the Aurix System is cleared by the FDA for treating chronic wounds with a simple one-minute spin. In a clinical study performed with the Centers for Medicare and Medicaid Services (CMS), the Aurix System demonstrated a higher healing rate and a significant time to heal advantage as compared to other advanced healing modalities.

About Nuo Therapeutics

Nuo Therapeutics, Inc. is a commercial stage medical device company pioneering leading-edge biodynamic therapies by focusing on emerging opportunities in the evolving healthcare landscape. The Company’s Aurix System is a biodynamic hematogel that harnesses a patient’s innate regenerative abilities for the management of a variety of wounds.

Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements. These forward-looking statements may include statements that are predictive in nature and depend upon or refer to future events or conditions, and may include words such as “believes,” “plans,” “anticipates,” “projects,” “estimates,” “expects,” “intends,” “strategy,” “future,” “opportunity,” “may,” “will,” “should,” “could,” “potential,” or similar expressions. You are cautioned not to unduly rely on forward-looking statements. Forward-looking statements are based on current expectations, assumptions, and information available to the Company’s management and are subject to known and unknown risks, uncertainties and other factors which may cause actual results to differ materially from the forward- looking statements. These risks, uncertainties, and factors are discussed under “Risk Factors” and elsewhere in the Company’s public filings with the U.S. Securities and Exchange Commission from time to time, including the Company’s annual report on Form 10-K, quarterly reports on Form 10-Q, and current reports on Form 8-K. You are advised to carefully consider these various risks, uncertainties, and other factors. The Company expressly disclaims any intent or obligation to update or revise publicly these forward-looking statements except as required by law.

Contact:
David Jorden
djorden@nuot.com

Seasoned Healthcare Executive David Bassin Joins the MolecuLight Board of Directors

Former Healogics CEO Brings Deep Wound Care Industry Experience to MolecuLight’s
Rapidly Growing Business

TORONTOJuly 6, 2023 /PRNewswire/ – MolecuLight Inc., the leader in point-of-care fluorescence imaging that locates and detects elevated, pathogenic bacterial loads in and around wounds, is pleased to announce the appointment of David Bassin to its Board of Directors as an Independent Board Member.

David Bassin brings a wealth of expertise and experience in the healthcare industry, particularly in the field of wound care. As the founder of GIO Advisory LLC, he has provided invaluable advisory services to numerous companies and private equity firms based on his extensive background in healthcare, spanning pharmaceutical/device, payer, and provider services. Most recently, Bassin served as the CEO of Healogics, the foremost provider of wound care services in the US, operating over 630 wound care centers and 300 providers. During his tenure, he successfully restructured and refocused the business, resulting in strong earnings growth prior to his transition into advisory services. Prior to his role as CEO, Bassin served as the CFO of Healogics, contributing to the company’s financial growth and success. Bassin’s impressive career also includes significant roles in other healthcare organizations. He served as the CFO of eviCore Healthcare, Inc., where he oversaw multiple dividend recapitalizations and facilitated a merger with the company’s largest competitor, leading to the creation of a company with over 3,000 employees. Additionally, Bassin held the position of CFO at InVentiv Health, Inc., a provider of services to pharmaceutical companies, where he successfully managed a high-growth company and orchestrated a go-private transaction valued at over $1 billion and delivered a significant premium to its shareholders.

“We are thrilled to welcome David Bassin to the MolecuLight Board of Directors,” said Anil Amlani, CEO of MolecuLight. “His extensive experience in optimizing and scaling organizations across the healthcare industry, particularly in wound care, will be invaluable to MolecuLight as we continue to expand our global presence. Our MolecuLight devices have already become indispensable tools in wound assessment and real-time decision-making for thousands of clinicians worldwide. David’s expertise will greatly support our mission to meet the increasing global demand for our innovative wound care diagnostics and establish them as the gold standard in the field.”

David Bassin expressed his excitement about joining MolecuLight’s Board of Directors, stating, “There are over 6.5 million patients living with wounds.  As an industry, we need to continue to develop new solutions that improve wound care treatment effectiveness and efficiency.  With a global drive to improve outcomes, reduce costs, and minimize antibiotic usage, MolecuLight’s point-of-care devices have demonstrated their ability to effectively address these critical clinical needs. I am deeply impressed by the organization, the technology’s alignment with market demands, and the significant market traction they have achieved. I am eager to contribute to their growth and help them achieve their ambitious goals.”

MolecuLight’s groundbreaking i:X® and DX™ imaging devices are the only FDA-cleared and CE and Health Canada approved devices for the real-time detection of elevated bacterial burden in wounds. Supported by over 80 peer-reviewed publications involving 2,600 patients, these devices are widely utilized by leading wound care facilities worldwide.

About MolecuLight Inc.

MolecuLight Inc. is a privately-owned medical imaging company that has developed and is commercializing its proprietary fluorescent imaging platform technology in multiple clinical markets. MolecuLight’s commercial devices, which include the MolecuLight i: and DX™ fluorescence imaging systems and their accessories, are point-of-care handheld imaging devices for the real-time detection and localization of bacterial load in wounds and digital wound measurement. MolecuLight procedures performed in the United States benefit from an available reimbursement pathway which includes two CPT® codes for physician work to perform “fluorescence imaging for bacterial presence, location, and load” and facility payment for Hospital Outpatient Department (HOPD) and Ambulatory Surgical Center (ASC) settings through an Ambulatory Payment Classification (APC) assignment. The company is also commercializing its unique fluorescence imaging platform technology for other global markets with relevant unmet needs in food safety, consumer cosmetics and other key industrial markets.

For more information, contact:

Rob Sandler 
Chief Marketing Officer
MolecuLight Inc.
T. +1.647.362.4684
rsandler@moleculight.com
www.moleculight.com

Image:

SOURCE MolecuLight

The Wound Company Launches With $4.25M In Funding To Curb the Amputation Epidemic And Save The Healthcare System Billions

Led by Susa Ventures and Sozo Ventures, the funding will be used to transform the $45B wound and ostomy care industry by bringing on-demand experts to more patients and providers in need via telehealth and in-person visits

 

Minneapolis, MN – WEBWIRE – Thursday, June 15, 2023

The Wound Company, a multi-channel on-demand wound and ostomy care delivery company that improves patient outcomes, today announced its launch from stealth with $4.25M in seed funding from Susa Ventures and Sozo Ventures. The funding will be used to expand the company’s national footprint, hire top talent, and to continue improving health outcomes in the most cost-effective way possible while bringing dignity to the over 13 million people in need of improved wound and ostomy care.

Why Wound Care Matters

The US is experiencing an amputation epidemic due to diabetic foot ulcers and other serious wounds. Despite medical advancements, Americans are amputating double the number of limbs today than during the Civil War. About 50% of lower extremity amputations would have been preventable if patients with type 2 diabetes and foot ulcers had access to better healthcare. This issue is one of the problems The Wound Company is solving for.

Often providers need more wound care expertise or, due to understaffing, don’t have time to offer comprehensive care continuously, leaving patients to figure it out on their own. This leads to wound care patients returning to the hospital due to improper wound care. But it can be prevented.

“The wound and ostomy care industry is broken,” said Nima Ahmadi, founder and CEO of The Wound Company. “It’s operating in the fee-for-service world, which pushes expensive procedures and products that help the bottom line, but don’t impact outcomes for the patient. We’re paid to heal wounds with continuous care and, in doing so, save money for health plans and at-risk providers.”

Enter The Wound Company

The Wound Company aims to fix the broken space of wound and ostomy care by using predictive analytics and multi-channel communications to deliver the right wound and ostomy care to the right patient in the right channel at the right time. The tech connects patients and providers to wound and ostomy experts virtually or via in-person visits to ensure they have top-tier care.

“The Wound Company’s innovative technologies have the potential to save health plans billions of dollars and transform the patient experience,” says Susa Ventures Investor Derick En’Wezoh. “With a dedicated team of highly experienced experts, a strong vision, and a passion for improving healthcare outcomes, this tech will save lives.”

The platform also offers clinical reporting, customer data integration, and workflow automation to make care delivery as painless as possible for providers.

While in stealth, The Wound Company has already partnered with health plans, health systems, home care providers, hospice providers, and patients, with significant results to date:

  • A potential 15-20% reduction in the total cost of care for wound and ostomy patients for payers
  • Up to 50% savings on supplies per patient for home and hospice care providers
  • 60% of patients demonstrated progressive healing week after week
  • 90% of Stage I/II pressure ulcers resolved without advancing to a higher stage
  • 100% of ostomy patients have a predictable pouching system and reduced chance of ER visits or readmissions

 

“Our blend of virtual and in-person services provided by passionate experts in wound care helps people heal quickly, safely, and with the dignity they deserve while helping to alleviate the pressure on overworked healthcare professionals,” said Chief Medical Officer Sanford Roberts.

The Wound Company is open to partnerships with health plans, at-risk providers, home health providers, and hospice care providers. For more information, visit www.thewound.co.

About The Wound Company

The Wound Company is a Minneapolis-based technology company dedicated to advancing wound and ostomy care. The company uses proprietary technology to connect providers with experienced and certified wound care specialists who can care for patients virtually or via in-person visits. The Wound Company partners with health plans, home care companies, and providers to bring dignity to patients with wounds and ostomies while increasing positive patient outcomes.

This article was originally published here

Venturis Therapeutics, Inc. Announces Affiliation With David G. Armstrong DPM MD PhD Leading Authority on Diabetic Foot

David G. Armstrong, DPM, PhD, is an internationally recognized leader in the field of podiatric surgery, diabetic foot, limb preservation, and wound healing.

DALLAS, TX, USA, June 12, 2023/EINPresswire.com/ — Venturis Therapeutics, Inc. (“VT” or the “Company”) announces that David G Armstrong, DPM MD PhD will assume the role of senior academic advisor for the surgeon board. This agreement was consummated following a review of the Company’s scientific and commercial opportunities.

Armstrong is the foremost expert in diabetic limb preservation and is recognized worldwide with a huge following through his prodigious authorship and lectures on diabetic limb salvage. This affiliation will further enhance the diabetic wound program and clinical research trials being undertaken by VT, and will improve the visibility of the Company dramatically among all those in the greater biotech wound healing community.

ABOUT VENTURIS THERAPEUTICS
Venturis Therapeutics, Inc. is a biopharmaceutical company developing protein drug candidates to address diseases such as severe coronary heart disease, diabetic wounds, peripheral artery disease, erectile dysfunction, stroke, and spinal disk disease. The active pharmaceutical ingredient (“API”) in our drug candidates is FGF-1, a human protein that stimulates the growth of new blood vessels, thereby increasing the blood supply to ischemic organs and tissues.

FORWARD LOOKING STATEMENTS
This news release contains forward-looking statements that involve risks and uncertainties. Actual results and outcomes may differ materially from those discussed or anticipated. For example, statements regarding expectations for new research, progress with clinical trials or future business initiatives are forward looking statements. Factors that might affect actual outcomes include, but are not limited to, FDA approval of VT drug candidates, market acceptance of VT products by customers, new developments in the industry, future revenues, future expenses, future margins, cash usage, and financial performance. Additionally, until VT is cash flow positive from operations, the Company is dependent upon raising capital to fund its operations and meet its obligations as they come due. There can be no assurance that VT will be able to raise the necessary capital when needed.

Amy Gordon
Venturis Therapeutics Inc
+1 972-904-2029
email us here

Dr. David G Armstrong The 18th Malvern Diabetic Foot Conference Future of Wound Treatment

Digital Innovation Initiative Aims to Reduce Amputations

RALEIGH, N.C.–(BUSINESS WIRE)–In the United States alone, a leg is amputated every two minutes. As announced at last week’s New Cardiovascular Horizons (NCVH) Annual Conference, this confronting statistic is being met head on by a digital innovation initiative referred to as SL2 for “Saving Limbs. Savings Lives.” Enrollment in SL2 is now open to all members of the American Podiatric Medical Association (APMA), the country’s largest non-profit organization dedicated to advancing the practice of foot and ankle medicine.

APMA members will have access to CarePICS, a software application purpose built to support best practices in wound care, including electronic consults and electronic referrals for optimal collaboration with peers in the vascular community. As an added benefit, many of the activities facilitated within CarePICS are eligible for reimbursement. The application may be used via mobile phones, desktop computers and iPads/tablets. It does not require any special devices.

For more information on SL2 and to enroll, visit https://carepics.com/apma/sl2.

The nationwide launch of SL2 is considered Phase 2 of the digital innovation initiative, with Phase 1 having drawn to a close at the end of May 2023, following a successful six-month pilot in Florida and Texas. Phase 2 will run for 12 months, through June 2023, at which time the potential for a permanent program will be evaluated.

The steadily increasing rate of lower extremity amputations in the United States – an estimated 60% deemed preventable – is shown to be the result of four key variables: (1) imprecise wound assessment and measurement (using manual tools), (2) inadequate and inconsistent wound documentation, (3) suboptimal patient follow-up and communication, and (4) fragmented coordination between providers who encounter wounds, such as podiatrists, and vascular specialists who treat associated medical conditions, mainly peripheral arterial disease (PAD) and critical limb ischemia (CLI). SL2 is positioned to combat these variables through a combination of digital tools, educational courses, data analysis and member support.

“When we look broadly at the medical histories of patients who have undergone lower extremity amputations, the evidence reveals that only about half have ever had a vascular evaluation or were referred to a vascular specialist. Their condition simply progressed to a stage where the limb could not be salvaged,” says Dr. Timothy Yates of Palm Vascular Centers, who participated in Phase 1 of SL2. “This is exactly the scenario SL2 is helping avoid. Using the CarePICS app, podiatrists can quickly and easily request an electronic consult with a vascular specialist, then convert it to an electronic referral when it’s indicated that the patient needs a vascular evaluation.”

“The CarePICS app has been a game changer for our wound care practice,” says Dr. Eric Lullove of West Boca Center for Wound Care, who also participated in Phase 1 of SL2. “Not only can we achieve precision and efficiency in our wound measurement and documentation, our patients can message with us, they can upload images, even participate in televisits. It is also possible to order wound dressings and cellular tissue products through the app.”

SL2 is governed by an advisory panel of physicians with expertise in podiatric and vascular medicine (in alphabetical order):

  • David B. Alper, DPM
    Member of Board of Trustees, American Podiatric Medical Association
    Board Member, American Diabetes Association – Northeast Region
  • M. Laiq Raja, MD, FACC, FSCAI
    Director and Co-Founder, Pulse Amputation Prevention Centers
    Interventional Cardiologist and Limb Salvage Specialist, El Paso Cardiology Associates, P.A.
    Medical Director of Cardiology and Critical Limb Ischemia Program, The Hospitals of Providence Memorial Campus

The SL2 advisory panel is directed by Christopher K. Bromley, DPM, FACFAS, Chief Medical Officer of CarePICS and Adjunct Professor at Kent State University College of Podiatric Medicine.

About CarePICS
CarePICS is a health tech company on a mission to save limbs and save lives through efficient, high-value digital tools purpose built to foster best practices in wound care, including precision measurement, compliant documentation, patient self-reporting, and streamlined collaboration among all providers in the continuum. CarePICS may be used in podiatry, vascular medicine, primary care, endocrinology, cardiology, oncology, plastic surgery, dermatology, geriatrics and myriad other clinical disciplines. The software platform serves as the backbone of two nationwide programs aimed at reducing preventable lower extremity amputations: SL2 and Collaborate4Wounds. CarePICS was founded by Paul Schubert and Terry Williams, both industry veterans of wound care and healthcare technology innovation. For more information, visit www.carepics.com.

Contacts

Joy Efron, Principal
Kibit Marketing
joy@kibitmarketing.com

The Most Positive Thing to Happen to Negative Pressure Wound Therapy

NEXA NPWT System Launched in the USA

OCEANSIDE, Calif.June 7, 2023 /PRNewswire/ — AOTI Inc, the global leader in multi-modality topical wound oxygen, announced exciting news from ongoing WOCNext conference in Las Vegas, Nevada, where their game changing NEXA Negative Pressure Wound Therapy (NPWT) system made its official USA debut.

The unique NEXA NPWT system is an incredibly flexible platform that is simple to use, silent, portable and affordable. NEXA seamlessly combines the simplicity of disposable NPWT with the performance features of more traditional durable NPWT technology platforms.

Dr. Mike Griffiths, CEO and President of AOTI commented; “Releasing the innovative NEXA NPWT platform in the USA is a major milestone for the company that will allow clinicians, payers, and patients alike to experience much improved performance at significantly lower cost. With NEXA, we have reimagined how NPWT should function.

Its addition to our portfolio only further enhances our mission of helping all people with chronic conditions get back to living their lives to the fullest.”

AOTI’s unique NEXA NPWT and Topical Wound Oxygen (TWO2) therapy are unlike any other treatment approaches. NEXA provided unrivaled flexibility and performance in a portable NPWT system. TWO2 is the only device that provides a multimodality treatment, combining higher pressure oxygen delivery with non-contact cyclical compression and humidity, in a therapeutic applied by the patient at home. This patented approach has been demonstrated in numerous Randomized Controlled Trial (RCT) and Real World Evidence (RWE) studies to not only heal chronic wounds at a far higher rate, but perhaps more importantly, keep them closed longer term, thereby reducing unnecessary hospitalizations and amputations.1, 2

1 Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers; The TWO2 Study. Robert G. Frykberg et al, Diabetics Care 2020; 43:616-624. https://doi.org/10.2337/dc19-0476.

Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real-World Outcomes; Jessica Izhakoff Yellin, et al; Advances in Wound Care 2022; http://doi.org/10.1089/wound.2021.0118

About AOTI

AOTI is a privately-owned company based in Oceanside, California USA and Galway, Ireland that provides innovative solutions to resolve severe and chronic wounds worldwide. Our mission is to help all people with chronic conditions get back to living their lives to the fullest. We do this by enhancing access to care, improving quality of life and advancing health equity. 
Our products reduce healthcare costs and improve the quality of life for patients with these debilitating conditions. Our patented Topical Wound Oxygen (TWO2) at home therapy is clinically proven to deliver Sustained Wound Healing that reduces both Amputations and Hospitalizations, So Life Can Get Back to Normal.

For more information see: www.aotinc.net

Contact:
Dr. Mike Griffiths
CEO & President
360322@email4pr.com
(760) 672 1920

SOURCE AOTI Inc.

Challenges faced by individuals living with foot and wound disease.

Foot and wound chronic disease is characterized by persistent ulcers, sores, and infections that primarily affect the feet. it is a condition that causes pain, affects mobility issues, and even long-term disability if left untreated. On today’s health beat, we delve deeper into the challenges faced by individuals living with foot and wound disease.

Placental Based Allografts: From Womb to Wound

In this webcast, Dr. Vincent W. Li reviews the biology of placental based allografts and the components relevant to wound healing, regeneration, and tissue repair. From May 2, 2019

To learn more about how amnio allografts can benefit your patients with chronic wounds as well as reimbursement information schedule a meeting at support@AmnioSource.com or call (336) 223-5050

DDI tackles diabetic foot complications

Dasman Diabetes Institute (DDI), established by the Kuwait Foundation for the Advancement of Sciences, held recently its specialized three-day course on the prevention and management of diabetic foot complications, in collaboration with the Primary Health Care Department at the Ministry of Health who assisted in coordinating this course. The program was held at the Institute…

Sonoma Pharmaceuticals Introduces Next Generation Solution for Pulse Lavage Irrigation in the European Union

BOULDER, CO / ACCESSWIRE / June 8, 2023 / Sonoma Pharmaceuticals, Inc. (Nasdaq:SNOA), a global healthcare leader developing and producing patented Microcyn® technology based stabilized hypochlorous acid (HOCl) products for a wide range of applications, including wound care, dermatology, and eye, oral and nasal care, today announced a new application for intraoperative pulse lavage irrigation treatment, which can replace commonly used IV bags in a variety of surgical procedures.

Sonoma developed this new application of its wound care technology in response to an unmet need for a non-toxic irrigation solution that can prevent infection and improve healing time. The intraoperative pulse lavage container is designed to be used in combination with a pulse lavage irrigation device, or flush gun, for abdominal, laparoscopic, orthopedic, and periprosthetic procedures. This product replaces commonly used non-antimicrobial saline and aggressive rinsing solutions with safe and effective Microcyn® Technology. Microcyn® Technology assists in the reduction of microorganisms, is non-toxic, and has regenerative properties, making it critical in preventing infection and promoting wound healing. Sonoma’s pulse lavage container is also cost competitive with IV bags, the current standard of care.

Sonoma developed the intraoperative pulse lavage irrigation treatment in close collaboration with the medical community and Sonoma’s existing distribution partners in Europe and expects this new application will be met with wide acceptance. Sonoma is now accepting orders for the pulse lavage irrigation treatment solution, which is expected to be ready for commercial use in Europe in September 2023. Sonoma anticipates commercial launch in the U.S. in 2024.

“Sonoma continues to lead in the innovation of products that improve outcomes for people with wounds or injuries or who are needing surgery. We continue to see increased demand for our wound care products in Europe, and we are excited to expand our offerings to include this next generation irrigation solution to help people heal faster following surgery,” said Amy Trombly, CEO of Sonoma Pharmaceuticals.

For more information, or to pre-order our pulse lavage irrigation treatment solution in Europe, please contact info.europe@sonomapharma.com.

About Sonoma Pharmaceuticals, Inc.

Sonoma Pharmaceuticals is a global healthcare leader for developing and producing stabilized hypochlorous acid (HOCl) products for a wide range of applications, including wound care, eye care, nasal care, oral care, dermatological conditions, animal health care and non-toxic disinfectants. The company’s products reduce infections, itch, pain, scarring and harmful inflammatory responses in a safe and effective manner. In-vitro and clinical studies of hypochlorous acid (HOCl) show it to have impressive antipruritic, antimicrobial, antiviral and anti-inflammatory properties. Sonoma’s stabilized HOCl immediately relieves itch and pain, kills pathogens and breaks down biofilm, does not sting or irritate skin, and oxygenates the cells in the area treated, assisting the body in its natural healing process. The company’s products are sold either directly or via partners in 55 countries worldwide and the company actively seeks new distribution partners. The company’s principal office is in Boulder, Colorado, with manufacturing operations in Guadalajara, Mexico. European marketing and sales are headquartered in Roermond, Netherlands. More information can be found at www.sonomapharma.com. For partnership opportunities, please contact busdev@sonomapharma.com.

Forward-Looking Statements

Except for historical information herein, matters set forth in this press release are forward-looking within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995, including statements about the commercial and technology progress and future financial performance of Sonoma Pharmaceuticals, Inc. and its subsidiaries (the “company”). These forward-looking statements are identified by the use of words such as “continue,” “develop,” “anticipate,” “expect” and “expand,” among others. Forward-looking statements in this press release are subject to certain risks and uncertainties inherent in the company’s business that could cause actual results to vary, including such risks that regulatory clinical and guideline developments may change, scientific data may not be sufficient to meet regulatory standards or receipt of required regulatory clearances or approvals, clinical results may not be replicated in actual patient settings, protection offered by the company’s patents and patent applications may be challenged, invalidated or circumvented by its competitors, the available market for the company’s products will not be as large as expected, the company’s products will not be able to penetrate one or more targeted markets, revenues will not be sufficient to meet the company’s cash needs, fund further development, as well as uncertainties relative to the COVID-19 pandemic and economic development, varying product formulations and a multitude of diverse regulatory and marketing requirements in different countries and municipalities, and other risks detailed from time to time in the company’s filings with the Securities and Exchange Commission. The company disclaims any obligation to update these forward-looking statements, except as required by law.

Sonoma Pharmaceuticals™ and Microcyn® are trademarks or registered trademarks of Sonoma Pharmaceuticals, Inc. All other trademarks and service marks are the property of their respective owners.

Media and Investor Contact:

Sonoma Pharmaceuticals, Inc.

ir@sonomapharmaceuticals.com

SOURCE: Sonoma Pharmaceuticals, Inc.

Wirelessly-powered ‘smart bandage’ could provide drug-free wound care

 

A new generation of wirelessly-powered, environmentally-friendly ‘smart bandages’ could help patients with non-healing wounds avoid infections, scientists say. The bandage could help improve the quality of life of people who live with chronic non-healing wounds, which currently frequently require painful cleaning and treatment. Non-healing wounds can be a side effect of certain medications or health factors like diabetes, cancer or damaged blood vessels. The smart bandage is built on technology initially developed by Dr Mahmoud Wagih of the James Watt School of Engineering and his colleagues from the University of Southampton. The research is showcased in a second paper, recently published in IEEE Transactions on Industrial Electronics. The paper demonstrates the first use of magnetic-resonant wireless power transfer to provide electricity to standard textiles using embroidery or screen printing – a feature which helped to make the smart bandage possible. In this case, the power was supplied to a newly-developed flexible electronic resistor made from silver and carbon which was printed into a textile surface to act as a wearable heating element. The system was capable of being heated to up to 60◦C while separated from the transmitter by 2cm at an efficiency exceeding 50%.

Swift Medical Announces Proven Outcomes Across 20 Million Wound Assessments

Swift’s AI-powered wound imaging technology shown to improve quality of care and costs to manage complex patients

June 01, 2023 09:00 AM Eastern Daylight Time
TORONTO–(BUSINESS WIRE)–Swift Medical, a digital health technology company focused on improving clinical and economic outcomes in wound care, today announced proven outcomes from more than 20 million wound assessments captured with Swift’s leading, AI-powered wound care platform. Deployed in nearly 4,000 healthcare facilities across North America, Swift’s technology has been shown to speed up wound healing by 37%, reduce wound prevalence and hospitalizations by 35% and 14%, respectively, and reduce hospital length of stay by 62%.

“We are proud to share the incredible impact our technology is having on the millions of patients living with wounds – one of today’s most expensive and overlooked threats to patients and our overall healthcare system”

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“We are proud to share the incredible impact our technology is having on the millions of patients living with wounds – one of today’s most expensive and overlooked threats to patients and our overall healthcare system,” said Brian Litten, CEO of Swift Medical. “These outcomes demonstrate the impact of having the most powerful wound image dataset in the world and its ability to deliver high quality wound care with reduced costs.”

The Swift Skin & Wound mobile application enables any mobile device to be equipped with AI-powered imaging capabilities to capture clinically validated, high-precision 3D images, measurements, and other clinical data. The imaging captured at the point of care enables real-time, at-risk patient monitoring, proactive decision-making, and remote wound consultations, reducing the time and cost spent evaluating wounds to create a more efficient wound care experience for both clinicians and patients.

Today, more people suffer from chronic wounds than those with breast cancer, colon cancer, lung cancer, and leukemia combined. Despite this costly, growing problem, the current standard of care is outdated and highly inaccurate. Clinicians typically receive less than 10 hours of formal education and rely on paper rulers for measurements and cotton swabs for depth assessment. This inefficient and ineffective approach is both painful for patients and leads to poor diagnostic accuracy, prolonged healing, and inappropriate selection of therapies, putting patients at greater risk for readmission, longer lengths of stay and higher care costs.

With its advanced analytics and proven outcomes, Swift is now poised to partner with health plans and risk-bearing providers to deliver high quality, value-based wound care at scale.

About Swift Medical

Swift Medical is the global leader in digital wound care. We are headquartered in Toronto, with operations expanding across the U.S. and Canada. Our mission is to make empathy-driven wound care ubiquitous through AI-powered diagnostic technology. We are the trusted wound technology partner of more than 4,000 healthcare facilities in North America across the continuum of care. Our solutions empower healthcare providers to deliver standardized, accessible and equitable wound care for every patient – with advanced, high-precision imaging, compliant documentation, clinical analytics and remote care. To learn more about Swift Medical, visit us at www.swiftmedical.com.

Contacts
Media

David Mannion
416-303-8020
david.mannion@swiftmedical.com

New Expert Guidelines from IWGDF Highlight the Growing International Recognition of Topical

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Oxygen Therapy for Diabetic Foot Ulcers

 

Evidence-based recommendations support the effective use of TOT in diabetic foot ulcer management, revolutionizing treatment approaches worldwide

CAMBRIDGE, EnglandMay 17, 2023 /PRNewswire/ — NATROX® Wound Care, a leading innovator in wound care technology, proudly announces the release of newly published expert recommendations on the use of topical oxygen therapy for wound healing1. The updated guidelines endorse topical oxygen therapy (TOT) as an adjunct therapy in the treatment of diabetic foot ulcers (DFUs) 1. With its endorsement by leading experts, this ground-breaking therapy is poised to transform the lives of millions of people worldwide, offering renewed hope for effective healing and improved quality of life.

New IWDGF Guidelines
The International Working Group on the Diabetic Foot (IWGDF) has just published its 2023 Guidelines. This set of recommended DFU interventions, developed by a panel of renowned experts, serves as a trusted resource for healthcare professionals worldwide.

Notably, among the 29 recommendations highlighted, TOT gained recognition as an accepted intervention when treating non-healing DFUs. Consider the use of topical oxygen as an adjunct therapy to standard of care for wound healing in people with diabetes-related foot ulcers where standard of care alone has failed and resources exist to support this intervention1.”  With its inclusion in the IWGDF guidelines, topical oxygen therapy emerges as a vital tool, poised to revolutionize the management and healing of foot ulcers in individuals with diabetes.

In addition, the guidelines note that evidence on topical oxygen has substantially expanded in the last four years with several new RCTs with a total of ten included in the systematic review for these guidelines (References 100-109) 1, which includes an RCT study published in 2021² which compared the healing effects of using standard care against a combination of standard care plus NATROX® O₂ topical oxygen therapy. In the study, patients completing the therapy experienced 71% greater healing rates² and 73% greater reduction in wound size² with NATROX® O₂.


Experts recommend updating algorithms to include TOT
In the Journal of Wound Care, experts reached a “clear consensus that adjunctive treatments with a solid evidence base, including NPWT and TOT, must be included3 in each of the four proposed regional guidelines. Most notably, the experts agreed that “all hard-to-heal wounds are likely to benefit from TOT³.”


TOT received “A grade” from the American Diabetes Association
The American Diabetes Association recently released its “Standards of Care in Diabetes⁴” which not only recommended TOT as an adjunctive therapy for chronic DFUs, but also gave it an “A grade” based on the quality of evidence⁴. The newly published recommendations acknowledge the remarkable potential of TOT⁴.

According to Dr. Windy Cole, DPM, CWSP, FAPWH, FACCWS, renowned authority in podiatric medicine and dedicated wound care advocate for over two decades, “The evidence supporting the efficacy of TOT is now undeniable. It is imperative that healthcare professionals embrace this innovative yet simple approach to achieve improved healing outcomes.”  After witnessing the positive impact topical oxygen therapy can have on healing DFUs in her own clinic, Windy recently joined the NATROX® team as Director of Global Medical Affairs to further advocate for the integration of topical oxygen therapy in the treatment pathway for chronic wounds.

NATROX® Wound Care CEO, Craig Kennedy, expressed great enthusiasm regarding the recognition and international acceptance of topical oxygen therapy, stating, “We’re delighted that topical oxygen therapy continues to gain international recognition, cementing its status as a game-changing treatment in wound care. The inclusion of topical oxygen in the IWGDF Guidelines further validates our mission to transform the quality of life for patients suffering from chronic wounds, particularly those with diabetic foot ulcers.”

What is NATROX® O₂ Topical Oxygen Therapy NATROX® Wound Care manufactures an award-winning5,6,7 topical oxygen therapy device known as NATROX® O₂The compact, wearable device generates and delivers a continuous flow of oxygen directly to the wound bed to promote accelerated healing and foster a healthy wound environment. Its non-invasive nature, coupled with its remarkable effectiveness², offers a significant advancement in chronic wound treatment, even allowing patients to be treated from the comfort of home.

To learn about NATROX® O₂ and request a demo, visit: https://bit.ly/NO2therapy

About NATROX® Wound Care 
NATROX® Wound Care is an Inotec AMD brand. The specialist wound care company based in Cambridge, England was formed specifically to introduce new technologies to healthcare professionals around the world to promote faster and better healing to patients. The company’s flagship product, NATROX® O₂, is positioned to become an integral part of global wound care treatment regimes in the coming years. To learn more, explore the website: natroxwoundcare.com.

See the references:  https://bit.ly/nwc-iwgdf-guidelines

Media Contact:

NATROX® Wound Care 
Nancy Stahulak
VP Global Marketing
marketing@natroxwoundcare.com 
+1 (888) 354 9772

Topical Oxygen Therapy Awarded Positive Treatment Recommendation by the International

Working Group on the Diabetic Foot in their 2023 Diabetic Foot Ulcer Guidelines   OCEANSIDE, Calif., May 15, 2023 /PRNewswire/ — AOTI Inc, the global leader in multi-modality topical wound oxygen, announced exciting news from the 9th International Symposium on the Diabetic Foot (ISDF). The ISDF is often referred to as the Olympics of the Diabetic Foot, due…

Largest Published Real-World Wound Imaging Study Reports MolecuLight®

led to Wound Treatment Plan Changes in up to 53% Cases   Results from 211 Facilities Show MolecuLight Imaging is a Valuable Toolin Improving Bacterial Infection Management TORONTO, May 23, 2023 /PRNewswire/ – MolecuLight Inc., the leader in point-of-care fluorescence imaging that locates and detects elevated, pathogenic bacterial loads in and around wounds, announced the publication of their…

Aurealis Therapeutics receives CTA approval for AUP-16 Phase 2 RCT in Diabetic Foot Ulcer patients

Multi-center, randomized, placebo-controlled diabetic foot ulcer (DFU) Phase 2 study to start May 2023 in Italy, Germany, and Poland After completing 12 months follow-up of our DFU Phase 1 study, and 10M CHF Series A financing round to accelerate our clinical program, these are fantastic news for the company”— Juha Yrjänheikki, CEO BASEL, SWITZERLAND, May…

Microbion Corp. Presents a Poster on Pravibismane’s Activity Against Diabetic Foot Infection Patient Isolates

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  • Poster highlights pravibismane’s MIC activity in testing against aerobic and anaerobic pathogens isolated from diabetic foot infection patients
  • Pravibismane demonstrated potent, broad-spectrum activity against a wide range
    of pathogens, including MRSA, MSSA, and P. aeruginosa

BOZEMAN, Mont., May 10, 2023 /PRNewswire/ – Microbion Corporation today announced that the company presented a poster focusing on pravibismane’s activity against diabetic foot ulcer infection pathogens at the 9th International Symposium on the Diabetic Foot that is currently ongoing from May 10th to 13th, 2023 at The Hague, Netherlands. The poster highlights pravibismane’s activity versus comparator antibiotics against pathogens isolated from diabetic foot infection (DFI) patients in an earlier Phase 1b clinical study.

Poster Details:
Representative image (CNW Group/Microbion Corporation)

Representative image (CNW Group/Microbion Corporation)

Title: Broad-Spectrum, Potent Activity of Pravibismane Versus Comparators Against Diabetic Foot Ulcer Infection Patient Isolates Collected in a Phase 1b Study

Presenter: Dr. Jeff Millard, CSO

Poster Highlights:
  • Most common pathogens isolated from DFI subjects (N = 44) at baseline were: methicillin-susceptible Staphylococcus aureus [MSSA (25%)]; methicillin-resistant Staphylococcus aureus [MRSA (18.2%)]; Enterococcus faecalis (13.6%); and Pseudomonas aeruginosa (11.4%).
  • Mean pravibismane minimum inhibitory concentration (MIC) (µg/mL) for S. aureus MSSA was 0.21, S. aureus MRSA was 0.17, E. faecalis was 2.53, and P. aeruginosa was 1.43.
  • Mean pravibismane MICs for 12 of the 13 anaerobic bacteria was ≤1 µg/mL, including against Finegoldia magna and Anaerococcus spp.
  • Pravibismane exhibited similar or lower MIC relative to a panel of comparator antibiotics, including (but not limited to) levofloxacin, linezolid, clindamycin, and piperacillin-tazobactam, against Gram-positive and Gram-negative, susceptible and resistant, aerobes and anaerobes.

"We are pleased that pravibismane demonstrated extremely potent MIC activity against clinical DFI isolates, which was in line with in vitro AST microbial pre-clinical studies," said Dr. Jeff Millard, CSO of Microbion Corp. "Diabetic foot infections are often infected by several different bacterial species concurrently, which may change over the chronicity of the wound, from predominantly aerobic to anaerobic. We believe pravibismane’s potent broad-spectrum activity is potentially a key treatment advantage since a single agent could eradicate both aerobic and anaerobic bacteria, thereby decreasing the need for multiple systemic therapies."

Bacterial cultures for this study were grown from swabs collected at the wound bed at baseline visit and antimicrobial susceptibility testing (AST) was performed on isolated pathogens. Pathogen isolation and AST was performed at Investigational Health Management Associates (IHMA, IL), using the Clinical & Laboratory Standards Institute (CLSI) standard methods.

Topical pravibismane has received QIDP and Fast Track drug designation from the US FDA for the adjunctive treatment of moderate and severe diabetic foot ulcer infections. Topical pravbismane is currently enrolling in a Phase 2 clinical study to further evaluate its safety and efficacy in subjects suffering from moderate infections associated with chronic diabetic foot ulcers.

About Microbion

Microbion is a clinical-stage pharmaceutical company developing a new class of therapeutic compounds to improve the lives of patients with rare and serious diseases. Microbion’s lead drug candidate, pravibismane, is the first product in this new class and has multiple novel modes of action offering unique potential to address the unmet needs of chronic and severe health conditions. Topical/local pravibismane is in Phase 2 development for the treatment of chronic wounds and orthopedic infections. The Company is advancing inhaled pravibismane in Phase 1 clinical development for the treatment of chronic lung diseases, including non-tuberculous mycobacteria (NTM) and cystic fibrosis-related lung infections. Pravibismane has received backing from the Cystic Fibrosis Foundation, NIH, US DoD, and CARB-X with over $21 million in grants. The FDA has granted pravibismane with Orphan Drug, Fast Track, and QIDP designations.

For more information visit: www.microbioncorp.com.

Safe Harbor Statement

Certain of the statements made in this press release are forward-looking, such as those, among others, relating to the success of clinical development of pravibismane and preparation for potential commercialization. These statements are subject to risks and uncertainties that could cause actual results and events to differ materially from those anticipated, including, but not limited to, risks and uncertainties related to: our ability to enroll patients in our clinical trials at the pace that we project; the size and growth of the potential markets for pravibismane or any future product candidates and our ability to serve those markets; our ability to obtain and maintain regulatory approval of pravibismane or any future product candidates; and our expectations regarding the potential safety, efficacy or clinical utility of pravibismane or any future product candidates. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Microbion Corporation disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

SOURCE Microbion Corporation