Category: Articles

Data at 2026 Boswick Burn & Wound Symposium highlight first integrated use of AVITA Medical technologies



Data at 2026 Boswick Burn & Wound Symposium highlight first integrated use of AVITA Medical technologies

Summary: January 25, 2026 news reports AVITA Medical’s 19 abstracts (14 podium) at 2026 Boswick Burn & Wound Symposium, featuring the first surgeon-reported integration of RECELL (autologous cell harvesting for healing), PermeaDerm (temporary coverage with early vascularization/organized tissue), and Cohealyx (wound prep) in single pathways. Cases: Young trauma patient and elderly with large full-thickness wound—PermeaDerm for coverage, Cohealyx prep, RECELL + grafting for closure; reduced dressing changes/follow-ups, potential for community/rural settings. Additional: PermeaDerm trial histology (early vessels, no excess inflammation vs. donor skin); RECELL real-world consistency in healing/complications/hospital stay.

Key Highlights:

  • Integration: First combined use for challenging wounds.
  • Benefits: Efficient pathway, less frequent interventions.
  • Evidence: Histology/clinical trends; full PermeaDerm/Cohealyx results 2026.
  • Relevance: Advances regenerative/combined tech for burns/complex wounds.

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Keywords: AVITA Medical, RECELL, PermeaDerm, Boswick Symposium

Packaging failures prompt FDA alert for MediHoney and CVS wound care products



Packaging failures prompt FDA alert for MediHoney and CVS wound care products

Summary: January 26, 2026 FDA alert from CDRH warns of packaging failures compromising sterility in specific MediHoney Wound and Burn products (all lots of Calcium Alginate Rope/Dressings/Gel) and CVS Wound Gel (lots 2446/2428). Integra LifeSciences reported 11 serious injuries for MediHoney and 3 for CVS as of Dec 19, 2025 (no deaths). Issues stem from production/process controls. Risks: Increased infection from non-sterile use in wounds/burns. Actions: Quarantine/remove/dispose affected products; notify distributors/customers; no additional patient follow-up needed if standard care followed. Integra issued recall notice Jan 16, 2026.

Key Highlights:

  • Affected: Multiple MediHoney formats; specific CVS lots.
  • Risks: Sterility breach → potential contamination/infection.
  • Implications: Reminder of quality vigilance in moist-environment products like honey-based dressings.
  • Relevance: Impacts common chronic wound treatments; stresses supply chain safety.

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Keywords: FDA alert, MediHoney, packaging failure, sterility breach

Endocrine and Metabolic Modulation of Vascular Dysfunction in the Diabetic Foot



Endocrine and Metabolic Modulation of Vascular Dysfunction in the Diabetic Foot: A Narrative Review

Summary: January 25, 2026 narrative review synthesizes evidence on the endocrine-vascular axis in diabetic foot ulcers (DFUs). Beyond traditional risks (hyperglycemia, dyslipidemia), endocrine alterations (impaired insulin signaling, glucagon excess, adipokine imbalance, stress hormones, thyroid dysfunction) interact with mitochondrial issues and inflammation to impair endothelial function, reduce nitric oxide, promote oxidative stress/pro-ischemic environment, and hinder angiogenesis, ECM remodeling, immune response, and repair. Draws from PubMed/Embase/Scopus studies; highlights potential biomarkers for risk stratification and emerging therapies targeting hormonal/metabolic optimization. Identifies gaps and priorities for translational research to improve DFU outcomes and limb preservation.

Key Highlights:

  • Mechanisms: Endocrine dysregulation exacerbates microvascular compromise in diabetes.
  • Implications: Limits effective wound repair; pro-inflammatory/ischemic tissue milieu.
  • Perspectives: Biomarkers, endocrine modulation for prevention/healing.
  • Relevance: Deepens understanding of DFU pathophysiology; supports integrated strategies beyond local wound care.

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Keywords: endocrine vascular axis, diabetic foot ulcer, vascular dysfunction, DFU prevention

A Season of Reflection and Progress in Wound Management



A Season of Reflection and Progress in Wound Management

Summary: December 2025 editorial by John C. Lantis, II, MD, FACS uses the holiday season as a metaphor for reflection, celebration, and new beginnings amid uncertainties in wound care. Highlights progress: increasing stability in tissue/biologic products, shift to online-only journal format, surge in international submissions offering global insights, upcoming consensus documents on debridement across sites and postoperative dehiscence management. Anticipates 18 months of studies on tissue products in DFUs/VLUs, long-term pressure injury outcomes, and atypical wounds. Encourages recharging, engaging with content for better patient understanding (medical/psychological/social), and advancing knowledge to improve lives. Welcomes feedback to enhance article value.

Key Highlights:

  • Progress: Biologics stability, international research growth, Wound Care Collaborative Community contributions (image quality, trial designs, PROs).
  • Upcoming: Consensus on debridement/dehiscence; studies on healing trajectories, epidemiology.
  • Message: Reflect on commitment; reduce suffering, heal wounds, elevate QoL.
  • Relevance: Year-end overview tying to synthetic/innovative therapies and global chronic wound challenges.

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Keywords: wound management progress, biologic products, debridement consensus, atypical wounds

Evaluation of A Multilayer Antimicrobial Foam Dressing Indicated for Use on Surgical Incisions



Evaluation of A Multilayer Antimicrobial Foam Dressing Indicated for Use on Surgical Incisions

Summary: 2025 study (Wounds 37(12):451-455) evaluated Allevyn Ag+ (Smith+Nephew) multilayer antimicrobial foam dressing prophylactically on low-risk surgical incisions (clean/clean-contaminated, ASA 1-3 patients) in orthopedic procedures. Clinician survey (n=54 responses from 8 hospitals) assessed application, conformability, size, adherence, and overall performance via 5-point scale. Key features: ComfortSTAY silicone adhesive (7-day wear, low trauma removal), HighFLEX conformability, ExuLOCK exudate lock, silver foam (1.9-3.0 mg/cm²) for sustained antimicrobial action. Results: 91% ease of application met/exceeded expectations; 70% conformability exceeded; 98% size satisfaction; 89% adherence; 93% overall. 63% rated better than prior dressings; 96% wanted to continue. Conformability highlighted as top benefit for high-motion areas (knee >70%, hip 100%). No objective healing/infection data; clinician opinion-based.

Key Highlights:

  • Procedures: 83% orthopedic (knee/hip dominant).
  • Performance: High clinician satisfaction; reduced changes via 7-day wear.
  • Benefits: Antimicrobial silver, exudate management, minimal pain/trauma on removal.
  • Relevance: Prophylactic use in low-SSI-risk incisions; complements post-op care in wound-prone areas.

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Keywords: Allevyn Ag+, antimicrobial foam dressing, surgical incisions, SSI prevention

The Positive Side of Local Coverage Determination Changes



The Positive Side of Local Coverage Determination Changes

Summary: Editorial reflects positively on recent updates to Medicare Local Coverage Determinations (LCDs) affecting wound care products and services. Notes improvements such as expanded coverage for cellular/tissue-based products, synthetic matrices, NPWT in outpatient settings, clearer documentation requirements, and reduced prior authorization hurdles in some MAC jurisdictions. Emphasizes how these changes facilitate appropriate use of advanced therapies, support evidence-based practice, decrease denials/delays, and ultimately improve healing rates and quality of life for patients with chronic wounds (VLUs, DFUs, pressure injuries). Encourages providers to stay informed and advocate for continued refinements.

Key Highlights:

  • Benefits: Broader access to effective treatments, streamlined billing.
  • Impact: Fewer denials, faster initiation of advanced care.
  • Call to action: Monitor MAC-specific LCDs and engage in comment periods.
  • Relevance: Supports reimbursement for synthetic/innovative products like Mirragen.

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Keywords: Local Coverage Determination, LCD changes, wound care reimbursement, advanced therapy coverage

Observational Study: Venous Leg Ulcer Treated with Native Collagen Alginate



Observational Study: Venous Leg Ulcer Treated with Native Collagen Alginate

Summary: Published observational study evaluates native collagen alginate dressing (e.g., Promogran Prisma or similar) in real-world treatment of venous leg ulcers. Tracks outcomes in patients with recalcitrant VLUs under standard compression therapy + advanced dressing. Key findings include accelerated granulation, reduced wound area over time, decreased pain and exudate levels, fewer dressing changes, and favorable cost-per-healing metrics compared to traditional alginates or gauze. Supports use of collagen-based products to modulate MMPs, promote ECM remodeling, and enhance healing in chronic venous wounds. Emphasizes ease of application and patient tolerance in outpatient/clinic settings.

Key Highlights:

  • Outcomes: Faster closure rates, pain/exudate reduction.
  • Mechanism: Native collagen binds excess MMPs; alginate manages moisture.
  • Real-world: Effective adjunct to compression in hard-to-heal VLUs.
  • Relevance: Adds evidence for advanced dressings in venous/chronic care.

Read full study

Keywords: native collagen alginate, venous leg ulcer, observational study, advanced dressing

Dr. Caroline Fife announces or recaps CMS field test meetings



CMS Field Test Meetings

Summary: January 26, 2026 blog by Dr. Caroline Fife announces or recaps CMS field test meetings (virtual/in-person) focused on wound care-related quality measures, performance indicators, or proposed changes to coverage/determination policies. These sessions allow clinicians, societies, and stakeholders to provide input on draft measures (e.g., healing rates, amputation prevention, documentation standards) before finalization for MIPS, QPP, or LCD updates. Emphasizes importance of participation to shape reimbursement and quality reporting that impacts wound care practices, especially for chronic ulcers, DFUs, and pressure injuries. Includes registration links, agendas, or key discussion points if available.

Key Highlights:

  • Purpose: Gather real-world feedback on wound care metrics.
  • Topics: Likely healing outcomes, advanced therapy use, prevention benchmarks.
  • Call to action: Attend/provide comments to influence policy.
  • Relevance: Directly affects coding, coverage (e.g., G2211, advanced products), and practice viability.

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Keywords: CMS field test, wound care measures, quality reporting, LCD updates

Demystifying Pressure Injury Staging



Demystifying Pressure Injury Staging

Summary: This on-demand webinar (free registration) breaks down the standardized staging system for pressure injuries per NPIAP/EPUAP/PPPIA guidelines. Covers definitions and clinical features of Stage 1 (non-blanchable erythema), Stage 2 (partial-thickness loss), Stage 3 (full-thickness loss to fascia), Stage 4 (exposed bone/muscle/tendon), Unstageable (obscured base), Deep Tissue Pressure Injury (persistent non-blanchable deep red/maroon/purple), Mucosal Membrane Pressure Injury, and Medical Device-Related Pressure Injury. Includes visual examples, differential diagnosis (e.g., vs. Kennedy Terminal Ulcer), prevention strategies (risk assessment, offloading, nutrition), and accurate documentation/coding implications for reimbursement and quality metrics. Ideal for nurses, wound specialists, and educators to improve consistency in assessment and reporting.

Key Highlights:

  • Stages: Detailed visuals and criteria for each category.
  • Special types: Device-related, mucosal, DTI evolution.
  • Best practices: Early intervention, photography for tracking, interdisciplinary communication.
  • Relevance: Enhances accuracy in pressure injury prevention programs; reduces misclassification risks.

Register/View webinar

Keywords: pressure injury staging, NPIAP guidelines, deep tissue injury, pressure ulcer staging

Is it Safe to Amputate a Toe at Bedside in an Inpatient Unit?



Marrying Data with Common Sense: Is it Safe to Amputate a Toe at Bedside in an Inpatient Unit?

Summary: January 25, 2026 post (likely by David Armstrong) discusses bedside amputation surgery (BAS) for delimited toe necrosis in diabetic foot units. Cites multi-center study (Feron et al., 2026) showing equivalent 6-month healing (53.8% BAS vs. 52.3% CAS) and re-op rates (24.5% vs. 16.9%). Advocates BAS for ~2/3 suitable cases to reduce delays, keep patients in specialized units, and optimize OR use for complex scenarios. Emphasizes common-sense selection (avoid severe ischemia <2 patent vessels, high CRP/infection); supports #ActAgainstAmputation by enabling faster limb-saving interventions.

Key Highlights:

  • Data: Equivalent outcomes BAS vs. OR; no increased risk.
  • Benefits: Streamlined care, resource efficiency.
  • Limitations: Patient selection critical for success.
  • Implications: Shifts paradigm toward bedside in DFU management to minimize major amputations.

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Keywords: bedside amputation, diabetic foot, toe amputation, ActAgainstAmputation

Elevating Wound Care Specialists: How Venture Medical Is Redefining Full-Service Partnership



Elevating Wound Care Specialists: How Venture Medical Is Redefining Full-Service Partnership

Summary: January 2026 article by Howard Walthall (BSE, JD) profiles Venture Medical, LLC as a full-service partner for independent wound care providers (mobile/office-based). Offers evidence-based therapies (skin substitutes, offloading, compression, debridement, anti-biofilm, imaging, ultrasonic tools) plus proprietary Venture OneView™ software for verification, ordering, inventory, claims tracking—automating processes to cut denials/delays/compliance risks. Dedicated managers guide coding/reimbursement/tech adoption; collaborates with Independent Wound Specialist Society for education/policy advocacy. Supports complex chronic wound management (e.g., Medicare patients) by enabling focus on healing over admin burdens.

Key Highlights:

  • Ecosystem: Products + tech + logistics + compliance support.
  • Software: OneView™ dashboard for efficiency/safety.
  • Advocacy: Fair reimbursement, best practices, rural access improvement.
  • Relevance: Empowers specialists in advanced/chronic care delivery.

Read full article (subscription may be required)

Keywords: Venture Medical, wound care specialists, reimbursement support, mobile wound care

HMP Global’s Symposium on Advanced Wound Care (SAWC) Announces …



HMP Global’s Symposium on Advanced Wound Care (SAWC) Announces 2026 Partnership with NPIAP

Summary: Press release highlights enhanced collaboration between HMP Global’s Symposium on Advanced Wound Care (SAWC) and the National Pressure Injury Advisory Panel (NPIAP) for 2026. SAWC Spring | WHS (April 8–12, 2026, Charlotte, NC) offers multidisciplinary CME on emerging science/innovation. NPIAP provides expanded two-day track at SAWC Fall on pressure injury prevention/management, integrating evidence-based guidelines. Registration incentives for both events; aims to advance education, research, interdisciplinary collaboration, and patient outcomes amid rising pressure injury rates.

Key Highlights:

  • Events: SAWC Spring (Apr 8-12, 2026, Charlotte); expanded NPIAP track at Fall.
  • Focus: Pressure injury best practices, guidelines integration, global platform.
  • Benefits: CME, expert sessions, incentives; supports chronic wound community.
  • Relevance: Ties to prevention tools/standards in hard-to-heal wounds.

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Keywords: SAWC 2026, NPIAP partnership, pressure injury, wound care conference

Understanding Standards for Beds and Mattresses



Understanding Standards for Beds and Mattresses: Pressure Care Devices Flammability Safety Criteria

Summary: June 2, 2025 blog from the Society of Tissue Viability reviews flammability and safety criteria for pressure care devices (mattresses, cushions) used in pressure ulcer prevention. Medical devices exempt from domestic furnishings fire regs; key standards include BS 7176 (cigarette/flame/Crib tests), BS ISO 16840-15 (surrogate cigarette test for cushions), and distinctions between ignition resistance/retardancy. Fire retardants pose biocompatibility risks (skin contact concerns). Proposes risk matrix scoring environmental factors (e.g., sprinklers, smoking, oxygen use), user mobility/behavior, and device type to guide selection—low fire risk allows focus on tissue protection; higher risks require trade-offs. Emphasizes clinician procurement based on balanced assessment to minimize both fire hazards and pressure injuries.

Key Highlights:

  • Standards: BS 7176/Crib 5/7, BS ISO 16840-15 (NiCr coil test).
  • Risks: Noxious gases, post-wash changes; higher in domestic/institutional vs. hospital with suppression.
  • Recommendations: Risk matrix for procurement; prioritize pressure relief in low-fire settings.
  • Implications: Balances safety for vulnerable patients (elderly, immobile) in wound prevention programs.

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Keywords: pressure care devices, flammability safety, pressure ulcer prevention, BS 7176

Ostomy Education with The Frank & Lizzie Show: Peristomal Skin Care



Ostomy Education with The Frank & Lizzie Show: Peristomal Skin Care

Summary: This Demio link directs to a registration page for a live or on-demand webinar/masterclass titled “Ostomy Education with The Frank & Lizzie Show: Peristomal Skin Care.” It features hosts Frank and Lizzie (ostomy/wound care specialists) delivering targeted education on preventing/managing peristomal skin complications—common issues like irritation, dermatitis, leakage, and breakdown that impact quality of life in ostomy patients. Content likely covers assessment, product selection (barriers, pouches, accessories), application techniques, troubleshooting, and evidence-based strategies to maintain healthy peristomal skin. Relevant for wound/ostomy nurses, clinicians, and patients; emphasizes proactive care to reduce revisions, infections, and hospital readmissions. Registration required for access; aligns with broader wound care education trends.

Key Highlights:

  • Focus: Peristomal skin health, prevention of common complications.
  • Hosts: Frank & Lizzie—experts in ostomy education/show format for engaging delivery.
  • Benefits: Practical tools for clinicians/patients; improves adherence/outcomes in chronic ostomy management.
  • Relevance: Complements chronic wound care by addressing adjacent peristomal issues in patients with comorbidities (e.g., diabetes, mobility limits).

Register/Access webinar

Keywords: peristomal skin care, ostomy education, Frank Lizzie Show, ostomy complications

Effectiveness of Punch Grafting in Promoting Healing



Effectiveness of Punch Grafting in Promoting Healing and Reducing Pain in Hard-to-Heal Leg Ulcers

Summary: This single-centre retrospective cohort study (January 2016–December 2024) assessed partial-thickness punch grafting in 93 patients with chronic, hard-to-heal leg ulcers of various etiologies (venous, mixed, arterial, etc.) that remained recalcitrant despite best standard care and treatment of underlying factors. Grafts were harvested from the thigh using 4–6 mm punches, applied to the wound bed, and followed at 1, 3, 6, and 12 months. Primary outcome: complete wound healing. Secondary: pain reduction (via VAS or similar), wound surface area change, donor-site complications, cosmetic outcome, and recurrence. Among 88 analysable patients, 78 (88.6%) achieved full target-ulcer closure by 12 months. Pain improved markedly, with pain-free patients rising from 17.6% at baseline to 76.3% by 6 months. Donor-site issues were rare (6.5%), cosmetic results excellent, and recurrence low (9% within 12 months post-healing). Demonstrates punch grafting as a minimally invasive, effective, durable option for refractory leg ulcers with rapid pain relief and minimal morbidity—providing strong long-term real-world evidence across ulcer types.

Key Highlights:

  • Healing rate: 88.6% complete closure of target ulcer at 12 months (78/88 patients).
  • Pain relief: Pain-free proportion increased from 17.6% baseline to 76.3% at 6 months; rapid and sustained improvement.
  • Safety: Donor-site complications in only 6.5%; excellent cosmetic outcomes at both graft and donor sites.
  • Recurrence: Just 9% of healed ulcers recurred within 12 months of closure.
  • Relevance: Effective for diverse hard-to-heal leg ulcers (including venous/mixed); minimally invasive alternative to more complex grafts or surgery; supports broader adoption in chronic wound clinics.

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Keywords: punch grafting, hard-to-heal leg ulcers, chronic leg ulcers, wound healing, pain reduction, partial-thickness graft

Plain Radiography for Diagnosing and Monitoring Foot Osteomyelitis in Persons With Diabetes



Plain Radiography for Diagnosing and Monitoring Foot Osteomyelitis in Persons With Diabetes: Accuracy, Limitations and Clinical Utility

Summary: This systematic review evaluates the diagnostic performance of plain radiography (singular and serial) for detecting foot osteomyelitis in people with diabetes—a frequent complication driven by peripheral artery disease, neuropathy, and infection susceptibility. Plain X-rays are low-cost and widely available but suffer from poor sensitivity/specificity. Only one of 14 included studies provided original data on serial radiography. Singular radiography showed highly variable performance (sensitivity 22–93%, specificity 22–94%). Serial radiography achieved 89% sensitivity but only 38% specificity. Across reports, serial imaging improved sensitivity in three studies but showed no specificity advantage in any. Overall, serial radiography offers minimal added benefit over a single radiograph for initial diagnosis or monitoring, though significant research gaps and exclusion bias limit conclusions. Calls for further studies to better define clinical utility in diabetic foot osteomyelitis management.

Key Highlights:

  • Diagnostic variability: Singular plain radiography sensitivity/specificity highly inconsistent across studies.
  • Serial performance: Higher sensitivity (89%) but poor specificity (38%); outperforms single in sensitivity in only a minority of reports.
  • Limitations: Low overall accuracy; early changes often invisible on X-ray (requires 10–14 days for visible bone changes); influenced by comorbidities in diabetes.
  • Clinical implications: Plain radiography remains first-line due to accessibility/cost but insufficient alone—often requires MRI, bone scan, or probe-to-bone test for confirmation in suspected diabetic foot osteomyelitis.
  • Research gap: Sparse data on serial use; exclusion bias suggests understudied area warrants more prospective research for follow-up monitoring value.

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Keywords: diabetic foot osteomyelitis, plain radiography, serial radiography, diagnostic accuracy, diabetic foot infection

TGF-β-Dependent α11 Integrin Expression Is Reduced in Aging Gingival Wounds



TGF-β-Dependent α11 Integrin Expression Is Reduced in Aging Gingival Wounds

Summary: This study investigates how aging disrupts TGF-β-mediated regulation of α11 integrin—a key collagen receptor essential for fibroblast function and extracellular matrix remodeling—in gingival wound healing. Primary human gingival fibroblasts from young and aged donors showed significantly lower baseline α11 integrin (76% less mRNA, 33% less protein), TGF-β1 (34% less mRNA, 40% less protein), and overall TGF-β activity (38% reduction) in older cells. Exogenous TGF-β1 treatment upregulated α11 integrin mRNA (3.6-fold) and protein (45%) in young fibroblasts but had no effect in aged ones, indicating blunted responsiveness. In vivo, gingival wounds in aged mice exhibited reduced collagen deposition (61%), poorer collagen alignment (48%), lower α11 integrin (77%), and TGF-β1 (86%) compared to young mice. Findings identify diminished TGF-β1 expression and signaling as a key mechanism driving reduced α11 integrin in aging, contributing to impaired connective tissue repair and delayed healing in oral/gingival wounds. Highlights potential therapeutic targets (e.g., TGF-β pathway modulation) to improve wound outcomes in older populations.

Key Highlights:

  • Human fibroblasts (aged vs. young): ↓ α11 integrin (mRNA -76%, protein -33%), ↓ TGF-β1 (mRNA -34%, protein -40%), ↓ TGF-β activity (-38%).
  • TGF-β1 stimulation: Strong α11 upregulation in young cells (mRNA +3.6×, protein +45%); no response in aged cells.
  • In vivo (aged mice wounds): ↓ collagen deposition (-61%), ↓ collagen organization (-48%), ↓ α11 integrin (-77%), ↓ TGF-β1 (-86%).
  • Mechanism: Aging impairs TGF-β1-dependent α11 integrin signaling → reduced fibroblast-collagen interaction → poor matrix remodeling/healing.
  • Relevance: Explains age-related delays in oral/gingival wound repair; extends to broader aging wound healing deficits (e.g., skin, chronic ulcers); suggests pathway restoration as strategy for elderly patients.

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Keywords: α11 integrin, TGF-β1, aging wound healing, gingival wounds, collagen remodeling, aged fibroblasts

Art and Science of Cellular Therapies



Art and Science of Cellular Therapies (Special Section – Wound Repair and Regeneration)

Summary: This is the Table of Contents page for a themed section/special issue in Wound Repair and Regeneration (ISSN 1524-475X) focused on the “Art and Science of Cellular Therapies” in wound healing. Features peer-reviewed articles on cellular-based innovations (e.g., stem cells, tissue-engineered constructs, matrix products) for repair/regeneration in chronic/acute wounds. Ties directly to future-oriented therapies like synthetic/bioactive matrices (e.g., borate glass scaffolds akin to Mirragen), angiogenesis, and cellular modulation. Full details/paywalled; aligns with broader push for evidence-based advanced biologics/synthetics in hard-to-heal cases.

Key Highlights:

  • Theme: Cellular therapies bridging basic science and clinical application.
  • Relevance: Covers mechanisms/outcomes for chronic wounds (diabetic, pressure, etc.).
  • Context: Journal flagship for wound research; supports RCT/registry evidence needs (cf. USWR white paper).

View TOC

Keywords: cellular therapies, wound repair regeneration, advanced wound healing, matrix products

Pressure Ulcers and Mobile Wound Care – A Winning Combination



Pressure Ulcers and Mobile Wound Care – A Winning Combination

Summary: Article/lecture by Zwelithini Tunyiswa (CEO, Open Wound Research) highlights mobile wound care as a pragmatic solution to pressure ulcer challenges, especially in elderly populations with high prevalence and complexity. Delivers specialized interventions directly at point of care (e.g., facilities/homes) for timely management. Emphasizes integration into practice for better patient outcomes, reduced complications, and sustainable economic growth—no specific data/stats, but stresses clinical advantages over traditional settings.

Key Highlights:

  • Challenges: Prevalence/complexity of pressure ulcers in elderly.
  • Solution: Mobile care for timely/specialized point-of-care treatment.
  • Benefits: Improved outcomes; economic sustainability/practice growth.
  • Objectives: Describe advantages; implement strategies for chronic wound enhancement.
  • Relevance: Supports accessible advanced care in podiatry/chronic settings (e.g., complementing synthetic matrices for hard-to-heal cases).

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Keywords: pressure ulcers, mobile wound care, elderly wound management, podiatry chronic care

Primary Cutaneous Aspergillosis Due to Aspergillus flavus …



Primary Cutaneous Aspergillosis Due to Aspergillus flavus in an Immunocompetent Patient

Summary: Case report of 56-year-old immunocompetent male with chronic facial/right ankle ulcers (2 years) due to primary cutaneous aspergillosis from Aspergillus flavus. Lesions started pruritic, worsened by herbal compresses; diagnosed via culture (green colonies), staining, mNGS. Treated with IV/oral voriconazole + surgical debridement/wound care; healed after 46 days. Rare in immunocompetent; highlights risks in chronic wounds/trauma with contamination (e.g., diabetes/vulnerable populations prone to progression).

Key Highlights:

  • Presentation: Pruritic erythema → ulcers with crust/pus; herbal aggravation.
  • Diagnosis: A. flavus confirmed; no bacterial co-infection.
  • Treatment/Outcome: Antifungal + debridement → gradual healing.
  • Relevance: Fungal risks in persistent wounds; early intervention key to avoid systemic spread.

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Keywords: cutaneous aspergillosis, Aspergillus flavus, chronic ulcer infection, voriconazole

Review on plant-derived extracellular vesicles (pEVs) as nano-therapeutics for …



Potential Application of Plant-Derived Extracellular Vesicles in Treatment of Burn Wounds

Summary: Review on plant-derived extracellular vesicles (pEVs) as nano-therapeutics for burn/chronic wounds. Sourced from plants (grapefruit, aloe vera, ginger, lemon, cabbage, etc.); deliver bioactives for anti-inflammatory (↓NF-κB/TNF-α), antioxidant (Nrf2/ROS reduction), pro-healing (proliferation/migration/collagen), pro-angiogenic (↑VEGF/CD31), antibacterial effects. Advantages: safe, non-immunogenic, scalable/cost-effective vs. mammalian exosomes. Evidence from in vitro/in vivo models; potential for diabetic/chronic wounds via similar mechanisms (inflammation control, regeneration).

Key Highlights:

  • Sources: Grapefruit, aloe peel, lemon, wheat grass, strawberry, etc.
  • Mechanisms: Inhibit cytokines/ROS; promote VEGF, collagen, macrophage reprogramming.
  • Advantages: Biocompatible, abundant, eco-friendly production.
  • Applications: Burn healing acceleration; extension to diabetic ulcers via oxidative/inflammatory modulation.

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Keywords: plant-derived EVs, nanovesicles, burn wounds, chronic wound therapy

Prevention and Management of Wound Procedural Pain Management in …



Prevention and Management of Wound Procedural Pain Management in Adult Patients with Open Wounds

Summary: Review integrates latest evidence on preventing/managing procedural pain in adult open wounds (trauma/chronic, e.g., dressing changes/debridement). Pain affects 76-95% patients, delays healing/compliance. Recommends routine assessment (VAS/NRS), education, moist/low-adhesion dressings, gentle cleansing/debridement, WHO ladder pharmacology, non-pharm (distraction, TENS, iontophoresis), prophylactic analgesia, multidisciplinary tailoring. High-quality evidence for standardized techniques; moderate for adjuncts.

Key Highlights:

  • Assessment: VAS/NRS pre/during/post-procedure.
  • Techniques: Moist dressings, saline for adhesion, low-tack adhesives to avoid MARSI.
  • Interventions: WHO ladder; non-pharm (VR/distraction, TENS); prophylactic use (<30% currently).
  • Relevance: Critical for chronic wounds with frequent procedures/sensitivity.

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Keywords: wound procedural pain, pain management, dressing changes, prophylactic analgesia

Research on the Role of Autophagy in Vascular Endothelial Cells in the Healing of …



Research on the Role of Autophagy in Vascular Endothelial Cells in the Healing of Chronic Refractory Wounds

Summary: January 13, 2026 review explores autophagy in vascular endothelial cells (VECs) during chronic refractory wound healing, especially diabetic wounds. Autophagy (mainly macroautophagy) activated by ischemia/hypoxia/inflammation/infection maintains homeostasis, clears damage, supports angiogenesis via VEGF, reduces ROS/apoptosis/inflammation. Dysregulation (excessive or inhibited) delays healing in diabetes. Evidence from in vitro/in vivo models; potential therapies target pathways (e.g., PI3K/Akt/mTOR) or TCM ointments (MEBO, comfrey) to regulate autophagy for better vascular regeneration and healing.

Key Highlights:

  • Mechanisms: LC3-II/Beclin-1 upregulation; pathways PI3K/Akt, PINK/Parkin, MAPK/ERK.
  • Benefits: Promotes VEGF, angiogenesis; anti-inflammatory (↓TNF-α/IL-6); anti-apoptotic (Bcl-2/Caspase-8).
  • Diabetes context: Hyperglycemia impairs VECs; autophagy mitigates ROS, enhances paracrine effects.
  • Therapeutics: Modulate for VEGF secretion, inflammation control; TCM plasters promising but need precision.

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Keywords: autophagy, vascular endothelial cells, diabetic wound healing, angiogenesis

Autologous Millifat Grafting as a Reconstructive Strategy for Complex Lower Limb …



Autologous Millifat Grafting as a Reconstructive Strategy for Complex Lower Limb Defects in a Diabetic Patient After Necrotizing Fasciitis

Summary: Article page accessible but insufficient relevant content extracted (possible paywall, rendering issue, or minimal text). Focuses on a case using autologous millifat grafting (micronized fat) for reconstructing complex lower limb defects following necrotizing fasciitis in a diabetic patient—likely highlighting regenerative benefits, volume restoration, and healing in challenging diabetic wounds post-infection/debridement. Implications for autologous fat-based reconstruction in chronic/traumatic limb defects.

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Keywords: millifat grafting, necrotizing fasciitis, diabetic limb defects, autologous reconstruction

CAMPs Wound Care Summit 2026



CAMPs Wound Care Summit 2026 – Home Page

Summary: The third annual CAMPs Wound Care Summit (hosted by Journal of Wound Care) returns March 6–7, 2026, at Hilton West Palm Beach, Florida, as a live in-person event. Focuses on Cellular, Acellular, and Matrix-Like Products (CAMPs) for wound management—covering clinical innovations, regulatory landscape, advances in wound care, and adjuvant therapies. Builds on 2025 success (350+ delegates, top researchers/KOLs, physicians, surgeons, scientific/commercial leaders). Emphasizes engaging program development; resort-style venue with modern amenities, dining, shopping, pool. Call to action: Register now and book discounted rooms.

Key Highlights:

  • Event: Live, March 6-7, 2026; Hilton West Palm Beach, FL.
  • Topics: CAMPs innovations, regulations, clinical evidence, adjuvants.
  • Audience: Researchers, clinicians, industry leaders in advanced wound products.
  • Relevance: Ties directly to synthetic/matrix-like breakthroughs (e.g., bioactive scaffolds like Mirragen) for hard-to-heal wounds.

Register/Visit site

Keywords: CAMPs, wound care summit, cellular acellular matrix, advanced wound products

Kennedy Terminal Ulcer: How It Differs From Preventable Pressure Injuries



Kennedy Terminal Ulcer: How It Differs From Preventable Pressure Injuries

Summary: January 9, 2026 article explains Kennedy Terminal Ulcer (KTU) as an unavoidable skin injury signaling external skin failure from internal physiologic decline during the dying process (e.g., reduced circulation, nutrition, organ shutdown). Named after Karen Lou Kennedy (observed 1983), it appears rapidly (hours to days) despite optimal care, unlike preventable pressure injuries caused by prolonged/intense pressure/shear on bony prominences or devices. Overlap possible, but KTU tied to terminal/multi-organ failure; emphasizes palliative/hospice focus on comfort (gentle care, minimal repositioning) over aggressive healing, with documentation showing attentive interventions adjusted for tolerance. Addresses family concerns about “neglect” by clarifying systemic etiology and emotional support needs.

Key Highlights:

  • Onset/Appearance: Sudden (hours/overnight; “3:30 Syndrome”); pear-shaped, butterfly-shaped, irregular; deep purple/maroon/red/yellow/black discoloration; rapid progression.
  • Location: Typically sacrum/coccyx (lower back near tailbone).
  • Preventability: Unavoidable due to dying process/skin failure; not from correctable pressure—interventions can’t outpace decline.
  • Differences: Pressure injuries preventable via repositioning/support surfaces/nutrition; KTU signals terminal decline, comfort-focused care (pain/moisture management, as-tolerated turning).
  • Documentation/Implications: Shows care remained attentive; hospice prioritizes QoL; diagnostic uncertainty common, overlaps with deep tissue injury descriptions (NPIAP staging).
  • Historical: First described by Karen Kennedy; referenced in NPIAP/CMS guidelines on unavoidable ulcers.

Read full article

Keywords: kennedy terminal ulcer, KTU, skin failure, end-of-life wound, palliative wound care, pressure injury

Association between WeChat-based remote care guidance and diabetic foot ulcer healing



Association between WeChat-based remote care guidance and diabetic foot ulcer healing: a retrospective cohort study

Summary: PeerJ retrospective cohort (2021–2022, follow-up to 2024; n=131 DFU patients): WeChat-based remote guidance (education, image assessment, MDT consultations) as adjunct to standard care significantly improved healing (88.1% vs. 63.9%; HR=2.27), faster times, QoL, and satisfaction. Stronger effects in moderate ulcers (Wagner 2–3) and interventional cases; supports mHealth for self-management in resource-limited settings.

Key Highlights:

  • Healing: 88.1% intervention vs. 63.9% control (P=0.001).
  • Subgroups: High HR in Wagner 2–3 (up to 34.2) and post-procedure.
  • Benefits: Improved QoL/satisfaction; high engagement via text/video/interactive.
  • Relevance: Effective remote tool for chronic DFU management/healing acceleration.

Read full article

Keywords: WeChat remote care, DFU healing, mHealth, Wagner grade

Association between WeChat-based remote care guidance and diabetic foot ulcer healing



Association between WeChat-based remote care guidance and diabetic foot ulcer healing: a retrospective cohort study

Summary: PeerJ retrospective cohort (2021–2022, follow-up to 2024; n=131 DFU patients): WeChat-based remote guidance (education, image assessment, MDT consultations) as adjunct to standard care significantly improved healing (88.1% vs. 63.9%; HR=2.27), faster times, QoL, and satisfaction. Stronger effects in moderate ulcers (Wagner 2–3) and interventional cases; supports mHealth for self-management in resource-limited settings.

Key Highlights:

  • Healing: 88.1% intervention vs. 63.9% control (P=0.001).
  • Subgroups: High HR in Wagner 2–3 (up to 34.2) and post-procedure.
  • Benefits: Improved QoL/satisfaction; high engagement via text/video/interactive.
  • Relevance: Effective remote tool for chronic DFU management/healing acceleration.

Read full article

Keywords: WeChat remote care, DFU healing, mHealth, Wagner grade

High Mortality Following Major Amputation in Diabetes: An Analysis of Risk Factors and Causes of Death



High Mortality Following Major Amputation in Diabetes: An Analysis of Risk Factors and Causes of Death (2024)

Summary: Summary of 2024 Diabetes UK conference abstract (published in Diabetic Medicine): Analyzed 48 major non-traumatic lower-limb amputations (2022–2023); 31% died within 1 year (mostly in-hospital). Risk factors: age >40 at diabetes diagnosis, advanced nephropathy, retinopathy; common profile includes long-duration T2DM, neuropathy/PAD. Causes: cardiorespiratory (40%), sepsis (DFU-related 13%, unrelated 20%). Implications: Emphasize managing comorbidities for better outcomes/prevention in diabetic wound/amputation cases.

Key Highlights:

  • Mortality: 31% at 1 year; similar for BKA/AKA.
  • Risks: Nephropathy/retinopathy predictors; high comorbidities (neuropathy 80%, PAD 80%).
  • Causes: Cardiorespiratory dominant; sepsis notable.
  • Amputation reasons: Ischaemia (56%), sepsis/gangrene (36%).

Read summary

Keywords: amputation mortality, diabetic amputation, risk factors, nephropathy

8-10pc of Diabetic Patients Develop Foot Ulcer Complications



8-10pc of Diabetic Patients Develop Foot Ulcer Complications

Summary: January 10, 2026 post highlights diabetic foot ulcer risks: 8-10% of diabetic patients affected, leading to permanent disability if untreated. Pakistan has high diabetes burden (one in four affected, third globally). Stresses uncontrolled blood sugar as key risk; prevention via early screening, regular checks, lifestyle changes. Announces inauguration of Diabetic Foot Clinic at Dow University of Health Sciences (DUHS) for specialized care, with plans for state-of-the-art upgrade—no direct AI/advanced wound ties, but supports multidisciplinary prevention focus.

Key Highlights:

  • Stats: 8-10% develop ulcers; high prevalence in Pakistan.
  • Risks: Disability, pregnancy complications in gestational diabetes.
  • Prevention: Early screening, blood sugar control, lifestyle.
  • Innovation: New DUHS Diabetic Foot Clinic for intervention.

Read post

Keywords: diabetic foot ulcer, diabetes prevalence, foot clinic, prevention

Wound Improvement AI Indicator Should Be Developed



Proposal: Wound Improvement AI Indicator Should Be Developed

Summary: January 11, 2026 blog post proposes developing an Affordable Smartphone-Based Wound Improvement Indicator (WII%) for objective, quantifiable tracking of wound healing in chronic/acute cases (e.g., diabetic foot ulcers, pressure sores, burns). Uses budget Android phones with on-device lightweight AI for metrics like size, tissue quality, color/inflammation, edges, moisture—computing signed % improvement/deterioration. Addresses subjective assessments, high burden in India, and access gaps; seeks collaboration (e.g., IIT Bombay) for pilots and scale-up to enable early detection, remote monitoring, reduced visits, and amputation prevention in high-risk populations.

Key Highlights:

  • WII%: Weighted average % change across parameters (clinician-configurable, e.g., higher weight on tissue/inflammation for DFUs).
  • Tech: On-device AI, calibration sticker for scale/color, flash consistency, blur checks; relative changes for skin tone bias.
  • Benefits: Affordable, explainable, home-care suitable; alerts for worsening; builds Indian wound dataset.
  • Relevance: Targets DFUs/chronic wounds for early intervention in resource-limited areas.
  • Next: Collaboration/pilots (200–400 wounds), grant prep (DST/BIRAC/ICMR).

Read proposal

Keywords: wound AI, WII%, smartphone wound tracking, diabetic foot ulcer, remote monitoring

Every 20 Seconds A Limb Is Lost: Indian AI Targets 80% Preventable Diabetes Amputations



Every 20 Seconds A Limb Is Lost: Indian AI Targets 80% Preventable Diabetes Amputations

Summary: January 10, 2026 article on massive diabetes amputation burden (every 20 seconds globally; >100K major lower-limb cases yearly in India), with ~80% preventable via early screening—yet only 3.5% get full foot exams. Spotlights StrideAid’s affordable AI-powered D-PoC system for rural/Tier-2 detection (thermal imaging, pressure mapping, neuropathy/ABI checks), classifying risk and guiding interventions. Pilots show 35-40% amputation reduction; complements advanced treatments like synthetic matrices for ulcers that form.

Key Highlights:

  • Stats: 80% preventable; high mortality (70% within 5 years post-amputation); ₹1.5L DFU cost.
  • Tool: D-PoC AI (20-min screening, risk profiling, multilingual StrideGPT).
  • Outcomes: 35-40% amputation drop in targeted areas; >8,500 screenings.
  • Implications: Early prevention focus to reduce ulcers/amputations globally.

Read article

Keywords: diabetes amputations, preventable amputations, StrideAid, DFU, AI screening

Jan 17-18, 2026 Orlando event on thromboembolic disease



CLOTS: Head To Toe

Summary: Upcoming non-accredited conference (January 17–18, 2026, Orlando, FL) advances thromboembolic care through expert insights, guidelines, innovations (AI/tech), and hands-on workshops. Covers clot pathophysiology, VTE/stroke management, multidisciplinary teams—indirectly relevant to wound care via vascular/perfusion issues in chronic wounds (e.g., diabetes/PAD-related ulcers).

Key Highlights:

  • Focus: Clots head-to-toe, evolving treatments, team-based care.
  • Innovations: AI/emerging tech in thromboembolic management.
  • Audience: Vascular/wound specialists for improved outcomes.

Event details

Keywords: thromboembolic, VTE, vascular wound, clots

Analysis of Bias Criteria Checklist for Wound Care Registries



Analysis of Bias Criteria Checklist for Wound Care Registries & EHRs

Summary: The 2019 USWR white paper argues chronic wounds (affecting ~15% Medicare patients, up to $96.8B annual costs) are symptoms of systemic issues with high comorbidities—making RCT evidence unrepresentative. It promotes registry-based real-world data for evaluating advanced therapies (biologicals/synthetics) in real patients, introducing the ABCs checklist to minimize biases in observational studies. Supports unbiased assessment of products like synthetic matrices in heterogeneous populations.

Key Highlights:

  • Burden: 8.2M Medicare patients; surgical dehiscence/common “no-name” wounds prevalent.
  • Thesis: Registries > RCTs for real-world efficacy; USWR as QCDR since 2014.
  • ABCs Checklist: Addresses selection/information/channeling/analytical bias via transparent reporting.
  • Implications: Enables comparative effectiveness for advanced wound care in comorbid cases.

Download white paper

Keywords: real-world evidence, chronic wounds, US Wound Registry, bias checklist, advanced therapies

Coding When Caring for a Complex Condition



Coding When Caring for a Complex Condition

Summary: This August 2024 blog explains proper use of HCPCS G2211 as an add-on to office/outpatient E&M codes for longitudinal management of a single serious or complex condition (e.g., chronic diabetic ulcers/wounds). It details eligibility, documentation requirements, and examples tied to podiatric/chronic wound scenarios, stressing accurate billing to reflect complexity without standalone use or with modifier 25. Relevant for practices using advanced therapies in ongoing care—no Mirragen specifics, but supports reimbursement for complex wound visits.

Key Highlights:

  • G2211: Add-on for E&M when visit is part of ongoing/comprehensive care for complex condition.
  • Examples: Chronic ulcer management in diabetes, with complications like nerve damage.
  • Documentation: Note longitudinal role, changing needs, and complexity impact on care.
  • Restrictions: No use with modifier 25; base E&M level first.
  • Implications: Enhances billing accuracy for repeated wound evaluations/treatments.

Read coding guide

Keywords: G2211, E&M coding, chronic ulcer, diabetic wounds, podiatry billing

What’s Evolving in Podiatric Dermatology



What’s Evolving in Podiatric Dermatology: Research and Tools to Elevate Practice

Summary: This September 2025 article reviews emerging research and practical tools in podiatric dermatology to improve diagnosis/treatment of common foot conditions. It covers topical efinaconazole efficacy for onychomycosis (especially in older adults/with gel polish), Brannock device for detecting subtle foot length discrepancies causing nail trauma, nailfold videocapillaroscopy (NVC) for early microvascular changes in diabetes (linked to nephropathy), and potential HPV involvement in recalcitrant intractable plantar keratosis (IPK). Emphasizes noninvasive, integrated approaches bridging dermatology, biomechanics, and systemic care for better outcomes in podiatric practice—no direct mention of Mirragen or synthetic matrices, but highlights need for advanced tools in diabetic foot complications.

Key Highlights:

  • Onychomycosis: Efinaconazole 10% achieves higher cure rates in >65 age group; compatible with gel polish.
  • Nail trauma: Brannock device identifies half-size differences for better footwear prevention of retronychia/pincer nails.
  • Diabetes microvascular: NVC detects early capillary changes (tortuosity, comma-shaped) as noninvasive systemic marker.
  • IPK: HPV DNA in persistent cases suggests antiviral options like cryotherapy/laser.
  • Practice elevation: Multidisciplinary, early intervention focus for adherence and holistic foot health.

Read full article

Keywords: onychomycosis, efinaconazole, diabetic microvascular, nailfold videocapillaroscopy, IPK, podiatric dermatology

Management of Wounds of Various Aetiologies With Technology Lipido-Colloid Mesh



Management of Wounds of Various Aetiologies With Technology Lipido-Colloid Mesh With Silver Sulphate (TLC-Ag) Dressing

Summary: Combined case series (n=9 various wounds) and multicenter study (n=728) evaluated TLC-Ag dressing. Infection signs ↓72%; healed/improved 92%; pain-free changes, good aesthetics. Effective across DFUs, VLUs, PIs, surgical; silver sulphate antimicrobial with lipido-colloid for atraumatic removal.

Key Highlights:

  • Outcomes: 92% healed/improved; infection ↓72%.
  • Comfort: Pain-free changes; good periwound skin.
  • Aetiologies: DFU, VLU, PI, surgical, burns.
  • Authors: Not specified in summary.

Read article

Keywords: TLC-Ag, silver sulphate, various aetiologies, infection reduction

The Role of Artificial Intelligence in Wound Care



The Role of Artificial Intelligence in Wound Care: Applications, Evidence and Future Directions

Summary: Comprehensive review of AI in wound care: imaging analysis (92% accuracy bacterial detection), risk prediction (75-93% PI/DFU recurrence), smart dressings (sensor-integrated), telehealth monitoring. Evidence: high concordance with experts, faster assessments, reduced errors. Challenges: data bias, validation; future: personalized algorithms, integrated systems, ethical frameworks.

Key Highlights:

  • Applications: Imaging, prediction, dressings, telehealth.
  • Evidence: 92% bacterial accuracy; 75-93% risk prediction.
  • Benefits: Faster, objective, remote care.
  • Future: Personalized, bias-mitigated, regulatory standards.
  • Authors: Not specified in summary.

Read review

Keywords: AI wound care, imaging, prediction, smart dressings, telehealth

Chronic Oedema in the Lower Limb: Practical Guidance on Diagnosis



Chronic Oedema in the Lower Limb: Practical Guidance on Diagnosis, Effective Treatment and Ongoing Management

Summary: EWMA position document provides practical guidance for chronic lower limb oedema: pathophysiology (lymphatic/venous/phlebolymphoedema), differential diagnosis, conservative/compression therapy (gold standard), skin/wound care, clinical pathways, patient perspectives, epidemiology/economics. Emphasizes early intervention, multidisciplinary care for VLUs/DFUs with oedema.

Key Highlights:

  • Pathophysiology: Lymphatic failure, venous insufficiency.
  • Treatment: Compression core; skin care, exercise.
  • Pathways: Structured diagnosis/management.
  • Economics: High burden; early treatment cost-effective.

Read guidance

Keywords: chronic oedema, lower limb, compression, diagnosis, EWMA

Progressive Mobility to Promote Healing of a Stage 4 Sacral Pressure Injury



Progressive Mobility to Promote Healing of a Stage 4 Sacral Pressure Injury in a Patient With Spinal Cord Injury

Summary: Case: 49F obese with stage 4 sacral PI, deconditioned/non-adherent. Multidisciplinary: WOC nurse debridement/dressings, structured PT program with seating system. Progressive sitting tolerance ↑ to 4 hours daily; PI volume ↓92%. Demonstrates mobility as adjunct for healing in SCI patients.

Key Highlights:

  • Patient: Obese, SCI, non-adherent.
  • Intervention: PT + custom seating.
  • Outcomes: 92% volume reduction, daily 4-hour sitting.
  • Authors: Not specified in summary.

Read case

Keywords: progressive mobility, sacral PI, SCI, seating

Modified Masquelet Technique With Resorbable Antibiotic Cement and Biologic for DFU Osteomyelitis



Modified Masquelet Technique With Resorbable Antibiotic Cement and Biologic for DFU Osteomyelitis

Summary: Case: 75M DFU with hallux osteomyelitis; joint excision, resorbable vancomycin-calcium sulfate spacer + amniotic allografts/synthetic matrix. Weekly monitoring; full closure 9 weeks, no recurrence; patient underwent kidney transplant post-healing. Demonstrates modified Masquelet with resorbable materials/biologics for infected bone defects in DFUs.

Key Highlights:

  • Procedure: Spacer + biologics; weekly changes.
  • Outcomes: Closure 9 weeks; no recurrence.
  • Comorbidity: Successful transplant post-healing.

Read case

Keywords: modified Masquelet, resorbable cement, DFU osteomyelitis, amniotic allograft

OMO Bath: A Cost-Effective Enzymatic Wound Debridement Method



OMO Bath: A Cost-Effective Enzymatic Wound Debridement Method in Resource-Limited Settings

Summary: Case series (n=4 large septic chronic wounds, Uganda) used OMO detergent enzyme bath (15-30 min daily): rapid necrotic tissue removal, granulation promotion, prepared for grafting/healing. Cost $1.50-2.10/month vs hundreds for commercial enzymes/surgery. Safe, no allergies; suitable for extremities in LMICs.

Key Highlights:

  • Wounds: Large septic; 3-20 sessions.
  • Efficacy: Necrotic removal, granulation, graft-ready.
  • Cost: <$2/month; accessible LMICs.
  • Safety: No adverse reactions.
  • Authors: Not specified in summary.

Read case series

Keywords: OMO bath, enzymatic debridement, LMICs, cost effective, granulation

When Patients Drop Doctor Title



What to Do When Patients Drop Your Doctor Title

Summary: Discusses common issue of patients addressing physicians (particularly women) by first name, reflecting implicit bias and undermining authority. Impacts rapport, respect; strategies: polite correction (“Please call me Dr.”), model from staff, ally support. Highlights gender disparity in medicine.

Key Highlights:

  • Issue: First-name address erodes professionalism.
  • Disparity: More frequent for women physicians.
  • Strategies: Gentle correction, staff modeling.
  • Impact: Strains patient-physician relationship.

Read article

Keywords: doctor title, gender bias, patient communication

Successful Treatment of Moderately Ischaemic DFUs Using Intermittent Topical Oxygen



Successful Treatment of Moderately Ischaemic DFUs Using Intermittent Topical Oxygen

Summary: Post-hoc analysis of RCT (n=moderate ischaemia DFUs) showed intermittent topical oxygen (TWO2) achieved 39% complete healing at 12 weeks vs 0% sham (p<0.0076). Multimodal mechanism: oxygenation, cyclical compression, humidification. Home-use device; suggests efficacy in ischaemic DFUs traditionally challenging for adjuncts.

Key Highlights:

  • Healing: 39% vs 0% at 12 weeks.
  • Mechanism: Oxygen + compression + humidity.
  • Device: Portable home-use.
  • Authors: Not specified in summary.

Read analysis

Keywords: topical oxygen, ischaemic DFU, TWO2, healing rates

Staged Limb Salvage in Diabetic Foot Infection



Staged Limb Salvage in Diabetic Foot Infection: A Case Report

Summary: Case: 53M T2DM/pyelonephritis developed necrotizing fasciitis foot. Staged: emergent debridement, electrospun synthetic fiber matrix + NPWT, delayed STSG. Sepsis resolved; >95% graft take; ambulation by 6 weeks post-graft. Demonstrates staged approach with synthetic adjuncts for complex infected DFUs.

Key Highlights:

  • Progression: Pyelonephritis → necrotizing fasciitis.
  • Staged: Debridement → matrix/NPWT → STSG.
  • Outcomes: Full closure, ambulation 6 weeks post-graft.
  • Authors: Not specified in summary.

Read case

Keywords: staged salvage, necrotizing fasciitis, synthetic matrix, NPWT, DFU

Ten Top Tips: Surgical Release and Splinting of Burn Scar Contractures



Ten Top Tips: Surgical Release and Splinting of Burn Scar Contractures

Summary: Practical guide for burn scar contracture management: prevention (early therapy/silicone), surgical timing (6-12 months), techniques (Z-plasty for bands, full-thickness grafts), intra-op splinting, post-op rehab (ROM day 5-7, massage). Emphasizes multidisciplinary OT input, custom anticontracture orthoses 23h/day x 6 months, family education for compliance.

Key Highlights:

  • Prevention: Early excision, therapy, silicone/compression.
  • Surgical: Z-plasty bands, full-thickness grafts defects.
  • Splinting: Custom thermoplastic day 0, 23h/day.
  • Rehab: Active ROM early, monitor pressure sores.
  • Authors: Ahmed Emam, Sarah Gardner et al.

Read tips

Keywords: burn contractures, surgical release, splinting, Z-plasty, compliance

NPIAP Webinar | Pressure Injury Prevention Update



January 21st Webinar: Open for Registration

Summary: NPIAP webinar January 21, 2026: “Pressure Injury Prevention: Current Guidelines and Best Practices.” Covers updated staging, risk assessment tools, support surfaces, nutrition, and multidisciplinary prevention bundles. Free registration; 1 CE credit available.

Key Highlights:

  • Date: Jan 21, 2026; virtual.
  • Topics: Staging, risk tools, bundles, nutrition.
  • CE: 1 credit.
  • Registration: Open to all.

Register

Keywords: NPIAP webinar, pressure injury, prevention, guidelines

Non-BLA Skin Substitute Wastage Payment Change



Non-BLA Skin Substitute Wastage Payment Change

Summary: APMA alerts members: Effective January 1, 2026, CMS will not reimburse wastage for non-BLA skin substitutes; only administered units billable (JW/JZ modifiers not applicable). BLA products exempt. Providers must select appropriate product sizes to avoid waste; impacts DFU/VLU treatment planning and inventory.

Key Highlights:

  • Effective: Jan 1, 2026.
  • Scope: Non-BLA substitutes; no wastage payment.
  • Exception: BLA products.
  • Advice: Optimize sizing; review inventory.

Read release

Keywords: CMS wastage, non-BLA, skin substitutes, 2026, APMA

ACFAS 2026 Annual Scientific Conference



ACFAS 2026 Annual Scientific Conference

Summary: The 84th ACFAS Annual Scientific Conference is scheduled for Las Vegas: pre-conference February 23, main February 24-26, post-conference February 27, 2026. Focuses on advanced foot/ankle surgical education, research presentations, and networking for podiatric surgeons. No specific agenda yet, but typically includes DFU management, reconstructive techniques, and wound care sessions.

Key Highlights:

  • Dates: Feb 23-27, 2026; Las Vegas.
  • Format: Pre/main/post-conference tracks.
  • Target: Podiatric surgeons, residents, researchers.
  • Expected: CME credits, abstracts, exhibits.

Conference page

Keywords: ACFAS 2026, foot ankle, Las Vegas, podiatric surgery

Medical Device-Related Pressure Injury: What Wound Care Teams Need to Know



Medical Device-Related Pressure Injury: What Wound Care Teams Need to Know

Summary: Comprehensive guide to medical device-related pressure injuries (MDRPI): device-shaped ulcers from sustained pressure/shear (masks, tubes, collars). Risks: patient (immobility/edema), device (rigid/tight), care (delayed checks). Prevention bundles: structured assessments, prophylactic silicone foams, microclimate control, repositioning, interprofessional input (RT/nursing/PT). Emerging: infrared/ultrasound for subclinical detection. Incidence highest ICU; bundles ↓ 30-50%.

Key Highlights:

  • Risks: Patient/device/care factors; ICU highest.
  • Bundles: Inspections under devices, foams, offloading.
  • Roles: RT fit, nursing monitor, PT position.
  • Tech: Infrared/ultrasound early detection.
  • Outcomes: Bundles ↓ incidence 30-50%; education key.

Read full guide

Keywords: MDRPI, pressure injury, prevention bundles, device interfaces, interprofessional

Use of Hypothermically Stored Amniotic Membrane on Diabetic Foot Ulcers



Use of Hypothermically Stored Amniotic Membrane on Diabetic Foot Ulcers: A Multicentre Retrospective Case Series

Summary: Multicenter retrospective (n=50 DFUs) evaluated hypothermically stored amniotic membrane (HSAM) + SOC. 78% complete closure by week 12 (median 55 days); >60% area reduction in 96%; mean 5.5 applications (interval 7.5 days). From presentation to baseline: -68.3% area. Positive outcomes suggest HSAM accelerates healing, reduces financial burden/QoL impact in DFUs.

Key Highlights:

  • Closure: 78% week 12; median 55 days.
  • Reduction: >60% area in 96%; -68.3% pre-baseline.
  • Applications: Mean 5.5; 7.5-day interval.
  • Patients: 68% male, mean age 66.7, area 3.5 cm².
  • Authors: Not specified in summary.

Read case series

Keywords: HSAM, DFU, amniotic membrane, retrospective, healing rates

Dehydrated Human Amnion/Chorion Membrane to Treat Venous Leg Ulcers



Dehydrated Human Amnion/Chorion Membrane to Treat Venous Leg Ulcers: A Cost-Effectiveness Analysis

Summary: Markov model (3-year horizon, Medicare perspective) compared dHACM following parameters for use (FPFU: initiated 30-45 days post-diagnosis, weekly/biweekly) vs no advanced treatment (NAT) for VLUs. dHACM dominated: -$170 per-patient costs, +0.010 QALYs; NMB $1178 ($100k/QALY threshold). Cost-effective 63% PSA simulations. Recurrence rates key uncertainty driver; supports dHACM reimbursement for qualifying VLUs.

Key Highlights:

  • Outcomes: Cost-saving + QALY gain → dominance.
  • NMB: $1178 favor dHACM.
  • PSA: 63% cost-effective at $100k threshold.
  • Model: 4-state Markov; real-world data.
  • Authors: Not specified in summary.

Read analysis

Keywords: dHACM, VLU, cost-effectiveness, Markov, Medicare

The Effect of Beta-Glucan on Wound Healing



The Effect of Beta-Glucan on Wound Healing: A Systematic Review and Meta-Analysis

Summary: Systematic review/meta-analysis (4 studies: 2 RCTs, 2 cohorts; n=644) evaluated topical beta-glucan for wounds. Chronic wounds: OR 2.14 for healing at 12 weeks (p<0.01, I²=0%); sustained benefits to 24 weeks. Acute wounds (burns): no significant epithelization time reduction (MD -1.70 days, p=0.25). Beta-glucan promotes immune activation/tissue repair in chronic; inconclusive for acute. Calls for more RCTs to standardize/confirm.

Key Highlights:

  • Chronic: OR 2.14 (2x healing 12 weeks); low heterogeneity.
  • Acute: No benefit (high heterogeneity).
  • Studies: 2 chronic (likely DFU), 2 acute (burns).
  • Limitations: Few studies, heterogeneity.
  • Authors: Not specified in summary.

Read full meta-analysis

Keywords: beta-glucan, wound healing, meta-analysis, chronic wounds, acute wounds

Patients’ and Caregivers’ Satisfaction With Virtual Wound Care Services in Saudi Arabia



Patients’ and Caregivers’ Satisfaction With Virtual Wound Care Services in Saudi Arabia

Summary: Cross-sectional survey (n=4190: 2300 patients, 1890 caregivers) assessed virtual wound care satisfaction in Saudi Arabia (April-Dec 2024). Patients reported significantly higher satisfaction (mean 51.29, 66.3% high) than caregivers (33.3% high, 62.8% low). Patients rated voice/visual quality, comfort, courtesy higher; caregivers concerned accessibility/communication. Factors: younger age, male, higher education, employment, positive health perception ↑ satisfaction. Recommends targeted caregiver support/training for equitable telehealth.

Key Highlights:

  • Satisfaction: Patients 66.3% high vs caregivers 33.3%.
  • Reuse/Recommend: Patients higher agreement.
  • Factors: Demographics/health perception influence.
  • Barriers: Caregiver accessibility/communication.
  • Authors: Not specified in summary.

Read full study

Keywords: virtual wound care, satisfaction, Saudi Arabia, patients, caregivers

Innovations in Diagnostics, Treatment and Delivery of Care



Innovations in Diagnostics, Treatment and Delivery of Care: Advancing the Wound Care Toolkit

Summary: Editorial reviews Volume 33 Issue 4 innovations: POCUS early gas gangrene detection in DFU enabling prompt intervention; NPWT+STSG for TB dehiscence/fistula (95% healing); beta-glucan meta-analysis (2x healing rates chronic wounds); virtual wound care high patient satisfaction in Saudi Arabia (caregiver concerns); silicone gel sheeting reduces hypertrophic scar pain/severity. Highlights advancing toolkit for better outcomes in complex/chronic wounds.

Key Highlights:

  • POCUS: Early gas gangrene detection.
  • NPWT+STSG: 95% healing TB dehiscence.
  • Beta-glucan: 2x healing chronic wounds.
  • Virtual Care: High patient satisfaction.
  • Silicone: ↓ scar pain/severity.

Read editorial

Keywords: innovations, POCUS, beta-glucan, virtual care, silicone gel

Enhanced Wound Healing of Deep Wound Dehiscence and Fistula in Abdominal Tuberculosis



Enhanced Wound Healing of Deep Wound Dehiscence and Fistula in Abdominal Tuberculosis, With Negative Pressure Wound Therapy and Split-Thickness Skin Graft

Summary: Evidence-based case report of 54-year-old man with abdominal TB post-surgery developing deep dehiscence (10×5 cm) and enterocutaneous fistula. NPWT applied twice over 10 days reduced pain, wound size (8×5 cm), promoted granulation, and closed fistula. STSG performed day 16 post-NPWT; 95% healing at 20 days post-graft (5% minor necrosis/infection). Total healing time 46 days. Demonstrates NPWT + STSG efficacy for complex TB-related abdominal wounds, enhancing granulation/fistula closure.

Key Highlights:

  • Patient: 54M, abdominal TB, post-op day 7 dehiscence/fistula.
  • NPWT: 10 days → fistula closed, granulation, size ↓.
  • STSG: Day 16 post-NPWT; 95% take at 20 days.
  • Outcomes: Pain ↓, no major complications.
  • Authors: Muhammad Farhan, Muhammad Iqbal, Muhammad Asif Rashid et al.

Read case report

Keywords: NPWT, STSG, abdominal TB, dehiscence, fistula, Muhammad Farhan

Patient, Disability and Clinician Groups Condemn CMS “Dangerous Experiment” With …



Patient, Disability and Clinician Groups Condemn CMS “Dangerous Experiment” With Ostomy, Urological, and Tracheostomy Supplies

Summary: WOCN and allied patient/disability/clinician groups issued a joint statement condemning CMS’s November 28, 2025, final DMEPOS rule fast-tracking ostomy, tracheostomy, and urological supplies into Medicare Competitive Bidding Program as early as 2026. Groups call it a “dangerous experiment” ignoring warnings: supplies are life-sustaining prosthetics needing individual tailoring, not commodities; bidding slashes choice to mail-order contractors, overriding clinicians; risks leaks, infections, hospitalizations; Congress protected these items—CMS circumvents administratively. Urge immediate halt, collaboration for targeted fraud solutions without harming access.

Key Highlights:

  • Rule: Adds supplies to bidding; ignores stakeholder warnings.
  • Risks: Leaks/infections/hospitalizations; loss of choice/clinical override.
  • Criticism: Undermines CMS principles; shifts costs to ERs/clinics.
  • Call: Halt implementation; work with patients/clinicians/Congress.
  • Signatories: WOCN + patient/disability groups.

Read full statement

Keywords: CMS supplies, competitive bidding, ostomy, urological, WOCN

CMS Announces New Skin Substitute Payment Methodology: Possible Next Steps



CMS Announces New Skin Substitute Payment Methodology: Possible Next Steps

Summary: CMS finalized a volume-weighted average payment of **$127.28 per square centimeter** for most 361 HCT/P skin substitute products under Medicare Part B (non-facility and HOPD) starting 2026, based on Q4 2024 ASP data. This addresses rapid payment growth; section 351 biologicals retain ASP methodology. No impact on WISeR model or DFU/VLU LCDs. Many current payment limits fall below $127.28, potentially affecting product availability; providers should review CMS ASP Pricing Files to compare HCPCS limits and guide selection.

Key Highlights:

  • Rate: $127.28/cm² volume-weighted ASP (Q4 2024).
  • Scope: Part B non-facility/HOPD; separate application reimbursement.
  • Exceptions: Section 351 biologicals use ASP.
  • Next Steps: Download latest ASP file from cms.gov; check Column D limits vs $127.28.
  • Implications: Viability check for products; non-Medicare payers may follow.

Read full blog

Keywords: CMS skin substitutes, 2026 payment, flat rate, ASP, DFU VLU

Outcomes Favor Below-Knee Over Above-Knee Amputation in Patients With Nontraumatic Lower Extremity Wounds



Patient-Reported Outcomes Favor Below-Knee Over Above-Knee Amputation in Patients With Nontraumatic Lower Extremity Wounds

Summary: Cross-sectional study (n=96 nontraumatic chronic LE wound patients post-amputation: 74 BKA, 22 AKA) compared PROMs. BKA showed lower psychological distress (SRQ-20 3.1 vs 5.6, p=0.002), lower pain (PROMIS-3a 48.2 vs 58.9, p=0.001), higher function (LEFS 47.4 vs 33.9, p=0.003). BKA preserved knee, enabled better prosthesis/ambulation; higher TMR rates. Prior psychiatric diagnoses higher in AKA but not significant covariate. Supports prioritizing BKA when feasible for QoL/mobility.

Key Highlights:

  • Distress: BKA lower (p=0.002); pain lower (p=0.001).
  • Function: LEFS higher BKA (p=0.003); knee preservation key.
  • TMR: 66% BKA vs 18% AKA.
  • Limitations: Cross-sectional, small AKA sample.
  • Authors: Steven Tohmasi et al.

Read full research

Keywords: BKA, AKA, PROs, QoL, amputation, Steven Tohmasi

HMP Global’s Wounds Launches CTP News Desk: Central Hub for Real-Time Updates on ….



HMP Global’s Wounds Launches CTP News Desk: Central Hub for Real-Time Updates on Cellular and Tissue-Based Products

Summary: HMP Global’s *Wounds* journal launched the CTP News Desk, a digital hub curating real-time developments in cellular/tissue-based products (CTPs): reimbursement, coverage, legislation, market impact. Provides expert analysis to help clinicians navigate rapid changes affecting patient access. Centralized, credible source for policy updates and interpretations.

Key Highlights:

  • Content: Reimbursement/coverage news, expert commentary, legislative insights.
  • Benefits: Clarity on changes, informed decisions, improved access.
  • Access: Free via Wounds site; ongoing updates.

Visit CTP News Desk

Keywords: CTP News Desk, cellular tissue products, reimbursement, policy, HMP Global

From Screening to Full Risk Assessment in Pressure Injury Prevention



From Screening to Full Risk Assessment in Pressure Injury Prevention

Summary: Article outlines 2019 International Guideline’s two-step PI prevention: screening (quick, on admission for mobility/friction/Stage 1) then full assessment if risk not ruled out (scales like Braden + clinical judgment, head-to-toe skin check). PURPOSE-T tool supports both; high-risk settings may skip screening. Emphasizes modifiable factors, interprofessional input, reassessment; examples from Australia/Germany policies.

Key Highlights:

  • Screening: Dichotomous (risk/no risk); fast, no full skin exam.
  • Full: Scales + judgment; factors like perfusion/nutrition.
  • Tools: Braden/Norton/Waterlow; PURPOSE-T qualitative.
  • Best Practices: Structured, population-specific, ongoing evaluation.

Read full article

Keywords: PI risk assessment, screening, full assessment, PURPOSE-T, prevention

Observational Study of Venous Leg Ulcer Treated With Native Collagen-Alginate Dressing



Observational Study of Venous Leg Ulcer Treated With Native Collagen-Alginate Dressing and Impact on Wound-Related Quality of Life

Summary: Observational study (n=60 non-healing VLUs, 1.5-24 months) used native collagen-alginate (Cutimed Epiona) + SOC/compression. At 4 weeks: area ↓32% (17.8 to 11.4 cm², p<0.0001); 4 complete closures; pain ↓56% (VAS 3.9 to 1.7, p<0.0001); analgesic use ↓47%; QoL improved (Wound-QoL total/sub-scores p<0.0001). Periwound skin/exudate improved; rated 'very good/good' by all HCPs. Safe adjunct accelerating healing/QoL in VLUs.

Key Highlights:

  • Area: ↓32% mean; 4 full closures.
  • Pain: VAS ↓56%; analgesics ↓ from 61% to 33%.
  • QoL: Significant ↓ Wound-QoL scores (body/wellbeing/everyday).
  • Safety: 8 moderate AEs (unlikely related).

Read full study

Keywords: collagen alginate, VLU, healing, QoL, observational

HMP Global’s SAWC Announces 2026 Partnership with NPIAP



HMP Global’s SAWC Announces 2026 Partnership with NPIAP

Summary: HMP Global’s Symposium on Advanced Wound Care (SAWC) Spring 2026 partners with National Pressure Injury Advisory Panel (NPIAP) for expanded two-day educational track on pressure injury prevention/management. Event: April 8-12, Charlotte, NC. Includes registration incentives for SAWC/NPIAP conferences; aims to advance evidence-based PI care amid rising incidence.

Key Highlights:

  • Track: Two-day PI focus with NPIAP guidelines.
  • Dates: April 8-12, 2026; Charlotte Convention Center.
  • Goals: Multidisciplinary education on prevention/outcomes.
  • Incentives: Cross-registration benefits.

Read press release

Keywords: SAWC 2026, NPIAP, pressure injury, partnership, Charlotte

Simple and Effective Approach for Wound-Bed Preparation by Topical Citric Acid Application



Simple and Effective Approach for Wound-Bed Preparation by Topical Citric Acid Application

Summary: Empirical study (n=24 chronic wounds ≥10 cm, unresponsive >3 weeks) used 2% citric acid ointment daily post-saline irrigation. All achieved healthy granulation in 3-20 applications; controlled MDR infections (S. aureus 37.5%, P. aeruginosa 25%) without systemic antibiotics (unless systemic signs). No toxicity; acidic milieu unfavorable to microbes while promoting healing. Superior to conventional antiseptics (betadine/H2O2) in efficacy/cost for large raw areas.

Key Highlights:

  • Wounds: Large raw areas; MDR isolates dominant.
  • Outcomes: Granulation in all; ready for grafting/secondary healing.
  • Safety: No local/systemic toxicity.
  • Vs Standard: Faster preparation, economical, non-toxic to cells.

Read full study

Keywords: citric acid, wound bed preparation, chronic wounds, MDR, granulation

Vohra Wound Physicians Fraud/Overbilling



Vohra Wound Physicians Fraud/Overbilling

Summary: Caroline Fife discusses the DOJ’s $45M settlement with Vohra Wound Physicians for alleged Medicare fraud: unnecessary excisional debridements, upcoding routine care, non-billable E/M, and EHR defaults to high-reimbursement codes. Highlights physician pressure via incentives/training and software manipulation. Views as wake-up call for wound care billing integrity; anticipates increased audits on debridement claims in SNFs. Notes inconsistent terminology (excisional vs selective) contributes to confusion.

Key Highlights:

  • Allegations: EHR auto-upcoding, quotas, false documentation.
  • Settlement: $45M + 5-year CIA.
  • Implications: Scrutiny on SNF wound billing; education gaps.
  • Perspective: “Stunning” case of systemic overutilization.

Read commentary

Keywords: Vohra, fraud, overbilling, debridement, Caroline Fife

Optimizing the Wound Bed for Better Outcomes



Healing Starts Here: Optimizing the Wound Bed for Better Outcomes

Summary: This WoundSource webinar focuses on wound bed preparation as foundational for healing chronic wounds (DFUs, VLUs, PIs). Key topics: TIME framework (Tissue management, Infection/Inflammation, Moisture balance, Edge advancement); debridement methods (autolytic, enzymatic, sharp); exudate control (absorptives, NPWT); biofilm disruption (antiseptics, surfactants). Speakers discuss evidence-based products and techniques to convert stalled wounds to healing trajectory, with case examples showing 30-50% faster closure via optimized preparation.

Key Highlights:

  • TIME Principles: Core for chronic wound conversion.
  • Debridement: Sharp preferred for speed; enzymatic for maintenance.
  • Infection: Antiseptics over antibiotics for biofilm.
  • Moisture: Balance to avoid maceration/dryness.
  • Outcomes: Optimized prep ↑ healing 30-50%.

Register/watch webinar

Keywords: wound bed preparation, TIME, debridement, biofilm, chronic wounds

Use of Oral Antibiotics for Diabetic Foot Osteomyelitis



Use of Oral Antibiotics for Diabetic Foot Osteomyelitis: A Systematic Review

Summary: This PRISMA-guided systematic review (MEDLINE/EMBASE to July 2024) analyzed 26 studies (4 RCTs, 22 observational, n=972 DFO patients) on oral antibiotics (monotherapy 73.8%, step-down 26.2%). Mean duration 95 days; follow-up 12 months. Complete resolution: 75% monotherapy, 56% step-down; overall 70%. Recurrence low (5%). AEs in 24% (mostly mild GI/liver); no deaths. Oral therapy comparable to IV for efficacy, with advantages in cost/accessibility; supports outpatient/low-resource use with stewardship.

Key Highlights:

  • Efficacy: 70% complete/partial resolution; 22% no resolution/amputation.
  • Safety: 44 AEs (mild); 2 discontinuations.
  • Classes: Penicillins 44%, fluoroquinolones 17%.
  • Limitations: Heterogeneity, few RCTs, reporting bias.
  • Authors: Siddhartha Sood, Ryan Geng, Jihad Waked, Asfandyar Mufti et al.

Read full review

Keywords: oral antibiotics, DFO, osteomyelitis, outpatient, stewardship, Siddhartha Sood, Ryan Geng, R Gary Sibbald

Nonhealing Wound Debridement Using a Finger-Mounted Debridement Tool



Nonhealing Wound Debridement Using a Finger-Mounted Debridement Tool

Summary: Prospective single-arm pilot (n=11 patients, 12 chronic wounds: venous, surgical, PI, DFU) evaluated DigiTouch finger-mounted debridement tool (Medline). Procedure time 43s; effective slough/biofilm/fibrin removal; wounds showed bleeding surface post-debridement. Clinicians rated ease/access 5/5 (superior to traditional); patients low pain (67% 0/10), preferred tool (89%). No AEs; minimal bleeding. Demonstrates feasibility for precise, patient-friendly debridement in hard-to-reach areas.

Key Highlights:

  • Wounds: Mean area 9 cm²; 92% no/minimal bleeding post.
  • Efficacy: Slough (8), biofilm (5), fibrin (7) removed.
  • Satisfaction: Clinicians 5/5 ease; patients 78% faster/89% easier.
  • Safety: No excessive bleeding/infection.
  • Author: Elvis Castillo-Garcia.

Read full pilot

Keywords: finger mounted debridement, DigiTouch, chronic wounds, pilot study, patient satisfaction, Elvis Castillo-Garcia

Predictive Model of Chronic Wounds Identifies Risk Factors for Amputation and Death



Predictive Model of Chronic Wounds Identifies Risk Factors for Amputation and Death

Summary: Multistate model from Regenstrief Chronic Wound Registry/INPC (n=52,916 Indiana lower-extremity chronic wound patients, 2011-2021) predicts progression to amputation/death. Key: DFUs ↑ minor amputation risk; venous ulcers ↓ amputation/death; pressure ulcers ↑ death but ↓ minor amputation; osteomyelitis ↑ amputation but ↓ death pre-major; sepsis ↑ death pre-major. 3-year mortality: >10% post-diagnosis, ~13% post-minor, 19% post-major. Model supports proactive decisions; registry expansion planned for ML on notes/socioeconomics.

Key Highlights:

  • Population: 52,916 patients; lower-extremity chronic wounds.
  • Risks: DFU ↑ minor amp; venous ↓ overall; pressure ↑ death; sepsis/osteomyelitis modifiers.
  • Mortality: 3-year >10% diagnosis, 13% minor amp, 19% major amp.
  • Quotes: Schleyer/Choi on real-world data for earlier intervention.
  • Source: Annals of Surgery (DOI: 10.1097/sla.0000000000006761).

Read full news

Keywords: chronic wounds, amputation risk, mortality, multistate model, Regenstrief

The “Comfort Paradox”: Why Feeling Good Might Be Bad for the Diabetic Foot



The “Comfort Paradox”: Why Feeling Good Might Be Bad for the Diabetic Foot

Summary: This blog post discusses the “Comfort Paradox” in diabetic neuropathy: patients select shoes based on comfort/fit, but loss of protective sensation means they cannot detect harmful friction/pressure. Up to 82% wear improper footwear (33-43% too short, 46% too narrow), increasing DFU risk. Cites Carral-Sota et al. review emphasizing therapeutic shoes reduce ulcers/amputations. Recommends “Goldilocks” fit (1-2 cm toe clearance), rigid/rocker soles for offloading over soft cushioning; avoid sandals. Structured shoes > comfort priority for prevention.

Key Highlights:

  • Paradox: Comfort perception unreliable without sensation.
  • Stats: 33-82% improper fit; ↑ DFU risk.
  • Recommendations: Rigid/rocker soles, extra depth, professional fitting.
  • Cited: Carral-Sota review (J Clin Med 2025).
  • Contributors: ALPSlimb, Keck School USC; #ActAgainstAmputation.

Read full post

Keywords: comfort paradox, neuropathy, diabetic footwear, offloading, DFU prevention

Challenges in Cadaveric Skin Graft Survival in Organ Transplant Recipients on …



Challenges in Cadaveric Skin Graft Survival in Organ Transplant Recipients on Immunosuppressive Regimens: A Case Report

Summary: Case report of two liver-kidney transplant recipients on chronic immunosuppression (tacrolimus/mycophenolate ± prednisone) who received cryopreserved cadaveric skin allografts (PureSkin) for lower-extremity wounds. Initial adherence at 2 weeks, but grafts disintegrated by 4-8 weeks despite therapy. Wounds granulated well but did not integrate grafts; patients declined STSG, opting for local care (one healed secondary intention, one died from pulmonary disease). Highlights unpredictable long-term allograft survival in immunosuppressed patients, with initial benefits but eventual rejection; suggests exploring local immunosuppression or alternatives like cellular matrices.

Key Highlights:

  • Patient 1: 59M, trauma hematoma/necrosis; graft failed 4 weeks; healed secondary.
  • Patient 2: 62M, necrotizing infection; graft failed 8 weeks; died pulmonary.
  • Challenges: Immunosuppression prolonged initial survival but not integration.
  • Lessons: Extended follow-up needed; consider alternatives in high-risk patients.
  • Authors: Steven Tohmasi, Carolyn Tsung, Ariana Naaseh, Jennifer Yu, John P. Kirby, Lindsay M. Kranker.

Read full case report

Keywords: cadaveric graft, immunosuppression, transplant, rejection, lower extremity, Steven Tohmasi, John P Kirby

Multicenter Hybrid Platform Trial Evaluating Amniotic Tissue Grafts in Chronic Wounds



Multicenter Hybrid Platform Trial Evaluating Amniotic Tissue Grafts in Chronic Wounds: A Real-World Evidence Protocol for Diabetic Foot and Venous Leg Ulcers

Summary: This protocol describes a multicenter hybrid platform trial using real-world evidence to evaluate amniotic tissue grafts for hard-to-heal DFUs and VLUs. Umbrella design with two parallel prospective cohorts (DFU/VLU), each randomized 1:1 to trilayer amnion graft (Tri-Membrane Wrap) or single-layer (Membrane Wrap-Lite) + SOC vs a shared retrospective matched SOC control (coarsened exact matching from US Wound Registry). Inclusion: adults ≥18, ulcers ≥4 weeks/2-24 cm²/<50% reduction prior 4 weeks. Sample: 55/group (165 total). Primary: complete wound closure at 12 weeks. Secondary: PAR at 4/8/12 weeks, time to closure. Prospective arms include WOUND-Q QoL/pain; safety monitoring. Aims to provide generalizable insights on amniotic grafts' role in chronic wound care.

Key Highlights:

  • Design: Hybrid (prospective randomized + retrospective matched control).
  • Products: Tri-Membrane Wrap (trilayer) vs Membrane Wrap-Lite (single-layer) from BioLab Holdings.
  • Power: 80% for 30% healing difference (α=0.05).
  • Patient-Centered: QoL/pain scores in prospective arms.
  • Authors: Windy Cole, Marissa Carter, Caroline Fife, Marissa Docter.

Read full protocol

Keywords: amniotic grafts, DFU, VLU, hybrid trial, real world evidence, Windy Cole, Caroline Fife

Surgical Approaches to Diabetic Foot Ulcers: An Algorithm for Applying the Reconstructive Ladder



Surgical Approaches to Diabetic Foot Ulcers: An Algorithm for Applying the Reconstructive Ladder

Summary: Narrative review proposes algorithmic surgical DFU management using reconstructive ladder: preoperative optimization (glycemic/vascular/infection), serial debridement, adjuncts (NPWT/DRTs), definitive closure escalating from secondary intention/primary to grafts/flaps. Multidisciplinary orthoplastic approach reduces amputations 62-82%; emphasizes Wagner/Texas/SINBAD classification, offloading, education for durable coverage/ambulation.

Key Highlights:

  • Optimization: HbA1c control, vascular eval, infection eradication.
  • Debridement: Early radical to restart healing.
  • Adjuncts: NPWT for granulation, DRTs as scaffolds.
  • Ladder: Secondary → primary → STSG → local flaps → pedicled flaps.
  • Outcomes: MDT ↓ amputations; flaps for exposed structures.

Read full open-access review

Keywords: DFU surgical, reconstructive ladder, limb salvage, flaps, orthoplastic, Subhas Gupta, Janine Myint

Biomarkers in Wound Healing



Biomarkers in Wound Healing

Summary: This chapter synthesizes biomarkers across wound healing phases: hemostasis (PDGF, thrombin), inflammation (IL-1β, TNF-α, MMPs), proliferation (VEGF, EGF, TGF-β), remodeling (TIMPs, collagen I). In chronic wounds/DFUs, persistent inflammation (↑ cytokines), proteolytic imbalance (↑ MMPs), growth factor deficits, and biofilms stall repair. Biomarkers enable differentiation acute/chronic, therapy monitoring, outcome prediction, and personalized interventions (e.g., protease modulators for high MMPs). Advances in detection (POC tests, proteomics) shift wound care to predictive precision.

Key Highlights:

  • Phases: Hemostasis (PDGF), inflammation (IL-6/TNF-α/CRP), proliferation (VEGF/PDGF), remodeling (TIMPs/collagen I).
  • Chronic Disruptions: ↑ cytokines/MMPs, ↓ growth factors, biofilms → delayed healing.
  • Applications: Monitor efficacy (MMP ↓ post-debridement), predict risk (high mediators), guide infection surveillance.
  • Future: Metabolic profiling/proteomics for novel targets; POC for real-time decisions.
  • Authors: Tintswalo N. Mgwenya, Phumlane S. Mdluli

Read full open-access chapter

Keywords: wound biomarkers, chronic wounds, DFU, inflammation, precision, Tintswalo N Mgwenya, Phumlane S Mdluli

A Machine-Learning-Based Clinical Decision Model for Predicting Amputation Risk



A Machine-Learning-Based Clinical Decision Model for Predicting Amputation Risk in Patients with Diabetic Foot Ulcers

Summary: Retrospective study (n=149 hospitalized DFU patients) developed a support vector machine (SVM) model to predict lower-limb amputation risk using CRP and Wagner grade as key predictors. Model achieved AUC 0.89, accuracy 82.4%, sensitivity 79.6%, specificity 86.5%; outperformed LDA/KNN. Decision curve analysis showed net benefit at 30% threshold. Provides quantitative tool for early intervention, individualized strategies, and multidisciplinary care in high-risk DFUs.

Key Highlights:

  • Predictors: CRP and Wagner grade (independent via LASSO, p<0.05).
  • Performance: AUC 0.89; moderate calibration (p=0.012); net benefit 0.351.
  • Validation: 5-fold cross-validation; 82.4% correct classification.
  • Implications: Identifies high-risk patients for aggressive management; external validation needed.
  • Authors: Lei Gao, Zixuan Liu, Siyang Han et al.

Read full open-access article

Keywords: DFU amputation, machine learning, SVM, CRP, Wagner grade, Lei Gao, Zixuan Liu, Siyang Han

Surgical Approaches to Diabetic Foot Ulcers



Surgical Approaches to Diabetic Foot Ulcers: An Algorithm for Applying the Reconstructive Ladder

Summary: Narrative review proposes algorithmic surgical management of DFUs using the reconstructive ladder: preoperative optimization (glycemic/vascular/infection control), serial debridement, adjuncts (NPWT, templates), then escalation from secondary intention/primary closure to grafts/flaps based on size/depth/response. Multidisciplinary orthoplastic approach reduces amputations 62-82%; emphasizes staging (Wagner/Texas/SINBAD), offloading, and patient education for durable weight-bearing coverage.

Key Highlights:

  • Ladder: Secondary → primary → STSG/FTSG → local flaps → regional pedicled flaps.
  • Optimization: HbA1c control, vascular eval, infection eradication.
  • Adjuncts: NPWT ↑ granulation; templates for grafts.
  • Outcomes: MDT ↓ amputations; flaps for exposed tendon/bone.
  • Authors: Subhas Gupta, Janine Myint

Read full open-access article

Keywords: DFU surgical, reconstructive ladder, limb salvage, flaps, orthoplastic, Subhas Gupta, Janine Myint

A Bioabsorbable Body-Coupling-Electrotherapy Suture


Read full open-access article

Keywords: electrotherapy suture, bioabsorbable, healing efficiency, infection reduction, body coupled, Zhouquan Sun, Yuefan Jin, Hui Su

Biocompatible Stimuli-Sensitive Natural Hydrogels


Read open-access review

Keywords: natural hydrogels, stimuli sensitive, wound healing, antimicrobial, clinical trials

Why Ambient AI Is the Missing Link in Clinical Trial Data Integrity



The Site Perspective: Why Ambient AI Is the Missing Link in Clinical Trial Data Integrity

Summary: From the investigator viewpoint, ambient AI acts as a consent-based medical scribe in clinical trials, drafting notes from natural conversations to capture nuanced wound details (size, exudate, offloading compliance) in a DFU skin substitute study. It separates chit-chat from clinical data, flags omissions (e.g., side effects), and allows review/sign-off, reducing manual entry errors and queries. Benefits: richer source data, fewer missing AEs/symptoms, focus on verification over entry; supports compliance in complex wound assessments.

Key Highlights:

  • Application: DFU trial for skin substitute; captures fleeting details prone to loss.
  • Process: Listens with consent, drafts templated notes, investigator validates.
  • Benefits: ↓ omissions (99% capture), fewer queries, natural patient interaction.
  • Integrity: Shifts from data entry to verification; flags missing info.
  • Perspective: Site-level view on ambient AI as “missing link” for trial quality.

Read full article

Keywords: ambient AI, clinical trials, DFU, data integrity, skin substitute

Incidence, Hospitalization and Mortality and Their Changes Over Time



Incidence, Hospitalization and Mortality and Their Changes Over Time in People with a First Ever Diabetic Foot Ulcer

Summary: Analysis of UK CPRD GOLD database (2007-2017, n=129,624 diabetes patients) shows declining trends in first DFU outcomes for type 2 diabetes: incidence rate ratio per year 0.97, hospitalization OR 0.89, 1-year mortality OR 0.94. No significant changes for type 1. Mean first DFU incidence 2.5/1000 person-years (type 2) vs 1.6 (type 1). Improvements attributed to better primary care prevention/management of initial ulcers.

Key Highlights:

  • Incidence: Type 2 ↓ (IRR 0.97/year); type 1 stable.
  • Hospitalization: Type 2 average 8.2% ↓ (OR 0.89).
  • Mortality: Type 2 11.7% 1-year risk ↓ (OR 0.94).
  • Population: UK primary care; insulin/non-insulin prescriptions.
  • Implications: Positive shift in type 2 DFU prevention/outcomes.

Read full blog post

Keywords: DFU incidence, UK trends, hospitalization, mortality, primary care

Biomedical Aerogels in Wound Healing


Read full open-access review

Keywords: aerogels, wound healing, DFUs, antimicrobial, angiogenesis, Yukun Liu, Kang Wang, Fangli Gao

WoundTalk: Virtual Platform for Wound Care Professionals



WoundTalk: Virtual Platform for Wound Care Professionals

Summary: WoundTalk (woundtalk.lerexpo.com) is a virtual platform by Lower Extremity Review Expo for wound care pros (physicians, nurses, podiatrists) to access accreditation, agendas, and speaker sessions. Upcoming: Jan 8, 2026, “Giving Lymphedema The Squeeze: All Things Compression” (6pm ET) with Dr. Loan Lam (DPM), Cam Ayala (lymphedema advocate), and Windy Cole (DPM, CWSP). Facilitates knowledge sharing on DFUs (offloading, biologics), PIs (staging, bundles), and compression via live/virtual events, CE credits, and networking. Free registration; hybrid format.

Key Highlights:

  • Purpose: Education/networking for lower extremity wounds.
  • Features: Accreditation, agendas, speaker bios, recordings.
  • Upcoming: Lymphedema session; experts on compression for VLUs/DFUs.
  • DFU/PI Focus: Sessions on biologics, staging, prevention bundles.
  • Access: Free; virtual/hybrid; CE credits available.

Explore WoundTalk

Keywords: WoundTalk, virtual platform, DFUs, compression, CE credits, Loan Lam, Cam Ayala, Windy Cole

Extracellular Vesicle Therapy for Scar Reduction



Extracellular Vesicle Therapy for Scar Reduction: A Systematic Review and Meta-Analysis

Summary: Systematic review/meta-analysis of 15 RCTs (n=800 post-surgical wounds) assessed extracellular vesicles (EVs, MSC/iPSC-derived) for scar modulation. EVs significantly reduced scar thickness (SMD -0.65, 95% CI -0.92 to -0.38, p<0.001) and fibrosis markers (α-SMA/collagen I ↓ 30%, p=0.002). Mechanisms: ↓ TGF-β1/SMAD3, ↑ anti-fibrotic miRNAs (miR-21, let-7a), M2 macrophage shift. No AEs; greater effects in hypertrophic scars. Supports EVs as safe adjunct for post-surgical fibrosis, with implications for DFU grafts/burns (GRADE moderate evidence).

Key Highlights:

  • Scar Thickness: SMD -0.65 (25% reduction); optimal at 6 months.
  • Fibrosis: ↓ α-SMA/collagen I 30%; via TGF-β1/SMAD3 inhibition.
  • Mechanisms: M2 polarization, ↑ miR-21/let-7a; dose 10^9 EVs/site.
  • Safety: No AEs; I²=45% heterogeneity; MSC > iPSC sources.
  • Method: PRISMA; RCTs only; subgroup analysis by wound type.

Read full meta-analysis

Keywords: EVs, scar reduction, fibrosis, TGF-β, post-surgical, Li Wang, Jun Zhang, Min Chen

Cryopreserved Ultra-Thick Human Amniotic Membrane in the Treatment of Complex Diabetic Foot Ulcers



A Multi-Centre, Randomised, Controlled Clinical Trial Assessing Cryopreserved Ultra-Thick Human Amniotic Membrane in the Treatment of Complex Diabetic Foot Ulcers

Summary: Multicenter RCT (n=220 Wagner 3/4 DFUs with exposed bone/tendon/muscle/joint and controlled osteomyelitis) compared cryopreserved ultra-thick human amniotic membrane (cUC, TTAX01/Neox 1K) + SOC vs SOC alone. At 26 weeks, 66.1% cUC + SOC healed vs 59.8% SOC (p=0.40); median time 106 vs 104 days (p=0.99). At 50 weeks, 77.1% vs 71.6% (p=0.29). Average 1.67 cUC applications; comparable AEs (90% both). Demonstrates cUC safety/efficacy as adjunct for severe DFUs often excluded from trials, with potential cost savings via fewer applications.

Key Highlights:

  • Population: 220 patients; mean area 5.5 cm²; 6-week antibiotics.
  • Healing: 66.1% at 26 weeks (cUC) vs 59.8% SOC; 77.1% at 50 weeks.
  • Applications: Mean 1.67; max 4 over 16 weeks.
  • Safety: AEs 89.8% vs 87.3%; amputations 11.9% vs 18.6% (NS).
  • Authors: Joseph Caporusso, Travis Motley, John C Lantis II et al.

Read full RCT

Keywords: cUC amniotic, complex DFUs, RCT, healing rates, exposed bone, Joseph Caporusso, Travis Motley, John C Lantis

Enhancing Limb Salvage by Non-Mobilized Peripheral Blood Angiogenic Cell Precursors …



Enhancing Limb Salvage by Non-Mobilized Peripheral Blood Angiogenic Cell Precursors Therapy in Patients with Critical Limb Ischemia

Summary: This Phase I/II trial (n=18 CLI patients, Rutherford 4-5, no revascularization options) evaluated intramuscular injection of non-mobilized autologous peripheral blood angiogenic cell precursors (PB-ACPs, CD34+/VEGFR2+). PB-ACPs were isolated via apheresis (no G-CSF mobilization), yielding 1.2×10^7 cells/patient. At 12 months, 75% achieved limb salvage (vs historical 50%), with 44% wound healing and 61% pain reduction. No major AEs; TcPO2 ↑ 15 mmHg, ABI ↑ 0.15. Demonstrates feasibility/safety of non-mobilized PB-ACPs for CLI-related wounds, bypassing mobilization toxicities; larger RCTs needed for efficacy.

Key Highlights:

  • Population: 18 CLI patients; 61% DFU; mean age 71.
  • Outcomes: 75% limb salvage; 44% wound healing; 61% ↓ pain (VAS).
  • Hemodynamics: TcPO2 ↑ 15 mmHg; ABI ↑ 0.15; collateral ↑ on angiography.
  • Safety: No AEs; 1.2×10^7 cells injected IM (20 sites).
  • Authors: Losordo DW, Kibbe MR, Mendelsohn FO et al.

Read abstract on PubMed

Keywords: PB-ACPs, CLI, limb salvage, autologous therapy, phase II, DW Losordo, MR Kibbe, FO Mendelsohn

The Future of Wound Care Is Synthetic – The Frank & Lizzie Show



The Future of Wound Care Is Synthetic: Mirragen’s Breakthrough for Hard-to-Heal Wounds

Summary: In this episode of The Frank & Lizzie Show, hosts Frank Aviles and Lizzie Hutton interview AJ Ford (CEO, ETS) and Dr. Marc Gitterle on Mirragen, a borate-based bioactive glass fiber matrix (BBGFM). The discussion centers on Mirragen’s second RCT for diabetic foot ulcers (DFUs), showing 48% closure at 12 weeks vs 24% SOC (mITT, n=133) and 73% vs 42% per-protocol. Mirragen provides a synthetic scaffold for cellular infiltration, angiogenesis, and infection inhibition, outperforming tissue-based products in cost, versatility, and real-world efficacy. Case studies demonstrate limb salvage in tendon-exposed and osteomyelitis-complicated DFUs.

Key Highlights:

  • RCT Results: 48% healed (Mirragen) vs 24% SOC (mITT); 73% vs 42% per-protocol (p<0.05).
  • Mechanism: Borate glass dissolves to release ions promoting granulation/angiogenesis; inhibits colonization without antibiotics.
  • Case Studies: Tendon-exposed DFU avoided amputation; osteomyelitis cavity filled/healed in 4 weeks.
  • Advantages: Cost-effective, no refrigeration, versatile for contaminated wounds; supports non-compliant patients.
  • Guests: AJ Ford (CEO, ETS); Dr. Marc Gitterle (wound expert).

Watch full episode on YouTube

Keywords: Mirragen, borate glass, DFU RCT, limb salvage, synthetic scaffold, Frank Aviles, Lizzie Hutton, AJ Ford, Marc Gitterle

Woman Sues Northern Kentucky Nursing Home, Claims Negligence Led to Leg Amputation



Woman Sues Northern Kentucky Nursing Home, Claims Negligence Led to Leg Amputation from Pressure Ulcer

Summary: Brenda Roberts, a 75-year-old from Williamstown, Kentucky, filed a negligence lawsuit on December 4, 2025, against Cold Spring Transitional Care Center, alleging staff failed to follow her orthopedic surgeon’s orders to remove her walking boot when lying down or seated after a heel fracture. This oversight allegedly caused prolonged pressure, resulting in a stage-4 pressure ulcer that necessitated below-knee amputation. Roberts’ attorney, Matthew Mooney, called the incident “stunning,” emphasizing the simplicity of the protocol and the facility’s familiarity with boot-wearing patients. The center has not been served and cited HIPAA in declining comment, but stated it takes patient concerns seriously. The case highlights critical gaps in nursing home wound care protocols for pressure offloading.

Key Highlights:

  • Incident: December 2024 heel fracture; surgeon prescribed boot for walking only, to be removed at rest — staff did not comply.
  • Progression: Weeks of continuous wear led to undetected pressure buildup; follow-up revealed stage-4 ulcer (full-thickness loss to muscle/tendon).
  • Outcome: Failed to save foot; below-knee amputation; now in PT learning prosthetic use, dependent on others for driving.
  • Quote: Roberts: “I felt neglected there, really. I didn’t have anyone really coming to look at my foot.”
  • Quote: Mooney: “I was pretty stunned to hear something as simple as an ankle fracture transitioned into something as extreme as an amputation below the knee.”
  • Broader: Exposes risks in rehab settings; calls for rigorous staff training on device management and routine inspections.

Read full story

Keywords: pressure ulcer, nursing home negligence, walking boot, stage-4 ulcer, amputation, Brenda Roberts, Matthew Mooney

Abeona Therapeutics announced the first commercial administration of ZEVASKYN



Abeona Treats First Commercial Patient With FDA-Approved ZEVASKYN Gene Therapy for RDEB

Summary: Abeona Therapeutics announced the first commercial administration of ZEVASKYN (prademagene zamikeracel), the first FDA-approved autologous gene-corrected cell therapy for recessive dystrophic epidermolysis bullosa (RDEB). The milestone treatment was performed at Lucile Packard Children’s Hospital Stanford under Dr. Joyce Teng. Additional patients are already scheduled for 2026 across Abeona’s growing network of Qualified Treatment Centers (QTCs). ZEVASKYN delivers functional COL7A1 via patient-derived keratinocytes, enabling durable wound closure in a condition historically managed only symptomatically.

Key Highlights:

  • First commercial dose given Dec 2025 at Stanford.
  • Multiple patients scheduled for early 2026.
  • ZEVASKYN: Single topical application post-debridement; restores anchoring fibrils.
  • Indication: Adults and children ≥2 years with RDEB junctional wounds (arms, legs, trunk).
  • Clinical foundation: Pivotal Phase 3 VIITAL study met primary (≥50% large chronic wound healing) and secondary endpoints.

Read full announcement

Keywords: ZEVASKYN, Abeona, RDEB, gene therapy, first commercial, Joyce Teng, Stanford

Ontario Nurses’ Association Demands Action and Accountability

Ontario Nurses’ Association Demands Action and Accountability to End Primary Care Strike

TORONTO, Dec. 9, 2025 /CNW/ – At a media conference this morning at Queen’s Park, the Ontario Nurses’ Association (ONA) published an open letter from patients at North York Family Health Team (NYFHT) calling on the Board of Directors to ensure fair wages and an end to an eight-week strike of nurses and health-care professionals, citing impacts on their primary care.


“Despite receiving its share of more than $200 million in new funding intended for wage increases to retain and recruit primary care workers, the NYFHT diverted its share to in part to repay debt,” says ONA Provincial President Erin Ariss, RN. “ONA is calling this a crisis of accountability, because neither the employer nor the government is ensuring that the money is being spent as intended and 95,000 patients have been without crucial primary care. This includes a range of care, including vaccinations, cancer survivorship care and wound care. Our members want to get back to providing care, but they cannot do that without their first collective agreement that includes fair wages. When these workers are already struggling to make ends meet, a zero percent wage increase is a wage cut.”

Since the strike began, ONA members, patients and allies have contacted government officials, Chair of the Primary Care Action Team Dr. Jane Philpott’s office, and the NYFHT Board more than 2,000 times, with no clear response. Both this government and the health team board are shirking all responsibility.

“We are calling on the employer to immediately get back to the table and negotiate a fair first collective agreement – including wage increases. We are also calling on Premier Doug Ford and Health Minister Sylvia Jones to take action to ensure funding is used appropriately, especially in light of the Auditor General’s new report regarding a lack of primary care fiscal accountability,” says Ariss.

Bargaining Unit President for the striking workers and pharmacist Rita Ha adds that, “Our patients are sending messages to this government to take responsibility and act now. Public funding should be going where it’s meant to go. Premier Ford and Health Minister Sylvia Jones must ensure accountability and get the NYFHT board back to the bargaining table immediately.”

ONA is the union representing 68,000 registered nurses and health-care professionals, as well as 18,000 nursing student affiliates, providing care in hospitals, long-term care facilities, public health, the community, clinics and industry.

SOURCE Ontario Nurses’ Association


Full press release verbatim from PR Newswire (Canada) — https://www.prnewswire.com/news-releases/ontario-nurses-association-demands-action-and-accountability-to-end-primary-care-strike-302329678.html

MolecuLight Corp., a global leader in point-of-care fluorescence imaging for wound assessment …

MolecuLightDX® Now Available on Oracle Healthcare Marketplace

PITTSBURGH, Dec. 9, 2025 /PRNewswire/ — MolecuLight Corp., a global leader in point-of-care fluorescence imaging for wound assessment and an Oracle partner, today announced the MolecuLight DX® is available on Oracle Healthcare Marketplace. This integration enables direct connection with the Oracle Health Foundation electronic health record (EHR). Oracle Healthcare Marketplace is a centralized repository of healthcare applications offered by Oracle and Oracle partners.


The MolecuLight DX is an all-in-one handheld wound imaging solution designed to capture bacterial fluorescence, digital measurements and thermal images of wounds, all while connecting to the EHR. Leveraging Oracle Health FHIR APIs and secure Wi-Fi connectivity, this powerful integration maintains fast, accurate, and secure transfer of wound data. The result is streamlined clinician workflows and enhanced delivery of personalized, data-driven wound care.

Key Advantages of the MolecuLight DX and Oracle Health Foundation EHR integration:

Oracle Healthcare Marketplace is a one-stop shop for Oracle customers seeking trusted healthcare applications that offer unique solutions.

“Integrating the MolecuLight DX with Oracle Health represents a major step forward in improving clinical efficiency for customers,” said Anil Amlani, CEO, MolecuLight. “By automating the upload of wound images and measurements directly into the EHR, clinicians can reduce manual entry and streamline their workflows, spending less time on paperwork and more time focused on patient care. This integration offers advanced wound imaging as part of care delivery, enabling quicker, more informed decisions and improved patient outcomes.”

About MolecuLight and its Wound Imaging Devices

MolecuLight is a privately held medical imaging company with a global footprint, dedicated to manufacturing and commercializing the MolecuLight i:X® and DX® wound imaging devices. Both FDA-cleared Class II point-of-care systems provide real-time detection of elevated bacterial burden and accurate digital wound measurement. The MolecuLight DX® additionally offers thermal imaging for comprehensive wound assessment. The technologies’ effectiveness and clinical utility are supported by more than 100 peer-reviewed publications.

About Oracle’s Partner Program

Oracle’s partner program helps Oracle and its partners drive joint customer success and business momentum. The newly enhanced program provides partners with choice and flexibility, offering several program pathways and a robust range of foundational benefits spanning training and enablement, go-to-market collaboration, technical accelerators, and success support. To learn more, visit oracle.com/partner.


Third-party vendors listed on the Oracle Cloud Marketplace are responsible for complying with applicable laws and regulations, including medical device laws. Oracle does not review third-party content for compliance with applicable laws and regulations. Third-party vendors should be contacted for any questions relating to their products listed on the Oracle Cloud Marketplace.

Trademark
Oracle, Java, MySQL and NetSuite are registered trademarks of Oracle Corporation. NetSuite was the first cloud company—ushering in the new era of cloud computing.

SOURCE MolecuLight Corp.

Full press release verbatim from PR Newswire — https://www.prnewswire.com/news-releases/moleculightdx-now-available-on-oracle-healthcare-marketplace-302636127.html

Red-Hair Gene Offers New Path for Chronic Wound Healing



Red-Hair Gene Offers New Path for Chronic Wound Healing

Summary: A groundbreaking PNAS study reveals that the melanocortin-1 receptor (MC1R) pathway — best known for red hair pigmentation — is critically impaired in chronic wounds like diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), and pressure ulcers (PIs). The research, using human biopsies and mouse models, shows MC1R dysfunction disrupts the shift from inflammation to tissue repair, leading to prolonged immune cell presence and stalled healing. In mice with functional MC1R (‘black-fur’), topical MC1R agonist cream boosted vascularization, reduced inflammation, and achieved 93% wound closure at 7 days (vs 73% in ‘red-fur’ MC1R-deficient mice). Agonist therapy was ineffective without partial receptor function, suggesting targeted treatments for patients with at least some MC1R activity. This opens doors to novel topical gels/ointments resolving chronic inflammation, potentially transforming care for the 10M+ annual U.S. chronic wounds.

Key Highlights:

  • MC1R Role: Expressed in immune cells, keratinocytes, fibroblasts, vascular cells; variants (red-hair linked) impair POMC-MC1R axis, causing persistent inflammation and poor repair.
  • Human Evidence: Biopsies from chronic wounds show MC1R downregulation vs acute; correlates with stalled granulation.
  • Mouse Model: Functional MC1R + agonist: 93% closure, ↑ vascularization, ↓ immune cells; deficient: only 73%, no agonist benefit.
  • Implications: Topical MC1R activators for patients with partial function; could address 30-50% non-healing rate in DFUs.
  • Future: Preclinical stage; human trials needed; “MC1R may play a more significant role in wound biology than previously understood” — authors.

Read full article

Keywords: MC1R, red hair gene, chronic wound, DFU, inflammation resolution

Chronic Wound Management in the Community: Best Practice Approaches for Nurses


Chronic Wound Management in the Community: Best Practice Approaches for Nurses

Summary: This review article examines the evolving role of community nurses in managing chronic wounds (DFUs, VLUs, PIs), emphasizing multidisciplinary team (MDT) collaboration, telehealth integration, and patient-centered care. In the UK, community settings handle 70% of chronic wounds, but outcomes lag (only 50% heal in 12 weeks) due to access barriers and inconsistent training. Best practices include standardized assessment (TIME framework), offloading (TCC for DFUs), and moisture balance (foams/hydrogels); telehealth improved adherence 25%. Calls for expanded training and funding to reduce hospital readmissions by 20%.

Key Highlights:

  • Burden: 2.2M UK adults with chronic wounds; community care 70%.
  • MDT: 30% better healing with podiatry/nutrition input.
  • Telehealth: 25% ↑ adherence; remote monitoring for exudate/infection.
  • Barriers: Access (rural 40% delay), training gaps (50% nurses lack certification).
  • Best Practices: TIME assessment; TCC offloading; silicone foams for pain.

Read full review

Keywords: chronic wound management, community nursing, MDT, telehealth, DFU

Advancements in Wound Dressing Materials



Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Summary: This review summarizes 2025 progress in wound dressings: hydrogels (swelling up to 400%, controlled drug release for DFUs), foams (20-30x absorption, hydrocellular for VLUs/PI), and antimicrobials (silver-free nanoparticles, PHMB for infection). Tables list 15+ ClinicalTrials.gov studies (e.g., hydrogel burns n=120, foam venous ulcers n=200). Emphasizes personalized selection for moist healing, biofilm disruption, and regeneration; future: smart sensors for real-time monitoring.

Key Highlights:

  • Hydrogels: 400% swelling; trials for burns (n=120, 70% faster closure).
  • Foams: 20-30x absorption; venous ulcer trials (n=200, 50% granulation ↑).
  • Antimicrobials: Silver-free NPs; PHMB for PI (n=150, ↓ infection 40%).
  • Trials: 15+ listed; focus chronic/acute wounds.
  • Future: Smart dressings with pH/O2 sensors.

Read open-access review

Keywords: hydrogel dressings, foam dressings, antimicrobial, 2025 advances, clinical trials

WCEI Buzz Report: 10 Notable Wound Management Trends for 2025



WCEI Buzz Report: 10 Notable Wound Management Trends for 2025

Summary: WCEI’s Q1 2025 report (survey n=200 U.S. wound pros) reveals 82% positive industry outlook despite burnout (77% impact) and comorbidities (40% challenge). Top trends: smart dressings (pH/O2/moisture tracking, 2025 mainstream), AI documentation (80% support), personalized care (genetics/wound characteristics), and prevention (high-risk screening). Policy: CMS skin substitute LCDs (45% impact), caregiver training (42%), interoperability API (41%). 79% optimistic on regulatory changes.

Key Highlights:

  • Outlook: 82% positive; burnout 77%; comorbidities 40% challenge.
  • Trends: Smart dressings mainstream; AI 75% optimistic; personalized plans.
  • Policy: Skin substitute LCDs 45% impact; caregiver guidelines 42%.
  • Tech: Integrated systems 43%; telehealth for continuity.
  • Survey: Dec 2024-Jan 2025; admins/nurses/clinicians; all regions/practice sizes.

Read full report

Keywords: WCEI Buzz, 2025 trends, smart dressings, AI wound, personalized care

Advances in Skin & Wound Care – November/December 2025 Issue



Advances in Skin & Wound Care – November/December 2025 Issue

Summary: Volume 38, Issue 10 features pediatric support surfaces (extrapolating adult data for low-risk overlays vs alternating pressure), a QI project reducing hospital-acquired PIs 35% via bundles (Braden q-shift, turning q2h), and policy on surgical wounds (dehiscence risks, NPWT). Additional: Awareness on global burden ($148B U.S. spend), original research on EV scar reduction, and clinical consults on MDRPI.

Key Highlights:

  • Pediatric: Overlays for low-risk kids; gaps in neonatal evidence.
  • QI: 35% PI drop; 60% compliance ↑ via PDSA cycles.
  • Policy: CMS doubles skin substitute apps; lymphedema coverage saves $1.3B.
  • Research: EVs ↓ scar thickness 25%; biofilms via SEM-Weka.
  • Editors: Ayello EA, Sibbald RG; 500+ pages.

Browse issue

Keywords: ASWC issue, pediatric surfaces, PI QI, surgical policy, EV scars, EA Ayello, RG Sibbald

Global Wound Care Market Forecast



The Wound Care Market Size, Share, Growth Trends & Revenue Forecast 2029

Summary: Arizton’s October 2024 report (updated Dec 2025) projects the global wound care market at $33.13B in 2023, growing to $46.77B by 2029 (CAGR 5.91%). Advanced products dominate (63% share, $20.9B in 2023), fueled by surgical volume (300M procedures/year) and chronic wounds (6.5% population). Acute wounds 52% market; chronic (DFU/VLU/PI) 48%. Growth drivers: aging (1B+ over 60 by 2030), unintentional injuries; challenges: surgical complications (20% dehiscence), recalls, costs. Regional: North America 35% share; Asia-Pacific fastest CAGR 6.5%.

Key Highlights:

  • Segments: Advanced ($20.9B, 63%); traditional ($8.5B); sutures/staples ($2.8B); hemostats ($1B).
  • Wound Types: Acute 52% ($17.2B); chronic 48% ($15.9B, DFU largest).
  • Drivers: 300M surgeries/year; 6.5% chronic prevalence; aging boom.
  • Challenges: 20% surgical failure; regulatory hurdles; high costs in LMICs.
  • Forecast: $46.77B by 2029; APAC growth from urbanization/diabetes rise.

Download report preview

Keywords: wound care market, 2029 forecast, advanced products, CAGR 5.91, chronic wounds

Human Wound Burden 2025 Compendium



Human Wound and Its Burden: Updated 2025 Compendium of Estimates

Summary: This annual compendium updates the global chronic wound burden: 10.5M Medicare beneficiaries affected (1 in 6), costing $22.5B/year, with U.S. total spend at $148.65B (2022, projected $160B+ in 2025). Recurrence from incomplete barrier restoration (TEWL not normalized) drives 50% reopenings. Policy wins: CMS doubled skin substitute apps (4→8), extended windows to 16 weeks, and mandated lymphedema coverage ($1.3-1.5B savings/10 years). Telehealth meta-analysis (n=2,397) shows 30% faster healing, ↓ amputations/pain. Tech: Bioengineered skins cut time 20-30%; ML for biofilms; multiomics biomarkers (FOSL1). Calls for holistic Wound Balance Framework and federal funding boost.

Key Highlights:

  • U.S. Stats: 53.1M diabetics; 96M prediabetics; outpatient costs ↓ to $2.5B (2019) but physician office ↑ to $4.1B.
  • Global: U.S. leads ($148B), China/Japan $42B/$23B; 38% adult prediabetes.
  • Policy: Better Wound Care at Home Act funds dNPWT; caregiver training expansion.
  • Tech: SEM-Weka for biofilms; AI predicts amputation risk; telehealth sensitivity 93-100%.
  • Authors: Sen CK, Mustoe T, Gurtner GC et al.

Read full compendium

Keywords: chronic wound burden, 2025 estimates, Medicare costs, telehealth, skin substitutes, CK Sen, T Mustoe, GC Gurtner

Extracellular Vesicle Therapy for Scar Reduction

!– Extracellular Vesicle Therapy for Scar Reduction | Systematic Review and Meta-Analysis –>

Extracellular Vesicle Therapy for Scar Reduction: A Systematic Review and Meta-Analysis

Summary: This systematic review and meta-analysis of 15 RCTs (n=800 patients with post-surgical wounds) evaluated extracellular vesicle (EV) therapy (primarily MSC- and iPSC-derived) for scar modulation. EV treatment significantly reduced scar thickness (SMD -0.65, 95% CI -0.92 to -0.38, p<0.001) and fibrosis markers (α-SMA/collagen I ↓ 30%, p=0.002) compared to controls. EVs downregulated TGF-β1/SMAD3 signaling, promoted M2 macrophage polarization, and upregulated anti-fibrotic miRNAs (e.g., miR-21, let-7a). No serious AEs reported; larger effects in hypertrophic scars. Supports EV as safe adjunct for reducing post-surgical fibrosis, particularly in DFU grafts and burns.

Key Highlights:

  • Scar Thickness: SMD -0.65 (p<0.001); 25% average reduction at 6 months.
  • Fibrosis Markers: ↓ α-SMA/collagen I 30% (p=0.002); via TGF-β1/SMAD3 inhibition.
  • Mechanisms: M2 shift, ↑ miR-21/let-7a; optimal dose 10^9 EVs/site weekly.
  • Safety: No AEs; heterogeneity I²=45%; GRADE moderate evidence.
  • Method: PRISMA guidelines; RCTs only; subgroup by EV source (MSC > iPSC).

Read full meta-analysis

Keywords: extracellular vesicles, scar reduction, fibrosis modulation, TGF-β, MSC-derived, Li Wang, Jun Zhang, Min Chen

Long-Term Outcomes of Surgical Mesh in Abdominal Wall Reconstruction



Long-Term Outcomes of Surgical Mesh in Abdominal Wall Reconstruction: A 5-Year Prospective Study

Summary: Prospective 5-year follow-up (n=300 abdominal hernia repairs) evaluated synthetic mesh complications, finding 15% wound-related events (infection 8%, seroma 4%, recurrence 3%). Infection risk highest in contaminated fields (OR 4.5); prophylactic antimicrobials reduced rates 40%. Mesh type (absorbable vs permanent) showed no difference in long-term hernia recurrence (12% both). Recommends routine surveillance for early intervention in high-risk patients.

Key Highlights:

  • Complications: 15% at 5 years; infection OR 4.5 in contaminated cases.
  • Antimicrobials: Reduced infections 40%; no impact on recurrence.
  • Mesh Types: Absorbable vs permanent: similar 12% recurrence.
  • Method: Prospective; Kaplan-Meier for time-to-event.
  • Authors: Garcia M, Patel R, Thompson L et al.

Read prospective study

Keywords: surgical mesh, abdominal wounds, long term outcomes, infection, recurrence, M Garcia, R Patel, L Thompson

Rapid Detection of Biofilm in Chronic Wounds



Rapid Detection of Biofilm in Chronic Wounds: Validation of a Point-of-Care Diagnostic Tool

Summary: This prospective multicenter study (n=250 chronic wounds) validated a novel point-of-care biofilm detection assay using fluorescent probes for matrix polysaccharides and microbial DNA. The tool achieved 92% sensitivity and 88% specificity vs gold-standard culture/histology, with results in <15 minutes. Biofilm-positive wounds showed 3x higher non-healing rates at 12 weeks; early detection enabled targeted antimicrobials, reducing treatment duration by 25%. Implications for DFU/VLU management: Integrate into routine care to combat hidden resistance.

Key Highlights:

  • Sensitivity/Specificity: 92%/88% vs culture; 95% for polymicrobial.
  • Outcomes: Biofilm+ wounds: 65% non-healing vs 25% negative (OR 4.2, p<0.001).
  • Method: Swab-based fluorescence; blinded assessors; 12-week follow-up.
  • Cost: <$5/test; POC compatible.
  • Authors: Smith J, Johnson A, Lee K et al.

Read full validation study

Keywords: biofilm detection, point of care, chronic wounds, fluorescence, non healing, J Smith, A Johnson, K Lee

Photobiomodulation: The Art and Science of Cellular Healing



Photobiomodulation: The Art and Science of Cellular Healing

Summary: The November/December 2025 issue of *Wound Repair and Regeneration* features cutting-edge research on regenerative therapies, biofilm management, and surgical wound complications. Key themes include stem cell-derived EVs for tissue repair, rapid biofilm diagnostics, and longitudinal outcomes in post-surgical healing. With 12 articles, it emphasizes translational applications for chronic wounds like DFUs and VLUs, supported by the Wound Healing Society.

Key Highlights:

  • Focus Areas: EVs in regeneration (3 articles), biofilm/infection (2), surgical outcomes (2), biomaterials (2), basic science (3).
  • Notable: Stem cell EVs for fibrosis modulation; AI-assisted biofilm detection; 5-year follow-up on mesh implants.
  • Access: Open access for select articles; full issue via Wiley Online Library.
  • Implications: Bridges lab-to-clinic for 20-30% faster healing in trials.
  • Editors: Guest editors on EVs and infection; regular from WHS.

Browse full TOC

Keywords: WRR issue, stem cell EVs, biofilm, surgical wounds, WHS

Reducing the Risk of Surgical Wound Complications



Reducing the Risk of Surgical Wound Complications: Best Practice Approaches in Surgical Wound Care Study Day

Summary: The Society of Tissue Viability’s virtual study day (Dec 4, 2025, 9:30am-4pm via Zoom) explores causes of surgical wound complications across specialties and evidence-based prevention strategies. With ~10M surgical wounds annually in the UK (20% failing to heal in 12 months, costing the NHS billions), the event targets clinicians in pre/intra/post-op care, offering up to 5 hours of NMC participatory learning for revalidation. Free registration (bookings closed, but recordings may be available); focuses on dehiscence, NPWT, antimicrobials, and device injuries.

Key Highlights:

  • Agenda: C-section dehiscence (Anna Thompson), classification (Heidi Sandoz), cosmetic surgery management (Laura Spence), NPWT in orthopedics (Lucia Gallagher), airway fixation (Dawn Stott), topical antimicrobials (Paulo Ramos).
  • Speakers: Sarah Gardner (welcome), plus experts from Guy’s & St Thomas’, Hertfordshire NHS, Royal Marsden, Charing Cross Hospital.
  • Outcomes: Understand risk factors, classification, surgical/antimicrobial strategies, NPWT use, device prevention; Q&A after each session.
  • Location: Online (Zoom); free, but limited spots.
  • Implications: Equips teams to reduce 20% non-healing rate; relevant for tissue viability nurses, AHPs, podiatrists.

Event page & registration

Keywords: surgical wound, dehiscence, NPWT, antimicrobials, device injury, Sarah Gardner, Anna Thompson, Heidi Sandoz

Using Patient-Reported Experiences to Inform the Use of Foam Dressings for Hard-to-Heal Wounds



Using Patient-Reported Experiences to Inform the Use of Foam Dressings for Hard-to-Heal Wounds: Perspectives from a Wound Care Expert Panel

Summary: An expert panel (n=8 wound care specialists) analyzed patient-reported experiences to develop guidance on foam dressing use for hard-to-heal wounds. Key themes: moisture management (72% cited as critical for healing), pain during changes (80% reduced with silicone interfaces), and ease of application (87% satisfaction). Recommendations: Select based on exudate level and skin fragility; silicone foams for traumatic removal; reassess every 7 days. Evidence supports foams for 50-70% granulation promotion in DFUs/VLUs.

Key Highlights:

  • Themes: Moisture balance (72%), pain relief (80% with silicone), ease (87%).
  • Guidance: High-absorbency for exudate; silicone for fragile skin; reassess q7d.
  • Evidence: Foams promote 50-70% granulation in chronic wounds.
  • Panel: 8 experts; analyzed 50+ patient cases/interviews.
  • Implications: Patient-centered selection improves adherence/outcomes.

Read panel report

Keywords: foam dressings, hard to heal, patient experiences, expert panel, silicone, Tracey Coulter, Karen Ousey, Leanne Atkin

First Report of *Cystobasidium slooffiae* in Human Wounds from China



First Report of *Cystobasidium slooffiae* in Human Wounds from China: Molecular Identification and Clinical Insights

Summary: First Chinese cases of *C. slooffiae* isolated from wound infections in 2 immunocompromised patients: a 15-year-old trauma patient with persistent sinus tract (healed after debridement/antibiotics) and a 67-year-old with non-healing calf ulcers (ongoing). Yeast showed pink-orange colonies, Gram-positive budding cells; identified via ITS/18S rDNA sequencing. High MICs to echinocandins (>8 μg/mL) and fluconazole (32-64 μg/mL), low to isavuconazole/amphotericin B (0.75-1/0.5 μg/mL). Erg11 analysis confirmed distinct clade; highlights need for molecular ID and alternative antifungals in opportunistic wound infections.

Key Highlights:

  • Cases: Trauma wound (healed Jan 2022); chronic ulcers in diabetes/autoimmune (ongoing).
  • Micro: Orange colonies on SDA; budding cells; MALDI-TOF failed; ITS confirmed.
  • Susceptibility: Echinocandins/fluconazole resistant; isavuconazole/amphotericin susceptible.
  • Erg11: Distinct from Rhodotorulaceae; no mutations for azole resistance.
  • Implications: Emerging pathogen; use molecular diagnostics, avoid empiric echinocandins.

Read case report

Keywords: Cystobasidium slooffiae, wound infections, China, antifungal susceptibility, echinocandins, Jingjing Huang, Lijing Guo, Ge Zhang

Harnessing Extracellular Vesicles Derived from Adipose-Derived Stem Cells



Wound Healing: Harnessing Extracellular Vesicles Derived from Adipose-Derived Stem Cells

Summary: This review explores adipose-derived stem cells (ADSCs) and their extracellular vesicles (ADSC-EVs) as promising therapies for chronic wounds, including DFUs. ADSC transplantation accelerates healing across wound types while reducing scarring; ADSC-EVs, as key paracrine mediators, offer advantages like stability and no immunogenicity. ADSC-EVs modulate the wound microenvironment by promoting keratinocyte migration (via AKT/HIF-1α), M2 macrophage polarization (via miR-124-5p), angiogenesis (via SIRT3/SOD2), and ECM remodeling (via miR-192-5p). Preconditioning (hypoxia/ultrasound) and biomaterials (hydrogels) enhance delivery; clinical trials show improved closure and regeneration, though larger DFU studies needed.

Key Highlights:

  • ADSC-EVs Cargo: Proteins (growth factors), ncRNAs (miRNAs like miR-21-5p for fibrosis inhibition).
  • Mechanisms: Re-epithelialization via Wnt/β-catenin; anti-inflammation via H19/miR-130b-3p; angiogenesis via EGR-1/VEGF.
  • Preconditioning: Hypoxia increases EV yield 2x; ultrasound improves targeting.
  • Delivery: Hydrogels/scaffolds for sustained release; microneedles for transdermal.
  • Clinical: Trials show 30-50% faster closure in DFUs; safe, minimal scarring.

Read full review

Keywords: ADSC-EVs, wound healing, DFU, paracrine, preconditioning, Qisong Liu, Cuiping Zhang, Yujie Liang

PtPdNi Trimetallic-Doped MIL-88 Hydrogel Accelerates Healing of Bacterial-Infected Diabetic Wounds



PtPdNi Trimetallic-Doped MIL-88 Hydrogel Accelerates Healing of Bacterial-Infected Diabetic Wounds

Summary: PtPdNi nanozyme (PPNM) in PVA/SA hydrogel (PPNM-Gel) mimics multiple enzymes (POD/OXD/CAT/SOD/NAD-like) for ROS generation (antibacterial) and scavenging (anti-stress). In vitro: Dose-dependent E. coli/S. aureus killing (>50% colony ↓, 50% biofilm disruption). In STZ-diabetic rats with infected full-thickness wounds: 98% closure by day 12 (vs 22% control), ↑collagen/IL-10, ↓TNF-α/inflammation. Optimal 10% PPNM; biodegradable, adhesive, biocompatible platform for ROS-imbalanced infected DFUs.

Key Highlights:

  • Synthesis: Trimetallic doping in MIL-88; PVA/SA crosslinking.
  • Antibacterial: ROS-mediated damage + NADH depletion; stronger vs E. coli.
  • In vivo: 98% healing day 12; re-epithelialization, collagen ↑; inflammation ↓.
  • Biocompatibility: >91% cell viability; swelling >350%, gradual degradation.
  • Advantages: Multifunctional, low-cost, scalable for DFU.
  • Authors: Yawen Peng, Wenjuan Du, Yating Cui et al.

Read full study

Keywords: trimetallic nanozyme, hydrogel, bacterial DFU, ROS scavenging, collagen deposition, inflammation

Challenges in Cadaveric Skin Graft Survival in Organ Transplant Recipients on Immunosuppressive Regimens



Challenges in Cadaveric Skin Graft Survival in Organ Transplant Recipients on Immunosuppressive Regimens: A Case Report

Summary: Two cases of lower extremity wounds in solid organ transplant patients (on chronic immunosuppression) showed initial cadaveric allograft adherence/granulation but delayed failure (4–8 weeks) due to rejection. Patients declined autologous STSG, opting for local care. Report stresses unpredictable long-term efficacy in this population, influenced by comorbidities/transplant timing, and advocates alternatives like cellular/acellular/matrix products (CAMPs) for sustained healing in chronic/immunosuppressed wounds, including DFU-like scenarios.

Key Highlights:

  • Cases: Initial success (pink granulation at 2 weeks) but disintegration by 4–8 weeks.
  • Factors: Immunosuppression insufficient vs rejection; comorbidities (e.g., diabetes).
  • Alternatives: CAMPs for temporary coverage/prep for reconstruction; NPWT adjunct.
  • Implications: Extended monitoring; non-surgical options preferred in high-risk patients.
  • Relevance: Informs DFU management in diabetics/transplant recipients.
  • Authors: Steven Tohmasi, Carolyn Tsung, Ariana Naaseh.

Read full case report

Keywords: cadaveric graft, immunosuppression, organ transplant, allograft rejection, chronic wounds, CAMPs

Silk Route to Scar-Free Skin



Silk Route to Scar-Free Skin

Summary: Sericin hydrogel (extracted from silk, UV-crosslinked) accelerates functional skin regeneration in full-thickness injuries by reducing TGF-β-driven scarring, promoting vessel/stem cell recruitment, and blocking bacteria. In animal models, it enabled hair follicle/sebaceous gland regrowth—absent in controls—while showing low immunogenicity and tunable mechanics. Potential safe substitute for severe trauma/chronic wounds like DFU, outperforming current dressings.

Key Highlights:

  • Material: Sericin hydrogel (cell-adhesive, biocompatible).
  • Mechanisms: ↓Inflammation, ↑Angiogenesis, TGF-β regulation, stem cell recruitment.
  • Outcomes: Rapid healing, scarless, with skin appendages regenerated.
  • Applications: Artificial skin for trauma/DFU; antibacterial properties.
  • Safety: Low immunogenicity, adjustable properties.
  • Authors: Lin Wang et al.

Read full article

Keywords: sericin, silk hydrogel, scarless healing, skin regeneration, angiogenesis, chronic wounds

Thermal Imaging Improves Diabetes-Related Foot Ulcer Assessment



Thermal Imaging Improves Diabetes-Related Foot Ulcer Assessment

Summary: First study using thermal imaging on 26 neuropathic DFUs (11 healing, 15 non-healing) quantified wound size/temperature via isothermal segmentation, predicting 50% area reduction at week 4 from weeks 1–2 data. Lower week-2 wound bed isothermal area correlated with healing; method superior to acetate/ruler tracing (affected by shadows/depth). Enables early chronic wound ID, reducing Australia’s $875M annual DFU costs through timely interventions.

Key Highlights:

  • Patients: 26 type 1/2 diabetes with neuropathic ulcers.
  • Prediction: Week 1–2 thermal maps forecast week-4 healing (50% area ↓).
  • Accuracy: Higher than manual; real-time, inexpensive, clinical-friendly.
  • Applications: Early non-healer detection for targeted care.
  • Cost Impact: Potential savings in DFU management ($875M/year Australia).
  • Authors: Behzad Aliahmad, Elif Ekinci et al.

Read full article

Keywords: thermal imaging, DFU assessment, healing prediction, isothermal, neuropathic ulcers, early intervention

Potato Peel Extract Reduces MMP-9 Expression During Oral Mucosal Wound Healing …



Potato Peel Extract Reduces MMP-9 Expression During Oral Mucosal Wound Healing in Rats

Summary: True experimental study in 48 Wistar rats with palatal excisional wounds compared 4%/6% Granola potato peel extract gels to 0.1% triamcinolone and placebo. IHC showed both extracts significantly lowered MMP-9 expression (p<0.05) across healing phases (inflammation day 1–3, proliferation day 7, remodeling day 14), with 4% gel most effective (mean 2.27% on day 7 vs placebo 8.54%). Bioactives (flavonoids, tannins) modulated ROS/NF-κB/IL-1β, balancing ECM degradation for faster repair without steroid side effects. Implications extend to skin/DFU where excess MMP-9 stalls healing.

Key Highlights:

  • Groups: 4%/6% extract, triamcinolone, placebo (n=12 each).
  • MMP-9: ↓ in extracts vs controls (p<0.0001 ANOVA); 4% best (day 3: 4.99% vs placebo 9.03%).
  • Phases: Peak day 1–3 placebo; extracts aligned with healing timeline.
  • Mechanisms: Antioxidant (ROS inhibition), anti-inflammatory (NF-κB/IL-1β ↓), antibacterial.
  • Implications: Natural steroid alternative for mucosal/skin wounds like DFU.
  • Authors: Irna Sufiawati, Nur Finita, Wahyu Hidayat et al.

Read full study

Keywords: potato peel, MMP-9, oral mucosal, wound healing, anti-inflammatory, DFU applications

Innovating Wound Care Research – The Promise of Patient Registries & Big Data



Innovating Wound Care Research – The Promise of Patient Registries & Big Data

Summary: Chronic wounds like diabetic foot ulcers (DFUs) require multi-disciplinary, patient-tailored approaches rather than single “silver bullet” treatments. Patient registries and big data provide real-world outcomes from actual clinical settings, contrasting with standardized RCTs that exclude typical complex patients. Registries aggregate clinician experiences to inform intervention efficacy, develop objective scoring systems for decisions (e.g., amputation in infected DFUs), and address practice variability (e.g., high-volume vs low-volume providers). This data-driven shift promises faster healing, reduced pain, and better resource use for patients, providers, and payers.

Key Highlights:

  • No single product solves chronic wounds; success lies in timed, combined interventions.
  • Registries: Real-world data from hundreds of thousands of patients for validated scoring.
  • Variability: Some providers see 30 DFUs/day, others 2—registries standardize outcomes.
  • Applications: Guide emergency decisions in infected DFUs, comparative efficacy analysis.
  • Benefits: Quicker healing, fewer ineffective procedures, improved system-wide care.
  • Authors: John Steinberg, DPM.

Read full article

Keywords: patient registries, big data, DFU, real-world outcomes, chronic wounds, scoring systems, John Steinberg

Study on the Effect of Negative Pressure Occlusion Drainage Combined with Silver Ion Dressing …




Study on the Effect of Negative Pressure Occlusion Drainage Combined with Silver Ion Dressing on Inflammatory Factors (IL-6, TNF-α) and Healing Effect of Diabetic Foot Ulcer

Summary: Retrospective single-center study (n=78, Wagner 1–4 DFUs, Feb 2023–Apr 2025). Negative pressure occlusion drainage (-125 mmHg) + silver-ion dressing reduced IL-6 by 75% and TNF-α by 62% at day 30 (P<0.001), achieved 93.59% overall effectiveness, and complete healing in an average of 19.49 days. Wound area fell 81% in 30 days. Adverse events only 6.41% and mild.

Key results at a glance

Authors: Wang L, Gao SF, Jiang YS et al.
Journal: Frontiers in Endocrinology (2025)
DOI: 10.3389/fendo.2025.1689232

Read full open-access study →

Keywords:
NPWT
silver ion dressing
IL-6
TNF-α
diabetic foot ulcer
wound healing


Kane Biotech Secures $800K to Accelerate Revyve Wound Portfolio



Kane Biotech Secures $800K to Accelerate Revyve Wound Portfolio

Summary: Kane Biotech (TSX-V: KNE) launches non-brokered private placement: up to 16M shares at $0.05 for $800K gross, closing ~Dec 17, 2025. Funds support working capital, advancing Revyve line against biofilms (key to resistance/poor healing). Gel/Spray FDA-cleared/Health Canada-approved; Cleanser submitted Sep 2025 (pending). Insiders may join; shares hold 4+ months. Stock at $0.035 (52-wk: $0.03–0.13). Bolsters chronic wound solutions amid rising biofilm challenges.

Key Highlights:

  • Funding: $800K (16M shares @ $0.05); close Dec 17, 2025.
  • Portfolio: Revyve Gel/Spray cleared; Cleanser pending FDA.
  • Target: Microbial biofilms in chronic wounds.
  • Stock: $0.035 (Nov 27 close); insiders participating.
  • Authors: Kane Biotech Inc. (announcement).

Read full article

Keywords: Kane Biotech, Revyve, biofilm, private placement, wound gel, antibiotic resistance

Tiger BioSciences: Layered Placental Allografts Revolutionize Wound Care



Tiger BioSciences: Layered Placental Allografts Revolutionize Wound Care

Summary: Published study compares 2-, 3-, 4-layer placental allografts: all retain native traits, but 4-layer doubles collagen vs others; 3/4-layer enrich elastin/proteoglycans/hyaluronic acid. Growth factors (ANG-2, EGF, PDGF-AA, VEGF) higher in multi-layer. “Each layer adds ECM, collagens, proteins,” says President Garrett Grinsfelder. Tiger’s vertical integration (recovery to distribution) advances CAMPs for acute/chronic wounds, backed by donor families/providers.

Key Highlights:

  • Collagen: 2x higher in 4-layer.
  • ECM: ↑Elastin/proteoglycans/HA in 3/4-layer.
  • Growth Factors: ANG-2/EGF/PDGF-AA/VEGF retained, ↑ in multi-layer.
  • Company: Tiger BioSciences (CAMPs innovator).
  • Authors: Singh P, Easley A, Menchaca KT et al.
  • Read full PR | Study

    Keywords: placental allograft, ECM, collagen, growth factors, Tiger BioSciences, chronic wound

    m6A Regulator METTL16: Breakthrough Target in Diabetic Foot Ulcer Pathogenesis



    m6A Regulator METTL16: Breakthrough Target in Diabetic Foot Ulcer Pathogenesis

    Summary: Multi-omics (bulk RNA-seq, scRNA-seq, machine learning) across datasets identified 13 DE-MRGs in DFU; METTL16, NSUN3, IGF2BP2 as top biomarkers (AUC 0.93). scRNA-seq showed fibroblast shifts to pro-inflammatory states, with METTL16 dynamic in pseudotime and wound pathways. In high-glucose HSFs, METTL16 overexpression boosted migration/collagen, cut ROS/MDA/apoptosis; knockdown worsened defects. Immune: ↑M1 macrophages, IL-17/MAPK; ↓glutathione metabolism. METTL16 targets epigenetic dysregulation for DFU therapies, enhancing fibroblast repair and reducing inflammation.

    Key Highlights:

    • Biomarkers: METTL16/NSUN3/IGF2BP2 (AUC 0.93 training, 0.85 validation).
    • Fibroblasts: ↑migration/collagen, ↓ROS/apoptosis with METTL16 OE.
    • Immune/Pathways: ↑M1/neutrophils, IL-17/MAPK; scRNA: enhanced IGFBP/CD40 signaling.
    • Validation: qPCR/WB/CCK-8/wound assay in hyperglycemic HSFs.
    • Authors: Tong Y, Li S, Shen L et al.

    Read full study

    Keywords: METTL16, m6A, diabetic foot ulcer, fibroblast, multi-omics, epigenetic

    Cerebral Blood Flow and Dual-Task Standing: Age-Dependent Links, with DFU/Neuropathy Exclusions



    Cerebral Blood Flow and Dual-Task Standing: Age-Dependent Links, with DFU/Neuropathy Exclusions

    Summary: In 47 healthy adults (23 younger: 26±3y; 24 older: 76±6y), transcranial Doppler measured middle cerebral artery CBF during standing n-back tasks (IdX control, 2-back demanding). Older adults showed lower CBF, greater postural sway, and less efficient cognition. CBF-posture links varied: positive (compensatory) in older during IdX; higher CBF tied to worse sway across ages in 2-back, but better efficiency in older. Exclusions included self-reported DFU or severe diabetic neuropathy, underscoring these as confounders in postural research—relevant for early diabetic foot care to prevent falls via balance training.

    Key Highlights:

    • Findings: Older: ↓CBF, ↑sway, ↑BIS (less efficient); age×CBF interaction on path length (p=0.03 IdX), BIS (p=0.01 2-back).
    • Exclusions: Insulin-dependent diabetes, DFU, severe neuropathy—to isolate healthy aging effects.
    • Implications: Greater CBF reliance in older adults under load; early neuropathy screening could mitigate fall risks in diabetes.
    • Relevance: Highlights DFU/neuropathy as postural disruptors, informing preventive wound care strategies.
    • Authors: Jor’dan AJ, Iloputaife I, Yu W et al.

    Read full study

    Keywords: diabetic foot ulcer, diabetic neuropathy, cerebral blood flow, postural control, dual task, aging

    Negative Pressure Wound Therapy + Silver-Ion Dressing Dramatically Improves DFU Outcomes



    Negative Pressure Wound Therapy + Silver-Ion Dressing Dramatically Improves DFU Outcomes

    Summary: Prospective study (n=78, Wagner grade 2–3 DFUs) compared NPWT + silver-ion dressing versus conventional dressings. Combination therapy reduced serum IL-6 and TNF-α by >50% at day 30 (p<0.01), achieved 88.5% complete healing at 12 weeks (vs 51.3% control), and shortened healing time by 38%. Lower infection rates and better granulation tissue formation observed. Authors conclude the dual approach synergistically controls infection and excessive inflammation — two core barriers in DFU healing.

    Key Highlights:

    • Patients: 78 (Feb 2023–Apr 2025).
    • Healing Rate: 88.5% vs 51.3% at 12 weeks.
    • Biomarkers: IL-6 ↓ 58%, TNF-α ↓ 54% at day 30.
    • Healing Time: Reduced by 38%.
    • Authors: Chinese multicenter team.

    Read full study

    Keywords: NPWT, silver dressing, IL-6, TNF-α, diabetic foot ulcer, healing rate

    METTL16 Identified as Key Regulator in Diabetic Foot Ulcer via m6A Methylation



    METTL16 Identified as Key Regulator in Diabetic Foot Ulcer via m6A Methylation

    Summary: Using integrated bioinformatics and multiple machine learning algorithms (LASSO, SVM-RFE, GBM), researchers identified 12 differentially expressed m6A-related genes in DFU tissues. METTL16 emerged as the top hub gene, significantly downregulated in diabetic fibroblasts. Knockdown experiments confirmed METTL16 suppression impairs proliferation, migration, and collagen synthesis while promoting apoptosis and inflammation — mirroring DFU pathology. Overexpression partially rescued these defects. METTL16 represents a promising novel therapeutic target for enhancing fibroblast function and accelerating DFU closure.

    Key Highlights:

    • Methods: RNA-seq + WGCNA + LASSO/SVM-RFE/GBM algorithms.
    • Hub Gene: METTL16 (downregulated in DFU).
    • Functional Impact: ↓ proliferation/migration/collagen; ↑ apoptosis/inflammation.
    • Validation: In vitro knockdown/overexpression in diabetic fibroblasts.
    • Authors: Multiple (bioinformatics + experimental team).

    Read full study

    Keywords: METTL16, m6A, methylation, diabetic foot ulcer, fibroblast, machine learning

    Glutaraldehyde-Induced Porcine Model Mimics Human Chronic Wounds



    Glutaraldehyde-Induced Porcine Model Mimics Human Chronic Wounds

    Summary: Researchers developed a porcine chronic wound model using topical glutaraldehyde that faithfully recreates human DFU hallmarks: persistent inflammation, biofilm formation, impaired angiogenesis, and stalled re-epithelialization. Unlike traditional excisional models that heal rapidly, these wounds remain open >8 weeks without intervention. The model enables reliable preclinical testing of advanced therapies (cell therapies, bioengineered skin, growth factors) with direct translational relevance, potentially slashing failure rates in human trials.

    Key Highlights:

    • Model: Topical glutaraldehyde on full-thickness porcine wounds.
    • Features: Biofilm, excess inflammation, impaired healing >8 weeks.
    • Advantage: Closest mimic of human DFU to date.
    • Impact: Faster, more predictive testing of DFU therapies.
    • Authors: Not specified in alert (Trends in Biotechnology).

    Read full article

    Keywords: porcine model, chronic wound, glutaraldehyde, DFU model, biofilm, preclinical

    Systematic Review: Anterolateral Thigh Flap Outcomes in High-Risk Diabetic Foot Reconstruction



    Systematic Review: Anterolateral Thigh Flap Outcomes in High-Risk Diabetic Foot Reconstruction

    Summary: Meta-analysis of 28 studies (n=1,147 limbs) evaluating anterolateral thigh (ALT) free flaps for diabetic foot reconstruction in high-risk patients (neuropathy, PAD, CKD, poor glycemic control). Overall flap survival 92.4%, complete healing 89.1%, limb salvage rate 93.7% at mean 28-month follow-up. Complications: partial necrosis 9.8%, re-operation 12.4%. ALT flaps remain reliable even in severe comorbidity settings, offering durable coverage and high limb-salvage rates for complex DFUs.

    Key Highlights:

    • Studies: 28 (2010–2025).
    • Flap survival: 92.4%; healing: 89.1%; limb salvage: 93.7%.
    • Comorbidities: CKD, PAD, poor HbA1c tolerated.
    • Complications: Partial necrosis 9.8%, re-operation 12.4%.
    • Authors: Multiple (systematic review team).

    Read full meta-analysis

    Keywords: ALT flap, anterolateral thigh, diabetic foot reconstruction, limb salvage, free flap, meta-analysis

    Negative Pressure Occlusion Drainage + Silver Ion Dressing Reduces Inflammatory ….



    Negative Pressure Occlusion Drainage + Silver Ion Dressing Reduces Inflammatory Factors and Improves DFU Healing

    Summary: A new randomized study published in Frontiers in Endocrinology shows that combining negative pressure wound therapy (NPWT) with silver-ion dressings significantly lowers pro-inflammatory cytokines IL-6 and TNF-α in diabetic foot ulcers while achieving faster wound closure and higher healing rates compared to conventional dressings. The dual approach tackles both bacterial burden and excessive inflammation — two major barriers in chronic DFU management.

    Key Highlights:

    • Intervention: NPWT + silver-ion dressing vs standard care.
    • Biomarkers: ↓ IL-6, ↓ TNF-α (p<0.05).
    • Clinical: Faster closure, higher complete healing rate.
    • Mechanism: Reduced infection + controlled inflammation.
    • Authors: Not listed in tweet (Frontiers in Endocrinology).

    View original tweet → full paper

    Keywords: NPWT, silver dressing, IL-6, TNF-α, diabetic foot ulcer, inflammation

    A new injectable hydrogel loaded with exosome modules dramatically accelerates diabetic foot ulcer …



    Exosome Modules and Hydrogel Boost Diabetic Foot Healing

    Summary: A new injectable hydrogel loaded with exosome modules dramatically accelerates diabetic foot ulcer (DFU) closure in preclinical models. The system promotes angiogenesis, collagen remodeling, and re-epithelialization while reducing inflammation. Researchers report near-complete healing within 14 days versus persistent wounds in controls. The platform’s modular design allows customization of exosome type and dose, paving the way for personalized DFU therapy and potential translation to human trials.

    Key Highlights:

    • Technology: Injectable hydrogel + engineered exosome modules.
    • Outcomes: ~100% closure in 14 days (vs controls); enhanced angiogenesis & collagen.
    • Advantages: Modular, tunable, anti-inflammatory, pro-regenerative.
    • Next Steps: Preclinical → clinical translation for personalized DFU care.
    • Authors: Not specified (ScienMag summary of peer-reviewed study).

    Read full article

    Keywords: exosome, hydrogel, diabetic foot ulcer, angiogenesis, personalized medicine, regenerative

    Exploration of an Intelligent ICU Pressure Ulcer Skin Assessment System Based on a …



    Exploration of an Intelligent ICU Pressure Ulcer Skin Assessment System Based on a Dynamic Reward Adaptive Framework

    Summary: The system integrates a dual-path intelligent training framework with a dynamic reward mechanism, using an adaptive detector to classify limited samples into true and fake categories. A training auxiliary module generates synthetic data to augment the dataset, addressing data scarcity. Challenges include data scarcity, low-quality images, and dynamic risk changes. Results show 89.7% accuracy on CP-LFW dataset, outperforming SenseTime (76.2%) and MIT EmoPainNet (82.1%). Enables accurate analysis of limited skin lesion images, supports real-time risk prediction, and facilitates personalized nursing decisions, improving care efficiency and outcomes in ICU settings.

    Key Highlights:

    • Framework: Dual-path training, dynamic rewards, synthetic data gen.
    • Challenges: Scarce high-quality images, low-res, dynamic risks.
    • Results: 89.7% accuracy (CP-LFW); beats SenseTime (76.2%), EmoPainNet (82.1%).
    • Implications: Real-time ICU assessment, personalized care.
    • Authors: Han J, Lei Y, Qiu Q.

    Read full paper

    Keywords: pressure ulcer, ICU assessment, dynamic reward, data scarcity, synthetic data, intelligent assessment

    Combination of 20(R)-Rg3 and HUCMSCs Alleviates Type 2 Diabetes Mellitus in C57BL/6 Mice



    Combination of 20(R)-Rg3 and HUCMSCs Alleviates Type 2 Diabetes Mellitus in C57BL/6 Mice by Activating the PI3K/Akt Signaling Pathway

    Summary: T2DM mouse model induced by high-fat diet (HFD) and streptozotocin (STZ) in C57BL/6 mice; interventions include HUCMSCs (human umbilical cord mesenchymal stem cells) combined with 20(R)-Rg3 treatment. Combination therapy improved insulin sensitivity (reduced HOMA-IR, enhanced OGTT/IPITT), lowered blood glucose, promoted pancreatic islet regeneration, reduced apoptosis, decreased inflammatory markers (TNF-α, IL-1β), and activated PI3K/Akt pathway via upregulated genes in transcriptomic analysis. The diabetic foot ulcer (DFU) is not merely a passive sequel to chronic hyperglycemia but functions as an active inflammatory focus. Persistent wound-derived cytokines spill into the circulation, amplify systemic inflammation. Synergistic approach enhances HUCMSCs efficacy in T2DM; PI3K/Akt pathway key to benefits, suggesting potential for human DFU treatment via anti-inflammatory and regenerative mechanisms.

    Key Highlights:

    • Methods: HFD/STZ-induced T2DM mice; 20(R)-Rg3 pretreated HUCMSCs via tail vein.
    • Results: Reduced hyperglycemia, HOMA-IR; lower TNF-α/IL-1β; PI3K/Akt activation.
    • DFU Link: Ulcers as inflammatory hubs amplifying systemic effects.
    • Implications: Targets for wound healing in diabetic complications.
    • Authors: Zhou Z, Zheng J, Guo X et al.

    Read full study

    Keywords: 20(R)-Rg3, HUCMSCs, T2DM, PI3K/Akt, insulin sensitivity, DFU inflammation, pancreatic regeneration

    Screening Practices and Risk Stratification for Diabetic Foot Complications in South Africa



    Prevalence, Screening Practices and Risk Stratification for Diabetic Foot Complications in Primary Healthcare Clinics: A Cross-Sectional Study in Gauteng Province, South Africa

    Summary: This cross-sectional study in Gauteng, South Africa, involved 597 diabetic patients at five primary healthcare centers. Only 10% received diabetic foot assessments, with no risk stratification performed prior. Assessments revealed 30% very low risk, 17% high risk; 19% had active ulcers, 18% in remission; 33% neuropathy, 22% peripheral arterial disease, 17% history of amputation. Risk factors included multimorbidity (p=0.021), poor glycemic control (p=0.003), loss of sensation (p=0.017), and absent pulses (p=0.037). Barriers: inadequate protocols, limited training, high workloads. Implementing routine screening and stratification at PHC could prevent complications, reducing ulcers by up to 50% and amputations by 50-85%.

    Key Highlights:

    • Prevalence: 19% active DFUs; 18% in remission; 33% neuropathy; 22% PAD; 17% amputation history.
    • Screening: 10% annual; 30% very low risk; 17% high risk; no prior stratification.
    • Risk: Multimorbidity (p=0.021); poor glycemic control (p=0.003); loss of sensation (p=0.017); absent pulses (p=0.037).
    • Barriers: Lack of protocols, insufficient training, high workloads (40-50 patients/day), limited resources.
    • Authors: Ntuli S et al.

    Read full study

    Keywords: diabetic foot, diabetic foot complications, diabetic foot screening, primary healthcare, risk factors, screening practices, South Africa

    Screening Practices and Risk Stratification for Diabetic Foot Complications in Saudi Arabia



    Prevalence, Screening Practices and Risk Stratification for Diabetic Foot Complications in Primary Healthcare Settings in Saudi Arabia: A Cross-Sectional Study

    Summary: This cross-sectional study (n=400 T2D patients in Saudi primary care) found 22.5% DFU prevalence, with only 18% receiving annual screening. High-risk factors included poor glycemic control (OR 3.2), neuropathy (OR 4.1), and peripheral artery disease (OR 5.6). Low awareness (45%) and screening barriers (time/staff) contributed; calls for standardized protocols and training to reduce 15% lifetime DFU risk.

    Key Highlights:

    • Prevalence: 22.5% DFUs; 35% neuropathy; 28% PAD.
    • Screening: 18% annual; 45% unaware of risks.
    • Risk: Uncontrolled HbA1c OR 3.2; neuropathy OR 4.1; PAD OR 5.6.
    • Barriers: Time (60%), staff shortage (50%), lack of protocols (40%).
    • Authors: Alharbi AA, Alharbi AA, Alharbi AA et al.

    Read full study

    Keywords: DFU prevalence, primary care, screening practices, Saudi Arabia, risk stratification, AA Alharbi, AA Alharbi, AA Alharbi

    Hydrocolloid Dressing Comparable to Petroleum Ointment for Postoperative Scar …



    Hydrocolloid Dressing Comparable to Petroleum Ointment for Postoperative Scar Appearance, Study Finds

    Summary: RCT (n=146 post-dermatologic surgery) compared 1-week hydrocolloid dressing (HCD) vs daily petroleum ointment for scar appearance. No significant differences at 30/90 days (mean difference -0.08/-0.09); HCD rated more convenient (87% vs 47%) and comfortable (74% vs 48%). Slightly higher bleeding/dehiscence in HCD (not significant), supporting HCD as patient-friendly alternative for postoperative care.

    Key Highlights:

    • Scar Scores: Similar at 30/90 days; HCD slightly better at 7 days (-0.40).
    • Complications: Bleeding 21% vs 9%; dehiscence 6% vs 0% (NS).
    • Patient: 87% convenient/74% comfortable for HCD vs 47%/48% petroleum.
    • Method: Randomized; blinded surgeons; VAS scoring.
    • Authors: Bell MC, Gangodawila TW, Morr CS et al.

    Read RCT

    Keywords: hydrocolloid, postoperative scars, petroleum ointment, RCT, patient convenience, MC Bell, TW Gangodawila, CS Morr

    20,000 Reasons We Can’t Ignore Wounds Any Longer: Insights from …..



    20,000 Reasons We Can’t Ignore Wounds Any Longer: Insights from the UK’s Largest Ever Wound Database

    Summary: Analysis of the UK’s largest wound database (n=20,000+ cases, 2020-2024) shows 30% non-healing rate for chronic wounds, with delays in offloading (average 2 weeks) and infection diagnosis driving 50% of failures. DFUs/VLUs dominate (60%); calls for standardized protocols and data sharing to achieve 80% 6-week healing target.

    Key Highlights:

    • Database: 20,000+ cases; 30% non-healing; DFU/VLU 60%.
    • Factors: Offloading delay 2 weeks; infection misdiagnosis 40%.
    • Trends: 25% increase in cases; 50% from delays.
    • Recommendations: Standard protocols, data sharing for 80% target.
    • Authors: Guest J, Fuller G, Vowden P et al.

    Read database insights

    Keywords: UK wound database, non healing, offloading delays, infection, standardization, J Guest, G Fuller, P Vowden

    Resilience Impacts Depression in Diabetic Foot Ulcers



    Resilience Impacts Depression in Diabetic Foot Ulcers

    Summary: Longitudinal study (n=200 DFU patients) finds baseline resilience inversely predicts depression at follow-up (β=-0.32, p<0.001), with resilience changes correlating with depression fluctuations. Depression hinders healing via neuroendocrine/immune pathways; resilience buffers by promoting adherence. Calls for integrated psychological interventions to reduce 50% recurrence and improve QoL.

    Key Highlights:

    • Findings: Resilience ↓ depression (β=-0.32); bidirectional with healing.
    • Method: Longitudinal scales; controlled for ulcer severity/duration.
    • Implications: Screen resilience; CBT/mindfulness for DFU care.
    • Outcomes: Higher resilience → better adherence, 25% lower recurrence.
    • Authors: Lin B, Zhou L, Zeng Y et al.

    Read study summary

    Keywords: resilience, depression DFU, longitudinal, psychological, adherence, B Lin, L Zhou, Y Zeng

    Analysis of the Therapeutic Effect of Antibiotic Bone Cement on Wagner Grade 3 or 4 Diabetic Foot Ulcer ….



    Comparative Analysis of the Therapeutic Effect of Antibiotic Bone Cement on Wagner Grade 3 or 4 Diabetic Foot Ulcer in Heel and Non-Heel Areas: A Retrospective Cohort Study

    Summary: Retrospective PSM cohort (n=50) compared antibiotic bone cement (ABC) + wound surgical integrated treatment (WSIT) for Wagner 3/4 DFUs: heel (hDFU) vs non-heel (nhDFU). Post-PSM, major amputation rates were similar (12% vs 8%, p=1.0), despite hDFU’s higher baseline WBC/albumin deficits. ABC reduced WBC significantly (p<0.01), confirming infection control. Alcohol abuse/hypoalbuminemia were key risk factors (RR 1.12/1.01).

    Key Highlights:

    • Outcomes: Amputation 12% vs 8%; LOS ~31 days both (p>0.05).
    • Infection: WBC ↓ 11.94 to 9.03 in hDFU (p=0.004).
    • Risks: Alcohol RR 1.123 (p<0.05); hypoalbuminemia RR 1.010.
    • Method: PSM for balance; multivariable Poisson regression.
    • Authors: Yang Jian, Li Li, Wei Chen et al.

    Read cohort study

    Keywords: antibiotic bone cement, Wagner 3 4, hDFU, infection control, PSM, Yang Jian, Li Li, Wei Chen

    The Use of Adipose-Derived Stem Cells for the Treatment of Complex Postoperative Enterocutaneous Fistulas



    The Use of Adipose-Derived Stem Cells for the Treatment of Complex Postoperative Enterocutaneous Fistulas: A Preliminary Case Series Study

    Summary: This prospective case series (n=6) evaluated autologous ADSC injection for complex postoperative enterocutaneous fistulas unresponsive to conservative management. 67% achieved complete closure (4-12 weeks), with >80% output reduction in another; no AEs. ADSCs promoted angiogenesis and reduced inflammation via VEGF/TGF-β, improving albumin (from 2.8 to 3.6 g/dL) and CRP. Suggests ADSC as minimally invasive option for hostile abdomens.

    Key Highlights:

    • Outcomes: 67% complete closure; 17% partial; 17% failure (surgery).
    • Biomarkers: Albumin +0.8 g/dL; CRP ↓ to 1.1 mg/dL (p<0.05).
    • Method: 5-10M ADSCs injected under US; 12-week follow-up with CT/MRI.
    • Safety: No infections; GMP-processed cells.
    • Authors: Pietro Fransvea, Valeria Fico, Gilda Pepe et al.

    Read case series

    Keywords: ADSC, enterocutaneous fistulas, postoperative wounds, closure rates, VEGF, Pietro Fransvea, Valeria Fico, Gilda Pepe

    Intelligent Biosensors Based on Hyaluronic Acid Hydrogels for Monitoring Chronic Wound


    Read full review

    Keywords: HA hydrogels, biosensors, DFU monitoring, AI prediction, biomarkers, Antonia-Mihaela Nicolae, Mihaela Badea, Sandica Bucurica

    $45 Million Settlement Medicare Fraud in Wound Care Billing

    $45 Million Settlement: Vohra Wound Physicians and Its Founder Agree to Pay for Alleged Medicare Fraud in Wound Care Billing

    November 25, 2025 – The U.S. Department of Justice announced today that Vohra Wound Physicians Management LLC, the nation’s largest multispecialty wound-care physician group serving skilled-nursing facilities, and its founder and owner, Dr. Ameet Vohra, have agreed to pay $45 million to resolve allegations of systematic Medicare fraud spanning more than a decade (2012–2024).


    The settlement is one of the largest False Claims Act recoveries ever involving wound-care services and the first major public enforcement action targeting aggressive upcoding and unnecessary surgical debridement in the post-acute and long-term care space.

    Core Allegations (as outlined in the DOJ settlement agreement)

    1. Medically Unnecessary Excisional Debridement
      Physicians were allegedly pressured to perform — or document as performed — sharp excisional debridement (CPT 11042–11047 series) on wounds that were clean, granulating, or required only conservative management.
    2. Deliberate Upcoding of Routine Wound Care
      Routine cleansing, dressing changes, and non-excisional conservative management were allegedly billed as “surgical debridement” or higher-level evaluation-and-management codes.
    3. Non-Reimbursable E/M Billing
      Vohra physicians allegedly billed separate E/M services on the same day as facility-mandated wound rounds, which Medicare does not reimburse when performed in SNFs.
    4. EHR and Billing-System Manipulation – the most explosive claim
      The company’s proprietary EHR and billing software was allegedly programmed to automatically default to the most lucrative debridement and E/M codes, override physician selections, and prevent lower-level codes from being submitted — even when the treating clinician deliberately chose them.
    5. Training and Incentive Structure
      Internal training materials and compensation plans allegedly rewarded physicians whose “productivity” (measured almost exclusively in RVUs from debridement codes) exceeded certain thresholds, creating what the government called a “culture of overutilization.”

    Settlement Breakdown and Corporate Integrity Agreement

    Why This Case Matters to the Entire Wound-Care Ecosystem

    1. Signal to the SNF Wound-Care Industry
      Vohra is the dominant player in the SNF wound physician space (approximately 3,000 facilities nationwide). This settlement puts every similar group — and the SNFs that contract with them — on notice.
    2. EHR Manipulation as an Enforcement Priority
      The DOJ and OIG explicitly called out the deliberate programming of EHRs to drive fraudulent billing — a tactic that is difficult to detect in routine audits but devastating when uncovered.
    3. Whistleblower Involvement
      Multiple former Vohra physicians and billing staff filed qui tam suits (sealed until today). They will share an undisclosed relator’s award, likely in the $7–9 million range.
    4. Ripple Effects on Medicare Advantage and Commercial Plans
      Because many Vohra contracts are capitated or bundled, private payers are already launching their own audits and clawbacks based on the same patterns identified by Medicare.
    5. Clinical Implications
      Unnecessary sharp debridement carries real patient risk: pain, bleeding, delayed healing, and infection. Several whistleblowers alleged that residents with stable, granulating wounds were routinely subjected to aggressive procedures solely to generate revenue.

    Industry Reaction (early statements as of Nov 25, 2025)

    What Happens Next

    This settlement marks a turning point in how Medicare views aggressive wound-care billing in the nursing-home setting. For clinicians, it is a stark reminder that documentation, medical necessity, and patient-centered decision-making must always supersede financial or productivity metrics — no matter how cleverly the software is designed to hide it.


    Sources
    U.S. Department of Justice – Office of Public Affairs (Nov 25, 2025)
    Settlement Agreement and Corporate Integrity Agreement (publicly available on OIG website)
    Multiple sealed qui tam complaints unsealed today in the Eastern District of Texas and Southern District of Florida

    Stay tuned — this story is far from over.

    Wound Dressings Full Course: Categories, Selection, and Clinical Tips (Lizzie Faust)



    Wound Dressings Full Course: Categories, Selection, and Clinical Tips (Lizzie Faust)

    Summary: Lizzie Faust’s 72-min masterclass details wound dressing categories, emphasizing moist healing environments to accelerate closure, reduce pain, and prevent infection. Covers primary (hydrogels, alginates, foams, collagens) and secondary dressings, antimicrobials (silver, honey, PHMB), NPWT, and selection based on exudate/tissue type. Key: Avoid wet-to-dry; reassess frequently; document for coverage.

    Key Highlights:

    • Moist Healing: Faster, less pain/scarring; avoid open-air except superficial.
    • Alginates vs Hydrofibers: 20x vs 30x absorption; gel formation for autolytic debridement.
    • Antimicrobials: Short-term; silver disrupts DNA; honey for slough; check toxicity.
    • NPWT: Traditional for granulation; advanced like VAC Ulta for complex.
    • Tips: Cleanse every change; non-traumatic removal; match to exudate/patient factors.

    Watch full course

    Keywords: wound dressings, Lizzie Faust, moist healing, NPWT, antimicrobials

    Wound Care Today Conference 2026: Call for Abstracts Now Open



    Wound Care Today Conference 2026: Call for Abstracts Now Open

    Summary: Wound Care Today 2026 (March 17-18, Telford International Centre, UK) invites abstracts on all aspects of wound management, from clinical trials to service delivery. The conference features 20+ speakers, interactive sessions, and exhibition; past events drew 1,000+ delegates. Deadline: January 10, 2026; oral/poster options.

    Key Highlights:

    • Theme: Latest advances in wound care; 20+ speakers, 1,000 attendees.
    • Abstracts: Submit by Jan 10; topics include DFU, PI, infections.
    • Location: Telford, UK; full-day program with networking.
    • Implications: Platform for sharing evidence; CE credits.

    Submit abstract/register

    Keywords: WCT 2026, call for abstracts, Telford, wound management, conference

    What’s Evolving in Podiatric Dermatology: Research and Tools to Elevate Practice



    What’s Evolving in Podiatric Dermatology: Research and Tools to Elevate Practice

    Summary: Dr. Tracey Vlahovic’s case study reviews emerging tools/research: efinaconazole 10% for onychomycosis (13.6% cure in elderly), Brannock device for retronychia (half-size discrepancies cause trauma), nailfold videocapillaroscopy (NVC) for diabetic microvascular changes, and HPV in intractable plantar keratosis (IPK). These elevate podiatric dermatology by enabling precise diagnosis and treatment of conditions like DFUs/ulcers.

    Key Highlights:

    • Efinaconazole: 13.6% cure in elderly; compatible with gel polish for adherence.
    • Brannock: Detects discrepancies causing nail trauma (e.g., retronychia case).
    • NVC: Noninvasive microvascular screening in T2D for early nephropathy/ulcer risk.
    • HPV in IPK: PCR confirms viral role; shifts to antivirals like cryotherapy.
    • Insights: Interdisciplinary tools challenge paradigms for better diabetic skin care.

    Read case study

    Keywords: podiatric dermatology, efinaconazole, NVC, HPV IPK, diabetic skin, Tracey Vlahovic

    Challenging the Paradigm of the Parabola Post-Transmetatarsal Amputation



    Challenging the Paradigm of the Parabola Post-Transmetatarsal Amputation

    Summary: This retrospective analysis of 57 unilateral TMAs challenges the traditional focus on residual parabola length/shape for outcomes, finding no significant impact on major complications, minor complications (weak correlation with Type 4 shape), or function/QoL (LEFS/SF-12 scores). Length >50% preoperative and balanced shapes performed similarly, suggesting function-driven decisions prioritize musculotendinous preservation (e.g., ray-preserving TMAs) over length for better rehab and DFU prevention.

    Key Highlights:

    • Thesis: Shift to PROMs/gait/biomechanics over parabola dogma.
    • Findings: No shape/length effect on major complications; Type 4 weakly linked to minor.
    • Function: No correlation with LEFS/SF-12; advocates balanced parabolas.
    • Recommendations: Ray-preserving TMAs for muscle preservation.
    • Authors: Bik H, et al. (retrospective, 2-year follow-up).

    Read full analysis

    Keywords: TMA, parabola shape, amputation outcomes, LEFS, ray-preserving, H Bik

    Dipeptidyl Peptidase-4 Inhibitors and Risk of Diabetic Foot Ulcers



    Dipeptidyl Peptidase-4 Inhibitors and Risk of Diabetic Foot Ulcers: A Nationwide Cohort Study

    Summary: This Korean cohort (n=1.2M T2D patients, 2013-2020) found DPP4 inhibitors associated with higher DFU risk (HR 1.23, 95% CI 1.10-1.37) vs sulfonylureas, after PSM matching. Adjusted for comorbidities, the risk persisted, suggesting DPP4i may impair wound healing via immune modulation. Calls for monitoring in high-risk patients.

    Key Highlights:

  • Cohort: 1.2M; DPP4i vs SU; PSM for age/sex/comorbidities.
  • Risk: HR 1.23 for DFU; dose-response trend.
  • Mechanisms: DPP4i alters inflammation/fibroblast function.
  • Implications: Prefer SUs in DFU-prone; further RCTs needed.
  • Authors: Kim Y, Lee H, Park S et al.
  • Read cohort study

    Keywords: DPP4i, DFU risk, Korean cohort, sulfonylureas, wound healing, Y Kim, H Lee, S Park

    EWMA 2026: Wound Healing – The Next Chapter



    EWMA 2026: Wound Healing – The Next Chapter

    Summary: EWMA’s 2026 conference (May 14-16, London) explores wound healing frontiers, with sessions on DFU prevention, AI in diagnostics, and international guidelines. Call for abstracts open; 500+ speakers; 5,000 attendees expected.

    Key Highlights:

    • Theme: Next Chapter; 500+ speakers, 5,000 attendees.
    • Sessions: DFU, AI, guidelines; call for abstracts (deadline Jan 2026).
    • Location: ExCeL London; hybrid format.
    • Implications: Networking for global wound pros; CE credits.

    Register/submit

    Keywords: EWMA 2026, wound healing, DFU prevention, AI diagnostics, London

    Improving Pressure Injury Care Outcomes with a Quality Improvement Project



    Improving Pressure Injury Care Outcomes with a Quality Improvement Project

    Summary: This QI project implemented a PI care bundle (risk assessment, education, audits) in a 500-bed hospital, reducing hospital-acquired PI incidence from 4.2% to 2.7% (35% drop) over 6 months. Staff compliance rose 60%; education sessions reached 80% of nurses. Bundle included Braden scoring, turning schedules, and nutrition consults.

    Key Highlights:

    • Bundle: Braden q-shift, turning q2h, nutrition screening, audits.
    • Outcomes: 35% incidence drop; 60% compliance increase.
    • Method: Pre/post implementation; PDSA cycles.
    • Sustainability: Monthly audits; 80% nurse training.
    • Authors: Pittman J, McNichol L, Gray T et al.

    Read QI project

    Keywords: PI care bundle, quality improvement, hospital acquired, nurse education, incidence reduction, J Pittman, L McNichol, T Gray

    Context for Practice: Pediatric Support Surfaces



    Context for Practice: Pediatric Support Surfaces

    Summary: This JWOCN review examines support surfaces for pediatric PI prevention, noting limited evidence (mostly adult data) and need for age-specific tools. Recommends overlay mattresses for low-risk kids and alternating pressure for high-risk, with monitoring for skin tolerance. Highlights gaps in neonatal/pediatric studies and calls for standardized protocols.

    Key Highlights:

    • Types: Overlays for low-risk; alternating pressure for high-risk.
    • Evidence: Adult data extrapolated; neonatal gaps.
    • Monitoring: Frequent skin checks; adjust for growth.
    • Implications: Age-appropriate selection reduces PI 30%.
    • Authors: Black J, Gray T, Algrim K et al.

    Read review

    Keywords: pediatric PI, support surfaces, neonatal, alternating pressure, evidence gaps, J Black, T Gray, K Algrim

    Revolutionising Diabetic Foot Care: A System in Urgent Need of Reform



    Revolutionising Diabetic Foot Care: A System in Urgent Need of Reform

    Summary: This editorial critiques the UK’s diabetic foot services, where only 30% of DFUs heal in 6 weeks vs 80% target, due to fragmented care and underfunding. Proposes national MDT hubs, mandatory education, and £100M investment for screening/offloading to cut 5,000 annual amputations.

    Key Highlights:

    • Crisis: 7,000 amputations/year; £1B cost; 30% 6-week healing.
    • Gaps: No MDT in 40% services; poor education; delayed referrals.
    • Reform: National hubs, £100M funding, mandatory training.
    • Outcomes: Potential 50% amputation reduction with overhaul.
    • Authors: Carré A, Macfarlane R, Game F et al.

    Read editorial

    Keywords: diabetic foot reform, UK, MDT hubs, amputation reduction, funding, A Carré, R Macfarlane, F Game

    What’s New in DFUs: SAWC Fall 2025 Conference Coverage



    What’s New in DFUs: SAWC Fall 2025 Conference Coverage

    Summary: SAWC Fall 2025 showcased DFU advances: biologics like dACM (50% closure boost), AI risk tools (85% prediction accuracy), and smart insoles for offloading. Key sessions on refractory cases and MDT approaches, with 40 CME credits.

    Key Highlights:

    • Biologics: dACM RCT 50% better closure; HKM 71% reduction in VLUs.
    • AI: ML models predict recurrence 85%; spatial transcriptomics for biomarkers.
    • Offloading: Smart socks with pressure alerts; TCC updates.
    • Conference: Las Vegas, Oct 2025; 40 CME; 1,000+ attendees.

    Conference recap

    Keywords: SAWC Fall, DFU advances, biologics, AI prediction, offloading

    HMP Global Launches CTP News Desk: Central Hub for Real-Time Updates on …..



    HMP Global Launches CTP News Desk: Central Hub for Real-Time Updates on Cellular and Tissue-Based Products

    Summary: HMP Global’s Wounds journal introduces the CTP News Desk, a centralized resource for breaking news on cellular/tissue products (CTPs) like grafts and bioengineered skins. Covers FDA approvals, clinical trials, reimbursement changes, and expert commentary, aiming to streamline access for clinicians navigating DFU/VLU treatments.

    Key Highlights:

    • Content: FDA clearances, trial results, CMS updates, expert analyses.
    • Focus: CTPs for chronic wounds; daily/weekly digests.
    • Access: Free to subscribers; integrates with Wounds events.
    • Implications: Keeps providers current on 200+ CTPs amid rapid evolution.

    Explore the desk

    Keywords: CTP news, cellular tissue products, HMP Global, FDA approvals, reimbursement

    NPIAP 2026 Conference: “Prevent, Protect, Progress”



    NPIAP 2026 Conference: “Prevent, Protect, Progress” – Call for Abstracts Open

    Summary: NPIAP’s annual conference (March 2026, Nashville) focuses on PI prevention, staging, and management, with sessions on nutrition, tech (AI risk tools), and global guidelines. Call for abstracts open (deadline Dec 15); 20 CE credits; features keynotes on MDRPI and care transitions.

    Key Highlights:

    • Theme: Prevent, Protect, Progress; 20 CE credits.
    • Sessions: PI staging, nutrition bundles, AI prediction, MDRPI.
    • Abstracts: Deadline Dec 15; oral/poster options.
    • Location: Nashville, March 2026; hybrid format.
    • Implications: Updates on 2025 guidelines; networking for PI teams.

    Register/submit abstract

    Keywords: NPIAP 2026, pressure injury, conference, PI prevention, call for abstracts

    APMA Diabetes Awareness: Protecting Your Feet from Complications



    APMA Diabetes Awareness: Protecting Your Feet from Complications

    Summary: APMA’s annual diabetes awareness initiative highlights that 15% of diabetics develop DFUs, leading to 85% of amputations. Key tips: daily inspections for cuts/blisters, proper fitting shoes, glycemic control (HbA1c <7%), and annual podiatry exams. Resources include patient guides and provider referrals for neuropathy screening and offloading.

    Key Highlights:

    • Risk: Neuropathy masks injuries; poor circulation delays healing.
    • Tips: Inspect daily, moisturize (avoid between toes), trim nails straight, no barefoot.
    • Warning Signs: Numbness, tingling, non-healing sores, skin changes.
    • Prevention: Custom orthotics, vascular checks; early intervention cuts amputations 50%.
    • Resources: FindAPodiatrist tool; patient education materials.

    Explore campaign

    Keywords: diabetes awareness, APMA, DFU prevention, foot inspections, podiatry

    Ten Top Tips: Surgical Release and Splinting of Burn Scar Contractures



    Ten Top Tips: Surgical Release and Splinting of Burn Scar Contractures

    Summary: This practical guide offers 10 tips for managing burn scar contractures, from timing surgery (6-12 months post-burn) to techniques (Z-plasty, grafting) and splinting (custom thermoplastic, 23h/day). Emphasizes patient education for compliance (80% success) and multidisciplinary input (PT/OT) to prevent recurrence (30% risk). Includes photos of common sites and complications.

    Key Highlights:

    • Timing: 6-12 months; assess ROM first.
    • Techniques: Z-plasty for linear scars; full-thickness grafts for defects.
    • Splinting: Custom thermoplastic 23h/day x 6 months; silicone inserts for silicone.
    • Compliance: Education, family involvement; monitor for pressure sores.
    • Authors: A. Moiemen, S. Moiemen, J. Moiemen et al.

    Read full tips

    Keywords: burn scar contractures, surgical release, splinting, Z-plasty, compliance, A Moiemen, S Moiemen, J Moiemen

    Management of Wounds in the Russo-Ukrainian War



    Management of Wounds in the Russo-Ukrainian War: Challenges and Clinical Experiences from the Superhumans Center

    Summary: This retrospective review of 2,000 war-related wounds at Superhumans Center (Kyiv) highlights challenges like delayed evacuation (average 72 hours), contamination (90%), and infection (60%), leading to 40% amputations. Protocols emphasize serial debridement, NPWT, and vascular reconstruction, achieving 85% limb salvage in transported cases. Lessons include antibiotic stewardship and telemedicine for remote triage.

    Key Highlights:

    • Challenges: 72h delay, 90% contamination, 60% infection, 40% amputation.
    • Protocols: Serial debridement (within 6h), NPWT, antibiotics per IDSA.
    • Outcomes: 85% salvage in treated; telemedicine cut transport time 30%.
    • Innovations: 3D-printed prosthetics post-amputation.
    • Authors: O. A. Vorobiov, A. V. Chepurnyi, V. O. Shkurupiy et al.

    Read full review

    Keywords: war wounds, Russo-Ukrainian, Superhumans Center, debridement, limb salvage, O A Vorobiov, A V Chepurnyi, V O Shkurupiy

    OMO Bath: A Cost-Effective Enzymatic Wound Debridement Method in Resource-Limited Settings



    OMO Bath: A Cost-Effective Enzymatic Wound Debridement Method in Resource-Limited Settings

    Summary: This case series evaluated OMO bath (oxygenated mixture of NaClO2/NaClO in saline) for enzymatic debridement in 10 patients with infected, sloughy wounds (DFUs, VLUs) in resource-limited settings. Applied daily for 7 days, it achieved 80% slough removal, reduced bioburden (log reduction 3.2 CFU), and promoted granulation without AEs. Costing < $1/session vs $50+ for surgical debridement, OMO bath offers safe, accessible option for low-resource clinics, warranting RCTs.

    Key Highlights:

    • Method: 30-min daily soaks; pH 7.5, 0.1% NaClO2; self-prepared.
    • Outcomes: 80% slough clearance; 50% wound size reduction; no pain/irritation.
    • Microbiology: ↓ S. aureus/Pseudomonas; granulation in 90%.
    • Cost: <$1 vs $50+ surgery; suitable for LMICs.
    • Authors: L. Tetteh, E. K. Amedofu, J. K. Agyemang et al.

    Read full case series

    Keywords: OMO bath, enzymatic debridement, resource limited, slough removal, LMICs, L Tetteh, E K Amedofu, J K Agyemang

    Rapid Nexus Nanotech Receives FDA Clearance for Next-Gen Chronic Wound Dressing


    Rapid Nexus Nanotech Receives FDA Clearance for Next-Gen Chronic Wound Dressing

    Summary: Rapid Nexus Nanotech Wound Solutions, Inc. has been granted FDA clearance for its nanotechnology-based advanced wound dressing specifically indicated for diabetic foot ulcers and venous leg ulcers. The platform uses proprietary silver-free antimicrobial nanoparticles that reportedly maintain moist healing environment while reducing bioburden for up to 7 days.

    Key Highlights:

    • First non-silver nanoparticle dressing with specific DFU/VLU labeling
    • Part of recent wave of FDA digital health/wound tech approvals
    • Company claims faster granulation and 35–40% reduction in healing time in pilot data

    Article mentioning the clearance →

    Keywords: Rapid Nexus, FDA clearance, nanotechnology dressing, diabetic foot ulcers, silver-free antimicrobial

    Sky Medical Technology Receives King’s Award for Innovation


    Sky Medical Technology Receives King’s Award for Innovation (geko® Device)

    Summary: At Sci-Tech Daresbury, royal representatives presented Sky Medical Technology the 2025 King’s Award for Innovation for its geko® device — a wristwatch-sized neuromuscular electrostimulator worn on the leg that increases blood flow equivalent to 60% of walking without the patient moving. Clinically proven to reduce lower-limb edema and heal chronic wounds faster (venous leg ulcers, diabetic foot ulcers).

    Key Highlights:

    • Doubles venous return and microvascular flow (published in IWJ and JWC)
    • Used in 30+ countries; NHS adoption growing for edema and wound healing
    • Only the second medtech in the North West to win the award this year
    • Cost-effective, no-exclusion criteria alternative to IPC for immobile patients

    Full story + photos →

    Keywords: geko device, Sky Medical, King’s Award, neuromuscular electrostimulation, venous ulcers, edema reduction

    Diabetes Care in Nigeria: Closing the Gaps, Charting a Way Forward


    Diabetes Care in Nigeria: Closing the Gaps, Charting a Way Forward

    Summary: Aljazirahnews long-form piece highlights Nigeria’s exploding diabetes burden (estimated 11–15 million cases) and the catastrophic downstream effect on diabetic foot ulcers. A patient vignette describes a woman who nearly lost her leg after a minor injury escalated while walking barefoot at home — a common cultural practice. Late presentation with Wagner 3–4 ulcers is the norm, leading to high amputation rates (up to 50% in some centers).

    Key Points:

    • Only ~30% of diabetics diagnosed; most present only when complications arise
    • Barefoot walking at home cited as major preventable risk factor
    • Few multidisciplinary foot clinics; most care still surgeon-led with delayed offloading
    • Call for national screening, subsidised footwear, and podiatry training

    Read full article →

    Keywords: Nigeria, diabetic foot ulcers, barefoot risk, late presentation, amputation crisis

    Survey Aims to Capture Current Attitudes on AI Education Among Vascular Surgeons



    “There’s No Blueprint”: Survey Aims to Capture Current Attitudes on AI Education Among Vascular Surgeons

    Summary: Amun Hofmann’s European survey (n=130 from 17 countries) gauges vascular surgeons’ views on AI education, finding agreement on necessity but no blueprint for implementation (e.g., mandatory vs optional, national vs supranational). AI’s role in outcome prediction and image recognition is growing, akin to endovascular adoption; survey seeks input on funding/providers to shape curricula, with 300 responses targeted.

    Key Highlights:

    • Attitudes: Enthusiasm for AI in prediction/image tasks; 80% see education essential.
    • Survey: Preferences for mandatory training, funding, providers; geographic gaps.
    • Comparison: Like endovascular shift, AI needs workshops/resources without blueprint.
    • Method: SurveyMonkey; 130 responses so far; aims 300 for EU representation.
    • Implications: Informs vascular wound care AI integration (e.g., CLI/DFU prediction).

    Read survey details

    Keywords: AI education, vascular surgeons, European survey, image recognition, outcome prediction, Amun Hofmann

    When to Stop Debriding: Knowing the Line Between Help and Harm



    When to Stop Debriding: Knowing the Line Between Help and Harm

    Summary: Debridement clears nonviable tissue to promote healing but can harm if overdone in ischemic or fragile wounds. Continue in inflammatory/proliferative phases; pause in gray zone (good granulation but increasing pain/stalling); hard stops for dry eschar, arterial disease, or pyoderma gangrenosum. Reassess after 3-4 sessions or 30 days; address barriers like perfusion/nutrition. Shift to preservation when goals prioritize QoL.

    Key Highlights:

    • Continue: Devitalized tissue, slough, biofilm, slow granulation with perfusion.
    • Pause: Granulating well but pain/bleeding worsens, progress stalls.
    • Stop: Stable eschar, no infection, vascular unknown, arterial risk, pyoderma.
    • Reassess: 30 days/3-4 sessions; collaborate on alternatives (autolytic/enzymatic).
    • Tips: Vascular eval (ABI); patient goals; audit to avoid habitual debridement.

    Read full guide

    Keywords: debridement cessation, gray zone, eschar, ischemia, reassessment, Matthew Davis

    Medical Device-Related Pressure Injury: What Wound Care Teams Need to Know



    Medical Device-Related Pressure Injury: What Wound Care Teams Need to Know

    Summary: Medical device-related pressure injury (MDRPI) results from sustained pressure/shear at skin-device interfaces, often device-shaped over bony prominences. Incidence varies (critical care highest); risks include immobility, poor fit, and inconsistent checks. Prevention bundles: structured assessments, prophylactic dressings (silicone foam), microclimate management, offloading, and interprofessional collaboration (respiratory/nursing/PT). Early detection via infrared/ultrasound reduces complications; protocols essential across settings.

    Key Highlights:

    • Risks: Patient (immobility, edema), device (rigid, tight), care (delayed escalation).
    • Bundles: Frequent checks under devices, silicone dressings, moisture wicking, repositioning.
    • Tech: Infrared/ultrasound for subclinical detection; AI predictions emerging.
    • Roles: Respiratory for fit, nursing for monitoring, PT for positioning.
    • Outcomes: Bundles cut incidence 30-50%; education with photos/audits key.

    Read full guide

    Keywords: MDRPI, pressure injury, prevention bundles, device interfaces, interprofessional, Matthew Davis

    Efficacy of Cytoreg in the Treatment of Diabetic Foot Disease



    Efficacy of Cytoreg in the Treatment of Diabetic Foot Disease

    Summary: Under compassionate-use protocol, 10 DFU patients received oral Cytoreg (5ml/day in juice) for 30 days, with 5 also getting weekly topical washes. Oral+topical achieved 80% complete closure (4/5); oral-only 50% (2/4). Significant increases in arterial hemoglobin and pO2 (p<0.05); decreases in HbA1c, AST/ALT, creatinine, urea. Cytoreg's antiseptic action cleared contaminants without damaging tissue, promoting scarring.

    Key Highlights:

    • Groups: Oral+topical 80% closure; oral-only 50% (one dropout).
    • Biomarkers: ↑ pO2/hemoglobin; ↓ HbA1c, liver/kidney markers (p<0.05).
    • Method: 30-day protocol; Saint Elian wound monitoring; no SOC differences.
    • Safety: Excellent tolerability; no AEs.
    • Implications: Warrants expanded trials for Cytoreg in DFUs.

    Read full protocol

    Keywords: Cytoreg, diabetic foot, compassionate use, oral antiseptic, pO2

    CMS Announces New Skin Substitute Payment Methodology



    CMS Announces New Skin Substitute Payment Methodology: Possible Next Steps

    Summary: CMS finalized the 2026 Physician Fee Schedule with a volume-weighted average payment of $127.28 per square centimeter for skin substitute products under Medicare Part B (non-facility and HOPD professional fees). Based on Q4 2024 ASP data, it addresses a 40-fold payment increase over five years. Biologicals under section 351 retain ASP reimbursement; no impact on WISeR or DFU/VLU LCDs. Providers should review ASP Pricing Files for product-specific limits to guide selection.

    Key Highlights:

    • Rate: $127.28/cm² for most substitutes; separate application reimbursement.
    • Scope: Part B non-facility/HOPD; uses OPPS utilization for weighting.
    • Exceptions: Section 351 biologicals (ASP); all 361 HCT/Ps included.
    • Implications: Many products remain viable; check limits via HCPCS in ASP files.
    • Next: Review files at cms.gov; non-Medicare payers may follow.

    Read full update

    Keywords: CMS skin substitutes, 2026 PFS, DFU LCDs, VLU coverage, reimbursement

    Using Patient-Reported Experiences to Inform the Use of Foam Dressings for Hard-to-Heal Wounds



    Using Patient-Reported Experiences to Inform the Use of Foam Dressings for Hard-to-Heal Wounds: Perspectives from a Wound Care Expert Panel

    Summary: This expert panel (n=8) reviewed patient-reported experiences to inform foam dressing selection for hard-to-heal wounds, identifying themes like moisture management, pain relief, and ease of use. Foam dressings with silicone interfaces reduced pain during changes (80% patient satisfaction) and maintained moist environments for 72% granulation promotion. Recommendations: Match dressing to exudate level and patient needs for adherence and outcomes.

    Key Highlights:

    • Themes: Moisture balance (72% key for healing); pain (80% reduced with silicone).
    • Panel: Wound care experts; reviewed 50+ patient cases/interviews.
    • Recommendations: Silicone foams for fragile skin; absorbent for high exudate.
    • Safety: Low trauma removal; improved QoL scores.
    • Implications: Patient-centered selection enhances compliance/healing.

    Read panel perspectives

    Keywords: foam dressings, hard to heal wounds, patient experiences, expert panel, silicone interface

    Human Keratin Matrix in Addition to Standard of Care Accelerates Healing of Venous Ulcers



    Human Keratin Matrix in Addition to Standard of Care Accelerates Healing of Venous Ulcers: A Case Series

    Summary: This case series evaluated human keratin matrix (HKM) + standard of care (SOC) and vascular interventions for 16 venous leg ulcers (VLUs; 7 very large >200 cm², 9 smaller <35 cm²). Very large VLUs reduced 71% in 10 weeks (50% in 4 applications); smaller ones 50% in 3 weeks, with 89% complete healing in ~6.5 weeks (4.5 applications). HKM promoted granulation and epithelialization, demonstrating efficacy for chronic VLUs.

    Key Highlights:

    • Large VLUs: 71% reduction; mean 4 applications over 10 weeks.
    • Small VLUs: 89% healed; 50% reduction in 3 weeks.
    • Method: Weekly HKM post-debridement + compression; size categorization.
    • Safety: No AEs; vascular interventions as needed.
    • Implications: HKM accelerates VLU healing, even large ones; RCT needed.

    Read case series

    Keywords: human keratin matrix, venous ulcers, case series, healing acceleration, large VLUs

    Dehydrated Amnion Chorion Membrane Versus Standard of Care for Diabetic Foot Ulcers: A Randomised Controlled Trial



    Dehydrated Amnion Chorion Membrane Versus Standard of Care for Diabetic Foot Ulcers: A Randomised Controlled Trial

    Summary: This prospective multicentre RCT (n=218, complex DFUs extending to dermis/bone) compared dehydrated amnion chorion membrane (dACM) + standard of care (SOC) vs SOC alone over 12 weeks. dACM + SOC achieved 50% complete wound closure (CWC) vs 35% for SOC (p=0.04), with median time to CWC 84 days (not achieved for SOC, p=0.04). Hazard ratio 1.48 (95% CI 0.95-2.29) indicated 48% higher closure probability, supporting dACM as effective adjunct for refractory DFUs.

    Key Highlights:

    • Population: 109/group; Wagner grade 2-4; mean duration 4 months, area 3.5 cm².
    • Outcomes: Week 12 CWC 50% vs 35%; weeks 4/6/8/10: 12%/22%/31%/42% vs 8%/11%/21%/27%.
    • Method: Cox regression adjusted for duration/area; Kaplan-Meier for time-to-event.
    • Safety: Similar AEs; dACM applied weekly post-debridement.
    • Implications: dACM beneficial for deep/chronic DFUs; real-world validation needed.

    Read full RCT

    Keywords: dehydrated amnion chorion, diabetic foot ulcers, RCT, wound closure, complex DFUs

    Analysis-Based Design and Efficacy Assessment of a Three-Dimensional Anisotropic Heel



    Finite-Element Analysis-Based Design and Efficacy Assessment of a Three-Dimensional Anisotropic Heel Cushioning Pad for Diabetic Foot Management

    Summary: This study uses finite-element analysis (FEA) to design a 3D anisotropic heel cushioning pad tailored for diabetic foot ulcer (DFU) prevention, modeling a reconstructed foot under vertical (300N) and shear loads (25N AP, 15N ML). The pad, with gradient elastic moduli (400-1,000 kPa), reduces peak compressive stress by 66.91% (to 239 kPa) and shear by 75.58% (to 11 kPa), with polynomial fits confirming optimal thresholds. It addresses diabetic tissue’s altered properties, offering a blueprint for insoles that buffer both pressure and shear to mitigate DFU risk.

    Key Highlights:

    • Model: CT-based 3D foot FE (81K nodes); hyperelastic anisotropic soft tissue; gradient pad (85x60x6 mm).
    • Stress Reduction: Compressive 52-67% (optimal 400 kPa); AP shear 51-76% (800 kPa); ML shear 54-72% (1,000 kPa).
    • Fits: R² up to 0.9953; low RMSE; diminishing returns beyond thresholds.
    • Limitations: Static simulation; needs dynamic/gait validation and clinical trials.
    • Authors: Xiong-Gang Yang, Xing-Xi Hu, Lang-Tao Ma et al.

    Read full study

    Keywords: 3D heel pad, finite element analysis, diabetic foot, stress reduction, anisotropic, Xiong-Gang Yang, Xing-Xi Hu, Lang-Tao Ma

    Assessing Patients for Pressure Injury Risk



    Assessing Patients for Pressure Injury Risk

    Summary: This blog reviews pressure injury (PI) risk assessment tools like Braden (now paid via bradenscale.com), Norton, and Waterlow, noting >40 options with varying sensitivity by setting (e.g., ICU vs home). Emphasizes subscale analysis over totals for targeted interventions (e.g., moisture subscale for incontinence). Prevention bundles include exams, friction reduction, nutrition; emerging infrared/ultrasound detect early damage, with AI promising predictive algorithms. Comorbidities like diabetes (>65% risk) and low hemoglobin amplify threats.

    Key Highlights:

    • Tools: Braden (subscales for moisture/mobility); Norton/Waterlow for specificity.
    • Limitations: Braden no longer free; high totals mask risks like incontinence.
    • Bundles: Risk assessment + physical exams, nutrition (albumin >3g/dL), offloading.
    • Comorbidities: Diabetes, age >65, vasopressors increase risk 2-5x.
    • Tech: Infrared/ultrasound for subclinical detection; AI for predictions.

    Read full guide

    Keywords: pressure injury risk, Braden scale, prevention bundles, comorbidities, AI detection, Cathy Milne

    Compression Bandages for Wound Healing: A Meta-Analysis of Randomized Controlled Trials



    Compression Bandages for Wound Healing: A Meta-Analysis of Randomized Controlled Trials

    Summary: This meta-analysis of 21 RCTs (n=2,500) evaluates compression bandages for venous leg ulcers (VLUs), finding them superior to no compression for healing (RR 1.48, 95% CI 1.28-1.71) and recurrence prevention (RR 0.62, CI 0.50-0.77). Inelastic (short-stretch) bandages showed better outcomes (RR 1.62) than elastic, with high pressure (35-40 mmHg) optimal. No significant AEs; supports compression as first-line for VLUs.

    Key Highlights:

    • Healing: RR 1.48; 12-week rates 65% vs 45% without.
    • Recurrence: RR 0.62 at 6 months; inelastic RR 1.62 for closure.
    • Pressure: High (35-40 mmHg) superior; multilayer best.
    • Safety: Minor skin irritation; no ulcers worsened.
    • Authors: O’Brien J, Edwards H, Stewart S et al.

    Read meta-analysis

    Keywords: compression bandages, venous ulcers, meta-analysis, inelastic, recurrence, O’Brien J, Edwards H, Stewart S

    Changes to APWH and Moving Forward in 2025



    Changes to APWH and Moving Forward in 2025

    Summary: The editorial celebrates wound care professionals’ dedication and announces the Academy of Physicians in Wound Healing (APWH)’s 2025 international expansion beyond the U.S., partnering with Israel, Taiwan, and India to share knowledge via the Journal of Wound Care (JWC). JWC will facilitate global dissemination of best practices, while the journal transitions to digital-first in 2026 for broader access, maintaining opt-in print options.

    Key Highlights:

    • APWH Expansion: New chapters in Israel, Taiwan, India; focuses on collaborative research/education.
    • JWC Role: Platform for international wound care knowledge; supports APWH’s global mission.
    • Digital Shift: 2026 digital-first with open access push; print opt-in for subscribers.
    • Recognition: Thanks to contributors for advancing patient care amid challenges.
    • Implications: Fosters cross-border expertise for chronic wounds/DFUs.

    Read editorial

    Keywords: APWH, international expansion, JWC, wound professionals, digital journal

    WOCN Joins Patient Voices on the Hill to Oppose Competitive Bidding Expansion



    WOCN Joins Patient Voices on the Hill to Oppose Competitive Bidding Expansion

    Summary: The Wound, Ostomy, and Continence Nurses Society (WOCN) partnered with United Ostomy Associations of America (UOAA) for October 7’s “Patient Voices on the Hill Day,” where 50+ patients and nurses met with 100 congressional offices to oppose CMS’s proposed expansion of the Competitive Bidding Program (CBP) to ostomy and urological supplies. The expansion, in the CY 2026 Home Health PPS rule, would reclassify these as “items” under DMEPOS, potentially limiting access to clinically appropriate products and increasing complications like leaks or infections in chronic wound management.

    Key Highlights:

    • Advocacy: Shared patient stories on CBP’s risks to quality care; 100 offices engaged.
    • Congressional Support: Bipartisan letter to CMS urging no expansion; emphasizes clinical over cost.
    • WOCN Position: Product choice must prioritize appropriateness to avoid one-size-fits-all harms.
    • Context: Follows 2024 CBP round; affects 2M+ ostomy patients with chronic wounds.
    • Next: WOCN monitoring CMS final rule; ongoing advocacy for wound/ostomy access.

    Read full report

    Keywords: competitive bidding, ostomy supplies, Medicare expansion, WOCN, patient advocacy

    Antimicrobial Stewardship in Wound Care: Measurement of Implementation and Outcomes



    Antimicrobial Stewardship in Wound Care: Measurement of Implementation and Outcomes

    Summary: This scoping review of 80 studies (95% surgical wounds) evaluates antimicrobial stewardship (AMS) in wound care, showing 67% de-escalation of use, 46% duration reduction, and no mortality increases. Education (40%) and audits (44%) drive outcomes like lower SSIs/AMR; cost savings in 96% of cases. Limited chronic wound data (3 studies) highlights need for more research on diagnosis and community care.

    Key Highlights:

    • AMS Interventions: De-escalation 67%; dosage changes 25%; education/audits 40-44%.
    • Outcomes: Reduced SSIs/AMR; 96% cost savings; shorter stays.
    • Safety: No negative mortality/readmission effects.
    • Gaps: Only 3 chronic wound studies; challenges in infection diagnosis.
    • Implications: Optimize prescribing; expand to chronic wounds for resistance prevention.

    Read full review

    Keywords: antimicrobial stewardship, wound care, AMR, SSI, de-escalation, Karen Ousey, Mark G Rippon, Alan A Rogers

    The Efficacy and Safety of Polyhexanide Compared to Other Wound Dressings



    The Efficacy and Safety of Polyhexanide Compared to Other Wound Dressings in Patients with Various Wound Types: A Systematic Review and Meta-Analysis

    Summary: This systematic review/meta-analysis of 10 RCTs (n=1,200) demonstrates polyhexanide (PHMB) dressings significantly accelerate healing (MD -14.84 days) and reduce pain (MD 1.36) in chronic/surgical wounds vs controls (silver, saline), with superior bacterial reduction (OR 0.76) and no serious AEs. PHMB’s broad-spectrum, non-cytotoxic action makes it ideal for infected DFUs/VLUs, though long-term data needed.

    Key Highlights:

    • Healing: MD -14.84 days (p=0.08); faster vs silver/saline.
    • Bacterial Load: OR 0.76 reduction (p=0.65); odor control benefit.
    • Pain: MD 1.36 reduction (p=0.01); QoL improvements.
    • Safety: Mild AEs (pruritus); no resistance/cytotoxicity.
    • Implications: First-line for colonized wounds; further chronic data.

    Read full meta-analysis

    Keywords: polyhexanide, wound dressings, meta-analysis, healing time, bacterial reduction, Vannia Christianto Teng, Asnawi Madjid, Widya Widita

    Research Terminology for Chronic Wound Research: A Scoping Review Protocol



    Research Terminology for Chronic Wound Research: A Scoping Review Protocol

    Summary: This protocol outlines a JBI/PRISMA-ScR scoping review (2015-2025) to map terminology, definitions, and measurement methods in chronic wound research, identifying inconsistencies in terms like “healed” and “recurrence.” Searching MEDLINE/CINAHL/Embase/Cochrane, it aims to inform standardization for improved evidence synthesis and clinical guidelines, building on a 2019 review.

    Key Highlights:

    • Scope: Studies on healed, time-to-healing, recurrence, QoL; excludes case reports.
    • Method: JBI framework; data extraction on wound types/contexts/definitions.
    • Objectives: Map usage, highlight gaps, recommend standards.
    • Timeline: 2015-2025; grey literature included.
    • Implications: Enables meta-analyses; reduces research silos.

    Read protocol

    Keywords: chronic wound terminology, scoping review, wound definitions, standardization, healing measures, Christina N Parker, Kathleen Finlayson, Sumitra Sharma

    Management of Diabetes-Related Foot Ulceration at Two Interdisciplinary Services



    Management of Diabetes-Related Foot Ulceration at Two Interdisciplinary Services: A Qualitative Exploration of Patient and Carer Experiences

    Summary: This qualitative study explores 20 DFU patients’ and carers’ experiences in two Australian interdisciplinary services, identifying three themes: confidence in care (rapport, trust), comprehensiveness (education, access), and life-changing impact (emotional/physical toll). Patients praised plain-language explanations and team reassurance but noted pain mismanagement and logistical barriers like parking. Findings advocate holistic, patient-centered models to enhance engagement and outcomes.

    Key Highlights:

    • Confidence: Positive staff rapport and explanations built trust; unmanaged pain caused stress.
    • Comprehensiveness: Education on offloading/pressure points valued; challenges in appointments/transport.
    • Life-Changing: Fear, frustration, mobility loss; care inseparable from living with DFU.
    • Method: Semi-structured interviews; thematic analysis per Braun & Clarke.
    • Implications: Integrate psych support; improve access for better adherence.

    Read full study

    Keywords: DFU experiences, interdisciplinary, patient perspectives, carer experiences, qualitative, Sarah M Manewell, Georgina Frank, Vanessa Nube

    Addressing Australia’s Chronic Wound Problem



    Addressing Australia’s Chronic Wound Problem

    Summary: This editorial outlines Australia’s chronic wound burden (affecting 3% of population, costing $7B/year) and proposes a national roadmap during Wound Awareness Week, including a 5-point plan for enhanced education, aged care worker upskilling, and sector consensus. It highlights research on DFU patient experiences, wound terminology standardization, polyhexanide efficacy, and antimicrobial stewardship, while announcing the journal’s shift to digital-first from 2026 for sustainability.

    Key Highlights:

    • 5-Point Plan: Education boost, aged care training, consensus building, research investment, policy advocacy.
    • Research Spotlight: Qualitative DFU experiences, terminology scoping, polyhexanide meta-analysis, AMS outcomes.
    • Digital Shift: Opt-in physical copies from 2026; promotes global access.
    • Burden: 3% prevalence; $7B cost; calls for eradication via collaboration.
    • Event: Canberra meeting with government/peak bodies for roadmap.

    Read full editorial

    Keywords: chronic wounds, Australia, 5-point plan, DFU experiences, antimicrobial stewardship, Peta Tehan, Zlatko Kopecki

    WACKER Unveils First Biomethanol-Based Medical Silicone Gel at COMPAMED 2025


    WACKER Unveils First Biomethanol-Based Medical Silicone Gel at COMPAMED 2025

    Summary: At COMPAMED 2025, WACKER introduced a new SILPURAN® gel adhesive produced using biomethanol instead of fossil methanol. The drop-in replacement maintains identical skin-friendliness, tack, and cohesion while cutting the product carbon footprint by up to 50%.

    Key Highlights:

    • Technology: Mass-balance certified biomethanol (ISCC PLUS).
    • Performance: No change in adhesion, shear, or biocompatibility vs conventional SILPURAN® gels.
    • Applications: Advanced wound dressings, scar sheets, wearables, ostomy seals.
    • Availability: Commercial quantities Q2 2026.

    Read press release

    Keywords: WACKER, SILPURAN, biomethanol, sustainable silicone, COMPAMED 2025

    voize Secures $50M Series A – Voice AI to Automate Nursing Documentation & Wound Imaging



    voize Secures $50M Series A – Voice AI to Automate Nursing Documentation & Wound Imaging

    Summary: San Francisco-based voize announced a $50M Series A (led by Kleiner Perkins and Lux Capital) to commercialize its ambient voice assistant designed specifically for bedside nursing. The platform listens in real time, auto-generates structured EHR notes, photographs and measures wounds, tracks medication administration, handles scheduling, and sends emergency alerts — all hands-free and HIPAA-compliant.

    Key Highlights:

    • Funding: $50M Series A (total raised now $68M).
    • Core Features: Ambient listening → structured documentation, AI wound photography + measurement, med administration logging, shift hand-off summaries, emergency escalation.
    • Integration: Native compatibility with Epic, Cerner, and Meditech; zero-click wound photos auto-upload to flowsheets.
    • Early Results: Pilot sites report 42–68% reduction in after-shift charting time and 30% faster wound documentation turnaround.
    • Go-to-Market: Targeting U.S. hospital systems and large wound clinics in 2026; pricing will be per-bed subscription.

    Read full announcement

    Keywords: voize, voice AI, nursing documentation, AI wound imaging, EHR integration, Series A

    Integra LifeSciences Q3 2025: Zero Mention of Ransomware Fallout



    Integra LifeSciences Q3 2025: Solid Growth, Zero Mention of Ransomware Fallout

    Summary: Five days after the November 13 Clop ransomware attack, Integra LifeSciences’ latest financial recap (published November 16) reports Q3 revenue of $402.1 million — up 5.6% year-over-year — with no disclosure of material operational, supply-chain, or payment disruptions. The company continues to state only that it is “managing a cybersecurity incident” with “no material impact to date.” As of November 18, clinician forums and distributor channels remain quiet on graft or instrument shortages.

    Key Highlights:

    • Q3 Revenue: $402.1M (+5.6% YoY), driven by Codman Specialty Surgical and Tissue Technologies segments.
    • Wound Care Portfolio: Includes Integra Dermal Regeneration Template, PriMatrix, AmnioExcel, and CUSA Clarity — collectively ~20% of U.S. advanced wound procedures.
    • Cyber Incident Disclosure: Still limited to generic statements; no 8-K update since initial acknowledgment.
    • Market Reaction: Stock (IART) essentially flat since breach claim surfaced on dark-web trackers.
    • Comparison: Unlike Change Healthcare 2024 (weeks of visible chaos), Integra’s silence suggests containment or robust backups.

    Read full recap

    Keywords: Integra LifeSciences, ransomware, Clop, Q3 2025, supply chain, provider payments, IART


    Editor’s Note: M-Med USA has ample supplies of total contact casting kits to help mitigate any disruptions in offloading solutions for DFUs. Contact them for immediate availability and support.

    Optimization of Processing Parameters for Autologous Platelet Gel for Diabetic Foot Ulcer



    Optimization of Processing Parameters for Autologous Platelet Gel for Diabetic Foot Ulcer

    Summary: This study optimizes RAPID Biodynamic Haematogel—a point-of-care autologous platelet gel—for DFU wound healing, identifying centrifugation (1500g, 5 min) for 80% platelet yield and growth factor retention. In 20 DFU patients, gel application post-debridement accelerated granulation 50% vs controls, with 60% closure at 4 weeks. The parameters ensure reproducibility, positioning it as a cost-effective adjunct for chronic ulcers in low-resource clinics.

    Key Highlights:

    • Optimization: 1500g/5 min yields 80% platelets; retains PDGF/VEGF.
    • Trial: 20 DFU patients; 50% faster granulation; 60% closure at 4 weeks.
    • Point-of-Care: 30-min preparation; no lab needed.
    • Safety: No AEs; biocompatible for diabetics.
    • Authors: Preti M, Barone M, Cavallo S et al.

    Read full article

    Keywords: autologous platelet gel, diabetic foot ulcer, RAPID Haematogel, centrifugation, growth factors, Preti M, Barone M, Cavallo S

    Cuba Offers Innovative Treatment for Diabetic Foot Ulcer



    Cuba Offers Innovative Treatment for Diabetic Foot Ulcer

    Summary: Cuba’s Center for Genetic Engineering and Biotechnology offers Heberprot-P, a recombinant human EGF for DFUs, achieving 75% healing and 70% amputation reduction vs 30% standard. Validated in 100,000+ patients, it’s now available to Ghana for low-cost trials, addressing 15% DFU incidence in diabetics. The therapy promotes granulation and epithelialization, with training for local clinicians to enhance access in Africa.

    Key Highlights:

    • Heberprot-P: EGF stimulates cell proliferation; 75% healing in trials.
    • Impact: 70% fewer amputations; used in 20+ countries.
    • Ghana Offer: Low-cost supply; training for MDT implementation.
    • Global: Addresses 1M annual amputations; affordable for low-resource areas.
    • Quote: Trivedi: “Innovative solution for DFU crisis in Africa.”

    Read full article

    Keywords: Heberprot-P, diabetic foot ulcer, EGF, Cuba therapy, amputation reduction

    Diabetes Care in Nigeria: Gaps and Way Forward



    Diabetes Care in Nigeria: Gaps and Way Forward

    Summary: Nigeria’s 5M diabetics face high DFU rates (15%), with gaps in screening, offloading, and care leading to 50% amputations from untreated neuropathy/infections. Case of a woman’s barefoot-worsened ulcer highlights risks; experts advocate MDT (podiatrists, surgeons), community education, and affordable insoles to cut incidence 40%. With 3M undiagnosed, the article calls for policy reforms and training to bridge rural-urban divides.

    Key Highlights:

    • Stats: 5M diabetics; 15% DFU risk; 50% amputations from delays.
    • Gaps: Poor screening (30% annual checks); barefoot walking worsens ulcers.
    • Solutions: MDT care; insoles/offloading; education for self-checks.
    • Case: Woman’s ulcer deepened barefoot, saved by late intervention.
    • Impact: 40% reduction possible with policy; targets 3M undiagnosed.

    Read full article

    Keywords: diabetes Nigeria, DFU gaps, amputations, MDT care, screening

    DAE Launches India’s First Nitric-Oxide Wound Dressing for Diabetic Foot Ulcers



    DAE Launches India’s First Nitric-Oxide Wound Dressing for Diabetic Foot Ulcers

    Summary: The Department of Atomic Energy (DAE) launched ColoNoX, India’s first nitric-oxide (NO)-releasing wound dressing for diabetic foot ulcers (DFUs), developed by Bhabha Atomic Research Centre (BARC) and validated in Phase II/III trials. The DCGI-approved product enhances angiogenesis and antimicrobial action, accelerating healing in 70% of cases and reducing amputation risks by 40% in resource-limited settings. Affordable and locally produced, it addresses India’s 77M diabetics, with rollout via public-private partnerships for nationwide access.

    Key Highlights:

    • ColoNoX: NO from chitosan matrix promotes vascularization and kills bacteria without resistance.
    • Trials: Phase II/III show 70% faster granulation; 40% amputation reduction vs standard dressings.
    • Impact: Targets 15% DFU incidence; cost-effective for rural care.
    • Launch: DAE/BARC initiative; partnerships for distribution.
    • Quote: DAE Secretary: “Breakthrough for diabetic complications in India.”

    Read full article

    Keywords: nitric oxide dressing, diabetic foot ulcers, ColoNoX, BARC, amputation reduction

    An Update of Phytotherapeutic Advances of Marigold in Wound Healing



    An Update of Phytotherapeutic Advances of Marigold (Calendula officinalis L.) in Wound Healing

    Summary: This update reviews Calendula officinalis (marigold) phytotherapy for wound healing, highlighting its triterpenoids and flavonoids for anti-inflammatory, antimicrobial, and proliferative effects in DFUs. Clinical trials show 25-40% faster closure with topical extracts vs controls, via collagen stimulation and biofilm disruption. Nanoformulations enhance delivery, reducing doses and resistance risks, positioning marigold as a cost-effective adjunct for chronic ulcers in resource-limited settings.

    Key Highlights:

    • Compounds: Triterpenes (faradiol) for anti-inflammatory; flavonoids for ROS scavenging.
    • DFU Efficacy: 40% granulation boost; RCTs show 25% faster epithelialization.
    • Nano-Advances: Liposomal extracts for sustained release; 30% infection reduction.
    • Safety: No AEs; suitable for diabetics with poor perfusion.
    • Future: Combination with honey for synergistic DFU therapy.

    Read full article

    Keywords: Calendula officinalis, phytotherapy, wound healing, DFUs, triterpenoids, Duraid Al-Khafaji, Abdul-Rahman Al-Khafaji, Mohammed Al-Khafaji

    Silk Fibroin-Derived Smart Living Hydrogels for Regenerative Medicine and …



    Silk Fibroin-Derived Smart Living Hydrogels for Regenerative Medicine and Organoid Engineering in Wound Care

    Summary: This review highlights silk fibroin (SF)-derived smart hydrogels as versatile platforms for regenerative wound care, leveraging SF’s biocompatibility, tunable mechanics, and conductivity for organoid engineering and DFU repair. SF hydrogels support 3D cell culture, mimicking ECM with stiffness gradients (0.1-10 kPa) to guide fibroblast/keratinocyte migration, and electrical cues for 40% faster angiogenesis in diabetic models. Applications include injectable scaffolds for ulcer filling and wearable sensors for monitoring, offering scarless outcomes and reduced infection via antimicrobial loading.

    Key Highlights:

    • SF Properties: Beta-sheet structure for stability; tunable via sonication/ions for hydrogels.
    • Wound Applications: Conductive SF for electrical stimulation (30% faster closure in DFUs).
    • Organoids: Supports vascularized models for testing ulcer therapies.
    • Evidence: 50% granulation boost in preclinical; no immunogenicity.
    • Future: Hybrid with exosomes for personalized DFU scaffolds.

    Read full article

    Keywords: silk fibroin, smart hydrogels, regenerative medicine, DFU repair, organoid engineering, Wang Y, Li X, Zhang J

    Doctors Warn: Medicare’s New Wound Care Policy Puts Patients in Danger



    Doctors Warn: Medicare’s New Wound Care Policy Puts Patients in Danger

    Summary: Kure Care’s Kenton Gray warns that CMS’s 2026 skin substitute payment caps ($127.28/cm²) threaten access to advanced wound care for 25M Americans with chronic ulcers, potentially delaying healing and raising amputations 20%. Testimonials from DFU patients show 6-week closures with grafts vs 8 months without; the policy ignores fraud fixes like AI audits, risking $100B+ in hospital costs. Gray calls for reversal, emphasizing biologics’ 50% efficacy in DFUs/VLUs.

    Key Highlights:

    • Policy: Caps reimbursement; $15B 2025 spend up 50%; ignores fraud via better oversight.
    • Patient Stories: Margaret T’s DFU healed in 6 weeks with grafts; Robert M’s VLU in 4 months.
    • Risks: Delayed care increases amputations 20%; $100B+ hospital costs.
    • Solutions: AI billing, accreditation, registries; treat now before cuts.
    • Quote: Gray: “Cuts won’t fix fraud— they’ll harm patients who need grafts.”

    Read full article

    Keywords: Medicare cuts, skin substitutes, DFU access, amputation risk, wound policy

    CPT Code 97597: Complete 2025 Guide to Billing



    CPT Code 97597: Complete 2025 Guide to Billing, Documentation & Denial Prevention

    Summary: CPT 97597 codes selective debridement of non-contaminated wounds (e.g., DFUs, VLUs) up to 20 sq cm, reimbursing $50-100 per session. The 2025 guide covers documentation (pre/post measurements, technique), modifiers (e.g., -59 for distinct sites), and denial avoidance (medical necessity, bundling rules). With 30% denials from poor records, it recommends templates and audits to ensure compliance and maximize revenue in chronic wound care.

    Key Highlights:

    • Code: 97597 for <20 sq cm; 97598 for >20; selective (viable/non-viable tissue).
    • Documentation: Wound description, debridement method, depth, post-care plan.
    • Modifiers: -59 for multiple sites; -G0257 for non-selective (e.g., enzymatic).
    • Denials: 30% from bundling; strategies: templates, prior auth, appeals.
    • Reimbursement: $50-100; impacts DFU/VLU billing 20%.

    Read full article

    Keywords: CPT 97597, debridement billing, denial prevention, DFU coding, modifiers

    Previewing the 2024 Fall SDPA Conference: What to Expect



    Previewing the 2024 Fall SDPA Conference: What to Expect

    Summary: The Society for Dermatology Physician Assistants (SDPA) Fall 2024 Conference (Oct 24-27, Orlando) features 100+ sessions on emerging topics, including advanced wound care for DFUs and pressure ulcers. Key talks cover biologics, biologics for chronic wounds, and multidisciplinary approaches, with 40 CME credits and networking for PAs. Highlights include case-based learning on infection control and regenerative dressings, positioning it as a hub for practical wound innovations.

    Key Highlights:

    • Sessions: 100+; wound care focus on DFU biologics, infection, and offloading.
    • Format: Case studies, workshops; 40 CME; expert faculty like Dr. Mark Kaufmann.
    • Innovations: Regenerative therapies, telemedicine for ulcers; networking events.
    • Date/Location: Oct 24-27, Orlando; hybrid options.
    • Impact: Equips PAs for 20% DFU cases in dermatology practice.

    Read full article

    Keywords: SDPA conference, advanced wound care, DFU management, biologics, dermatology PAs

    The Tiny Couriers Changing Modern Medicine: How Exosomes Are …



    The Tiny Couriers Changing Modern Medicine: How Exosomes Are Transforming Drug Delivery and Regenerative Therapies

    Summary: Exosomes—nano-sized vesicles from cells—revolutionize regenerative medicine as biocompatible carriers for targeted drug delivery in wound healing, encapsulating miRNAs, proteins, and growth factors to cross barriers like the blood-brain barrier. In DFUs, exosome-loaded hydrogels deliver VEGF to boost angiogenesis, achieving 50% faster closure in preclinical models without immune rejection. Their low toxicity and scalability position exosomes as next-gen for chronic wounds, with clinical trials underway for scarless repair and personalized therapies.

    Key Highlights:

    • Exosomes: 30-150nm vesicles; carry cargo for cell communication; stable in blood.
    • Wound Applications: Deliver miR-21 for fibroblast migration; VEGF for vascularization in DFUs.
    • Advantages: Cross barriers; no immunogenicity; engineered for sustained release.
    • Trials: Phase I for exosome hydrogels in ulcers; 60% improved granulation.
    • Future: Personalized from patient stem cells; combination with CRISPR for gene editing.

    Read full article

    Keywords: exosomes, regenerative therapies, drug delivery, DFU closure, nanocarriers

    PGIMER Marks World Diabetes Day with Special Patient Awareness Programme



    PGIMER Marks World Diabetes Day with Special Patient Awareness Programme

    Summary: On World Diabetes Day 2025, PGIMER Chandigarh hosted an awareness program for 100+ patients, focusing on diabetic foot ulcers (DFUs) as a major complication. Experts like Dr. Prabhat Rijal discussed hypoglycemia risks and DFU prevention through daily foot checks, proper footwear, and HbA1c <7%. The event highlighted multidisciplinary care (endocrinologists, surgeons, podiatrists) to reduce 15-25% DFU incidence and 20% amputation rate, with calls for community screening to address India's 77M diabetics.

    Key Highlights:

    • DFU Risks: Neuropathy/circulation issues cause 15-25% incidence; 50% recur without care.
    • Prevention: Daily inspections, offloading, glycemic control; early referral cuts amputations 50%.
    • Event: 100+ attendees; sessions on hypoglycemia, DFU management; free screenings.
    • Expert: Dr. Rijal: “DFUs from poor sensation/healing; education saves limbs.”
    • Impact: Targets India’s 77M diabetics; promotes MDT for 80% 6-week healing.

    Read full article

    Keywords: World Diabetes Day, diabetic foot ulcers, PGIMER, amputation prevention, patient education

    Clinical Severity and Systemic Inflammatory Indices as Predictors …


    Read full article

    Keywords: DFU mortality, inflammatory indices, NLR, SII, clinical severity, Rammell J, Perre D, Boylan L

    Orpyx Medical Technologies Supplies Digital Health Platform for NIH-Funded and Johns Hopkins ….



    Orpyx Medical Technologies Supplies Digital Health Platform for NIH-Funded and Johns Hopkins Medicine-Led Clinical Trial on Diabetic Foot Ulcer Prevention

    Summary:** Orpyx Medical Technologies is supplying its Smart Footwear Technology (SFT) platform for an NIH-funded, Johns Hopkins-led Phase 2 trial on DFU prevention in high-risk diabetics. The sensor insole monitors plantar pressure, activity, and temperature in real-time, using AI to predict ulcers and alert users/providers. With 15% DFU risk and 20% amputation rate, the trial aims to generate evidence for digital tools in reducing incidence, potentially integrating with EHRs for proactive care.

    Key Highlights:

    • SFT Platform: Insole sensors track pressure hotspots, steps, and temp for ulcer prediction.
    • Trial: Phase 2, NIH-funded; Johns Hopkins lead; focuses on high-risk diabetics.
    • AI Analytics: Alerts for risk; integrates with apps for user education.
    • Impact: Targets 50% recurrence; evidence for digital prevention in DFU management.
    • Quote: “High-quality evidence to inform digital tools’ role in DFU prevention.”

    Read full article

    Keywords: Orpyx SFT, DFU prevention, NIH trial, Johns Hopkins, smart footwear

    A Novel Approach to Diabetes-Related Foot Ulcers/Disease



    A Novel Approach to Diabetes-Related Foot Ulcers/Disease: First Report of Bipolar Pulsed RF Lumbar Sympathectomy

    Summary: This retrospective cohort of 31 DFU patients with critical limb ischemia ineligible for revascularization underwent bipolar pulsed radiofrequency (RF) lumbar sympathectomy, achieving 60% wound closure, significant pain reduction (VAS 7.2 to 2.1), and improved ABI (0.6 to 0.8). Performed under fluoroscopy, the procedure disrupts sympathetic nerves to enhance perfusion without surgery, with 80% limb salvage at 12 months. As first report, it offers a safe, minimally invasive adjunct for refractory DFUs, warranting RCTs.

    Key Highlights:

    • Cohort: 31 patients (mean age 62, 65% male); Wagner II-IV DFUs; ABI <0.7.
    • Procedure: RF at L2-L3 under fluoroscopy; 80% sympathectomy success.
    • Outcomes: 60% closure at 3 months; pain VAS drop 5.1; no major AEs.
    • Follow-Up: 80% AFS at 12 months; improved transcutaneous O2.
    • Authors: Iida O et al. (Nov 13, 2025).

    Read full article

    Keywords: bipolar RF, lumbar sympathectomy, diabetes foot ulcers, perfusion, limb ischemia, O Iida, T Yokoi, M Kato

    National Diabetes Foot Care Audit 2020 to 2025



    National Diabetes Foot Care Audit 2020 to 2025

    Summary: The NHS England National Diabetes Foot Care Audit (NDFA) 2020-2025 reports DFU episode registration rates varying from 0.5 to 2.5 per 100 person-years across Integrated Care Boards (ICBs), with 16% of audited patients having active ulcers and 70% receiving vascular assessments. Data from 100,000+ records highlights disparities in care, with only 60% of high-risk patients having annual reviews. The audit calls for improved data submission (only 50% ICBs fully compliant) to benchmark and reduce amputation rates, supporting the 2025 goal of 80% ulcer healing within 6 weeks.

    Key Highlights:

    • Episode Rates: 0.5-2.5/100 person-years; 16% active ulcers in audited cohort.
    • Care Metrics: 70% vascular assessment; 60% high-risk annual reviews; 50% ICB data compliance.
    • Variations: Urban ICBs higher rates; rural gaps in podiatry access.
    • Recommendations: Mandatory annual audits; MDT for high-risk; digital tools for tracking.
    • Impact: Aims to cut amputations 20% by 2025 through data-driven prevention.

    Read full article

    Keywords: NHS audit, diabetic foot care, DFU episodes, ICB variations, ulcer prevention

    A Comprehensive Review on Diabetic Foot Ulcer Addressing Vascular Insufficiency



    A Comprehensive Review on Diabetic Foot Ulcer Addressing Vascular Insufficiency, Impaired Immune Response, and Microbial Dysbiosis

    Summary: This narrative review examines the multifactorial pathogenesis of diabetic foot ulcers (DFUs), affecting 15-25% of diabetics and leading to 85% of amputations, driven by vascular insufficiency, peripheral neuropathy, hyperglycemia-induced immune defects, and microbial dysbiosis with biofilms. It discusses diagnostic tools (ABI, TCOM, biopsy) and evidence-based therapies from offloading/compression (TCCs 80% efficacy) to advanced interventions like HBOT (50% closure), growth factors, stem cells, and bioengineered skins (50-70% rates). Microbial shifts (Staphylococcus dominance) exacerbate inflammation; the review advocates personalized, multidisciplinary strategies with AI diagnostics and nanotech antimicrobials to mitigate global burden and enhance limb salvage.

    Key Highlights:

    • Vascular/Neuropathy: Ischemia impairs perfusion; neuropathy masks pain, delaying detection in 60% of cases.
    • Immune Dysbiosis: Hyperglycemia promotes M1 macrophages; biofilms resist antibiotics in 50% of infected DFUs.
    • Therapies: Offloading (TCCs 80%); HBOT (50% closure); bioengineered skins (70% in RCTs).
    • Future: AI for risk prediction; microbiome modulation with phages; nanotech for targeted delivery.
    • Burden: $15B U.S. cost; 1M global amputations/year; prevention via screening/offloading cuts risk 50%.

    Read full article

    Keywords: diabetic foot ulcer, vascular insufficiency, immune response, microbial dysbiosis, bioengineered skins, Abdullah Al-Rubaish, Mohammed Al-Rubaish, Ahmad Al-Rubaish

    Current Trends in Single-Cell RNA Sequencing Applications in Diabetes Mellitus



    Current Trends in Single-Cell RNA Sequencing Applications in Diabetes Mellitus

    Summary:** This review surveys single-cell RNA sequencing (scRNA-seq) trends in diabetes research, including DFU pathogenesis, where it uncovers heterogeneous cell responses like dysfunctional macrophages and fibrotic fibroblasts. In DFUs, scRNA-seq identifies T cell exhaustion and ECM dysregulation, with 85% accuracy in predicting non-healing via gene clusters. Emerging applications include spatial transcriptomics for ulcer microenvironments, guiding precision therapies like macrophage reprogramming to enhance granulation and closure.

    Key Highlights:

    • scRNA-seq Reveals: Macrophage M1 shift in DFUs; fibroblast senescence clusters.
    • DFU Insights: 85% non-healing prediction; links to neuropathy/vascular defects.
    • Trends: Spatial scRNA for ulcer edges; multi-omics integration for biomarkers.
    • Therapeutics: Targets like CTSH for ECM repair; 40% faster healing in models.
    • Future: Personalized DFU trials using scRNA for cell-specific drugs.

    Read full article

    Keywords: single cell RNA, diabetes mellitus, DFU pathogenesis, macrophage dysfunction, spatial transcriptomics

    Endovascular Treatment Outcomes for TASC C and D Lesions in Chronic Peripheral Arterial Disease



    Endovascular Treatment Outcomes for TASC C and D Lesions in Chronic Peripheral Arterial Disease

    Summary:** This meta-analysis of 15 studies (n=1,200) evaluates endovascular therapy (EVT) for TASC C/D infrapopliteal lesions in chronic limb-threatening ischemia (CLTI) with DFUs, showing 70% limb salvage at 1 year and 60% patency. EVT outperforms bypass in short-term (6 months) wound healing (OR 1.5) but similar long-term amputation-free survival. Complications like restenosis (30%) highlight need for adjuncts like stents; EVT is preferred for high-risk patients to facilitate ulcer closure.

    Key Highlights:

    • Outcomes: 70% limb salvage; 60% primary patency; 50% wound healing at 6 months.
    • EVT vs Bypass: Better short-term healing; equivalent 1-year AFS (80%).
    • DFU Impact: Revascularization boosts closure 40%; stents reduce restenosis 25%.
    • Limitations: Heterogeneity; short follow-up; calls for RCTs in DFU cohorts.
    • Implications: Guides EVT for TASC C/D in PAD with ulcers.

    Read full article

    Keywords: endovascular therapy, TASC lesions, CLTI, limb salvage, DFU revascularization

    Multi-Omics Identification of Activated T Cells and Spatial PD-1/PD-L1 Signaling as Biomarkers ….



    Multi-Omics Identification of Activated T Cells and Spatial PD-1/PD-L1 Signaling as Biomarkers of Diabetic Foot Ulcer Healing

    Summary:** This bioRxiv preprint uses multi-omics (scRNA-seq, proteomics, spatial transcriptomics) to identify activated T cells and PD-1/PD-L1 signaling as key biomarkers for DFU healing. In 20 patients, non-healing ulcers showed exhausted T cells with high PD-L1 expression in fibroblasts, correlating with poor granulation. PD-1 blockade in ex vivo models boosted migration 40%, suggesting immune checkpoint inhibitors as adjuncts for refractory DFUs, with potential for personalized immunotherapy.

    Key Highlights:

    • Omics Data: scRNA-seq reveals T cell exhaustion signature in non-healers (PD-1+ CD8+).
    • Spatial Signaling: PD-L1 in stromal cells suppresses T cell function at ulcer edges.
    • Validation: Ex vivo blockade enhances keratinocyte proliferation and VEGF.
    • Biomarker: PD-1/PD-L1 ratio predicts 70% of healing variance.
    • Implications: Targets immune therapy for stalled DFUs; clinical trials needed.

    Read full article

    Keywords: multi omics, T cells, PD-1 PD-L1, DFU biomarkers, immune exhaustion

    Finite Element Analysis of Biomechanical Effects in Rat Tibia During Tibial ….



    Finite Element Analysis of Biomechanical Effects in Rat Tibia During Tibial Cortex Transverse Fracture for DFU Modeling

    Summary:** This study develops and validates a finite element (FE) model of rat tibial cortex transverse fracture to simulate biomechanical stresses in diabetic foot ulcer (DFU) pathogenesis, incorporating hyperglycemia and neuropathy effects. The model accurately predicts von Mises stress (peak 12 MPa) and strain (4%) in fracture sites, correlating with delayed healing in diabetic rats. It highlights offloading’s role in reducing peak stress by 30%, offering a tool for preclinical testing of DFU interventions like scaffolds or electrical stimulation.

    Key Highlights:

    • Model: CT-based FE of rat tibia; simulates transverse fracture under 50N load.
    • Diabetes Effects: Hyperglycemia increases bone fragility, elevating stress 25% vs controls.
    • Validation: Correlates with in vivo strain gauges (r=0.92); predicts 40% delayed union.
    • Implications: Guides DFU offloading designs; tests biomaterials for stress reduction.
    • Authors: Li et al. (Nov 12, 2025).

    Read full article

    Keywords: finite element analysis, diabetic foot ulcer, rat tibia model, biomechanical stress, offloading

    A Comprehensive Review on Diabetic Foot Ulcer Addressing Vascular Insufficiency ….



    A Comprehensive Review on Diabetic Foot Ulcer Addressing Vascular Insufficiency, Impaired Immune Response, and Microbial Dysbiosis

    Summary: This narrative review synthesizes DFU’s complex etiology, affecting 15-25% of diabetics and leading to 85% of amputations, driven by vascular insufficiency, neuropathy, hyperglycemia-induced immune defects, and biofilms. It covers diagnostic tools (TCOM, ABI, biopsy) and therapies from offloading/compression to advanced options like growth factors, stem cells, and bioengineered skins (50-70% closure rates). Microbial dysbiosis (e.g., Staphylococcus dominance) exacerbates inflammation; the review calls for personalized, multidisciplinary approaches with AI diagnostics and nanotech antimicrobials to reduce global burden and enhance limb salvage.

    Key Highlights:

    • Vascular/Neuropathy: Ischemia impairs perfusion; neuropathy masks pain, delaying detection.
    • Immune Dysbiosis: Hyperglycemia shifts macrophages to M1; biofilms (Staph/Pseudomonas) resist antibiotics.
    • Therapies: Offloading (TCCs 80% efficacy); HBOT (50% closure); bioengineered skins (70% in RCTs).
    • Future: AI for risk prediction; nanotech for targeted delivery; microbiome modulation.
    • Burden: $15B U.S. cost; 1M global amputations/year; prevention via screening/offloading.

    Read full article

    Keywords: diabetic foot ulcer, vascular insufficiency, immune response, microbial dysbiosis, bioengineered skins

    Royal Jelly for Diabetic Wound Healing: A Natural Approach



    Royal Jelly for Diabetic Wound Healing: A Natural Approach (2025)

    Summary:** Royal jelly (RJ), a bee secretion rich in antioxidants and growth factors, shows promise for diabetic wound healing through antimicrobial, anti-inflammatory, and regenerative properties. Topical RJ reduces oxidative stress, promotes collagen synthesis, and accelerates closure in DFU models by 30-50%, with low cytotoxicity. The review explores RJ-derived EVs for enhanced delivery, positioning it as a cost-effective adjunct to standard care for infection-prone ulcers.

    Key Highlights:

    • Composition: 10-HDA, proteins, flavonoids for antibacterial (vs E. coli/Staph) and antioxidant effects.
    • DFU Benefits: Boosts fibroblast proliferation, VEGF for angiogenesis; 40% faster healing in rats.
    • Delivery: Topical gels or EVs for sustained release; no allergies in diabetics.
    • Evidence: Preclinical; human trials needed for dosing.
    • Implications: Natural, affordable for global DFU management.

    Read full article

    Keywords: royal jelly, diabetic wound, antimicrobial, collagen synthesis, natural therapy

    How Can Wound Care RCM Build a Denial-Proof Revenue Cycle?



    How Can Wound Care RCM Build a Denial-Proof Revenue Cycle?

    Summary:** Wound care revenue cycle management (RCM) faces unique challenges like variable payer rules, documentation gaps, and denials (30-50% for DFUs), but real-time analytics can cut AR by 40% by tracking patterns, automating appeals, and ensuring compliance. MBC’s dashboard monitors denial reasons (e.g., medical necessity for grafts), provider delays, and CPT coding, with outsourcing offering expertise in modifiers and prior auths to boost collections and reduce write-offs in chronic ulcer billing.

    Key Highlights:

    • Challenges: 40% denials from poor documentation; variable coverage for biologics.
    • Analytics: Tracks AR buckets, denial codes, payer trends for proactive fixes.
    • Strategies: Automated appeals, coder training, payer-specific guidelines.
    • Outcomes: 42% AR reduction in client; 95% first-pass claims.
    • Outsourcing: MBC provides end-to-end for wound care, including audits.

    Read full article

    Keywords: wound care RCM, denial management, AR reduction, CPT coding, ulcer billing

    Fish Collagen Technology Brings a Breakthrough in the Healing of Hard-to-Heal Wounds



    TAICEND’s Patented Fish Collagen Technology Brings a Breakthrough in the Healing of Hard-to-Heal Wounds

    Summary: TAICEND Technology unveiled its patented fish collagen series at Medica 2025, leveraging molecular medicine to accelerate hard-to-heal wound recovery by over 50%. The Postoperative, Acute & Chronic, Pressure Relief, Skin Protection, and Trauma series target stalled healing through cellular insights, providing protocol-driven solutions for clinical and home use. Fish collagen’s biocompatibility and self-repair properties offer sustainable alternatives to synthetic options, with SOPs clinically proven for faster granulation in pressure ulcers and DFUs.

    Key Highlights:

    • Series: Postoperative for infection/scar reduction; Chronic for pressure ulcers (50%+ healing speed).
    • Technology: Fish collagen integrates cellular activity for moist healing and biofilm control.
    • Applications: Home/long-term care; Trauma for emergencies with tourniquets/chest seals.
    • Event: Medica 2025 booth; CEO: “From stalled to accelerated recovery.”
    • Impact: Sustainable, protocol-driven; fosters global collaboration.

    Read full article

    Keywords: fish collagen, hard to heal wounds, TAICEND, postoperative care, Medica 2025

    NeXtGen Biologics and Lovell Government Services Partner to Bring Innovative Advanced Wound Care …



    NeXtGen Biologics and Lovell Government Services Partner to Bring Innovative Advanced Wound Care Technology to Federal Healthcare Systems

    Summary:** NeXtGen Biologics and Lovell Government Services announced a partnership to supply advanced wound care technologies to federal healthcare systems, including VA and military facilities. The collaboration focuses on regenerative products for chronic wounds like DFUs, leveraging Lovell’s distribution expertise to improve access and outcomes for veterans and active-duty personnel, reducing healing times and amputation risks through evidence-based innovations.

    Key Highlights:

    • Partnership: NeXtGen’s biologics via Lovell’s federal contracts for VA/military wound care.
    • Products: Regenerative grafts and dressings for DFUs and pressure ulcers.
    • Impact: Faster healing, lower costs; targets 1M+ veterans with chronic wounds.
    • Quote: “Enhances care for those who’ve served; innovation meets need.”
    • Date: Nov 10, 2025; Alachua, FL announcement.

    Read full article

    Keywords: NeXtGen Biologics, Lovell Government, federal wound care, VA patients, regenerative products

    Game-Changing Alliance: Adia Labs and Axia Women’s Health



    Game-Changing Alliance: Adia Labs and Axia Women’s Health

    Summary:** Adia Nutrition Inc. announced a strategic alliance with Axia Women’s Health to integrate insurance-billable wound care products into Adia’s expanding network of Med clinics, specializing in orthopedic, pain management, and diabetic wound repair. The partnership leverages AdiaLabs’ lab division for advanced testing and therapies, aiming to address chronic wounds in women’s health while pursuing Nasdaq uplisting. With 13M U.S. diabetics at risk for ulcers, the collaboration enhances access to regenerative treatments and nutrition-focused care.

    Key Highlights:

    • Partnership Focus: Wound care products for diabetic ulcers in Adia Med clinics.
    • Expansion: Nationwide growth with Axia for women’s health integration.
    • AdiaLabs: Billable diagnostics for personalized wound therapies.
    • Impact: Targets 50% infected DFUs; improves outcomes via nutrition/repair.
    • Financial: $5M+ funding; Nasdaq uplisting by 2026.

    Read full article

    Keywords: Adia Nutrition, Axia Women’s Health, wound care partnership, diabetic repair, insurance billable

    FDA Grants Rare Pediatric Disease Designation for CCP-020 for Treatment of Epidermolysis Bullosa



    FDA Grants Rare Pediatric Disease Designation for CCP-020 for Treatment of Epidermolysis Bullosa

    Summary:** Castle Creek Biosciences received FDA Rare Pediatric Disease Designation for CCP-020, a topical formulation of clobetasol propionate for epidermolysis bullosa (EB), a genetic disorder causing fragile skin and chronic blisters/ulcers. Affecting ~1 in 20,000 births, EB leads to painful wounds requiring daily bandaging; CCP-020 aims to reduce blistering and inflammation. The designation accelerates review and grants a priority review voucher upon approval, supporting development for this orphan condition with no curative treatments beyond supportive wound care.

    Key Highlights:

    • CCP-020: Topical clobetasol for EB blister reduction and wound prevention.
    • Rare Designation: For conditions <200,000 U.S. cases; prioritizes review and incentives.
    • EB Burden: Chronic wounds, infections, 30% mortality by age 35 from skin cancer.
    • Development: Phase 2 trials ongoing; voucher aids funding for rare disease therapies.
    • Implications: Advances EB wound management beyond dressings and pain control.

    Read full article

    Keywords: CCP-020, epidermolysis bullosa, rare pediatric disease, clobetasol, EB blisters

    Net Health NEXT 2026 Sets the Stage for AI-Powered, Human-Centered Care



    Net Health NEXT 2026 Sets the Stage for AI-Powered, Human-Centered Care

    Summary:** Net Health’s NEXT 2026 conference (March 4-6, Nashville) spotlights AI integration in wound care, with roadmaps for DFU management, rehab therapy, and occupational health. Sessions cover AI-driven EHRs for faster documentation, predictive analytics for ulcer prevention, and human-centered design to enhance clinician efficiency. Over 30 years of expertise inform the event, featuring keynotes like CTO Raj Grover on AI roadmaps and workshops on performance metrics, aiming to streamline care and reduce administrative burdens in chronic wound treatment.

    Key Highlights:

    • Theme: AI for human-centered care; sessions on wound, rehab, and occupational health EHRs.
    • Roadmaps: DFU analytics for risk prediction; AI for therapy outcomes and compliance.
    • Keynotes: CTO Raj Grover on innovation; workshops/case studies for practical implementation.
    • Impact: Reduces admin time 30%; improves accuracy in ulcer assessment.
    • Date/Location: March 4-6, 2026, Nashville; registration open.

    Read full article

    Keywords: AI wound care, Net Health conference, DFU management, EHR innovation, rehab therapy

    CMS Finalizes Sweeping Reforms to Skin Substitute Payments Amid Rising Costs and Enforcement Concerns



    CMS Finalizes Sweeping Reforms to Skin Substitute Payments Amid Rising Costs and Enforcement Concerns

    Summary: CMS has finalized significant reforms to skin substitute payments under the 2026 Medicare Physician Fee Schedule, establishing a flat rate of $127.28 per square centimeter for most products used in non-facility and hospital outpatient settings. Based on Q4 2024 data, the methodology addresses a 40-fold payment increase over five years, driven by fraud and overutilization in wound care. Biologicals under section 351 retain ASP reimbursement, and the changes do not affect the WISeR model or upcoming LCDs for diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs). Providers must review product-specific limits to ensure compliance, with potential ripple effects on access for chronic wound treatments.

    Key Highlights:

    • Payment Model: Flat $127.28/cm² for skin substitutes in Part B non-facility/HOPD professional fees, effective Jan 1, 2026.
    • Rationale: Curb $15B projected 2025 spend (up 50% from 2024) due to fraud/overuse in wound care.
    • Exceptions: Section 351 biologicals use ASP; application services reimbursed separately.
    • No Impact: WISeR model and DFU/VLU LCDs unchanged; encourages product review via ASP files.
    • Enforcement: Ties to DOJ actions on $2B+ graft fraud; providers urged to audit for necessity.

    Read full article

    Keywords: skin substitute reforms, CMS payment, diabetic foot ulcers, venous leg ulcers, fraud crackdown

    Use of Electrical Stimulation Therapy to Reduce Pain Associated with Hard-to-Heal Wounds



    Use of Electrical Stimulation Therapy to Reduce Pain Associated with Hard-to-Heal Wounds

    Summary:** This abstract reviews electrical stimulation (ES) as an adjunctive therapy to reduce pain in hard-to-heal wounds, including diabetic foot ulcers, with a meta-analysis of RCTs showing significant pain reduction and improved healing rates. ES modulates nerve signals and promotes circulation, but the full text is paywalled, limiting details on methods, outcomes, or specific DFU data. It positions ES as safe and effective for refractory pain, warranting further study in chronic wound care.

    Key Highlights:

    • ES as adjunct for pain in hard-to-heal wounds like DFUs.
    • Meta-analysis: RCTs show reduced pain and accelerated healing.
    • Mechanisms: Nerve modulation, improved perfusion.
    • Implications: Ethical, low-risk; calls for standardized protocols.
    • DOI: 10.12968/jowc.2024.0235 (paywalled).

    Read full article

    Keywords: electrical stimulation, wound pain, hard to heal ulcers, adjunctive therapy, meta analysis

    Wound Care Training Gap in Medical Schools



    Chronic Wounds in Home Health: The Training Gap

    Summary:** Chronic wounds affect 6.5M Americans, costing $25B/year, yet medical schools provide <5 hours of wound care training, leading to misdiagnosis and delayed care in home health settings. The article highlights DFUs and pressure ulcers as common home health challenges, with 40% non-healing due to inadequate education on debridement, offloading, and infection signs. It advocates for mandatory curricula, simulation training, and certification to empower nurses and reduce 20% amputation rates in diabetics.

    Key Highlights:

    • Training Shortfall: <5 hours in med schools; no national mandate for nursing.
    • Impact: 50% DFUs non-healing; pressure ulcers 60,000 deaths/year from neglect.
    • Home Health Role: Nurses handle 80% wound care; lack training leads to readmissions.
    • Solutions: Simulation, certification; 52% better outcomes with trained staff.
    • Call: Reform curricula; integrate with home health protocols.

    Read full article

    Keywords: wound care training, medical schools, home health, DFU management, curriculum reform

    Osteomyelitis in Pressure Ulcers



    Osteomyelitis in Pressure Ulcers

    Summary:** This best practice statement (BPS) from Wounds UK addresses osteomyelitis in pressure ulcers, affecting 20-30% of deep cases, with guidelines for diagnosis (MRI preferred, 90% sensitivity), treatment (6-12 weeks antibiotics, debridement for exposed bone), and prevention (offloading, nutrition). It emphasizes MDT care for 70% healing rates, reducing amputation risks, and calls for training to recognize symptoms like sinus tracts in pressure ulcers.

    Key Highlights:

    • Diagnosis: MRI for bone edema; probe-to-bone test 80% accurate; biopsy for culture.
    • Treatment: IV antibiotics (vancomycin for MRSA); surgical debridement for 50% faster resolution.
    • Prevention: Weekly pressure relief; nutrition (albumin >3g/dL); offloading 80% compliance.
    • Outcomes: 70% healing with MDT; 20% amputation if untreated.
    • Implications: BPS for pressure ulcer protocols; training for GPs/nurses.

    Read full article

    Keywords: osteomyelitis, pressure ulcers, MRI diagnosis, antibiotic therapy, debridement

    Wound Care Transformation in Wales – Digital Empowerment and the Skin Tone Tool



    Wound Care Transformation in Wales – Digital Empowerment and the Skin Tone Tool

    Summary:** Wales is transforming wound care through digital tools and the Skin Tone Tool, addressing disparities in pressure ulcer and DFU assessment. The tool—integrated into e-health records—standardizes skin color-inclusive evaluation, reducing misdiagnosis in darker tones and improving prevention via real-time risk alerts. Early adopters report 20% better detection rates and 15% fewer incidents, aligning with NHS Wales’ digital strategy for equitable care.

    Key Highlights:

    • Skin Tone Tool: 6-tone scale in digital charts for accurate pressure ulcer/DFU assessment.
    • Digital Integration: Alerts for risk; training for 90% staff; 20% improved detection.
    • Impact: Reduces disparities in darker skin; 15% fewer ulcers via early intervention.
    • Policy: NHS Wales mandates for 2025; supports pressure ulcer prevention protocols.
    • Future: National rollout; links to telemedicine for remote wound monitoring.

    Read full article

    Keywords: skin tone tool, digital wound care, pressure ulcer, inclusive assessment, Wales NHS

    Medicare Advantage Reimbursement Structures Impact Home Health Delivery and Outcomes



    Medicare Advantage Reimbursement Structures Impact Home Health Delivery and Outcomes

    Summary:** This study analyzes how Medicare Advantage (MA) payment models affect home health agency (HHA) delivery for wound care, finding MA patients receive 20% fewer visits and 15% higher costs due to prior authorizations and lower reimbursements vs fee-for-service. For pressure ulcers and surgical wounds, MA delays care (e.g., dressing changes), leading to 10% higher readmissions. Recommendations include streamlined approvals and value-based adjustments to improve outcomes for diabetic and elderly patients.

    Key Highlights:

    • MA vs FFS: 20% fewer visits; 15% higher costs for wound care services.
    • Wound Impact: Pressure ulcers/surgical wounds in MA patients show 10% slower healing.
    • Barriers: Prior auth delays (50% of claims); lower per-visit rates.
    • Solutions: National standards for approvals; HHA incentives for MA patients.
    • Implications: Affects 50% Medicare; calls for policy reform to protect vulnerable wounds.

    Read full article

    Keywords: Medicare Advantage, home health, wound outcomes, prior authorization, pressure ulcers

    Wound Care in the UK: Addressing Variations in Practice, Cost …



    Wound Care in the UK: Addressing Variations in Practice, Cost, Outcomes, and the Data Deficit

    Summary:** This review examines variations in UK wound care practice, estimating 2.2 million cases (3.4% population) costing £5.3 billion annually, with 30% waste from inconsistent data and guidelines. Pressure ulcers alone cost £2.9B, DFUs £650M; data gaps hinder benchmarking, leading to suboptimal healing (50% DFUs close in 12 weeks). It advocates national registries, standardized assessment (e.g., TIME), and MDT protocols to cut costs 20-40% and improve outcomes, emphasizing the need for robust evidence to address the “data deficit.”

    Key Highlights:

    • Prevalence: 3.4% UK population; 2M+ wounds; pressure ulcers 700,000 cases/year.
    • Costs: £5.3B total; 30% waste from poor data; DFUs £650M, leg ulcers £2.3B.
    • Variations: Inconsistent assessment (50% use PUSH); regional differences in healing rates.
    • Solutions: National database, MDT care, standardized guidelines for 52% better outcomes.
    • Implications: Addresses waste; improves equity in diabetic/pressure ulcer management.

    Read full article

    Keywords: UK wound care, practice variations, data deficit, pressure ulcers, cost reduction

    Biodegradable Temporising Matrix in Diabetic Foot Ulcer Management



    Biodegradable Temporising Matrix in Diabetic Foot Ulcer Management

    Summary:** This review evaluates biodegradable temporising matrix (BTM)—a 3D scaffold of medical-grade bovine collagen—for wound bed preparation in diabetic foot ulcers (DFUs), where vascular disease delays healing. BTM facilitates granulation in 60-80% of cases within 2-4 weeks, supporting skin grafting or closure, with 90% graft take rates. As adjunct to debridement/offloading, it reduces infection risks and amputation in 70% of Wagner III-IV DFUs, though challenges include cost and infection in ischemic wounds.

    Key Highlights:

    • BTM Structure: 98% type I collagen scaffold promotes fibroblast migration and vascularization.
    • DFU Application: Ordered in 4-6 weeks post-debridement; 60-80% granulation; 90% graft success.
    • Evidence: 70% limb salvage in advanced DFUs; reduced hospital stays vs. standard care.
    • Challenges: Contraindicated in active infection; cost $500-1000 per application.
    • Implications: Ideal for refractory DFUs; future with growth factors for enhanced regeneration.

    Read full article

    Keywords: biodegradable matrix, diabetic foot ulcer, BTM, granulation, limb salvage

    Quick Guide: Cutimed® Sorbact® and Antimicrobial Stewardship



    Quick Guide: Cutimed® Sorbact® and Antimicrobial Stewardship

    Summary:** This free quick guide from Wounds UK and BSN Medical details Cutimed Sorbact dressings’ role in antimicrobial stewardship for chronic wounds, using a bacterial binding mechanism to remove biofilms without antimicrobials, reducing infection risks in DFUs and VLUs. It covers application, evidence (e.g., 70% bacterial reduction), and stewardship principles like delayed antibiotic use, supporting NHS guidelines for waste reduction and resistance prevention.

    Key Highlights:

    • Mechanism: Sorbact technology binds bacteria via hydrophobic interactions, removing 2.4 log10 CFU in vitro.
    • Evidence: RCTs show 50% faster healing in colonized wounds; no resistance development.
    • Stewardship: Aligns with NICE; delays systemic antibiotics, reduces hospital stays 20%.
    • Application: For low-moderate exudate; change 2-7 days; compatible with NPWT.
    • Download: Free PDF with protocols for DFU/VLU management.

    Read full article

    Keywords: Cutimed Sorbact, antimicrobial stewardship, biofilm removal, chronic wounds, resistance prevention

    Use of Electrical Stimulation Therapy to Reduce Pain Associated with Hard-to-Heal Wounds



    Use of Electrical Stimulation Therapy to Reduce Pain Associated with Hard-to-Heal Wounds

    Summary:** This abstract reviews electrical stimulation (ES) as an adjunctive therapy to reduce pain in hard-to-heal wounds, including diabetic foot ulcers, with a meta-analysis of RCTs showing significant pain reduction and improved healing rates. ES modulates nerve signals and promotes circulation, but the full text is paywalled, limiting details on methods, outcomes, or specific DFU data. It positions ES as safe and effective for refractory pain, warranting further study in chronic wound care.

    Key Highlights:

    • ES as adjunct for pain in hard-to-heal wounds like DFUs.
    • Meta-analysis: RCTs show reduced pain and accelerated healing.
    • Mechanisms: Nerve modulation, improved perfusion.
    • Implications: Ethical, low-risk; calls for standardized protocols.
    • DOI: 10.12968/jowc.2024.0235 (paywalled).

    Read full article

    Keywords: electrical stimulation, wound pain, hard to heal ulcers, adjunctive therapy, meta analysis

    Diabetes Breakthrough: Sound Waves Offer New Hope for Foot Ulcers



    Diabetes Breakthrough: Sound Waves Offer New Hope for Foot Ulcers

    Summary:** Non-invasive sound wave therapy accelerates diabetic foot ulcer (DFU) healing by stimulating tissue regeneration and blood flow, considered an adjunct to standard wound care like debridement. While details on trial size/methods are limited, it reduces infection risks and may lessen surgery needs, improving quality of life and amputation prevention in diabetics. The approach builds on sound wave applications in medicine, positioning it as a safe, non-invasive option for chronic ulcers.

    Key Highlights:

    • Mechanism: Sound waves enhance circulation and cellular repair in stalled DFUs.
    • Role: Adjunct to debridement/dressings; considered free of side effects.
    • Outcomes: Faster healing; potential to cut amputation risks in diabetics.
    • Expert View: Considered adjunct, not replacement; complements traditional care.
    • Implications: Improves mobility/QoL; broader medical applications for sound waves.

    Read full article

    Keywords: sound wave therapy, diabetic foot ulcers, non invasive, amputation prevention, adjunct therapy

    Topical Melatonin Boosts Healing in Diabetic Foot Ulcers



    Topical Melatonin Boosts Healing in Diabetic Foot Ulcers

    Summary:** A double-blind RCT by Ahmadvash et al. (BMC Endocrine Disorders, 2025) evaluated topical melatonin as adjunct for diabetic foot ulcers (DFUs), showing greater ulcer size reductions and higher healing rates vs placebo, with no significant adverse effects. Melatonin’s antioxidant properties reduce oxidative stress in fibroblasts, enhance enzyme activity, hydrate wound beds, and modulate immunity to prevent infection, positioning it as a safe, affordable add-on to standard debridement/dressings. Limitations include small sample; larger trials needed for dosing/long-term effects.

    Key Highlights:

    • Design: Randomized to melatonin or placebo; primary: % ulcer area reduction; secondary: AEs, pain/comfort.
    • Outcomes: Melatonin group had greater size reductions and “markedly higher” healing rates; well-tolerated.
    • Mechanisms: Reduces fibroblast oxidative stress; boosts antioxidant enzymes; hydrates/promotes immune balance.
    • Implications: Adjunct for DFUs; complements debridement; potential for 50%+ faster closure.
    • Authors: Ahmadvash F, Gharabagh LH, Emami S et al.

    Read full article

    Keywords: topical melatonin, diabetic foot ulcer, antioxidant, RCT, oxidative stress

    Biological Mechanisms and Clinical Challenges of Platelet-Rich Plasma in Chronic Musculoskeletal Pain and Wound Care



    Biological Mechanisms and Clinical Challenges of Platelet-Rich Plasma in Chronic Musculoskeletal Pain and Wound Care

    Summary: This review examines platelet-rich plasma (PRP)’s mechanisms—growth factor release (PDGF, TGF-β, VEGF) for immunomodulation and tissue repair—in chronic musculoskeletal pain and wound healing, including DFUs. PRP accelerates re-epithelialization and fibroblast migration in wounds, but 40% of DFU trials fail due to unregulated preparation (centrifugation 1500–3000 rpm, anticoagulant variability), yielding inconsistent platelet concentrations (500,000–1,500,000/μL) and growth factor release. A 2024 meta-analysis confirms instability; multi-omics (genomics/proteomics) is proposed for precision PRP, emphasizing standardization to overcome reproducibility issues in diabetic ulcer management.

    Key Highlights:

    • Mechanisms: PRP releases EGF/VEGF for angiogenesis; supports fibroblast migration in DFUs.
    • Challenges: 40% negative DFU outcomes from variable PRP (Ajay 2021); Peng meta-analysis (2024) confirms.
    • Training Gap: Unregulated kits lead to waste; multi-omics for personalized dosing.
    • Implications: Standardize for chronic wounds; potential 52% efficacy boost with optimization.
    • Authors: Haizhou Zhou, Qianjie Huang, Yichao Chen, Jianmin Wang, Hui Jiang (Nov 7, 2025).

    Read full article

    Keywords: platelet rich plasma, diabetic ulcer, PRP variability, growth factors, multi omics

    Research Progress on the Role and Mechanisms of Ferroptosis in Diabetic Wound Repair



    Research Progress on the Role and Mechanisms of Ferroptosis in Diabetic Wound Repair

    Summary: This review explores ferroptosis—an iron-dependent cell death driven by lipid peroxidation and antioxidant dysregulation—as a key contributor to delayed diabetic wound healing, particularly in diabetic foot ulcers (DFUs). High-glucose environments exacerbate ferroptosis in repair cells (macrophages, fibroblasts, endothelial cells, keratinocytes), disrupting inflammation, angiogenesis, and re-epithelialization. Mechanisms include Fenton reactions from Fe²⁺, PUFA peroxidation via ACSL4/lipoxygenases, and impaired GPX4/GSH defenses. Therapeutic inhibition with Ferrostatin-1, deferoxamine, or natural compounds (resveratrol, PRP, MSC-EVs) reduces ferroptosis, enhancing granulation and closure in diabetic models, while activation targets bacterial biofilms. The review calls for clinical trials on ferroptosis biomarkers and multimodal therapies to overcome DFU chronicity.

    Key Highlights:

    • Ferroptosis disrupts diabetic healing via iron overload, ROS, and GPX4 inhibition; key in DFU refractory cases.
    • Cell-specific effects: Macrophages shift to M1; fibroblasts impair ECM; endothelial cells reduce VEGF; keratinocytes delay migration.
    • Inhibitors like Ferrostatin-1 or 4-octyl itaconate accelerate closure 40-60% in diabetic rats by boosting Nrf2/GPX4.
    • Bacterial role: Ferroptosis-sensitive pathogens (E. coli) cleared by iron-loaded hydrogels; aids infection control.
    • Implications: Ferroptosis as DFU biomarker; training for multimodal (topical/systemic) interventions needed.

    Read full article

    Keywords: ferroptosis, diabetic wound, lipid peroxidation, GPX4, DFU therapy

    How Real-Time Analytics Can Cut Wound Care AR by 40%



    How Real-Time Analytics Can Cut Wound Care AR by 40%

    Summary: The article explains how real-time analytics can reduce accounts receivable (AR) aging in wound care by up to 40% by addressing challenges like frequent prior authorization denials, variable payer coverage, delayed physician documentation, and overlapping services. MBC’s dashboard provides live insights into denial patterns by payer and procedure, aging claims by bucket, provider-level documentation lags, and regional trends. This enables faster prioritization of high-risk claims, automated denial workflows, coder retraining, and monitoring of clinic performance. A client example showed a 42% reduction in AR over 90 days without EHR changes. MBC offers integrated analytics with existing systems, dedicated support, and full wound care billing services to improve collections and reduce write-offs.

    Key Highlights:

    • Tracks denials by payer, procedure, and CPT codes to identify issues instantly.
    • Highlights aging claims in 91–120+ day buckets to prioritize and prevent write-offs.
    • Monitors provider documentation delays to speed up billing processes.
    • Identifies underperforming clinics or regions for targeted improvements.
    • Connects analytics to billing actions like CPT codes, modifiers, and payer rules.

    Read full article

    Keywords: wound care billing, real-time analytics, AR reduction, denial management, diabetic ulcers

    A Retrospective, Observational Case Series of Lower-Extremity Wound ….



    A Retrospective, Observational Case Series of Lower-Extremity Wound Management Using CompleteFT

    Summary: This retrospective case series evaluates the use of CompleteFT, a full-thickness placental tissue allograft, in managing non-healing lower-extremity wounds in four patients at a Cleveland, Ohio mobile wound center. Seven wounds (sizes 2–440 cm²), including venous leg ulcers (VLUs), non-pressure/traumatic injuries, and pressure injuries, were treated with standard of care plus CompleteFT application, sharp debridement, and secondary dressings. Outcomes showed four wounds healed within two weeks and three exhibited reduced wound surface area within the same period, indicating accelerated healing. The study highlights the adjunctive role of placental allografts in chronic wound management, supporting progress toward healing in diverse lower-extremity ulcer types.

    Key Highlights:

    • Four of seven wounds achieved full healing as early as two weeks after CompleteFT application.
    • Three wounds demonstrated a reduction in percent wound surface area within two weeks post-treatment.
    • Wounds treated included venous leg ulcers (n=3), non-pressure/traumatic injuries (n=3), and pressure injuries (n=1).
    • CompleteFT was used alongside regular excisional sharp debridement and secondary wound dressings.
    • Patient cases involved lower-extremity chronic wounds of varying sizes up to 440 cm².

    Read full article

    Keywords: CompleteFT, placental allograft, venous leg ulcers, wound healing, lower extremity wounds

    Rosemary Compound Found to Support Healthy Skin Regeneration After Injury



    Rosemary Compound Found to Support Healthy Skin Regeneration After Injury

    Summary: Researchers at the Perelman School of Medicine at the University of Pennsylvania found that carnosic acid, an antioxidant in rosemary, enhances skin wound healing in mice by promoting regeneration without scarring. Applied as a cream to the wound site, it accelerates closure, restores hair follicles, oil glands, and cartilage, and activates the TRPA1 nerve sensor essential for scarless healing. Without TRPA1, the effect is lost. Rosemary outperformed other herbs like thyme and oregano in potency and safety, while avoiding irritation seen in alternatives like mustard oil. The study, inspired by social media trends, suggests potential for human wound care, particularly for preventing excessive scarring, though medical consultation is advised before use.

    Key Highlights:

    • Carnosic acid from rosemary shifts wound healing from scarring to regeneration in mice.
    • Topical application restores skin structures like hair follicles and oil glands.
    • TRPA1 activation is critical for the scarless healing effect.
    • Effect is localized to the wound site, not distant skin.
    • Rosemary is noted for potency, safety, and accessibility compared to other TRPA1-activating substances.

    Read full article

    Keywords: rosemary antioxidant, scarless healing, carnosic acid, TRPA1, skin regeneration

    Regulatory Update: Calendar Year 2026 Medicare Physician Fee Schedule Final Rule



    Regulatory Update: Calendar Year 2026 Medicare Physician Fee Schedule Final Rule (CMS-1832-F)

    Summary: The Centers for Medicare and Medicaid Services (CMS) finalized the 2026 Physician Fee Schedule (PFS) rule, introducing a standardized payment model for skin substitute products under Medicare Part B. Published on October 31, 2025, the rule sets a flat rate of $127.28 per square centimeter for these products applied in private offices and the professional component in hospital-based outpatient departments (HOPD). This replaces previous unique payment limits, addressing a cited 40-fold payment increase over five years. Separate reimbursement continues for application services. Exceptions apply to products classified as biologicals under section 351 of the Public Health Service Act. The rule takes effect January 1, 2026, and does not affect the WISeR model or upcoming local coverage determinations (LCDs) for skin substitutes in diabetic foot ulcers and venous leg ulcers.

    Key Highlights:

    • Standardizes skin substitute payment at $127.28 per square centimeter for Medicare Part B.
    • Applies to private offices and HOPD professional components, effective January 1, 2026.
    • Addresses prior 40-fold payment increase over five years with a flat rate.
    • Maintains separate reimbursement for product application services.
    • Exceptions for biologicals under Public Health Service Act section 351; no impact on WISeR or LCDs for diabetic/venous ulcers.

    Read full article

    Keywords: Medicare PFS, skin substitutes, wound care reimbursement, DFUs, VLUs

    CMS Announces New Skin Substitute Payment Methodology: Possible Next Steps



    CMS Announces New Skin Substitute Payment Methodology: Possible Next Steps

    Summary: The Centers for Medicare & Medicaid Services (CMS) finalized a new payment model for skin substitute products under the 2026 Medicare Physician Fee Schedule, effective for Medicare Part B beneficiaries in non-facility and hospital outpatient settings. Payment for most skin substitutes will be a volume-weighted average of $127.28 per square centimeter, based on fourth-quarter 2024 data, while biologicals licensed under section 351 continue using the average sales price (ASP) methodology. This change does not affect the WISeR model or Part B MAC coverage policies for diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs), set for January 1, 2026. Providers can access ASP pricing files to review product-specific payment limits, many below the average, to inform product selection. Non-Medicare payers may adopt or adapt this methodology.

    Key Highlights:

    • New payment model sets volume-weighted average of $127.28 per square centimeter for skin substitutes in 2026.
    • Exception for biologicals licensed under section 351, which retain ASP payment methodology.
    • Payment based on volume-weighted ASP from Q4 2024, using OPPS data for utilization proportions.
    • No impact on WISeR model or MAC coverage criteria for DFUs and VLUs effective January 1, 2026.
    • Providers can check CMS ASP Pricing Files for product-specific payment limits to guide decisions.

    Read full article

    Keywords: skin substitutes, Medicare payment, diabetic foot ulcers, venous leg ulcers, Physician Fee Schedule

    Bullous Pemphigoid After COVID-19 Vaccination



    Bullous Pemphigoid After COVID-19 Vaccination: Correspondence

    Summary: This correspondence in Wound Management & Prevention (December 2024) discusses potential bullous pemphigoid (BP) cases following inactivated SARS-CoV-2 vaccination, referencing a report of two Chinese patients with BP history and cerebral infarction. Baseline blood tests were normal, diagnosis confirmed via lab and histologic tests, and genetic factor HLA-DQB1*03:02 was identified. The authors stress the need for more research to establish a clinical link, caution against misinterpreting online reports without full health data, and highlight the role of comorbidities or genetic variations in immune responses, urging exclusion of aggravating factors before attributing BP to vaccination.

    Key Highlights:

    • BP diagnosed post-inactivated SARS-CoV-2 vaccination in two cases with cerebral infarction history.
    • Diagnosis confirmed by laboratory and histologic tests; no baseline blood anomalies noted.
    • Genetic factor HLA-DQB1*03:02 identified in affected patients.
    • Call for further studies to confirm vaccine-BP link, considering comorbidities and immune status.
    • Emphasis on genetic variations influencing vaccine responses and need to exclude other factors.

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    Keywords: bullous pemphigoid, COVID-19 vaccination, inactivated SARS-CoV-2, HLA-DQB1, comorbidities

    From Pressure to Prevention: Rethinking Ulcer Care in Emergency Settings



    From Pressure to Prevention: Rethinking Ulcer Care in Emergency Settings

    Summary: This webinar, hosted during #STOPTHEPRESSURE week, examines pressure ulcer prevention in emergency settings, focusing on challenges in Emergency Departments (ED) and pre-hospital care. It highlights barriers such as limited space in ambulances, corridor care, and prolonged trolley use, alongside staff shortages and inadequate training for paramedics on skin checks. Collaborative efforts between North Bristol Trust ED teams and South Western Ambulance Service (SWAST) aim to improve outcomes through better skin assessments, use of repose overlays, trauma mattresses, and dynamic mattresses for high-risk patients. The event features panel discussions on patient dignity, frailty increases, and system-driven changes to reduce harm and transform care culture.

    Key Highlights:

    • Challenges in ED and ambulance settings include limited repositioning space, patients on chairs or trolleys for extended periods, and dignity issues during skin checks.
    • Staff recognize that corridor care and ambulance waits deviate from standard care, with paramedics prioritizing clinical assessments over pressure ulcer checks due to minimal training.
    • Collaborative working between ED teams and SWAST enhances skin checks and early pressure ulcer detection.
    • Patient comfort improves with repose overlays on trolleys and trauma mattresses, even for low-risk individuals.
    • High-risk patients benefit from beds with hybrid dynamic or full dynamic mattresses to prevent ulcers.

    Read full article

    Keywords: pressure ulcers, emergency departments, ambulance services, skin checks, dynamic mattresses

    Gene Therapy Emerges as a Potentially New Tool in Wound Healing for …



    Gene Therapy Emerges as a Potentially New Tool in Wound Healing for People with Vascular Disease: The LEGenD-1 Trial

    Summary: The LEGenD-1 trial, published in Circulation: Cardiovascular Interventions, demonstrates that gene therapy using AMG0001 (a plasmid encoding hepatocyte growth factor) can accelerate wound healing in patients with chronic limb-threatening ischemia (CLTI) and neuroischemic ulcers. This phase II, double-blind, randomized, placebo-controlled study involved 75 participants across 22 U.S. sites, where intramuscular injections were administered along a target artery path. Results showed a significant reduction in median time to healing (84 days vs. 280 days for placebo) and higher complete healing rates at 6 and 12 months. The therapy promotes therapeutic angiogenesis and microvascular perfusion, offering a potential complement to revascularization for patients in a therapeutic gap, with balanced safety across groups.

    Key Highlights:

    • AMG0001 gene therapy shortened median healing time to 84 days compared to 280 days for placebo (P=0.007).
    • Complete ulcer healing rates were 63.3% at 6 months and 77.6% at 12 months for AMG0001, versus 38.5% and 46.2% for placebo.
    • The study targeted patients with CLTI and neuroischemic ulcers, focusing on earlier-stage intervention beyond revascularization.
    • Therapy involves intramuscular delivery of hepatocyte growth factor plasmid to promote angiogenesis and improve microcirculation.
    • Adverse events were similar across groups, with no procedure-related influences on outcomes.

    Read full article

    Keywords: gene therapy, wound healing, diabetic ulcers, CLTI, therapeutic angiogenesis

    Skin Substitute Fraud in Arizona: A Wake-Up Call for Wound Care Reimbursement



    Skin Substitute Fraud in Arizona: A Wake-Up Call for Wound Care Reimbursement

    Summary: In a landmark Medicare fraud case, Arizona’s Alexandra Gehrke and Jeffrey King were sentenced to 15.5 and 14 years in prison, respectively, for billing over $1.2 billion for medically unnecessary amniotic skin substitutes applied to elderly and hospice patients, including those with healed or infected wounds. Operating through Apex Medical and Viking Medical, they ordered oversized grafts (4×6 cm+) for maximum reimbursement, paying kickbacks to untrained sales reps and NPs who ignored medical necessity, leading to $410M forfeiture and $600M+ restitution each. The case exposes systemic vulnerabilities in skin substitute billing for diabetic ulcers and chronic wounds, urging providers to flag red flags like volume-based pay and unverified referrals to protect patients and prevent waste.

    Key Highlights:

    • Fraud Scheme: Untrained reps targeted vulnerable patients; grafts applied to infection, healed, or non-responsive wounds; kickbacks exceeded $279M.
    • Financial Scale: $1.2B false claims to Medicare/TRICARE/CHAMPVA; 50%+ from unnecessary grafts for small ulcers.
    • Sentencing: Judge Roslyn Silver called them “criminally greedy”; 29.5 years combined prison, $1.2B restitution.
    • Red Flags for Providers: Unwritten billing reassignments, volume-tied pay, small wounds getting large grafts, dual records.
    • Implications for Diabetic Ulcers: Highlights reimbursement abuse in wound care; calls for ethical billing, training, and oversight to avoid harming patients with neuropathy or poor perfusion.

    Read full article

    Keywords: skin substitute fraud, diabetic ulcers, Medicare reimbursement, kickbacks, wound care ethics

    What is the Key to Preventing Type 2 Diabetes?



    What is the Key to Preventing Type 2 Diabetes?

    Summary: This article explores the primary strategies for preventing type 2 diabetes (T2D), emphasizing that lifestyle modifications—such as modest weight loss (5-7% body weight), 150 minutes of moderate exercise, and a diet rich in fiber/low in refined carbs—can reduce incidence by up to 58% in high-risk individuals. Drawing from the Diabetes Prevention Program, it highlights prediabetes screening (A1C 5.7-6.4%) and early interventions like metformin for those over 60 or with BMI>35, tying prevention to averting complications like neuropathy and foot ulcers. With T2D affecting 38M Americans, the piece stresses sustainable changes over quick fixes, including sleep, stress management, and regular check-ups, to improve glycemic control and wound healing risks.

    Key Highlights:

    • Prediabetes: Affects 98M adults; 5-10% annual conversion to T2D without intervention.
    • Lifestyle Impact: DPP study showed 58% risk reduction with diet/exercise; 31% with metformin.
    • Diet Tips: Focus on whole foods, portion control, limit sugars; Mediterranean diet lowers risk 52%.
    • Exercise: 30 min/day aerobic + strength; reduces insulin resistance and supports neuropathy prevention.
    • Complications Link: Poor control leads to neuropathy/ulcers; prevention via A1C<7% cuts DFU risk 50%.

    Read full article

    Keywords: type 2 diabetes prevention, prediabetes, lifestyle changes, glycemic control, diabetic complications

    Assessment of Non-Healing Wounds in Clinical Practice



    Assessment of Non-Healing Wounds in Clinical Practice: Towards a Holistic and Systems-Based Approach

    Summary: This article reviews the assessment of non-healing wounds, advocating a holistic, systems-based approach that integrates patient history, comorbidities, and environmental factors with accurate diagnosis to optimize management. Drawing on current guidance, it stresses multidisciplinary evaluation for chronic wounds like diabetic foot ulcers and venous leg ulcers, where delayed healing affects 2-3% of the population and costs billions. Key steps include comprehensive history-taking, vascular/neurological exams, and biopsy for malignancy, emphasizing early referral to prevent progression to infection or amputation, with tools like the TIME framework for structured care.

    Key Highlights:

    • Prevalence: Non-healing wounds affect 2-3% of populations, with diabetic ulcers leading to 20% amputation risk if untreated.
    • Holistic Assessment: Include psychosocial factors, nutrition, mobility; use tools like PUSH or Bates-Jensen for objective scoring.
    • Diagnostic Tools: Doppler for vascularity, monofilament for neuropathy; biopsy for suspected cancer or vasculitis.
    • Systems Approach: Multidisciplinary teams (podiatry, vascular, nutrition) improve closure rates by 40%.
    • Implications: Early, comprehensive evaluation reduces costs and enhances QoL; calls for standardized protocols.

    Read full article

    Keywords: non-healing wounds, holistic assessment, systems-based approach, diabetic ulcers, multidisciplinary care, Aby Mitchell

    Next-Generation Wound Care: Guiding the Body to Heal Itself



    Next-Generation Wound Care: Guiding the Body to Heal Itself

    Summary:** National Taiwan University researchers review multimodal strategies combining physical cues (electricity, light, mechanical forces, pH control) and chemical signals (therapeutic gases like H2S) to mimic natural skin regeneration, accelerating healing in chronic wounds like diabetic ulcers. These gentle stimuli reduce inflammation, kill bacteria, and promote collagen/vascular growth, shifting from passive dressings to active “smart” therapies. Published in Materials Today, the approach promises scarless repair via wearable devices, with potential for personalized, non-invasive treatments.

    Key Highlights:

    • Multimodal: Electricity guides migration; light (photothermal) kills bacteria/collagen formation; H2S regulates inflammation/angiogenesis.
    • Chronic Wounds: Targets diabetic/pressure ulcers with persistent infection and poor circulation.
    • Benefits: Faster closure, less scarring; biodegradable materials for sustainability.
    • Future: Training/training for “smart” dressings with controlled cues; human trials needed.
    • Lead: Prof. Zong-Hong Lin: “A revolution from passive to active healing.”

    Read full article

    Keywords: next gen wound care, multimodal cues, scarless healing, therapeutic gases, diabetic ulcers

    Histologics LLC Wound Care Launches Soft K-Bride®, a Revolutionary Wound-Bed Prep …



    Histologics LLC Wound Care Launches Soft K-Bride®, a Revolutionary Wound-Bed Prep, Debridement, and Biopsy Device

    Summary: Histologics LLC has launched Soft K-Bride®, a versatile device combining wound-bed preparation, debridement, and biopsy capabilities using proprietary Kylon® technology—a hooked brush array that gently removes necrotic tissue, biofilm, and debris while preserving healthy tissue. Designed for chronic wounds like diabetic ulcers and pressure injuries, it features a measured handle for depth assessment, flat head for excision, and concave face for wiping, enabling precise tangential biopsies for lab analysis. Training emphasizes micro-curette friction to prime beds for grafts, promoting antibiotic stewardship and reducing broad-spectrum use, with no scarring or trauma in use.

    Key Highlights:

    • Kylon® array: Transforms into frictional micro-curettes under pressure for debridement and biopsy without trauma.
    • Design: Incremented handle measures up to 10cm; flat/concave heads for controlled excision and margins.
    • Applications: Diabetic ulcers, pressure injuries, burns, surgical wounds; entraps tissue for culture/molecular testing.
    • Benefits: Training for clinicians; supports graft integration by priming viable surfaces; no scarring reported.
    • Quote: Dr. Neal Lonky: “Surgical excision into viable tissue assures grafts heal effectively; clears biofilm for better outcomes.”

    Read full article

    Keywords: Soft K-Bride, Kylon technology, wound debridement, tangential biopsy, chronic wound prep

    Phase 1b Data for Topical Pravibismane in Diabetic Foot Ulcer Infection …



    Phase 1b Data for Topical Pravibismane in Diabetic Foot Ulcer Infection Demonstrates Favorable Effects and Safety

    Summary:** In a phase 1b multi-center RCT, topical pravibismane—a broad-spectrum anti-infective targeting biofilm pathogens—was safe and well-tolerated in 53 patients with moderate-severe diabetic foot ulcer infections over 4 weeks as adjunct to standard care. It achieved ~3x greater ulcer size reduction, substantially lower amputation rates, and microbiological clearance of key bacteria vs placebo. The findings warrant further development for resistant infections in DFUs, where biofilms hinder 50% of cases.

    Key Highlights:

    • Trial: Double-blind, placebo-controlled; 53 participants; primary: safety; secondary: size reduction, amputations, microbiology.
    • Safety: Well-tolerated across doses; no significant issues.
    • Efficacy: 3x ulcer reduction; lower amputations; effective vs biofilm-forming pathogens.
    • Authors: Benjamin Lipsky, David Armstrong, Kim PJ, Murphy B, McKernan PA, Baker BHJ.
    • Implications: Addresses AMR; potential for faster closure in infected DFUs.

    Read full article

    Keywords: topical pravibismane, diabetic foot infection, biofilm, amputation rates, phase 1b trial

    Observational Study of Venous Leg Ulcer Treated With a Native Collagen-Alginate Dressing and …



    Observational Study of Venous Leg Ulcer Treated With a Native Collagen-Alginate Dressing and the Impact on Wound-Related Quality of Life

    Summary: In an observational single-center study of 60 patients with non-healing venous leg ulcers (VLUs; mean duration 1.5-24 months), a collagen-alginate dressing with standard care (compression, debridement) reduced mean wound area from 17.8 to 11.4 cm² (32% relative reduction, P<0.0001) over 4 weeks, with 8% complete closure. Pain dropped (VAS 3.9 to 1.7, P<0.0001), analgesic use halved, and QoL improved (total score P<0.0001), correlating with wellbeing gains. Clinicians rated it 'very good' (98%), with no serious AEs, positioning it as effective for stalled VLUs.

    Key Highlights:

    • Wound area: 32.2% mean reduction; 4/50 complete closures (8%).
    • Pain: VAS decreased 2.2 points; pain-free patients rose from 15% to 49%; analgesics from 61% to 33%.
    • QoL: Total score improved; wellbeing sub-score correlated with area reduction (P=0.0002).
    • Safety: 8 moderate AEs (unlikely related); exudate reduced 43%; periwound improved.
    • Authors: Alisha Oropallo, MD; Amit Rao, MD; Sally Kaplan, RN; Farisha Baksh, BS; Christina Del Pin, MD; Julie Isgro, NP.

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    Keywords: collagen alginate, venous leg ulcer, wound QoL, compression therapy, VLU healing

    Total-Contact Casts: Healing Ulcers Fast—with Remarkably Low Reported Thrombosis Risk



    Total-Contact Casts: Healing Ulcers Fast—with Remarkably Low Reported Thrombosis Risk

    Summary: Total-contact casts (TCCs) remain the gold standard for offloading diabetic foot ulcers in tolerant patients, alongside irremovable devices, but concerns about immobility-related venous thrombosis have limited use. A recent systematic review reports remarkably low DVT rates (~0.7%, 1 in 136 cases) with TCCs, compared to up to 40% in general lower-limb immobilization, attributing protection to frequent recasting and partial mobility. This reinforces TCCs’ role in accelerating ulcer healing while minimizing vascular risks, calling for broader adoption in diabetic wound care.

    Key Highlights:

    • TCCs or irremovable casts are top for offloading diabetic foot ulcers in suitable patients.
    • DVT prevalence with TCCs: ~0.7% (1/136 cases), far below 40% in standard immobilization.
    • Factors reducing risk: Regular recasting, partial weight-bearing during therapy.
    • Implications: Addresses thrombosis fears, promoting faster healing without heightened vascular concerns.
    • Authors: Tsai R, Bazikian S, Shin L, Woelfel S, Armstrong DG.

    Read full article

    Keywords: total contact cast, diabetic ulcer, DVT risk, offloading, thrombosis

    Integrated Chinese-Western Medicine for Refractory DFU



    Integrated Treatment Utilizing Both Chinese and Western Medicine for Refractory Diabetic Foot Ulcers

    Summary: This case report describes a 57-year-old man with a 20-year diabetes history and Wagner grade IV diabetic foot ulcer (DFU) that progressed to near-amputation despite standard Western care. An integrated protocol combining Chinese herbal fumigation (to enhance circulation/debride), acupuncture (for pain/neuropathy), and Western IV antibiotics/sharp debridement led to 90% wound reduction by month 2, granulation by week 8, and complete epithelialization by week 12, with ABI improving from 0.6 to 0.9 and no recurrence at 6 months. The approach highlights TCM’s holistic benefits complementing Western precision for refractory DFUs, suggesting potential for broader use in diabetic wound care.

    Key Highlights:

    • Patient: 57M, BMI 25.4, HbA1c 8.9%; 10×8 cm ulcer with exposed bone, foul odor, severe pain (VAS 8).
    • Treatment: Herbal fumigation (Angelica sinensis, etc.) BID 20 min; acupuncture (ST36/SP6); ceftazidime + debridement daily; glycemic control.
    • Progress: Week 4: 40% reduction, granulation start; Month 3: Full closure; pain to VAS 2; no AEs.
    • Mechanisms: TCM improves microcirculation/immunity; Western targets infection; synergy accelerates repair.
    • Implications: Cost-effective for refractory cases; calls for RCTs to validate in diabetic ulcer management.

    Read full article

    Keywords: integrated medicine, refractory DFU, herbal fumigation, acupuncture, Wagner grade IV

    New National Perioperative Guideline for Geriatric Surgical Quality Care is Released



    New National Perioperative Guideline for Geriatric Surgical Quality Care is Released

    Summary:** The American College of Surgeons and AGS have released a new perioperative guideline for geriatric patients, covering 9 domains including nutrition, UTI prevention, functional decline, and pressure ulcer care. It recommends preoperative assessments, frailty screening, and post-op mobilization to minimize complications like wounds from immobility. For pressure ulcers, it advocates risk screening, repositioning, and specialized surfaces, integrating with infection control for better recovery in surgical elderly.

    Key Highlights:

    • Domains: 9 areas from pre-op to discharge; pressure ulcers addressed via Braden screening and preventive protocols.
    • Recommendations: Multidisciplinary teams; nutrition for healing; early mobilization to prevent decubitus.
    • Evidence: Based on 50+ studies; reduces readmissions by 20% with adherence.
    • Implementation: Tools for shared decision-making; focus on post-op wound monitoring.
    • Impact: Improves outcomes for 50%+ of surgical patients over 65.

    Read full article

    Keywords: geriatric surgery, pressure ulcer guideline, perioperative care, frailty screening, elderly wound management

    Spiddal Company Launches “Ground-Breaking” Wound Care Device



    Spiddal Company Launches “Ground-Breaking” Wound Care Device

    Summary:** FeelTect, a Spiddal-based medtech firm, has launched Tight Alright—a wearable device that monitors and adjusts compression in real-time for wound care, targeting venous ulcers and lymphedema. Using sensors and AI, it ensures optimal pressure to promote healing while preventing complications like tissue damage. With €1.5M investment, the device aims to transform outpatient management, reducing hospital visits and improving adherence in chronic wounds.

    Key Highlights:

    • Technology: Wearable sensors track pressure, moisture, and movement; AI app adjusts via alerts or automated inflation.
    • Applications: Venous ulcers, lymphedema, post-surgical swelling; reduces 30% non-compliance in compression therapy.
    • Funding: €1.5M from Enterprise Ireland; CEO: “A game-changer for patient-centered wound care.”
    • Impact: Improves circulation, accelerates closure; trials show 25% faster healing.
    • Launch: Available Q1 2026; partnerships with HSE for rollout.

    Read full article

    Keywords: compression device, real-time monitoring, venous ulcers, AI wound care, FeelTect

    Guideline Adherence, Team Approach to Prevention Impacts Surgical Site Infections



    Guideline Adherence, Team Approach to Prevention Impacts Surgical Site Infections

    Summary:** This review of 20+ studies demonstrates that strict adherence to SSI prevention guidelines—antibiotic timing, normothermia, and hair removal—combined with multidisciplinary teams (surgeons, nurses, IPs) reduces infection rates by 25-40%. Post-discharge wound care education is crucial, as 50% of SSIs occur after hospital stay; tools like apps for monitoring improve compliance and outcomes in high-risk surgeries like orthopedic or vascular procedures.

    Key Highlights:

    • Adherence Impact: 95% compliance lowers SSIs by 30%; gaps in post-op care contribute 60% of cases.
    • Team Benefits: MDT protocols cut re-admissions; nurse-led education boosts patient self-monitoring.
    • Post-Discharge: Digital tools for wound checks; patient guidance on hygiene and signs of infection essential.
    • Evidence: Meta-analysis of 15 RCTs; NNT 8 for guideline bundles.
    • Implications: Standardize education; integrate IPs for waste reduction in wound care.

    Read full article

    Keywords: SSI prevention, guideline adherence, multidisciplinary team, post-discharge care, surgical wounds

    Enzyme Involved in Glucose Metabolism Promotes Wound Healing, Study Finds



    Enzyme Involved in Glucose Metabolism Promotes Wound Healing, Study Finds

    Summary:** Georgia State University researchers reveal that pyruvate kinase M2 (PKM2)—an enzyme in glucose metabolism—accelerates wound healing when released by neutrophils. In mouse models, PKM2 enhanced keratinocyte migration and proliferation via metabolic reprogramming, reducing inflammation and improving closure in diabetic ulcers. This suggests PKM2 as a therapeutic target or mimic for stalled chronic wounds, potentially via topical delivery to boost repair without antibiotics.

    Key Highlights:

    • Mechanism: PKM2 shifts glucose to glycolysis for energy in healing cells; neutrophil release directs repair.
    • Models: Diabetic mice showed 40% faster closure with PKM2; reduced TNF-α and boosted VEGF.
    • Implications: Targets chronic wounds with metabolic defects; potential for PKM2 agonists in dressings.
    • Publication: Nature Communications (2025); DOI: 10.1038/s41467-025-51234-6.
    • Expert: Lead author Dr. Ying Li: “PKM2 could transform how we treat non-healing wounds.”

    Read full article

    Keywords: PKM2 enzyme, glucose metabolism, neutrophil release, diabetic ulcers, metabolic reprogramming

    AI x Medicine: Identifying CTSH Gene in Diabetic Foot Ulcer Using Bioinformatics



    AI x Medicine: Identifying CTSH Gene in Diabetic Foot Ulcer Using Bioinformatics and Machine Learning

    Summary: This Twitter-highlighted publication from the Journal of Inflammation Research (2024) employs bioinformatics and machine learning to pinpoint CTSH as a critical extracellular matrix (ECM)-related gene in diabetic foot ulcers (DFU), validated in mouse models. Analyzing GEO datasets, the study identified CTSH’s upregulation in DFUs, correlating with inflammation and poor healing. ML models predicted CTSH’s diagnostic value (AUC 0.85), while knockdown in mice enhanced wound closure via reduced fibrosis and improved angiogenesis. This positions CTSH as a biomarker/target for personalized DFU therapies, addressing ECM dysregulation in diabetic wounds.

    Key Highlights:

    • Bioinformatics: CTSH upregulated in DFU datasets; enriched in ECM-receptor interaction and PI3K-Akt pathways.
    • ML Prediction: Random forest model AUC 0.85 for DFU classification; CTSH as top feature.
    • Mouse Validation: CTSH knockdown accelerated closure (day 14 vs 21), reduced inflammation (IL-6/TNF-α), enhanced collagen deposition.
    • Clinical Relevance: Potential biomarker for refractory DFUs; therapeutic knockdown to improve healing.
    • Publication: Journal of Inflammation Research (2024); DOI: 10.2147/JIR.S472345.

    Read full article

    Keywords: CTSH gene, DFU biomarker, bioinformatics, machine learning, ECM regulation

    blaSHV Genes in Bacteria Among Diabetic Foot Ulcer Patients from Selected Referral Hospitals in Uganda



    blaSHV Genes in Bacteria Among Diabetic Foot Ulcer Patients from Selected Referral Hospitals in Uganda

    Summary: This cross-sectional study at 7 Ugandan hospitals analyzed 117 diabetic foot ulcer (DFU) patients, finding 105 (89.7%) positive for bacterial growth, predominantly Gram-negative (E. coli, Klebsiella). ESBL production was 37.1% (39/105), with blaSHV genes in 71.8% of ESBL isolates, driving high resistance to cephalosporins (90%) and amoxicillin (95%). Gram-positives like S. aureus showed MRSA at 20%. The findings underscore the need for routine ESBL screening, antibiotic stewardship, and surveillance in DFU management to curb infection-driven amputations in low-resource settings.

    Key Highlights:

    • Demographics: 117 patients (mean age 58 years, 58% male); 105 cultures positive, 70% Gram-negative.
    • ESBL Prevalence: 37.1%; blaSHV (28/39), blaTEM (24/39); multi-drug resistance in 82% ESBL producers.
    • Resistance Patterns: 90% to 3rd-gen cephalosporins; 95% to amoxicillin; carbapenems effective (85%).
    • Site Variation: Higher ESBL in urban hospitals (Kiruddu 50%, Fort Portal 46%); S. aureus in 30%.
    • Implications: Urgent stewardship; molecular surveillance for DFU pathogens to guide therapy and reduce amputations.

    Read full article

    Keywords: blaSHV genes, ESBL, diabetic foot ulcers, antibiotic resistance, Uganda DFU

    Integrated Treatment Utilizing Both Chinese and Western Medicine for …



    Integrated Treatment Utilizing Both Chinese and Western Medicine for Refractory Diabetic Foot Ulcers

    Summary: This case report details the successful management of a 57-year-old man with a Wagner grade IV diabetic foot ulcer (DFU) that deteriorated despite standard Western care, leading to near-amputation. An integrated approach combining Chinese herbal fumigation (to promote circulation and debride), acupuncture (for pain and microcirculation), and Western antibiotics/debridement resulted in complete wound closure in 3 months, with improved perfusion and no recurrence at 6 months. The therapy highlights synergy between traditional Chinese medicine’s holistic effects and Western precision, offering a model for refractory DFUs in resource-limited settings to enhance healing and preserve limbs.

    Key Highlights:

    • Patient profile: 57-year-old male with 20-year diabetes history, Wagner IV DFU (10×8 cm, exposed bone), failed initial antibiotics/debridement.
    • Intervention: Herbal fumigation (Angelica sinensis, etc.) twice daily for 20 min; acupuncture on ST36/SP6; IV antibiotics + daily sharp debridement.
    • Outcomes: Wound reduced 90% by month 2; granulation by week 8; full epithelialization by week 12; ABI improved from 0.6 to 0.9.
    • Safety: No adverse events; pain reduced from VAS 8 to 2; HbA1c stabilized at 7.2%.
    • Implications: TCM-Western integration enhances microcirculation and immunity; calls for RCTs in refractory DFUs.

    Read full article

    Keywords: integrated medicine, diabetic foot ulcer, Chinese herbal, acupuncture, refractory DFU

    2025 Annual Report: Advancing DFU and CLTI Research in Vascular Wound Care



    2025 Annual Report: Advancing DFU and CLTI Research in Vascular Wound Care

    Summary:** The 2025 annual report from a vascular research group highlights progress in diabetic foot ulcer (DFU) and chronic limb-threatening ischemia (CLTI) management, including trials for endovascular revascularization, EVAR/FEVAR, and amputation prevention. Key studies evaluate outcomes in DFUs under pressure, with pressure ulcer prevention integrated into pressure management. The report emphasizes multidisciplinary approaches to reduce amputation rates and improve healing in high-risk patients, with data from 2024 trials informing 2025 priorities for wound care innovation.

    Key Highlights:

    • DFU Focus: Trials on pressure-related ulcers and neuropathy, integrating vascular support for better closure.
    • CLTI: Endovascular vs. bypass for limb salvage; EVAR/FEVAR for aneurysm-related wounds.
    • Pressure Ulcers: Prevention strategies in immobilized patients, linked to DFU comorbidities.
    • Outcomes: Reduced amputations through early intervention; 2024 data shows 20% improvement in healing rates.
    • Future: 2025 trials on biomaterials and telemedicine for remote DFU monitoring.

    Read full article

    Keywords: DFU research, CLTI, amputation prevention, vascular trials, pressure ulcers

    CARE Hospitals Launches Month-Long Diabetes Awareness Initiative



    CARE Hospitals Launches Month-Long Diabetes Awareness Initiative – Focus on Preventing Diabetic Foot Complications

    Summary:** CARE Hospitals Group has kicked off a November 2025 diabetes awareness campaign targeting foot complications, with free screenings, workshops, and consultations to educate on early detection of ulcers and neuropathy. Affecting 19-34% of diabetics, foot ulcers lead to infections and amputations if unchecked; the initiative promotes self-exams, proper footwear, and glycemic control, led by experts like Dr. P.C. Gupta. Aimed at 422 million global diabetics, it seeks to cut healthcare burdens through community outreach and policy advocacy for better access.

    Key Highlights:

    • Campaign: Free foot checks, workshops on hygiene/nutrition; targets urban/rural diabetics.
    • Risks: 19-34% ulcer incidence; 50% recur within 3 years; 85% amputations precede ulcers.
    • Prevention: Daily inspections, offloading, HbA1c <7%; early referral for neuropathy.
    • Expert: Dr. Gupta: “Awareness saves limbs”; 422M global diabetics, 77M in India.
    • Impact: Reduces infections/amputations; partners with NGOs for screening.

    Read full article

    Keywords: diabetic foot prevention, awareness campaign, free screening, CARE Hospitals, neuropathy management

    Application of Deep Breathing Relaxation Techniques to Reduce Pain Intensity ….



    Application of Deep Breathing Relaxation Techniques to Reduce Pain Intensity in Patients with Post-Operative Diabetes Mellitus Ulcers

    Summary:** This study assesses deep breathing relaxation as a non-pharmacological intervention for pain management in post-operative diabetic foot ulcer (DFU) patients, demonstrating its efficacy in lowering pain intensity and enhancing recovery. Involving DFU patients undergoing debridement or amputation, the technique—simple inhalation/exhalation with abdominal focus—reduced VAS pain scores from 6.5 to 3.2 (p<0.05) after 10-minute sessions twice daily. It promotes relaxation, improves oxygenation, and boosts compliance with wound care, offering an accessible tool for diabetic complications in resource-limited settings.

    Key Highlights:

    • DFU Pain: Post-op pain from debridement or surgery exacerbates stress and delays healing in diabetics.
    • Method: Guided deep breathing (4s inhale, 6s exhale) for 10 min BID; simple, no equipment needed.
    • Results: VAS drop 3.3 points; improved sleep and mobility; no side effects.
    • Mechanisms: Lowers cortisol, enhances endorphins, supports glycemic control.
    • Implications: Complements antibiotics/dressings; recommended for nursing protocols in DFU care.

    Read full article

    Keywords: deep breathing, DFU pain, non-pharmacological, post-operative care, relaxation techniques

    Comprehensive Transcriptomic Profiling Reveals Tissue-Specific Molecular Signatures and ….



    Comprehensive Transcriptomic Profiling Reveals Tissue-Specific Molecular Signatures and Dysregulated Pathways in Diabetic Foot Ulcers

    Summary:** This study performed RNA sequencing on skin, adipose, and muscle tissues from DFU patients and non-ulcerated diabetic controls to uncover tissue-specific molecular drivers of DFU pathogenesis. Differential expression analyses identified 105 overlapping targets across tissues, with hub genes like AKT1 and MMP9 enriched in oxidative stress, inflammation, and bacterial response pathways (e.g., AGE-RAGE, TNF, IL-17). Refractory DFUs showed upregulated pro-inflammatory genes and downregulated repair factors, suggesting personalized therapies targeting fibrosis and angiogenesis for improved healing in diabetic wounds.

    Key Highlights:

    • Dataset: Skin/adipose/muscle from 10 DFU patients vs. 10 controls; 105 common DEGs, 10 hubs (AKT1, EGFR, MMP9).
    • Pathways: Enriched in AGE-RAGE (diabetic complications), TNF/IL-17 (inflammation), bacterial invasion; tissue-specific: skin fibrosis, muscle ECM degradation.
    • Refractory signatures: Upregulated IL6, CDKNs; downregulated CCNA2; links to poor granulation and chronicity.
    • Therapeutic targets: AKT1/HSP90AA1 for survival; MMP9/MAPK8 for matrix preservation and inflammation control.
    • Implications: Supports precision medicine for DFUs; future: RT-qPCR validation in larger cohorts.

    Read full article

    Keywords: transcriptomic profiling, diabetic foot ulcers, tissue-specific genes, inflammatory pathways, refractory wounds

    Smart Hybrid Nanomaterials for Chronic Infections



    Smart Hybrid Nanomaterials for Chronic Infections: Microbiome-Responsive and Sustainable Therapeutic Strategies

    Summary:** This review explores smart hybrid nanomaterials for treating chronic infections in diabetic foot ulcers (DFUs), leveraging microbiome-specific triggers like pH, redox, or enzymes for on-demand drug release. DFUs, affecting 15-25% of diabetics, often involve biofilms and antibiotic resistance, leading to amputations. Nanomaterials—liposomes, dendrimers, metal-organic frameworks—enhance penetration, target bacteria, and minimize side effects, with examples like pH-sensitive liposomes releasing vancomycin in acidic infected sites. Sustainable aspects include biodegradable polymers and green synthesis, promising cost-effective, localized therapies to overcome systemic antibiotic limitations in DFU management.

    Key Highlights:

    • DFU Pathogenesis: Neuropathy, ischemia, and hyperglycemia foster biofilms; 50% become infected, with 20% requiring amputation.
    • Nanomaterial Types: Liposomes for encapsulation, dendrimers for branching delivery, MOFs for high loading; responsive to bacterial metabolites.
    • Mechanisms: pH/redox-responsive release in infected microenvironments; photothermal therapy with nanoparticles kills bacteria via heat.
    • Sustainability: Biodegradable carriers reduce environmental impact; green synthesis using plant extracts for eco-friendly production.
    • Challenges/Future: Clinical translation needed; combination with phage or CRISPR for multi-modal DFU therapy.

    Read full article

    Keywords: nanomaterials, diabetic foot ulcers, microbiome-responsive, biofilm therapy, sustainable nanotech

    Risk Management Is Important to Healthcare Facilities in Order to Prevent Pressure Ulcers



    Risk Management Is Important to Healthcare Facilities in Order to Prevent Pressure Ulcers

    Summary: This article discusses the critical role of risk management in healthcare to mitigate pressure ulcers (bedsores), a common complication in nursing homes and hospitals from prolonged immobility. It highlights prevention programs including regular skin assessments, repositioning schedules, and specialized mattresses to redistribute pressure, alongside staff training and documentation to avoid legal and financial liabilities. By addressing root causes like poor nutrition and incontinence, facilities can reduce incidence, enhance patient outcomes, and comply with regulations, ultimately lowering waste from extended stays and treatments.

    Key Highlights:

    • Pressure ulcers form from sustained pressure on bony prominences, leading to tissue damage and infection risks in immobile patients.
    • Prevention strategies: Hourly turning, barrier creams for incontinence, high-protein diets, and Braden Scale assessments for early risk detection.
    • Specialized equipment: Alternating air mattresses or foam overlays reduce shear and friction for high-risk individuals.
    • Legal implications: Proper documentation defends against negligence claims; failure to prevent can result in lawsuits and fines.
    • Overall benefits: Proactive management cuts readmissions, shortens healing time, and improves quality of life for vulnerable patients.

    Read full article

    Keywords: pressure ulcers, risk management, nursing home care, skin assessment, repositioning schedules

    Hospital Safety Climate and Organizational Characteristics Predict HAIs and …



    Hospital Safety Climate and Organizational Characteristics Predict HAIs and Occupational Health Outcomes

    Summary: This multi-site study reveals that a robust patient safety climate and adherence to standard precautions significantly reduce hospital-acquired infections (HAIs) like MRSA and CAUTI, as well as occupational exposures, explaining 23-43% of variance alongside factors like nurse staffing and Magnet status. Observed adherence is suboptimal at 64.4%, particularly in hand hygiene, highlighting opportunities for infection preventionists (IPs) to use observational tools for cross-cutting surveillance, including pressure ulcer prevention, to enhance situational awareness and integrate care standards for better wound and occupational safety outcomes.

    Key Highlights:

    • Safety Climate: Stronger climate boosts adherence to precautions, lowering HAIs (e.g., MRSA, CAUTI) and injuries (needlesticks, mucocutaneous).
    • Adherence Gaps: 64.4% overall; role differences (e.g., nurses higher in hand hygiene); underreporting worsens trends.
    • Organizational Factors: Nurse staffing and professional environments influence outcomes; Magnet hospitals show better safety.
    • Pressure Ulcers: IPs coordinate prevention as part of complex care; surveillance tools aid awareness in wound-related HAIs.
    • Future: AHRQ-funded SIPPS Trial tests simulation for precautions; calls for IP-led interventions.

    Read full article

    Keywords: hospital safety climate, HAIs, pressure ulcer prevention, standard precautions, infection preventionists

    Diabetic Foot Care: New Tech & Preventing Amputations


    Diabetic Foot Care: New Tech & Preventing Amputations

    Summary: With 1 in 5 diabetics facing foot ulcers and up to 20% leading to amputation (costing >$30,000/case), this article explores innovations like AI for early detection, bioengineered skin substitutes, hyperbaric oxygen therapy (HBOT), phage therapy, and telehealth to improve outcomes and accessibility. Emphasizing prevention through daily inspections, proper footwear, and glycemic control, it highlights tools like Podimetrics’ remote monitoring and community education to enhance adherence, ultimately reducing mobility loss and long-term healthcare burdens.

    Key Highlights:

    • Stats: 15% lifetime DFU risk; 25-33% amputation rate; $9B+ annual U.S. cost.
    • AI Detection: Analyzes gait/genetics for risk prediction; Podimetrics uses images/patient data for proactive care.
    • Wound Tech: Stem cells/platelet-rich plasma accelerate healing; bioengineered scaffolds support growth; HBOT boosts perfusion; phage targets resistant bacteria.
    • Telehealth: Remote consults cut amputations (e.g., VA programs); challenges: equity, privacy.
    • Prevention: Foot checks, smoking cessation, BMI control; peer support for adherence.

    Read full article

    Keywords: diabetic foot care, amputation prevention, AI prediction, phage therapy, telehealth wounds

    Atom Insights, Superbug Cure & Healing Advances – Oct 29, 2025



    Science News: Atom Insights, Superbug Cure & Healing Advances – Oct 29, 2025

    Summary: This roundup spotlights emerging regenerative therapies for chronic wounds, including electrical stimulation to reprogram macrophages for faster diabetic ulcer healing, flatworm stem cell mechanisms for long-distance tissue communication, and a novel antibiotic 100 times more potent against superbugs like MRSA with no resistance development. Building on decades of research, these innovations promise to shift wound care from management to true regrowth, improving outcomes for conditions like arthritis and enhancing healthspan by tackling inflammation and injury at the cellular level.

    Key Highlights:

    • Macrophage reprogramming: Targeted electrical stimulation accelerates tissue repair in hard-to-heal diabetic ulcers by boosting immune response.
    • Flatworm regeneration: Insights into stem cell signaling enable distant cellular coordination, potential for organ repair in chronic wounds.
    • Superbug antibiotic: 100x stronger than current drugs, kills MRSA without resistance, addressing biofilm challenges in ulcers.
    • Microbiome focus: Novel compounds from gut flora enhance healing and combat chronic inflammation.
    • Broader impact: Beyond wounds, applications in arthritis and aging, emphasizing preventive regenerative strategies.

    Read full article

    Keywords: regenerative medicine, diabetic ulcers, superbug therapy, macrophage reprogramming, antibiotic resistance

    CAMPs Evidence Compendium 2025: Unifying Cellular, Acellular, and ….



    CAMPs Evidence Compendium 2025: Unifying Cellular, Acellular, and Matrix Products for Chronic Wound Care

    Summary: This October 2025 compendium from the Journal of Wound Care consolidates evidence on Cellular, Acellular, and Matrix-like Products (CAMPs), including placental allografts and ECM scaffolds, for chronic wounds like DFUs, VLUs, and pressure ulcers. Featuring 40+ authors, it reviews RCTs, case series, and economic models showing 50-98% closure rates, 35-80% amputation reductions, and $170/pt savings, while addressing reimbursement caps and fraud. It advocates MDT integration, fixed-fee models ($400-704/cm²), and registries for standardized coverage, positioning CAMPs as early interventions to enhance granulation and prevent complications.

    Key Highlights:

    • Authors: 50+ experts, including William Tettelbach, Martha Kelso, David Armstrong; editorial team led by Shruti Kamath.
    • Evidence: dACM RCT (50% closure vs 35% SOC); FT-DPM (48% vs 27%); carePATCH (77.4-100% PAR); overall 86% closure in series.
    • Reimbursement: Proposes $400/cm² fixed fee for $2B savings; LCD limits (8 apps/16 wks) cause 30% failure; calls for AI oversight.
    • Policy: National Coverage Determination for equity; registries for accountability; targets fraud without access barriers.
    • Outcomes: QALY gains, fewer admissions; mechanisms: granulation promotion, infection control, ECM support.

    Read full article

    Keywords: CAMPs, placental allografts, chronic wounds, reimbursement policy, wound care evidence

    The Skin-Substitute Debate: Balancing Access and Costs in Wound Care



    The Skin-Substitute Debate: Balancing Access and Costs in Wound Care

    Summary: Medicare’s skin substitute spending for chronic wounds is projected at $15B in 2025, up 50% from 2024, prompting a debate between ACOs alleging fraud/waste and manufacturers warning of access barriers. CMS proposes capping reimbursement at $125/cm² to curb $7.7B first-half spend, but the MASS Coalition argues it ignores root causes like promo and could drive $100B+ in hospital costs. With 25M affected Americans, the piece highlights calls for AI oversight, accreditation, and registries to protect evidence-based therapies like allografts for DFUs and VLUs.

    Key Highlights:

  • Spending: $7.7B in H1 2025; total $15B projected, from $1.6B in 2022.
  • ACOs’ View: Wasteful/fraudulent; NAACOS urges CMS action for Medicare sustainability.
  • Industry Response: CMS cuts won’t fix fraud; may increase costs via longer hospital stays.
  • Proposed Fixes: AI for billing, national coverage, provider accreditation, outcomes registries.
  • Impact: Risks patient harm; uniform LCDs needed for equity in wound care access.
  • Read full article

    Keywords: skin substitutes, Medicare reimbursement, wound care policy, wasteful spending, DFU access

    Lakewood-Amedex Biotherapeutics Announces Peer-Reviewed Publication Demonstrating Potent Antimicrobial ….



    Lakewood-Amedex Biotherapeutics Announces Peer-Reviewed Publication Demonstrating Potent Antimicrobial Activity of Bisphosphocin® Class Against Resistant Pathogens

    Summary: Lakewood-Amedex Biotherapeutics announces a peer-reviewed publication in Antimicrobial Agents and Chemotherapy detailing Bisphosphocin® Nu-3’s broad-spectrum activity against resistant pathogens, including MRSA, E. coli, Pseudomonas, Klebsiella, and Acinetobacter. The study shows Nu-3 kills bacteria in minutes via membrane destabilization, with no resistance in 21-passage tests, positioning it as a topical gel for mildly infected diabetic foot ulcers (iDFUs). With 13 million U.S. iDFU cases yearly and 50% infection rate, Nu-3 addresses systemic antibiotic failures in poor-perfusion tissues, advancing to Phase 2 trials for chronic wound care.

    Key Highlights:

  • Publication: “In Vitro and In Vivo Characterization of Bisphosphocin® Nu-3 – A Novel Broad Spectrum Antimicrobial Compound with High Potency Against Resistant Pathogens” (Oct 22, 2025).
  • Efficacy: Rapid cidal action at topical concentrations; low resistance propensity due to unique mechanism.
  • iDFU Focus: Targets 50% infected ulcers; overcomes poor penetration of systemic antibiotics.
  • Development: Gel formulation for Phase 2; potential for UTI/pulmonary infections.
  • Impact: Addresses 5M global AMR deaths; CEO Kelvin Cooper: “A game-changer for wound care.”
  • Read full article

    Keywords: Bisphosphocin Nu-3, antimicrobial, diabetic foot ulcers, AMR, membrane destabilization

    Wound Bed Preparation with Topical Desiccating Agent



    Early Clinical Experience with a Topical Desiccating Agent for Wound Bed Preparation in Diabetic Foot Ulcers

    Summary: This retrospective case series evaluated a novel topical desiccating agent (TDA) under compassionate use for wound bed preparation in 67 patients with chronic diabetic foot ulcers (DFUs) from 2020-2023. TDA facilitated debridement and granulation, achieving granulation in 88.1% (mean 44.3 days) and complete re-epithelialization in 85.1%, with no adverse events. The agent offers a safe, non-invasive option for high-risk cases, supporting further prospective validation for DFU protocols.

    Key Highlights:

    • Cohort: 67 adults with stalled DFUs; ethics-approved compassionate use.
    • Granulation: 88.1% success; mean time 44.3 days to ready for grafting/closure.
    • Healing: 85.1% full re-epithelialization; rapid progression post-TDA.
    • Safety: No AEs; well-tolerated in diabetics.
    • Implications: Chemical debridement adjunct; calls for RCTs.

    Read full article

    Keywords: topical desiccating agent, diabetic foot ulcers, wound bed preparation, granulation, chemical debridement

    Epidermolysis Bullosa Argentina: Butterfly Skin & Garrahan Hospital Care



    Epidermolysis Bullosa Argentina: Butterfly Skin & Garrahan Hospital Care

    Summary: In Argentina, epidermolysis bullosa (EB) affects ~1,200 people with “butterfly skin” that blisters from minor friction, requiring lifelong wound care to prevent infections. Garrahan Hospital leads with multidisciplinary teams for diagnosis, nutrition, pain management, and mental health, while CEDIGEA advances genetic sequencing for mutation-specific therapies. Challenges include malnutrition from esophageal strictures, chronic pain, and social isolation, but hope lies in gene therapy, protein replacement, stem cells, and bioengineered skins. Support groups like Alas de Mariposa advocate for funding and awareness to shift from symptom relief to cures.

    Key Highlights:

  • EB spectrum: Lethal infancy forms to adult chronic cases; skin adhesion gene mutations cause fragility beyond skin to organs.
  • Diagnosis: Genomic sequencing at CEDIGEA pinpoints mutations for tailored care and therapy targeting.
  • Care at Garrahan: Integrates wound prevention, nutrition, pain relief, and psych support; model for regional EB management.
  • Emerging therapies: Gene therapy restores proteins; stem cells regenerate skin; advanced dressings/bioengineered substitutes reduce infections.
  • Advocacy: Alas de Mariposa provides resources; calls for donations, awareness, and policy for rare disease access.
  • Read full article

    Keywords: epidermolysis bullosa, butterfly skin, Garrahan Hospital, gene therapy, EB care

    Technion Scientists Create Mollusk-Inspired Adhesive That Seals Wounds in Seconds



    Technion Scientists Create Mollusk-Inspired Adhesive That Seals Wounds in Seconds

    Summary: Researchers at Israel’s Technion have engineered a mussel-inspired bioadhesive that bonds tissues in seconds, even underwater, revolutionizing wound closure for chronic and surgical sites. Mimicking mussel foot proteins with catechol groups for wet adhesion and oxidized crosslinking, the gel forms a strong, flexible seal without sutures, promoting hemostasis and preventing infection. Tested on rat skin and liver models, it outperforms commercial glues in bond strength and biocompatibility, offering a non-invasive solution for diabetic ulcers, burns, and trauma wounds where traditional methods fail.

    Key Highlights:

    • Mechanism: Catechol oxidation creates covalent bonds for rapid curing (5-10 seconds) in moist environments.
    • Materials: Biodegradable polymers with mussel-mimicking peptides; tunable viscosity for injection or spraying.
    • Efficacy: 10x stronger adhesion than fibrin glues; full hemostasis in liver incisions; no inflammation in 7-day implants.
    • Applications: Ideal for DFUs, internal bleeding, and minimally invasive surgery; scalable for clinical use.
    • Future: Human trials planned; potential to reduce scarring and infection in chronic wound care.

    Read full article

    Keywords: mussel-inspired adhesive, instant wound sealant, catechol chemistry, biocompatible glue, Technion innovation

    Kenya’s Wound Care Crisis and the Urgent Need for Early Intervention to Prevent Amputations



    Kenya’s Wound Care Crisis and the Urgent Need for Early Intervention to Prevent Amputations

    Summary: Kenya grapples with a mounting wound care crisis, where 15% of adults suffer injuries yearly, leading to untreated chronic conditions, infections, and preventable amputations, particularly in rural areas with 13% wound prevalence. Diabetes amplifies risks, with 22% of wounds developing secondary infections, as seen in cases like Kennedy Chesi Amunavi’s near-amputation from a neglected diabetic ulcer. Experts like Dr. Shilpa Mulki and Dr. Chris Kibiwott advocate for decentralized services, clinician training in diabetic foot management, compression therapy, and biotherapy, alongside awareness campaigns for early screening to save limbs and reduce healthcare burdens.

    Key Highlights:

    • Stats: 15% annual adult injuries; 4% from road crashes, 10.9% unintentional; rural 13% wound rate; 22% secondary infections.
    • Case: Amunavi’s diabetic boil worsened by herbs, nearly requiring amputation, saved via grafting after delays.
    • Gaps: No public hospital wound programs; 46% NCD specialists; rural shortages in nutrition/lab support.
    • Recommendations: Daily foot checks, compression, biotherapy; train generalists; integrate podiatrists/nutritionists.
    • Impact: Early care prevents amputations, preserves livelihoods; calls for county/MoH prioritization.

    Read full article

    Keywords: wound care crisis, diabetic amputations, early intervention, rural wound care, compression therapy

    Thane Fisherman’s Hand Saved from Amputation After Rare Eel Fish Bite in Uttan



    Thane Fisherman’s Hand Saved from Amputation After Rare Eel Fish Bite in Uttan

    Summary: In a dramatic case at Wockhardt Hospitals, Mira Road, a 42-year-old fisherman, Sandip Bhoin, was rescued from limb-threatening infection after a rare double bite from an eel during a fishing trip at Uttan Beach. Arriving 17 hours later with a grossly swollen, pale hand lacking circulation and sensation, he was diagnosed with acute compartment syndrome. Led by Dr. Sushil Nehete, the surgical team performed an emergency fasciotomy to release pressure, restoring blood flow instantly. Post-op, ICU monitoring prevented kidney failure from metabolic waste, and he’s now on track for full recovery with skin grafting and physiotherapy, underscoring the critical role of prompt wound intervention in traumatic marine injuries.

    Key Highlights:

    • Incident: Eel bite caused deep lacerations and heavy bleeding; initial pressure bandage by peers delayed but helped temporarily.
    • Symptoms on arrival: Excruciating pain, swelling, pallor, absent sensation—hallmarks of compartment syndrome obstructing blood flow.
    • Surgery: Fasciotomy released forearm/carpal tunnel pressure; immediate circulation return with rapid sensation/movement improvement.
    • Post-op: ICU averted renal complications; ongoing wound care, grafting, and physio for hand function restoration.
    • Outcome: Hand saved from amputation; full recovery expected in months, emphasizing early referral for trauma wounds.

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    Keywords: traumatic wound, compartment syndrome, fasciotomy, marine injury, wound infection

    Hypoxia-Induced Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells …

    Hypoxia-Induced Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Regulate Macrophage Polarization and Enhance Angiogenesis to Promote Diabetic Wound Healing

    Summary: Researchers engineered extracellular vesicles (EVs) from human umbilical cord MSCs under hypoxia and showed that these EVs boost fibroblast and endothelial function, activate HIF-1α–VEGFA signaling, promote M2 macrophage polarization, reduce ROS, and accelerate healing in a diabetic wound model.

    Key Highlights:

    • Hypoxia-induced EVs (hy-EVs) improved human skin fibroblast activity and endothelial proliferation/migration versus normoxic EVs.
    • Evidence of angiogenesis via increased HIF-1α, VEGFA, and CD31 expression; aligns with enhanced neovascularization in vivo.
    • Immunomodulation: hy-EVs shifted macrophages from M1 (CD86) to M2 (CD206), dampening inflammatory responses at the wound site.
    • Reduced oxidative stress by inhibiting ROS in fibroblasts and endothelial cells.
    • In diabetic wound models, hy-EVs increased collagen deposition, angiogenesis, and overall healing metrics.
    • Authors propose hy-EV cargo (miRNAs/proteins) as a basis for next-gen EV therapeutics for chronic diabetic wounds.

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    Keywords: extracellular vesicles, HUCMSC, hypoxia, HIF-1α, angiogenesis, macrophage polarization, reactive oxygen species, diabetic wound healing, Yongfeng Su, Junda Lu, Feiyuan Liang, Jianwen Cheng

    The impact of PANoptosis-related genes on immune profiles and subtype classification in ischemic stroke

    The impact of PANoptosis-related genes on immune profiles and subtype classification in ischemic stroke

    Summary: This open-access computational study profiles PANoptosis-related genes (integrating pyroptosis, apoptosis, and necroptosis) in ischemic stroke blood datasets to define diagnostic gene signatures and immune-infiltration subtypes. While not a wound-care trial, the work offers mechanistic insights into inflammatory cell-death pathways that may inform future translational research across ischemia-driven tissue injury and chronic wound inflammation.

    Key Highlights:

    • Analyzed GEO datasets (e.g., GSE58294) to identify differentially expressed PANoptosis-related genes and build diagnostic models (ROC performance reported).
    • Constructed interaction networks (genes–miRNAs–TFs–drugs) and a nomogram to visualize diagnostic potential.
    • Single-cell re-analysis (GSE174574) mapped candidate genes to immune-cell subpopulations relevant to post-ischemic inflammation.
    • Unsupervised clustering defined two immune subtypes with distinct infiltration patterns and functional pathways.
    • Authors suggest these signatures could guide early diagnosis and targeted therapies in ischemic stroke; pathways overlap with inflammation and cell-death mechanisms studied in chronic wounds.

    Read full article

    Keywords: PANoptosis, pyroptosis, apoptosis, necroptosis, ischemic stroke, bioinformatics, immune infiltration, biomarkers, Xinrui Cai, Yu Ren, Qin Yang

    Molnlycke Health Care Expands Wound Care Manufacturing Facility



    Molnlycke Health Care Expands Wound Care Manufacturing Facility

    Summary: Molnlycke Health Care is investing $135 million to expand its Brunswick, Maine facility, increasing U.S. wound care production capacity with completion targeted for late 2026 or early 2027. The upgrade features advanced U.S.-sourced machinery, renewable energy (wind/solar), and streamlined logistics for sustainability. Over five years, it will create ~10% more jobs (local contractors/suppliers) and faster delivery of products like advanced dressings for chronic wounds, pressure ulcers, and surgical sites. CEO Zlatko Rihter emphasizes resilience and patient access, while GM Chris Biddle highlights community partnerships.

    Key Highlights:

    • Investment scope: $135M for expansion; boosts production of wound care solutions amid rising demand.
    • Sustainability: Integrates wind/solar power; reduces carbon footprint through efficient logistics.
    • Job creation: 10% workforce growth in Maine; engages local economy with suppliers and contractors.
    • Product impact: Enhances supply of dressings for chronic wounds, supporting faster, smarter care.
    • Quotes: Rihter: “A bold step… to deliver high-quality solutions sustainably.” Biddle: “A win for Molnlycke, community, and patients.”

    Read full article

    Keywords: Molnlycke expansion, wound care manufacturing, advanced dressings, sustainable production, chronic wound supply

    From Webs to Wound Healing: ASU Scientists Harness Silk for Medical Innovation



    From Webs to Wound Healing: ASU Scientists Harness Silk for Medical Innovation

    Summary: Arizona State University researchers, led by Professors Jeff Yarger and Kaushal Rege, are pioneering silk proteins from silkworms and spiders for advanced wound healing, as detailed in ACS Biomaterials Science & Engineering. Their laser-activated sealants (LASEs) embed gold nanorods or indocyanine green in silk fibroin matrices, enabling near-infrared laser-triggered heating to seal wounds in seconds—stronger than sutures while minimizing trauma. Versatile forms (fibers, hydrogels, sponges) loaded with antibiotics like vancomycin promote sustained release, biocompatibility, and biodegradation, targeting chronic wounds such as diabetic foot ulcers and pressure sores by enhancing tissue repair and infection prevention.

    Key Highlights:

    • LASEs close wounds instantly via photothermal activation, outperforming sutures in strength and reducing scarring/infection.
    • Silkworm silk fibroin serves as biocompatible matrix; spider egg-case silk explored for tendon-like scaffolds due to superior toughness.
    • Drug delivery: Sustained vancomycin release combats biofilms in chronic wounds; preclinical models confirm efficacy.
    • Versatility: Processable into 3D scaffolds for tissue engineering, personalized dressings with growth factors.
    • Future: Recombinant spider silk production to scale up; applications in DFUs, burns, and surgical sites for faster, safer healing.

    Read full article

    Keywords: spider silk, silk fibroin, laser-activated sealant, chronic wound healing, biodegradable scaffold

    Prevention of Infection in Peripheral Arterial Reconstruction of the Lower Limb



    Prevention of Infection in Peripheral Arterial Reconstruction of the Lower Limb

    Summary: This Cochrane review synthesizes evidence from 40 RCTs and quasi-RCTs involving 7970 participants on pharmacological and non-pharmacological interventions to prevent infections after lower limb peripheral arterial reconstruction. Prophylactic antibiotics likely reduce surgical site infections (SSIs) and graft infections (low-certainty evidence), but no clear differences exist between short- vs. long-duration regimens or antibiotic types (very low-certainty). Closed incision negative pressure therapy (ciNPWT) may lower SSI and graft infection risks compared to standard closure (very low-certainty), while other methods like dressings or sutures show little benefit. The review highlights the need for standardized trials to guide wound care protocols in vascular surgery, where infections complicate healing and increase amputation risks.

    Key Highlights:

    • Antibiotics vs. none: Reduced SSIs (RR 0.20, 95% CI 0.11-0.34; NNT 9) and graft infections (RR 0.19, 95% CI 0.06-0.63; low-certainty).
    • Short vs. long antibiotics: No difference in SSIs (RR 0.75, 95% CI 0.40-1.40) or graft infections (very low-certainty).
    • ciNPWT vs. standard: Possible reduction in SSIs (RR 0.49, 95% CI 0.27-0.86) and graft infections (RR 0.55, 95% CI 0.19-1.59; very low-certainty).
    • No effects on mortality, re-intervention, or amputation across comparisons (very low- to low-certainty evidence).
    • Implications: Suggest antibiotics for prevention; ciNPWT promising for high-risk surgical wounds; more research needed for dressings and techniques.

    Read full article

    Keywords: peripheral arterial reconstruction, surgical site infection, prophylactic antibiotics, closed incision NPWT, vascular wound care

    The Trump Administration Must Protect Patient Access to Advanced Wound Care



    The Trump Administration Must Protect Patient Access to Advanced Wound Care

    Summary: This opinion piece by Martha Kelso and Rajendra S. Gogia criticizes the Trump administration’s proposed CMS rulemaking to slash reimbursement for advanced wound care therapies, arguing it threatens millions with chronic wounds by ignoring their evidence-based benefits in reducing infections, amputations, and costs. Affecting 25 million Americans (including 6.5 million at any time), these treatments—like bio-engineered substitutes and cellular products—shorten recovery and prevent complications, yet face arbitrary cuts amid fraud concerns. The authors call for smarter reforms: AI-aided billing, accreditation, national coverage determinations, and outcomes registries to balance costs with innovation, noting Trump’s own venous insufficiency as a personal stake in preserving access.

    Key Highlights:

    • Chronic wounds cost billions; advanced care saves money by avoiding hospitalizations/amputations, but proposed cuts risk exacerbating this.
    • Misconceptions: Treatments aren’t wasteful; fraud should be tackled with AI verification, not blanket reductions punishing patients.
    • Policy fixes: National Coverage Determination for uniform access; AI for medical necessity docs; provider accreditation; national registries for accountability.
    • Patient impact: 15% of Medicare beneficiaries affected; delays in care lead to pain, disability, and higher long-term expenses.
    • Personal note: Trump’s venous insufficiency highlights need; urges reversal to protect vulnerable populations.

    Read full article

    Keywords: advanced wound care, CMS reimbursement, chronic wounds, cellular products, wound care policy

    BioLab Holdings Inc. Announces Multiple Clinical Trials to Advance Chronic Wound Care



    BioLab Holdings Inc. Announces Multiple Clinical Trials to Advance Chronic Wound Care

    Full Press Release:

    Phoenix, AZ, October 22, 2025 – BioLab Holdings, Inc., a Phoenix-based medical manufacturer specializing in wound care solutions, announced the ongoing development of several clinical trials to demonstrate the efficacy and safety of its Cellular, Acellular, and Matrix-like Products (CAMPs) in covering and protecting non-healing wounds, including diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs). The trials are in response to mandates from the MAC region for robust data to support product efficacy for inclusion in the upcoming Local Coverage Determination (LCD), effective January 1, 2026, for DFUs and VLUs.

    The trials include:

    1. BIOCAMP Trial: A multicenter, prospective, randomized controlled study assessing human placental membrane products combined with standard of care (SOC) versus SOC alone for non-healing DFUs and VLUs. Preliminary data will be presented at the TRES conference on October 30, 2025.

    2. CAMP RWE Trial: A multicenter hybrid platform study comparing tri-layer and single-layer amnion grafts to a matched retrospective control cohort for hard-to-heal DFUs and VLUs. The study will be submitted for publication with Dr. Windy Cole’s assistance.

    3. Retrospective Study: A real-world data collection trial evaluating human amniotic membrane(s) on DFUs, VLUs, pressure ulcers, and post-operative wounds, corroborated by randomized controlled trials.

    4. Meta Analyses & Mega Meta Analysis: BioLab is supporting meta-analyses by Serena Group, including a mega-meta-analysis, to demonstrate similar healing rates across membrane products regardless of brand.

    5. LCD Timeline: The proposed LCD for DFUs and VLUs is effective January 1, 2026, with other wound types requiring standard care prior to use.

    “These trials represent a significant step forward in providing the clinical evidence needed to ensure that our innovative wound care solutions are accessible to patients who need them most,” said BioLab CEO [Name not specified]. “We are committed to advancing the science of chronic wound management and improving outcomes for patients with DFUs and VLUs.”

    About BioLab Holdings, Inc.

    BioLab Holdings, Inc. is a leading manufacturer of advanced wound care products, specializing in human amniotic membrane allografts such as Membrane Wrap Lite™, Tri-Membrane Wrap™, Membrane Wrap™, and Membrane Wrap-Hydro™. These products are designed to support the healing of chronic and non-healing wounds, including DFUs, VLUs, pressure ulcers, and post-operative wounds.

    For more information, visit www.biolabholdings.com.

    Contact: [Contact info not specified]

    Key Highlights:

    • BIOCAMP Trial: Prospective RCT for placental membranes in DFUs/VLUs; preliminary data at TRES October 30, 2025.
    • CAMP RWE Trial: Hybrid study comparing graft layers to controls; submission for publication with Dr. Windy Cole.
    • Retrospective Study: Real-world data on amniotic membranes for multiple wound types, backed by RCTs.
    • Meta-Analyses: Supported by Serena Group to show consistent healing across products for LCD inclusion.
    • LCD Impact: Effective January 1, 2026 for DFUs/VLUs; aims to ensure coverage for BioLab’s allografts.

    Read full article

    Keywords: BioLab Holdings, amniotic membrane, diabetic foot ulcers, venous leg ulcers, LCD coverage

    Artacent Amniotic Tissue for Treatment of Chronic Lower Extremity Diabetic Ulcers



    Clinical Trial: Artacent Amniotic Tissue for Treatment of Chronic Lower Extremity Diabetic Ulcers

    Summary: Sponsored by Tides Medical, this completed interventional Phase 2 trial (NCT07219004, started March 3, 2023) investigates the efficacy of Artacent—a tri-layered dehydrated human amnion/chorion/amnion composite graft—as a treatment for chronic lower extremity diabetic ulcers persisting despite standard care. Enrolling patients with non-healing wounds, the study assesses whether the amniotic tissue promotes closure over 12 weeks, addressing the high burden of diabetic ulcers that affect millions and often lead to amputations. While specific outcomes remain pending publication, the trial underscores amniotic products’ potential in regenerative wound healing by providing a structural matrix for tissue repair and reducing inflammation.

    Key Highlights:

    • Trial design: Interventional, single-group assignment; focuses on 12-week healing in chronic diabetic lower extremity ulcers.
    • Product: Artacent tri-layered graft supports cellular migration and vascularization for stalled wounds.
    • Relevance: Targets non-healing ulcers post-standard care, common in diabetics with vascular/neurological complications.
    • Sponsor: Tides Medical; status: Completed (recruitment finished); no interim efficacy/safety data released yet.
    • Implications: Builds evidence for amniotic membranes in DFU management, potentially improving closure rates and limb salvage.

    Read full article

    Keywords: Artacent, amniotic tissue, diabetic ulcers, phase 2 trial, regenerative graft

    Nagaland University Researchers Find Plant Compound to Treat Diabetic Wound Foot Ulcers



    Nagaland University Researchers Find Plant Compound to Treat Diabetic Wound Foot Ulcers

    Summary: Researchers at Nagaland University have identified sinapic acid, a naturally occurring antioxidant from edible plants, as a powerful therapeutic for accelerating wound healing in diabetic patients, particularly foot ulcers. Published in Nature Scientific Reports, the study demonstrates that oral administration of sinapic acid activates the SIRT1 pathway to promote tissue repair, angiogenesis, and inflammation control in preclinical models. Notably, a lower dose (20 mg/kg) proved more effective than higher doses (40 mg/kg), exhibiting an inverted dose-response curve. This discovery offers a safe, natural, and affordable alternative to synthetic drugs, potentially reducing amputation risks and improving accessibility in resource-limited settings, with pilot clinical trials planned next.

    Key Highlights:

    • Sinapic acid targets diabetic foot ulcers by addressing neuropathy, poor circulation, infections, and oxidative stress through SIRT1 activation.
    • Preclinical results: Oral low-dose sinapic acid enhanced metabolic health, wound closure, and reduced side effects compared to higher doses.
    • Global impact: Diabetes affects millions; delayed healing leads to ulcers and amputations—sinapic acid provides a non-invasive oral solution.
    • Lead researcher: Prof. Pranav Kumar Prabhakar, Head of Biotechnology at Nagaland University, highlights limited efficacy of existing drugs.
    • Future steps: Pilot trials to validate in humans, focusing on rural accessibility and patentable formulations.

    Read full article

    Keywords: sinapic acid, diabetic foot ulcers, SIRT1 activation, oral wound therapy, Nagaland University

    Tips for Scalp Dressings: Securing Head Wounds Effectively



    Tips for Scalp Dressings: Securing Head Wounds Effectively

    Summary: This practical guide from Wounds Africa tackles the unique challenges of dressing scalp wounds on hairy heads, where traditional bandages often slip or cause discomfort. Focusing on malignant wounds (e.g., basal/squamous cell carcinomas), actinic keratoses, burns, and trauma, it outlines eight alternative methods to ensure secure, comfortable coverage while preserving patient vanity and mobility. Techniques range from simple hair clips to advanced turban bandaging, emphasizing soft, non-irritating options like chemotherapy caps. Ideal for chronic or post-surgical care, these tips promote healing by maintaining consistent pressure relief and infection prevention without invasive fixation.

    Key Highlights:

    • Common challenges: Dressings slip on hair, causing pain or exposure; solutions prioritize non-adherent, customizable methods for daily changes.
    • Hair clips method: Secure bandages with clips to avoid tape on hair; combine with underlying tape for stability, removing clips when lying down to prevent marks.
    • Hair tying technique: Use Steri-Strips to tie hair over small dressings for easy, painless removal; effective for minor abrasions or grafts.
    • Tie-over bolster: Reusable sutures anchor bolsters over grafts, ideal for larger scalp defects post-surgery.
    • Net stocking: Soft tubular netting holds multiple dressings; choose finer mesh for comfort on sensitive scalps.
    • Turban bandaging: Preferred long-term method; wrap gauze/tubigrip around head for secure fit—practice recommended for even pressure.
    • Soft coverings: Beanies or chemotherapy caps conceal and secure dressings, boosting patient confidence during healing.
    • Visual aids: Includes illustrations and video links (YouTube/Vimeo) demonstrating each technique for hands-on learning.

    Read full article

    Keywords: scalp dressings, head bandages, turban technique, hair clips, post-surgical scalp wounds

    Essity’s Cutimed launches its first brand campaign

    Essity and Publicis London Reimagine Healing with “Imagine a World” Campaign

    Summary: Essity’s wound-care brand Cutimed launches “Imagine a World,” a new campaign by Publicis London aimed at shifting public perception of chronic wound care. Creative assets spotlight advanced technologies across the Cutimed portfolio and reinforce the message that every wound deserves the right to heal.

    Key Highlights:

    • Brand campaign centered on chronic wound-healing possibilities.
    • Creative includes a master brand film and shorter social formats.
    • Highlights innovations across Cutimed dressings.
    • Supports broader awareness efforts around chronic wounds.

    Read full article

    Keywords: Essity, Cutimed, Publicis London, brand campaign

    Real-world outcomes of a placenta-based tissue product versus standard …

    Real-world outcomes of a placenta-based tissue product versus standard of care for lower extremity diabetic ulcers: a Medicare cohort study

    Summary: This Journal of Wound Care study analyzes Medicare data to compare a placenta-based tissue product with standard care in lower-extremity diabetic ulcers. The product cohort demonstrated favorable healing outcomes in routine practice settings, adding real-world evidence to existing clinical data.

    Key Highlights:

    • Large Medicare dataset; comparative effectiveness design.
    • Placenta-based tissue product associated with improved healing endpoints vs SOC.
    • Supports reimbursement and protocol decisions in outpatient wound centers.
    • Authors call for prospective trials to validate observational signals.

    Read full article

    Keywords: placenta-based tissue product, real-world evidence, Journal of Wound Care, Tettelbach, Tucker

    Activated PRP Plus Angioplasty Enhances Healing in Diabetic Foot Ulcers

    Activated PRP Plus Angioplasty Enhances Healing in Diabetic Foot Ulcers, suggests study

    Summary: Reporting on new evidence from the World Journal of Diabetes, this piece highlights improved DFU healing when vascular intervention (angioplasty) is paired with activated PRP. The dual strategy targets ischemia and tissue regeneration, though authors call for larger randomized trials to standardize PRP protocols.

    Key Highlights:

    • Combination therapy: revascularization + biologic (activated PRP).
    • Enhanced wound-closure metrics compared to single-modality care.
    • Clinical rationale: restore perfusion and stimulate local tissue repair.
    • Next steps: standardize PRP activation, dosing, frequency in RCTs.

    Read full article

    Keywords: PRP, angioplasty, diabetic foot ulcer, World Journal of Diabetes, Huang

    Phase 1b Data for Topical Pravibismane in Diabetic Foot Ulcer Infection Demonstrates ….

    Phase 1b Data for Topical Pravibismane in Diabetic Foot Ulcer Infection Demonstrates Favorable Effects and Safety

    Summary: Dermatology Times reports Phase 1b results for topical pravibismane used adjunctively in moderate to severe infected diabetic foot ulcers. The therapy was well-tolerated and associated with favorable healing signals alongside standard care, with the source article published in the International Wound Journal.

    Key Highlights:

    • Adjunct topical pravibismane vs placebo in infected DFUs.
    • Safety and tolerability demonstrated across tested doses.
    • Signals toward greater ulcer-size reduction and fewer ulcer-related amputations.
    • Larger, confirmatory trials are warranted.

    Read full article

    Keywords: pravibismane, diabetic foot ulcer, International Wound Journal, Lipsky

    Effects of Oral Cholecalciferol on Chronic Wound Healing in Patients with Vitamin D Insufficiency

    Effects of Oral Cholecalciferol on Chronic Wound Healing in Patients with Vitamin D Insufficiency or Deficiency

    Summary: This peer-reviewed study evaluates whether correcting vitamin D insufficiency with oral cholecalciferol accelerates healing of chronic wounds. Participants receiving vitamin D plus conventional wound care showed faster reductions in wound area/depth and shorter time to healing versus conventional care alone, supporting the integration of deficiency screening and supplementation into routine protocols.

    Key Highlights:

    • Adults with chronic wounds and serum 25(OH)D < 30 ng/mL received short-term, high-dose cholecalciferol.
    • Improved wound-area and depth reduction rates; shorter time-to-healing compared with controls.
    • Findings align with holistic frameworks (e.g., TIME) where systemic factors impact local healing.
    • Authors note need for larger trials to standardize dosing and confirm outcomes.

    Read full article

    Keywords: vitamin D, cholecalciferol, chronic wounds, 25(OH)D, JMDH, Zhao

    The Mesenchymal Component of Human Amniotic Membrane Drives Wound Healing



    The Mesenchymal Component of Human Amniotic Membrane Drives Wound Healing

    Summary: This study dissects the therapeutic roles of epithelial (hAEC) and mesenchymal stromal cells (hAMSC) in human amniotic membrane (hAM) for wound healing, using a chronified keratinocyte model (SSTC-HaCaT) to mimic diabetic foot ulcers. Conditioned media from hAMSC significantly enhanced migration (via c-Jun/ERK pathway), cytoskeletal remodeling (F-actin/paxillin), proliferation (G1 rescue), and gene modulation (down IL6/CDKNs, up CCNA2) compared to hAEC or intact hAM. hAMSC’s potency persisted across passages, confirming its primary contribution to hAM’s efficacy in chronic wounds, with implications for scalable cell-based therapies to overcome stalled healing.

    Key Highlights:

  • hAMSC-CM boosted keratinocyte migration in scratch assays, stronger than hAEC-CM or hAM, via c-Jun overexpression at wound edges.
  • Cytoskeletal effects: hAMSC-CM induced focal adhesions and F-actin reorganization for motility in both serum-starved and TGF-β chronified models.
  • Proliferation rescue: Reduced G1 arrest in SSTC-HaCaT cells, with hAMSC-CM restoring cell cycle more effectively than hAEC-CM.
  • Gene expression: Downregulated inflammatory/arrest genes (IL6, CDKN2B, CDKN1A) and upregulated CCNA2, mimicking hAM’s anti-chronic effects.
  • Relevance: hAMSC as key driver for DFU therapies; supports targeted mesenchymal components for clinical translation.
  • Read full article

    Keywords: human amniotic membrane, hAMSC, chronic wound model, c-Jun pathway, keratinocyte migration

    Artacent Amniotic Tissue for Chronic Lower Extremity Diabetic Ulcers



    Clinical Trial: Artacent Amniotic Tissue for Chronic Lower Extremity Diabetic Ulcers

    Summary: Sponsored by Tides Medical, this completed interventional Phase 2 trial (NCT07219004, started March 3, 2023) investigates the efficacy of Artacent—a tri-layered dehydrated human amnion/chorion/amnion composite graft—as a treatment for chronic lower extremity diabetic ulcers persisting despite standard care. Enrolling patients with non-healing wounds, the study assesses whether the amniotic tissue promotes closure over 12 weeks, addressing the high burden of diabetic ulcers that affect millions and often lead to amputations. While specific outcomes remain pending publication, the trial underscores amniotic products’ potential in regenerative wound healing by providing a structural matrix for tissue repair and reducing inflammation.

    Key Highlights:

    • Trial design: Interventional, single-group assignment; focuses on 12-week healing in chronic diabetic lower extremity ulcers.
    • Product: Artacent tri-layered graft supports cellular migration and vascularization for stalled wounds.
    • Relevance: Targets non-healing ulcers post-standard care, common in diabetics with vascular/neurological complications.
    • Sponsor: Tides Medical; status: Completed (recruitment finished); no interim efficacy/safety data released yet.
    • Implications: Builds evidence for amniotic membranes in DFU management, potentially improving closure rates and limb salvage.

    Read full article

    Keywords: Artacent, amniotic tissue, diabetic ulcers, phase 2 trial, regenerative graft

    Indian Researchers Discover Natural Molecule to Speed Diabetic Wound Healing



    Indian Researchers Discover Natural Molecule to Speed Diabetic Wound Healing

    Summary: Led by Professor Pranav Kumar Prabhakar at Nagaland University and Dr. Jeena Gupta at Lovely Professional University, a groundbreaking study published in Nature Scientific Reports identifies sinapic acid—a plant-derived antioxidant—as the first oral therapy to accelerate diabetic wound healing through SIRT1 pathway activation. In preclinical models, low-dose oral sinapic acid (20 mg/kg) promoted tissue repair, angiogenesis, and inflammation control more effectively than higher doses, addressing systemic barriers like poor circulation and oxidative stress in diabetic foot ulcers. With an inverted dose-response curve, this accessible molecule offers a non-invasive, patentable solution for resource-limited settings, potentially reducing global amputation rates via upcoming pilot clinical trials and scalable formulations.

    Key Highlights:

    • Sinapic acid, from fruits/vegetables, targets SIRT1 to enhance blood vessel formation and reduce inflammation, tackling diabetic healing delays.
    • Preclinical results: Low dose outperformed higher ones, showing faster closure without side effects; first global oral demonstration.
    • Delivery advantage: Systemic bioavailability via oral route avoids invasive topicals, ideal for rural diabetics.
    • Publication: Nature Scientific Reports (DOI: 10.1038/s41598-025-03890-z); researchers developing affordable, patentable versions.
    • Impact: Could transform wound care accessibility, lowering amputation risks in high-burden areas like India.

    Read full article

    Keywords: sinapic acid, diabetic wound healing, SIRT1 pathway, oral therapy, Nagaland University

    The “Butterfly Skin” Crisis: Lack of Support in Ireland’s Wound Care



    Epidermolysis Bullosa: Ireland’s “Butterfly Skin” Patients Left Without Adequate Support

    Summary: A new report by Debra Ireland and Ernst & Young highlights the dire lack of support for the approximately 300 people living with epidermolysis bullosa (EB), a rare genetic disorder causing fragile “butterfly skin” that blisters and tears from minor friction. Patients endure painful daily wound bandaging to prevent infections, but face staff shortages, high nurse turnover, limited training in home care, inconsistent access to essential dressings, and no national bandage scheme—imposing heavy financial burdens. Psychological and dental support is virtually absent, exacerbating mental health issues and family strain, with calls for coordinated community care to alleviate the “devastating” and “prison-like” realities of living with this incurable condition.

    Key Highlights:

    • EB affects skin layers, causing blisters from everyday activities; severe cases require daily bandage changes to manage wounds and infections.
    • Support gaps: Fragmented home nursing with untrained staff; no national scheme for free dressings, leaving patients to pay out-of-pocket.
    • Financial/psychological toll: Complex welfare systems exhaust families; mental health support lacking, with parents feeling “punished” and “stuck in a hole.”
    • Patient voices: Amanda Nugent on guilt (“I gave that to him”); Liz Collins on caregiver isolation (“Carers often feel like prisoners”).
    • Recommendations: Dedicated community coordinators, sustainable nursing, and integrated care to improve wound management and quality of life.

    Read full article

    Keywords: epidermolysis bullosa, butterfly skin, wound bandaging, home nursing, EB support

    Bravida Medical Unveils Silverlon® NPD-212



    Bravida Medical Unveils Silverlon® NPD-212, Advancing Antimicrobial Protection in Incisional NPWT

    Full Press Release:

    NPD-212

    GENEVA, IL, UNITED STATES, October 21, 2025 /EINPresswire.com/ — Bravida Medical, a leader in infection prevention and advanced wound care solutions, announced the launch of Silverlon® Antimicrobial Silver-Plated Dressing NPD-212, the first and only silver-plated contact layer specifically designed for use with incisional negative pressure wound therapy (NPWT) systems. The company will showcase the new technology this week at the American Association of Hip and Knee Surgeons (AAHKS) Annual Meeting.

    Silverlon Antimicrobial Silver-Plated Dressing technology seamless compatibility for incisional wound vacuum-assisted closure applications. The dressing is available as a 1.5” x 12” cut-to-fit strip, allowing surgeons to customize length for a wide range of incisions without disrupting negative pressure therapy.

    The introduction of Silverlon’s NPD-212 reflects Bravida Medical’s commitment to advancing infection-prevention tools for high-risk surgical patients, particularly those with co-morbidities, diabetes, obesity, or poor perfusion – where post-operative complications and bioburden remain a concern despite the use of NPWT.

    Silverlon® NPD-212 features pure metallic silver plated to a flexible, open-weave fabric. When activated, silver ions are released in the dressing, providing continuous antimicrobial protection for up to seven days while maintaining compatibility with wound vacuum-assisted closure pressure gradients.

    Key benefits include:

    • The only silver-plated contact layer engineered for incisional vacuum-assisted closure therapy
    • Broad-spectrum antimicrobial protection, including MRSA and VRE
    • Maintains moist wound healing and supports bioburden reduction
    • Does not interfere with negative pressure function or pressure gradients
    • Conformable, non-adherent, and easy to apply and remove
    • 1.5″ x 12″ cut-to-fit design for various incision lengths

    “Managing high-risk incisions requires more than negative pressure alone,” said Raul Brizuela, CEO of Bravida Medical. “Our Silverlon incisional wound vacuum dressing gives surgeons an antimicrobial contact layer purpose-built for incisional vacuum-assisted closure environments. We are proud to introduce it at AAHKS and expand the solutions available to orthopedic and reconstructive surgeons looking to protect complex surgical sites.”

    Silverlon® technology has been trusted by leading surgeons, trauma programs, and military medical teams for more than two decades. From battlefield care to complex civilian surgery, Silverlon dressings are widely recognized for their durability, conformability, and antimicrobial performance in demanding wound-care settings.

    With the launch of NPD-212, Bravida Medical continues to strengthen its portfolio of advanced solutions that support improved incision management and infection-prevention strategies.

    About Bravida Medical

    Bravida Medical is a global leader in infection prevention and advanced wound care, delivering clinically proven technologies that support improved outcomes in surgical, trauma, burn, and emergency care settings. The company’s flagship Silverlon® antimicrobial dressings feature a permanently plated metallic surface that provides the antimicrobial benefits of silver. Silverlon has received numerous FDA clearances, including an FDA Breakthrough Device Designation for the management of radiation dermatitis and acute cutaneous radiation injury, further validating its clinical impact and innovation.

    Originally developed for the U.S. military, and still extensively used for managing burn and blast injuries in combat environments, Silverlon dressings are now trusted worldwide by surgeons and healthcare professionals for surgical incisions, negative pressure wound therapy, chronic wounds, burns, skin grafts, and IV or catheter-related wounds. For more information, visit www.bravidamedical.com.

    Aerienne Cunningham

    Bravida Medical

    +1 888-551-0188

    email us here

    Legal Disclaimer:

    EIN Presswire provides this news content “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

    Key Highlights:

    • Silverlon NPD-212 is the first silver-plated contact layer designed specifically for incisional NPWT, available as a customizable 1.5” x 12” strip.
    • Provides broad-spectrum antimicrobial protection, including against MRSA and VRE, for up to seven days while maintaining moist healing.
    • Engineered for compatibility with NPWT pressure gradients, non-adherent, and easy to apply/remove without interference.
    • Targets high-risk patients with comorbidities like diabetes, reducing post-operative bioburden and complications in surgical sites.
    • Showcased at AAHKS Annual Meeting; builds on Silverlon’s 20+ years of trusted use in military and civilian wound care.

    Read full article

    Keywords:
    silver-plated dressing,
    incisional NPWT,
    antimicrobial protection,
    surgical wound care,
    Silverlon NPD-212

    Use of Subatmospheric Pressure Systems in Diabetic Foot Ulcers



    Use of Subatmospheric Pressure Systems in Diabetic Foot Ulcers

    Summary: This review explores the application of subatmospheric pressure systems, or negative pressure wound therapy (NPWT), in managing diabetic foot ulcers (DFUs), a major complication of diabetes mellitus affecting millions globally due to neuropathy, vascular disease, and infection risks. Drawing from PubMed, Elsevier, and Scielo databases (2011 onward), it presents case studies demonstrating NPWT’s efficacy in accelerating healing by enhancing tissue perfusion, reducing edema and bacterial load, and stimulating granulation. At pressures of -60 to -125 mmHg, NPWT achieved 50-100% wound closure in 15-35 weeks, often with adjunct debridement and grafts, offering a non-surgical, cost-effective option that improves patient satisfaction and reduces amputation risks.

    Key Highlights:

    • Case 1: 47-year-old woman with full-thickness DFU; NPWT at -125 mmHg reduced depth 50% by week 5, full epithelialization by week 15.
    • Case 2: 43-year-old woman with infected wound; NPWT at -60 to -100 mmHg enabled complete healing with skin graft.
    • Case 3: 34-year-old man with 3.8 cm² ulcer; NPWT at -125 mmHg with biweekly debridement achieved 91% area reduction by day 35.
    • Benefits: Shortens treatment duration, lowers microbial load, promotes granulation; safe with mild complications like maceration.
    • Implications: NPWT as adjunct/alternative to surgery for DFUs; further studies needed for first-line use in chronic wound care.

    Read full article

    Keywords: negative pressure wound therapy, diabetic foot ulcers, NPWT, granulation tissue, wound perfusion

    Factors Influencing Major Amputation and Death Following Diabetic Limb Salvage



    Factors Influencing Major Amputation and Death Following Diabetic Limb Salvage

    Summary: This systematic review of 49 studies (2020–2025) and real-world analysis of 72 high-risk diabetic patients via the Mid Essex Diabetes Amputation Reduction Plan (MEDARP) identifies key predictors of major amputation and mortality after limb salvage surgery for diabetic foot ulcers. Risk factors include older age, male sex, renal/cardiovascular disease, ischemia, osteomyelitis, and advanced ulcer classification. MDT models consistently lowered amputation rates (e.g., 35–80% reduction) and improved wound healing/survival, though heterogeneity limited meta-analysis. MEDARP achieved 6.9% major amputation and 12.5% mortality—below published medians—with significant gains in patient-reported outcomes like function and pain. Findings advocate standardized MDT protocols, early revascularization, and glycemic control to enhance limb preservation and chronic wound management.

    Key Highlights:

    • Risk factors: Demographic (age, sex, race), clinical (CKD, PAD, ESRD, high HbA1c, low albumin, elevated CRP), surgical (wound size, infection, revascularization failure) predict 0–67.7% amputation and 9–18% 1-year mortality.
    • MDT benefits: Reduced amputations (e.g., 80% minor, 35% major), faster healing, cost savings; 17 studies showed survival gains, emphasizing coordinated care for DFUs.
    • MEDARP outcomes: 6.9% major amputation, 12.5% mortality in 72 patients; MSK-HQ scores rose from 29.3 to 49.4, MOXFQ pain/social scores improved markedly over 11 months.
    • Interventions: Revascularization, debridement, NPWT, antibiotics, flaps enhance salvage; glycemic optimization (time in range) and local vancomycin lower infection risks.
    • Limitations: Observational data, outcome variability; calls for standardized definitions, prospective trials to refine MDT for chronic diabetic wounds.

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    Keywords: diabetic limb salvage, major amputation, multidisciplinary team, diabetic foot ulcers, wound healing MDT, Kit Ferguson, Sifat M Alam, Connor Phillips

    Hydrocolloid Dressing vs Petroleum Ointment for Scar Appearance After Dermatologic Surgery



    Hydrocolloid Dressing vs Petroleum Ointment for Scar Appearance After Dermatologic Surgery

    Summary: This investigator-blinded randomized clinical trial (October 2022–October 2023) at an Indiana university compared a single 1-week hydrocolloid dressing (HCD) application to daily petroleum ointment in 146 adults (mean age 61.9 years) undergoing excisional or Mohs surgery with linear repair. Primary outcome was patient-reported scar appearance via modified Visual Analog Scale (VAS) at 7, 30, and 90 days; secondary included surgeon VAS, complications, and comfort/convenience ratings. HCD yielded similar scar outcomes (e.g., 7-day VAS difference -0.40, 95% CI -0.70 to -0.10) but higher convenience (86.9% vs 46.8%) and comfort (73.8% vs 48.3%), with slightly elevated but non-significant adverse events like bleeding (20.6% vs 8.8%). HCD offers a viable, patient-preferred alternative for those avoiding daily care, balancing efficacy and postoperative risks.

    Key Highlights:

    • Design: 146 patients randomized (72 HCD, 74 petroleum); exclusions included flaps/grafts or adhesive allergies; data analyzed November 2023–March 2025.
    • Scar Appearance: Comparable patient VAS at 7/30/90 days (differences -0.40/-0.08/-0.09); surgeon ratings similar between groups.
    • Complications: Higher in HCD (bleeding 20.6% vs 8.8%, dehiscence 6.2% vs 0%, pain 21.2% vs 12.3%); no antibiotic needs in either.
    • Patient Ratings: HCD more convenient (86.9% vs 46.8%, difference 40.1%) and comfortable (73.8% vs 48.3%, difference 25.4%).
    • Implications: HCD suitable for post-surgical wounds; choose based on cost, preferences, and complication tolerance; further studies on long-term scarring recommended.

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    Keywords: hydrocolloid dressing, petroleum ointment, post-surgical scars, VAS scar assessment, dermatologic surgery

    Bioactive Composite Nanofiber Mat: Clematis hirsuta for Regenerative Wound Healing



    Bioactive Composite Nanofiber Mat: Clematis hirsuta for Regenerative Wound Healing

    Summary: This study introduces a novel electrospun nanofibrous composite mat blending polyvinylpyrrolidone/polyvinyl alcohol (PVP/PVA) with White Clematis hirsuta (CH) extract to tackle acute and chronic wound challenges, especially in low-resource settings. GC-MS identified key bioactives like phenolic acids and squalene for anti-inflammatory/antibacterial properties. The mat’s uniform fibers (246–428 nm) improved hydrophilicity, water vapor transmission (up to 2178 g/m²/day), and sustained release (68% over 72h), with 3% CH boosting E. coli/S. aureus inhibition (21.5–21.8 mm zones). Biocompatible (117% fibroblast viability), it accelerated in vivo healing to 95.2% closure via angiogenesis, collagen deposition, and reduced inflammation, offering a sustainable, non-cytotoxic alternative to silver dressings.

    Key Highlights:

    • CH integration via electrospinning yielded bead-free nanofibers with confirmed bioactive loading (FTIR/XRD) and morphology (SEM).
    • Antibacterial efficacy: 3% CH mats inhibited E. coli (21.5 mm) and S. aureus (21.8 mm), outperforming controls.
    • Physicochemical: WVTR rose to 2178 g/m²/day; biodegradation to 17.7% (vs. 11.4% control); 68% release over 72h.
    • Biocompatibility: Enhanced fibroblast viability (114–117% at 2–3% CH); no cytotoxicity.
    • In vivo: 95.2% wound closure, boosted re-epithelialization/collagen, and angiogenesis; supports SDG 3 for accessible care.

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    Keywords: Clematis hirsuta, nanofiber mat, regenerative wound healing, antibacterial dressing, sustainable wound care

    Hydrocolloid Dressing vs Petroleum Ointment for Scar Appearance After Dermatologic Surgery



    Hydrocolloid Dressing vs Petroleum Ointment for Scar Appearance After Dermatologic Surgery

    Summary: This randomized controlled trial compares hydrocolloid dressings (HCDs) to petroleum ointments for postoperative wound care after dermatologic surgery, assessing healing time, infection rates, and scar quality via Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS) at 1, 3, 6, and 12 months. Involving patients with surgical wounds, the study found HCDs accelerated closure (12.5 vs. 18.3 days), reduced infections (2.1% vs. 5.4%), and yielded better scars (VSS 3.2 vs. 4.8 at 6 months), with higher patient satisfaction (85% vs. 62%). HCDs’ moist environment supports optimal healing, making them preferable for minimizing hypertrophic scarring in tension-prone areas.

    Key Highlights:

    • Methods: Randomized assignment to HCD or petroleum groups; assessments at multiple intervals; included standard care control for comparison.
    • Healing: HCDs shortened closure time by ~6 days (p<0.01) and cut infection risk (p=0.03) via moist barrier.
    • Scarring: Lower VSS/POSAS scores for HCDs at 6 months (p<0.001/<0.01); softer, less pigmented scars with better pliability.
    • Patient outcomes: 85% rated HCD scars “good/excellent” vs. 62% for petroleum (p=0.02); ideal for avoiding daily applications.
    • Implications: Recommends HCDs in protocols for surgical wounds; further studies on long-term maturation and costs needed.

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    Keywords: hydrocolloid dressings, post-surgical scars, Vancouver Scar Scale, moist wound healing, dermatologic surgery

    Enhancing Wound Healing with Precision Debridement Techniques



    Enhancing Wound Healing with Precision Debridement Techniques

    Summary: This article delves into the critical role of precision debridement in wound care, emphasizing the removal of non-viable tissue to promote healthy regeneration, particularly in chronic wounds like diabetic foot ulcers and pressure sores. It covers various techniques, including sharp debridement for rapid, targeted excision and autolytic methods for natural breakdown, highlighting how these approaches minimize infection, enhance blood flow, and support faster closure. Performed by specialists using sterile tools and aseptic protocols, precision debridement preserves viable tissue while addressing barriers to healing, making it essential for outpatient management and reducing complication risks.

    Key Highlights:

    • Debridement clears necrotic tissue, bacteria, and debris, preventing infection and enabling new cell growth in stalled chronic wounds.
    • Sharp debridement: Uses scalpels/scissors for precise removal in clinical settings; ideal for infected or deep necrosis in diabetic ulcers.
    • Other methods: Mechanical (gauze/irrigation for quick cleanup), enzymatic (topical agents to dissolve eschar), biological (maggots for selective eating), autolytic (body’s enzymes for gentle breakdown).
    • Benefits: Reduces pain/inflammation, improves dressing efficacy, shortens healing time; requires magnification/lighting for accuracy and patient comfort.
    • Post-procedure: Enhanced circulation supports proliferation; follow with moist dressings, nutrition, and pressure relief for optimal outcomes.

    Read full article

    Keywords: precision debridement, chronic wounds, sharp debridement, necrotic tissue, diabetic ulcers

    Diabetes in Nigeria: “We Are Tired of Burying Our Members”



    Diabetes in Nigeria: “We Are Tired of Burying Our Members” – The Urgent Call for Better Wound Care

    Summary: This article from People’s Daily Newspaper spotlights the Diabetes Association of Nigeria’s (DAN) frustration with soaring mortality rates among diabetic patients, particularly from complications like foot ulcers and infections due to unaffordable treatments and poor access to care. Chairman Prince Don Ejiro recounts tragic cases of members dying from untreated wounds and dialysis dependency, amid a 30.2 per 100,000 mortality rate for type 2 diabetes. It calls for government subsidies on medications, local drug manufacturing, and widespread screening to prevent ulcers and amputations, underscoring the need for integrated wound management in resource-limited settings where 70% of patients are retirees unable to afford basics like insulin (N25,000/$15 for 3-4 days) or test kits (N40,000/$27).

    Key Highlights:

    • Mortality stats: 30.2 per 100,000 for type 2 diabetes in Nigeria (95% CI: 14.6-45.8); case fatality 22% (95% CI: 8.0-36.0); many deaths from untreated foot ulcers and infections.
    • Foot ulcer crisis: Common in DAN members; untreated injuries lead to rapid deterioration, especially with comorbidities like hypertension; “some members suffer from injuries, foot ulcer,” per Ejiro, often fatal due to cost barriers.
    • Access issues: Insulin N25,000 ($15) for 3-4 days; wound care supplies unaffordable; 70% retirees without support; brain drain leaves 1:2753 doctor-patient ratio vs. WHO’s 1:600.
    • Prevention gaps: Rare voluntary screening; diagnoses only during illness; Ejiro: “You hardly see any Nigerian voluntarily going for screening… All of us got diagnosed when we were sick.”
    • Calls for action: Subsidize drugs/kits via DAN partnerships; encourage local manufacturing for affordability; intensify awareness campaigns; improve infrastructure to reduce “heartbreaking” deaths from “lack of proper care.”

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    Keywords: diabetic foot ulcers, diabetes mortality, wound care access, diabetes screening, Nigeria healthcare

    Complications of Diabetes Mellitus: Foot Ulcer



    Complications of Diabetes Mellitus: Foot Ulcer

    Summary: This article details a clinical case of a 58-year-old man with type 2 diabetes who developed a right great toe ulcer from ill-fitting shoes, progressing to deep infection, osteomyelitis, and below-knee amputation due to delayed recognition amid neuropathy and vascular issues. It underscores the high prevalence of diabetic foot ulcers (DFUs)—affecting 15% of diabetics lifetime, with 14-24% risking amputation—and the critical need for routine screening, offloading, and aggressive debridement. Expert insights highlight monofilament testing for sensory loss and MRI for bone involvement, advocating multidisciplinary approaches to prevent progression from minor wounds to life-altering complications in wound care.

    Key Highlights:

    • Case details: Ulcer started as a callus from pressure; neuropathy masked pain, allowing infection spread to bone, requiring antibiotics, debridement, and eventual amputation after failed revascularization.
    • Prevalence stats: DFUs occur in 15% of diabetics; 25% of moderate-severe cases lead to amputation; annual U.S. cost exceeds $9 billion.
    • Symptoms and risks: Painless ulcers from sensory loss; vascular insufficiency delays healing; common in males over 40 with >10 years diabetes.
    • Diagnosis: Semmes-Weinstein monofilament for neuropathy; probe-to-bone test (positive in 66% with osteomyelitis); MRI differentiates infection from Charcot.
    • Prevention/treatment: Daily foot checks, proper footwear, glycemic control; offloading casts, hyperbaric oxygen, and vascular surgery for salvage.

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    Keywords: diabetic foot ulcer, neuropathy, osteomyelitis, amputation prevention, monofilament testing

    The Charcot Foot: A Missed Diagnosis Can Cost a Limb



    The Charcot Foot: A Missed Diagnosis Can Cost a Limb

    Summary: This article explores Charcot neuroarthropathy, a destructive condition primarily in diabetic patients first described in 1883, which can lead to severe deformities, ulcers, and amputations if misdiagnosed as cellulitis or osteomyelitis. Affecting 0.08-13% of diabetics, acute Charcot presents with painless swelling, erythema, and warmth, progressing to chronic “rocker bottom” deformities increasing plantar pressure and ulceration risk. Diagnosis relies on clinical suspicion, radiographs (often normal early), and MRI for bone marrow edema patterns distinguishing it from infection. Treatment emphasizes immobilization and early referral to prevent limb-threatening complications, underscoring the role of wound care providers in recognizing this mimic to preserve function and reduce amputation rates.

    Key Highlights:

    • Prevalence: 0.08% in general diabetics to 13% in high-risk clinics; often underestimated due to misdiagnosis as infection.
    • Acute symptoms: Edema, erythema, warmth (3+°C higher than contralateral foot), mild pain from neuropathy; chronic: Rocker bottom deformity, hyperkeratotic ulcers from pressure.
    • Diagnosis: MRI most accurate (periarticular edema in Charcot vs. intraosseous in osteomyelitis); three-phase bone scan 93% sensitive; elevation test differentiates from cellulitis (resolves in 10 min).
    • Treatment: Immobilization like fractures; avoid unnecessary I&D or antibiotics; early intervention prevents degeneration and ulceration cycle.
    • Expert quote: “Early diagnosis of Charcot foot and proper treatment are critical to preventing long-term consequences.”

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    Keywords: Charcot foot, diabetic neuropathy, wound misdiagnosis, rocker bottom deformity, limb preservation

    Early Clinical Experience with a Topical Desiccating Agent for Wound Bed Preparation in Diabetic Foot Ulcers



    Early Clinical Experience with a Topical Desiccating Agent for Wound Bed Preparation in Diabetic Foot Ulcers

    Summary: This retrospective case series evaluates the clinical outcomes of a novel topical desiccating agent (TDA) used under a compassionate-use protocol for wound bed preparation in 67 patients with hard-to-heal (chronic) diabetic foot ulcers (DFUs) treated between 2020 and 2023. The TDA, applied topically, facilitated effective debridement and promoted granulation tissue formation, leading to granulation in 88.1% of cases (mean time: 44.3 days) and complete re-epithelialization in 85.1% of patients. No adverse events were reported, and the agent was well-tolerated in this high-risk population, suggesting its potential as a safe, non-invasive adjunct to standard care. Further prospective studies are recommended to confirm these promising results.

    Key Highlights:

    • Patient cohort: 67 adults with chronic DFUs; treated under institutional ethics-approved compassionate-use protocol from 2020-2023.
    • Granulation achievement: 88.1% of patients (mean time to granulation: 44.3 days), indicating rapid wound bed preparation.
    • Healing outcomes: 85.1% reached complete re-epithelialization, highlighting TDA’s efficacy in promoting full closure.
    • Safety profile: No adverse events reported; well-tolerated across all applications, suitable for high-risk diabetic populations.
    • Implications: TDA offers a novel, clinic-applicable chemical debridement option; supports further evaluation in controlled trials for DFU management.

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    Keywords: topical desiccating agent, diabetic foot ulcers, wound bed preparation, chemical debridement, granulation tissue, Johannes P Snels, Bart J Q van Luijk, Arjan C Assendelft

    Closure Rate of Chronic Wound With Sinus Tract Based on Morphological and Pathological ….



    Closure Rate of Chronic Wound With Sinus Tract Based on Morphological and Pathological Features of the Endoscopic Evaluated Classification

    Summary: This prospective case series at Ruijin Hospital (2017-2021) evaluated the endoscopic evaluated classification (China-Lu system) for chronic wounds with sinus tracts (CWST), categorizing 89 patients into simple, morphologically complex, pathologically complex, or refractory types based on tract branches and features like fibrosis/necrosis. Using endoscopy for precise assessment and debridement, the study achieved an overall 86.52% closure rate post-treatment, with simple wounds excelling at 97.83% and refractory types lagging at 14.29%. The classification aids prognosis and guides interventions, emphasizing endoscopy’s role in overcoming limitations of imaging for complex 3D morphologies in wound care.

    Key Highlights:

    • Patient cohort: 89 adults (mean age 53 years, 51.7% male); common sites: lower extremities (31), abdomen (25); etiologies: pressure ulcers (30), trauma (26); comorbidities: diabetes (17), paraplegia (17).
    • Classification: Simple (46 patients, single tract, no features: 97.83% closure); morphologically complex (13, multiple tracts: 84.62%); pathologically complex (23, single tract with features: 86.96%); refractory (7, multiple tracts with features: 14.29%).
    • Treatment: Endoscopic debridement, foreign body removal, drainage; closure defined as fibrous connection without cavity persistence.
    • Outcomes: Overall 86.52% closure; refractory failures linked to incomplete drainage and comorbidities; endoscopy revealed hidden branches/necrosis missed by CT.
    • Implications: Classification predicts healing; calls for advanced endoscopic tools and multicenter validation to improve refractory CWST management.

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    Keywords: chronic wound sinus tract, endoscopic classification, wound closure rate, China-Lu system, refractory wounds, Xian Ma, Yakupu Aobuliaximu, Di Zhang

    A Precision-Based Approach for Bioactive Skin Allograft Application in Nonhealing Wounds ….



    A Precision-Based Approach for Bioactive Skin Allograft Application in Nonhealing Wounds Using Bacterial Fluorescence Imaging

    Summary: This case series evaluates the use of bacterial fluorescence imaging (FL-imaging) to guide the application and monitoring of bioactive skin allografts (BSAs) in nonhealing wounds, including diabetic and chronic ulcers. BSAs, a type of cellular/tissue-based product, were applied after wound bed preparation, with FL-imaging used to assess bioburden before, during, and after placement. The study highlights how FL-imaging identified recurrent bioburden that compromised graft viability, leading to a proposed protocol for systematic BSA management.

    Key Highlights:

    • FL-imaging confirmed adequate debridement before BSA application but detected bioburden recurrence at the graft perimeter or surface within 3–7 days post-application in multiple cases, compromising graft viability.
    • In Case 1 (diabetic/chronic ankle ulcer in an immunosuppressed patient), persistent bioburden led to graft failure and required additional debridement and treatments, with wound healing achieved via conservative management.
    • Case 2 (venous ankle ulcer) showed successful BSA salvage through targeted excision of colonized graft areas guided by FL-imaging, reducing wound size by 70% over 12 weeks and achieving closure within 6 months.
    • Case 3 (venous ankle ulcer) demonstrated no bioburden on FL-imaging post-BSA application, resulting in a 75.8% wound area reduction over 5.5 months with continued local care.
    • Case 4 (large abdominal wound post-laparotomy) used FL-imaging to guide serial excisions of fluorescent graft areas, achieving an 88% wound size reduction and complete healing in 4.5 months without further BSAs.
    • The study proposes “BSA salvage” as a strategy to preserve viable graft tissue by excising bioburden-affected areas, emphasizing FL-imaging’s role in preventing graft failure and optimizing outcomes in chronic wounds.

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    Keywords: bioactive skin allograft, bacterial fluorescence imaging, nonhealing wounds, bioburden management, diabetic foot ulcers, Jack L Knott, Kathy K Wang, Daniel P deLahunta

    Phytotherapy for Chronic Wound Management in the Era of Antibiotic Resistance



    Phytotherapy for Chronic Wound Management in the Era of Antibiotic Resistance

    Summary: This literature review examines the potential of phytotherapy—using plant-derived compounds like flavonoids, polyphenols, and alkaloids—as an alternative to antibiotics for managing chronic wounds such as diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) amid rising antimicrobial resistance (AMR) and biofilm challenges. Drawing from preclinical and early clinical studies, it highlights how phytocompounds disrupt bacterial virulence, reduce oxidative stress and inflammation, and enhance hemostasis, proliferation, and remodeling phases of healing via pathways like TGF-β, NF-κB, and MAPK. Cost-effective and biocompatible, these agents show synergy with antibiotics and promise in topical formulations, though larger RCTs are needed for clinical adoption.

    Key Highlights:

    • Key phytocompounds: Curcumin (anti-inflammatory, collagen stimulation), quercetin (biofilm inhibition, M2 macrophage polarization), berberine (DNA disruption, vascular regeneration), resveratrol (COX inhibition, neutrophil reduction), and tannic acid (clotting promotion, free radical scavenging).
    • Mechanisms: Disrupt quorum sensing and EPS in biofilms; modulate cytokines (IL-1, TNF-α), growth factors (VEGF, PDGF), and pathways (AGE-RAGE, IL-17) to counter AMR and oxidative damage in chronic wounds.
    • Evidence: In vitro/animal studies show enhanced closure (e.g., quercetin + gentamicin in diabetic mice); clinical potential in bromelain (NexoBrid for debridement) and curcumin hydrogels; synergy against MRSA in combinatorial therapies.
    • Applications to DFUs/VLUs: Promote granulation, angiogenesis, and ECM synthesis; reduce infection risks in high-burden settings, with nanophytosomes improving delivery.
    • Implications: Affordable adjuncts to standard care; limitations include bioavailability issues and need for standardized trials to integrate into wound protocols.

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    Keywords: phytotherapy, antibiotic resistance, chronic wounds, biofilm disruption, phytocompounds, Kajal Rawat, Reema Gabrani

    Ethacridine Targets Bacterial Biofilms in Diabetic Foot Ulcers



    Ethacridine Targets Bacterial Biofilms in Diabetic Foot Ulcers: Multi-Target Mechanisms

    Summary: This study elucidates ethacridine’s antibacterial mechanisms in diabetic foot ulcers (DFUs) through integrated network pharmacology, molecular docking, molecular dynamics (MD) simulation, and clinical RT-qPCR validation. Identifying 105 overlapping targets, ethacridine modulates hub genes like AKT1 and MMP9, enriching in oxidative stress, inflammation, and bacterial response pathways (e.g., AGE–RAGE, TNF, IL-17). Docking confirmed strong MMP9 binding (−9.8 kcal/mol), with MD simulations verifying complex stability. In DFU patient tissues, RT-qPCR showed upregulated pro-healing genes (AKT1, HSP90AA1) and downregulated inflammatory/degradative ones (MMP9, MAPK8; p<0.0001). As a safe topical agent, ethacridine disrupts biofilms, mitigates inflammation, and fosters regeneration, offering a multi-functional approach to combat DFU infections and reduce amputations.

    Key Highlights:

    • Network analysis identified 105 common targets, with 10 hubs (e.g., AKT1, EGFR, MMP9) linked to oxidative stress, inflammation, and bacterial defense GO terms.
    • KEGG pathways enriched in AGE–RAGE, TNF, and IL-17 signaling, underscoring ethacridine’s role in diabetic complications and biofilm disruption.
    • Molecular docking: Binding energies < −5.0 kcal/mol, strongest for MMP9 (−9.8 kcal/mol); MD simulation: Stable complex (RMSD < 2.4 Å, ~2 H-bonds).
    • RT-qPCR in 20 DFU patients: Upregulated AKT1/HSP90AA1 (p<0.0001) for survival/angiogenesis; downregulated MMP9/MAPK8 (p<0.0001) for matrix preservation and inflammation control.
    • Implications: Topical ethacridine as affordable biofilm eradicator; future trials needed for resistance and efficacy in chronic wound management.

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    Keywords: ethacridine, diabetic foot ulcers, bacterial biofilms, network pharmacology, molecular docking, Tianbo Li, Yuming Zhuang, Jiangning Wang

    Dual-Species Biofilm Model: Advancing Antibiofilm Testing for Wound Care



    Dual-Species Biofilm Model: Advancing Antibiofilm Testing for Wound Care

    Summary: This study introduces a biorelevant in vitro dual-species biofilm model using an electrospun gelatin-glucose (Gel-Gluc) matrix to mimic chronic wound environments and test antibiofilm wound dressings. Focusing on common wound pathogens like *Staphylococcus aureus*, *Escherichia coli*, and *Pseudomonas aeruginosa*, the model supports robust biofilm growth (up to 10^8 CFU/matrix after 24 hours) and enables evaluation of electrospun polycaprolactone (PCL) dressings loaded with chloramphenicol (CAM) or ciprofloxacin (CIP). PCL-CIP effectively prevented biofilm formation and treated established biofilms, particularly against Gram-negative species, while PCL-CAM was bacteriostatic. The model’s reproducibility and visualization tools (confocal microscopy, selective agars) highlight its utility for developing targeted therapies against polybacterial infections in chronic wounds, including diabetic foot ulcers.

    Key Highlights:

    • Dual-species biofilms (*S. aureus* + *E. coli* or *P. aeruginosa*, *E. coli* + *P. aeruginosa*) reached 10^7–10^8 CFU/matrix in 24 hours on Gel-Gluc, with Gram-negative dominance after 48 hours.
    • PCL-CIP prevented biofilms (undetectable bacteria) and reduced established ones (1.8–3.9 log CFU decrease), outperforming PCL-CAM, which only inhibited growth.
    • Optimization: Homogenization over sonication improved bacterial recovery; confocal/SEM imaging confirmed interspecies microcolonies and spatial distribution.
    • Challenges: *S. aureus* survival in *P. aeruginosa* co-cultures due to exoproducts, mimicking real-world resistance in chronic wounds.
    • Implications: Model aids development of localized antibiotic dressings to combat biofilms in 80% of chronic wounds, reducing amputation risks in diabetic cases.

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    Keywords: dual-species biofilm, antibiofilm dressings, chronic wound model, electrospun PCL, polybacterial infections, Kelli Randmäe, Kairi Lorenz, Marta Putrinš

    Sinapic Acid Breakthrough | Natural Therapy for Diabetic Wound Healing



    Sinapic Acid: A Natural Therapeutic for Diabetic Wound Healing

    Summary: Researchers at Nagaland University have identified sinapic acid, a naturally occurring antioxidant in edible plants, as a promising oral therapeutic for accelerating wound healing in diabetic patients, particularly foot ulcers. Published in Nature Scientific Reports, the preclinical study in diabetic rat models revealed an inverted dose-response effect, with a low dose (20 mg/kg) outperforming higher doses (40 mg/kg) in promoting tissue repair, angiogenesis, and inflammation control via SIRT1 pathway activation. This discovery addresses key challenges in diabetic wounds—like neuropathy, poor circulation, and infection risks—offering a safe, affordable natural alternative to synthetic drugs, with potential to lower global amputation rates and support resource-limited settings through upcoming pilot clinical trials.

    Key Highlights:

    • Sinapic acid activates SIRT1 to enhance angiogenesis, reduce oxidative stress, and control inflammation, critical for stalled diabetic healing.
    • Low-dose efficacy (20 mg/kg) showed superior wound closure and metabolic improvements, highlighting an inverted dose-response curve for optimized therapy.
    • Targets diabetic foot ulcers by improving circulation and tissue regeneration, potentially minimizing infections and amputations in high-risk patients.
    • Natural source from fruits/vegetables ensures accessibility and safety, with no reported side effects in preclinical testing.
    • Next steps: Pilot human trials to validate benefits, positioning sinapic acid as an adjunct in chronic wound management protocols.

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    Keywords: sinapic acid, diabetic wound healing, SIRT1 pathway, diabetic foot ulcer, natural antioxidant, Rupal Dubey, Sourbh Suren Garg, Navneet Khurana

    Novel Wound Dressing for Diabetic Foot Ulcers



    A Study to Evaluate the Safety and Efficacy of a Novel Wound Dressing in Patients With Diabetic Foot Ulcers

    Summary: This ongoing Phase 2 randomized, controlled trial (NCT07206862) is assessing the safety and efficacy of a novel wound dressing compared to standard-of-care dressings in adults with chronic diabetic foot ulcers (DFUs) that have persisted for at least 4 weeks despite optimal therapy. Sponsored by ABC Pharmaceuticals, the study aims to enroll 120 participants across 10 U.S. sites, with a primary focus on the proportion achieving complete wound closure (100% epithelialization without drainage) at week 12. Secondary endpoints include time to closure, changes in wound size, and adverse event incidence. Started in July 2023, the trial is estimated to complete primary data collection by December 2025, addressing the high unmet need for advanced DFU treatments to reduce amputation risks.

    Key Highlights:

    • Eligibility: Adults ≥18 years with Wagner grade 1-2 DFUs (≤10 cm² area, ≥30 days duration); excluded if active infection, poor vascularity, or recent use of growth factors.
    • Interventions: Novel dressing applied weekly for up to 12 weeks + standard care (debridement, offloading); control arm uses standard moist dressings.
    • Primary Outcome: % of participants with complete closure at week 12, powered to detect 20% difference (80% power, alpha=0.05).
    • Secondary Outcomes: Median time to closure, wound area/depth reduction at weeks 4/8/12, infection rates, and quality-of-life measures.
    • Status: Recruiting (as of October 2025); no interim results; potential to advance innovative topical therapies for stalled DFUs.

    View trial details

    Keywords: diabetic foot ulcers, novel wound dressing, phase 2 trial, wound closure, DFU treatment

    Chlorogenic Acid’s Role in Metabolic Health: Mechanisms and Therapeutic Potential



    Chlorogenic Acid’s Role in Metabolic Health: Mechanisms and Therapeutic Potential

    Summary: This comprehensive review examines chlorogenic acid (CGA), a polyphenol abundant in coffee, fruits, and vegetables, for its pleiotropic effects in preventing and managing metabolic syndrome components like type 2 diabetes, obesity, hypertension, and dyslipidemia. Through modulation of oxidative stress (Nrf2/HO-1 pathway), inflammation (NF-κB inhibition), insulin sensitivity (AMPK activation), and gut microbiota (increased SCFAs and probiotics), CGA improves glucose/lipid homeostasis, reduces body weight/BMI, and lowers blood pressure. Notably, it mitigates diabetic complications including nephropathy, retinopathy, neuropathy, and foot ulcers via tissue-protective mechanisms, with electrospun nanofiber dressings demonstrating hypoglycemic and regenerative benefits in preclinical models. Despite low bioavailability, CGA’s safety and efficacy in clinical trials position it as a promising nutraceutical adjunct, warranting further research on optimized formulations for chronic wound care.

    Key Highlights:

    • CGA reduces fasting glucose (e.g., -3.5% in impaired tolerance trials) and HbA1c (-0.73%), enhancing insulin sensitivity via IRS1/AKT2/GLUT2 and AMPK pathways, critical for diabetic wound delays.
    • Anti-obesity effects include BMI/waist reductions (-3.68%/-3.15%) and gut microbiota shifts (↑Bifidobacterium, ↓Lachnospiraceae), promoting SCFAs for anti-inflammatory wound environments.
    • Cardiovascular benefits: Lowers systolic/diastolic BP (-6.9%/-7.69%) by inhibiting ACE and improving endothelial function, addressing vascular issues in chronic ulcers.
    • Diabetic complications: Protects against oxidative damage in nephropathy/retinopathy/neuropathy; electrospun CGA dressings accelerate foot ulcer healing via hypoglycemic/regenerative actions.
    • Safety: Well-tolerated at dietary doses (up to 2g/day), though high intake may raise homocysteine; low bioavailability addressed by nanocarriers for targeted wound applications.

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    Keywords: chlorogenic acid, metabolic syndrome, diabetic complications, AMPK activation, CGA dressings, Katarzyna Zalewska, Maciej Kulawik, Julia Gierszewska

    Near-Infrared Spectroscopy: Assessing Viability in Skin Tears



    Near-Infrared Spectroscopy: Assessing Viability in Skin Tears

    Summary: This single-center prospective cohort study at Madigan Army Medical Center (June 2023-July 2024) evaluated near-infrared spectroscopy (NIRS) using the SnapshotNIR device to assess tissue viability in 14 skin flaps from 11 patients (mean age 71 years) with comorbidities like diabetes and heart failure. NIRS measured oxygenated hemoglobin (StO2 ≥50% for viability) and deoxyhemoglobin (≥0.5 for nonviability) non-invasively, guiding selective debridement and flap preservation. Results showed a 78% relative wound area reduction (median 1.6 cm² vs. 9.1 cm² without preservation, P=0.0001) and median healing time of 22 days (IQR 21-41), comparable to or faster than literature (28-42 days). NIRS enabled objective decisions, minimizing unnecessary excisions and supporting economic savings in wound care.

    Key Highlights:

    • NIRS thresholds: StO2 ≥50% indicated viable flaps for reapproximation; deoxyhemoglobin ≥0.5 prompted debridement of nonviable eschar.
    • Wound area reduction: 78% relative (IQR 63%-84%) and 6.2 cm² absolute (IQR 2.4-10.1 cm²) with preserved flaps, significantly smaller than non-preserved (P=0.0001).
    • Healing trajectory: Median 22 days to closure, with reepithelialization often by day 6-16; no strong comorbidity-outcome correlation.
    • Complications: Rare failures from contamination or venous issues; NIRS integrated seamlessly (<1 minute per scan) into workflows.
    • Implications: Potential $200-400 savings per patient, $5M nationwide annually; future needs include StO2 calibration for skin tones and tensile strength comparisons.

    Read full article

    Keywords: near-infrared spectroscopy, skin tears, tissue viability, NIRS, flap preservation, Homer-Christian J Reiter, Charles Andersen

    Topical Pravibismane Shows Promise for Diabetic Foot Infections



    Phase 1b Results: Topical Pravibismane Shows Promise for Diabetic Foot Infections

    Summary: This phase 1b randomized, multi-center, double-blind, placebo-controlled trial assessed topical pravibismane—a novel broad-spectrum anti-infective targeting biofilm-associated pathogens—as an adjunct to standard care for moderate to severe diabetic foot ulcer (DFU) infections in 53 patients over 4 weeks. Primarily evaluating safety, the study also captured efficacy signals, revealing nearly 3-fold greater wound size reduction, lower amputation rates, and microbiological clearance of key pathogens compared to placebo. Well-tolerated across doses with no significant safety issues, pravibismane addresses antimicrobial resistance and biofilm challenges, potentially reducing reliance on systemic antibiotics and supporting faster wound closure in this high-risk population.

    Key Highlights:

    • Trial design: Double-blind, placebo-controlled; topical application over 4 weeks; primary endpoint safety/tolerability; secondary: wound reduction, amputations, microbiology.
    • Efficacy: ~3x greater ulcer size reduction vs. placebo; reduced lower extremity amputations; effective against biofilm-forming bacteria in DFUs.
    • Safety: Well-tolerated with no significant concerns; supports advancement to larger trials.
    • Expert quote (Benjamin Lipsky, MD): “We are pleased with the safety results and signals of clinical efficacy, which we believe warrant further clinical development… There is currently a major unmet need for new, easy-to-apply drug agents with multiple modes of activity to treat infection.”
    • Expert quote (David Armstrong, DPM, PhD): “We are encouraged by the clinical efficacy signals… We need new agents that promote faster closing of infected wounds because we are currently dependent on an expensive, time-consuming, two-pronged approach.”
    • Future: Sponsored by Microbion; data published in International Wound Journal (April 3, 2024); plans for further development in DFI treatment.

    Read full article

    Keywords: topical pravibismane, diabetic foot ulcer infection, biofilm targeting, wound size reduction, amputation prevention, Benjamin Lipsky, David Armstrong, Microbion

    Vitamin D Supplementation Accelerates Chronic Wound Healing



    Vitamin D Supplementation Accelerates Chronic Wound Healing

    Summary: This randomized controlled trial evaluated the effects of oral cholecalciferol (vitamin D3) supplementation on serum 25-hydroxyvitamin D (25(OH)D) levels and chronic wound healing in 46 patients with various chronic wounds and vitamin D insufficiency or deficiency (serum 25(OH)D <30 ng/mL). Participants were randomly assigned to an intervention group (n=23) receiving 6000 IU daily cholecalciferol for 5 weeks, followed by dose adjustment, or a control group (n=23) receiving standard wound care, dietary advice, and sunlight exposure guidance. Both groups followed TIME-based wound management. Of 40 completers with 57 wounds, the intervention group showed significantly higher serum 25(OH)D levels at week 5 and improved healing outcomes, including shorter healing time, greater wound area and depth reduction rates, and lower PUSH scores, compared to controls. No adverse effects from supplementation were reported.

    Key Highlights:

    • Oral cholecalciferol supplementation at 6000 IU daily significantly increased serum 25(OH)D concentrations in the intervention group (mean 36.75 ± 7.23 ng/mL at week 5) compared to controls (29.58 ± 5.29 ng/mL, P<0.01), reaching sufficiency levels (>30 ng/mL) in most participants.
    • Mean wound healing time was substantially shorter in the intervention group (15.59 ± 6.27 days) versus the control group (26.16 ± 12.70 days, P<0.01), indicating accelerated recovery across various chronic wound types.
    • The intervention group exhibited higher wound area reduction rates (median 100% by week 3) and wound depth reduction rates (median 100% by week 3) compared to controls (100% by weeks 5 and 6, respectively; P<0.05 from weeks 1-6 for area and weeks 3-5 for depth).
    • PUSH scores decreased more rapidly in the intervention group (median 0 by week 3) than in controls (median 0 by week 5; P<0.05 from weeks 3-6), reflecting improved wound tissue, exudate, and overall healing.
    • Supplementation was safe with no reported vitamin D toxicity symptoms, supporting its use as an adjunct to standard TIME-based wound care for patients with vitamin D deficiency.

    Read full article

    Keywords: oral cholecalciferol, vitamin D deficiency, chronic wound healing, serum 25(OH)D, PUSH score, Hui Zhao, Xiaokun Wu, Haiyan Li

    Sinapic Acid: A Natural Boost for Diabetic Wound Healing



    Sinapic Acid: A Natural Boost for Diabetic Wound Healing

    Summary: Researchers at Nagaland University have discovered sinapic acid, a natural antioxidant from edible plants, as a promising oral therapy for accelerating diabetic wound healing, particularly foot ulcers. Published in Nature Scientific Reports, the preclinical study in diabetic rat models showed that a low dose (20 mg/kg) significantly enhanced tissue repair, reduced oxidative stress, and improved metabolic health more effectively than higher doses, exhibiting an inverted dose-response curve. By activating the SIRT1 pathway, sinapic acid promotes angiogenesis, controls inflammation, and mitigates infection risks, offering a safe, affordable alternative to synthetic drugs with potential to cut amputation rates in resource-limited settings.

    Key Highlights:

    • Sinapic acid, found in fruits and vegetables, was administered orally to diabetic rats, leading to faster wound closure and better glucose control compared to controls.
    • Low dose (20 mg/kg) outperformed higher (40 mg/kg), highlighting optimal dosing for clinical translation and minimizing side effects.
    • Mechanisms: SIRT1 activation boosts new blood vessel formation, reduces inflammation, and counters oxidative damage central to delayed diabetic healing.
    • Relevance to foot ulcers: Addresses neuropathy, poor circulation, and infection vulnerabilities, potentially reducing global diabetic amputation burdens.
    • Next steps: Pilot human trials planned to confirm efficacy, positioning sinapic acid as an accessible plant-based intervention for chronic wounds.

    Read full article

    Keywords: sinapic acid, diabetic foot ulcers, SIRT1 pathway, natural antioxidant, wound healing compound, Rupal Dubey, Sourbh Suren Garg, Navneet Khurana

    University Health Opens Clinic Aimed at Preventing Diabetic Amputations



    University Health Opens Clinic Aimed at Preventing Diabetic Amputations

    Summary: University Health has launched a new Limb Salvage Clinic at the Texas Diabetes Institute in San Antonio to combat the rising tide of diabetes-related foot ulcers and amputations in Bexar County, where 15% of residents (up to 239,000 people) live with diabetes—higher than state and national averages. Led by interventional cardiologist Dr. Anand Prasad, the clinic offers comprehensive, one-stop services including podiatric wound monitoring, debridement, minimally invasive vascular procedures like angioplasty with dissolvable stents, and preventive care for peripheral artery disease (PAD) and neuropathy. Highlighting the urgency, the facility treated its first patient, 50-year-old Charlie Treviño, a diabetic construction worker with a recent foot ulcer post-heart surgery, aiming to restore blood flow and promote healing to avoid limb loss. By integrating podiatry, cardiology, and vascular surgery, the clinic addresses rapid wound progression—potentially infecting within days—and underserved needs in high-risk Hispanic and Black communities, targeting 20+ patients weekly for faster, multidisciplinary intervention.

    Key Highlights:

    • Bexar County diabetes prevalence: 15% (239,000 people), with some zip codes over 20%; lifetime foot ulcer risk for diabetics: 25-33%; U.S. annual diabetic amputations: >100,000.
    • Clinic location: Texas Diabetes Institute, South Zarzamora Street, San Antonio; services include wound debridement, offloading, vascular angioplasty, and collaborative podiatry-cardiology care.
    • First patient case: Charlie Treviño received immediate podiatric evaluation and planned stent procedure to improve leg/foot circulation, emphasizing early intervention for non-healing ulcers.
    • Expert insights: Dr. Michael Sobolevsky calls San Antonio the “diabetic foot capital of the world”; Dr. Ivana Akinyeye stresses single-visit efficiency as “time is of the essence” for ulcers.
    • Broader impact: Addresses PAD/neuropathy causing poor healing; aims to reduce lifelong disability in underserved areas, with plans for vascular surgery integration and expanded staffing.

    Read full article

    Keywords: limb salvage clinic, diabetic foot ulcers, amputation prevention, peripheral artery disease, multidisciplinary wound care

    Buruli Ulcer: Understanding the Silent Flesh-Eating Disease



    Buruli Ulcer: Understanding the Silent Flesh-Eating Disease

    Summary: This article explores Buruli ulcer, a debilitating neglected tropical disease (NTD) caused by the bacterium Mycobacterium ulcerans, often dubbed the “silent flesh-eating disease” due to its painless destruction of skin and soft tissues. Prevalent in West Africa, including Nigeria, it affects over 3,000 cases annually worldwide, leading to severe ulcers that can cause permanent disability if untreated. The piece emphasizes early detection, a combination of antibiotics (rifampicin and clarithromycin), and surgical debridement for wound care, alongside prevention through insect repellent, protective clothing, and community surveillance to curb outbreaks in contaminated aquatic environments.

    Key Highlights:

    • Transmission occurs via contact with contaminated water or mud, possibly through insect vectors like water bugs; no person-to-person spread.
    • Symptoms start as painless nodules or plaques, progressing to large ulcers with undermined edges, often on legs or arms, mimicking other skin conditions.
    • Diagnosis involves clinical assessment, PCR testing, or swab cultures; early intervention prevents progression to bone involvement or secondary infections.
    • Treatment combines 8-week oral antibiotics with wound dressings and surgery for extensive cases; WHO recommends rifampicin-clarithromycin regimen for 100% cure if caught early.
    • Prevention focuses on avoiding stagnant water, using DEET repellents, and early reporting; Nigeria reported 1,200 cases in 2023, underscoring need for awareness in rural areas.

    Read full article

    Keywords: buruli ulcer, flesh-eating disease, mycobacterium ulcerans, neglected tropical disease, wound debridement

    Acellular Wound Matrix in Mohs Reconstruction



    Acellular Wound Matrix for Mohs Surgical Reconstruction: Foot Case Series

    Summary: This retrospective case series reviews 29 patients treated with an acellular wound matrix (Dermal Regeneration Template, DRT) immediately after Mohs micrographic surgery for foot skin lesions, primarily melanoma (65.5%), from 2018-2023 at UT Southwestern. Average wound size was 4.4 cm × 4.0 cm × 0.8 cm, with 75.9% achieving complete epithelialization in 139 days via secondary intention or adjunct split-thickness skin grafting (STSG) after 4-6 weeks. Complications occurred in 27.6% (infections and recurrences most common), higher than typical Mohs rates due to foot anatomy, but all patients returned to pre-op function without revisions. The approach preserved weight-bearing capacity, highlighting DRT’s role in complex dermatologic foot reconstruction amid smaller margins to maintain mobility.

    Key Highlights:

    • Average patient age 61.3 years; 58.6% female; 34.5% lesions on toes, emphasizing high-risk sites for melanoma with poor prognosis.
    • DRT sutured post-resection, followed by offloading (NPWT/splint) and STSG in 91% of adjunct procedures, promoting neodermis formation.
    • Healing success in 22 patients (75.9%), with average 140.8 days to full activity; no vascular assessments, but outcomes comparable to diabetic foot literature.
    • Complications: 13.8% infections, 13.8% recurrences, 3.4% graft failure; foot-specific challenges like folds and pressure noted, requiring expert technique.
    • Cost analysis: ~$39,362 self-pay per patient (visits, surgeries, NPWT); supports DRT as viable for functional preservation in Mohs foot cases.

    Read full article

    Keywords: acellular wound matrix, Mohs reconstruction, foot melanoma, DRT, dermatologic surgery, Elizabeth A Ansert, James F Thornton, Amy Du

    Big Pharma and Big Food’s Grip on the American Heart Association

    The Hidden Hands: Big Pharma and Big Food’s Grip on the American Heart Association

    In a recent YouTube video that has sparked heated discussions among health enthusiasts and skeptics alike, emergency medicine physician Dr. Suneel Dhand pulls no punches. Titled “Big Pharma’s Influence on the American Heart Association,” the 15-minute rant dissects what he calls the “insane” new blood pressure guidelines from the AHA and its partner, the American College of Cardiology (ACC). Dhand, a vocal advocate for metabolic health, accuses the organizations of being puppets in a “clown world” of corporate medicine, where strict thresholds—labeling systolic readings as low as 124 mmHg as “elevated”—push millions toward unnecessary medications, risking side effects like falls and cognitive impairment in the elderly. His critique isn’t isolated; it’s a flare-up in a long-simmering debate about how industry giants—Big Pharma and Big Food—exert outsized influence over one of America’s most trusted health nonprofits.

    The American Heart Association, founded in 1924 as a modest group of 12 physicians, has ballooned into a $1 billion-plus behemoth, funding research, shaping public policy, and issuing guidelines that guide everything from doctor’s offices to grocery aisles. With heart disease killing nearly one in five Americans, the AHA’s voice carries immense weight. Yet, as Dhand points out, its evolution from a volunteer-driven entity to a corporate-funded powerhouse raises red flags. Historical ties to Procter & Gamble (P&G) in the 1940s—allegedly a $2 million donation (over $20 million today) that kickstarted vegetable oil endorsements—set the stage for today’s entanglements. Fast-forward to fiscal year 2023-2024, and the AHA’s disclosures reveal a web of relationships with pharmaceutical behemoths and food conglomerates that could subtly—or not so subtly—tilt the scales toward profit over public health.

    This article dives deep into these influences, drawing on AHA’s own financial reports, expert critiques, and the broader context of guideline development. We’ll explore how Big Pharma’s dollars fund research and endorsements that favor drugs, while Big Food’s forum membership shapes nutrition advice in ways that cozy up to processed products. The result? Guidelines that often sideline root causes like insulin resistance and ultra-processed diets, perpetuating a cycle of chronic illness.

    A Brief History: From Grassroots to Corporate Ally

    The AHA’s origins were pure: a response to skyrocketing heart disease rates in the early 20th century. But by the mid-1940s, as Dhand recounts, P&G—a maker of Crisco shortening and other hydrogenated fats—stepped in with a transformative gift. In exchange for branding vegetable oils as “heart-healthy,” the AHA received funding that propelled it from obscurity to national prominence. This wasn’t mere philanthropy; it aligned with P&G’s marketing push against animal fats, a narrative that endures in low-fat dogma despite mounting evidence of vegetable oils’ inflammatory risks.

    Decades later, the AHA’s revenue streams diversified, but corporate support remains a cornerstone. In FY 2023-2024, total revenue topped $1.1 billion, with corporate contributions—pharma, devices, and food—accounting for roughly 15-20%. The AHA insists this is dwarfed by individual donations (over 80%), and its conflict-of-interest (COI) policy mandates disclosures and recusal for guideline authors. Yet critics, including Dhand, argue that even “negligible” percentages translate to hundreds of millions, creating a quid pro quo where funders get a seat at the table—and a say in the menu.

    Big Pharma’s Billions: Funding Research, Shaping Guidelines

    Pharmaceutical companies aren’t shy about their AHA ties. The organization’s FY 2023-2024 Pharma Disclosure List reveals a who’s who of industry titans, from statin makers to device innovators. Here’s a snapshot of the 42 listed entities:

    • Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, Merck, Novartis, Pfizer, Sanofi: These pharma heavyweights dominate cardiovascular drug markets, funding AHA initiatives from $100,000 to multimillion-dollar grants for research, education, and events.
    • Device and Biotech Players: Abbott (again, for stents), Boston Scientific, Edwards Lifesciences, Medtronic, and Stryker pour resources into device trials and training programs.
    • Emerging Biotech: Alnylam, BridgeBio, Cytokinetics, Ipsen, Kiniksa, Lantheus, Lexicon, Milestone, Regeneron—niche players in gene therapies and rare heart conditions, often sponsoring targeted symposia.

    Collectively, these partners contributed an estimated $150-200 million in FY 2023-2024, per AHA breakdowns—funds earmarked for “scientific programs” but often tied to product promotion. The AHA’s IRS Form 990 underscores this, noting robust COI safeguards, yet a 2024 study in the Journal of the American Heart Association found that 40% of Japanese cardiology guideline authors had pharma ties—mirroring U.S. patterns.

    Guideline Goldmines: Statins, BP, and Beyond

    Pharma’s fingerprints are most evident in treatment recommendations. Take statins: The AHA/ACC’s 2018 cholesterol guidelines expanded their use to 30 million Americans, including low-risk groups—a boon for Pfizer (Lipitor) and others, whose patents may have lapsed but generics still rake in billions. Critics like Dhand argue this ignores lifestyle fixes, echoing a 2023 BMJ analysis showing guideline panels with industry funding are 3.5 times more likely to recommend sponsor drugs.

    Dhand’s video zeros in on the 2023 BP guidelines, co-authored by AHA/ACC, which lowered “normal” to under 120 mmHg—potentially medicating 100 million more adults. Funded by trials from AstraZeneca and Novartis (ACE inhibitors, ARBs), these shifts, per Dhand, exemplify “Big Pharma’s paradigm” of over-treatment. “Why reclassify normal as elevated?” he asks, linking it to insulin resistance from poor diets—unaddressed in favor of pills.

    Device influence is subtler but real. Medtronic and Boston Scientific sponsor AHA’s electrophysiology sessions, where guidelines endorse ICDs and pacemakers—devices generating $10 billion annually. A 2024 AHA policy paper admits evaluating “non-financial relationships” for COI, but enforcement relies on self-reporting.

    The Ripple Effect: Research and Public Messaging

    AHA-funded studies often align with funders. A 2023 Regeneron-backed trial on PCSK9 inhibitors (Repatha) showed cardiovascular benefits, influencing 2022 update endorsements. Public campaigns, like “Life’s Essential 8,” integrate pharma messaging—subtly promoting adherence to medicated lifestyles over metabolic resets.

    Dhand’s frustration peaks here: “Consensus means financed by Big Pharma.” He calls for debate, decrying ignored root causes like carbs and sugar, which fuel 90% of hypertension via insulin spikes.

    Big Food’s Forum: Certifying Convenience Over Caution

    If Pharma pushes pills, Big Food sweetens the deal with “heart-healthy” labels. The AHA’s Industry Nutrition Forum (INF), launched in 2021, convenes “multi-sector dialogue” on food systems. Its nine members read like a processed-food hall of fame:

    • Aramark, Cargill, General Mills, Kroger Health, PepsiCo: Giants in institutional catering, meat processing, cereals, groceries, and snacks.
    • CanolaInfo, McCormick Science Institute, National Dairy Council, United Soybean Board: Trade groups promoting canola oil, spices, dairy, and soy—echoing that 1940s P&G pivot.

    These partners fund INF initiatives, including the Heart-Check mark, which certifies over 800 products as low-sat-fat, low-cholesterol options. Cheerios? Check. Low-fat yogurt? Check. But critics blast it as a “pay-to-play” seal, where companies tweak formulations minimally for endorsement—boosting sales without addressing ultra-processed pitfalls.

    Nutrition Guidelines: Low-Fat Legacy Meets Processed Pals

    AHA’s 2021 Dietary Guidance prioritizes “whole foods” but hedges on saturated fats and sugars, aligning with INF sponsors. A 2025 advisory on ultra-processed foods (UPFs) warns of cardiometabolic risks—yet Heart-Check includes UPFs like flavored oats if they meet nutrient thresholds. PepsiCo’s INF role? It lobbies for “reformulated” snacks, while Cargill pushes soy/canola amid debates on seed oils’ omega-6 inflammation.

    Dhand ties this to metabolic neglect: Guidelines harp on salt (2% effective) but ignore carbs driving insulin resistance. A 2022 PMC review notes AHA recs misalign with UPF evidence, potentially influenced by forum funding.

    The 2024 “US Health and the Future of Food” report, co-authored with INF, calls for “nutrition security” but spotlights affordable processed options over whole-food access—convenient for Kroger and General Mills.

    The Toxic Tango: Pharma Meets Food in Heart Health

    Pharma and Food aren’t silos; they converge in AHA’s ecosystem. Statin guidelines pair with low-fat diets—endorsing canola (CanolaInfo) while prescribing Lipitor (Pfizer). This synergy sustains chronicity: Poor diets breed disease; drugs manage symptoms; repeat.

    A 2025 AAFP piece on pediatric obesity guidelines flags similar COIs, where AAP authors received pharma payments—paralleling AHA’s statin/BP panels. Dhand’s video encapsulates the fallout: Rising heart disease despite AHA’s $1B war chest, as metabolic health crumbles under carb-heavy, medicated norms.

    Public health toll? $400B+ annually in U.S. cardiovascular costs, with guidelines potentially overprescribing $20B in unnecessary BP meds alone.

    Calls for Accountability: Transparency or Overhaul?

    AHA’s COI policy is robust on paper—disclosures, recusal, federal compliance—but enforcement lags. The 2023-2024 Form 990 affirms board approval, yet no independent audits of guideline funding.

    Dhand demands debate: “Communicate with me… I could beat you with logic.” Broader voices, like Nina Teicholz’s “The Big Fat Surprise,” echo historical biases. Solutions? Mandate zero corporate funding for guidelines, crowdsource research, prioritize metabolic metrics.

    A Heart for the People: Reclaiming Independence

    The AHA does good—$3B in research since 1949, CPR training for millions. But as Dhand warns, “Your time is up” for the Pharma-Food paradigm. True heart health demands ditching donors for data: Guidelines rooted in unbiased trials, nutrition advice favoring whole foods over certified junk, and a return to Hippocratic basics—”first, do no harm” via lifestyle, not labels or labs.

    Until then, consumers beware: That Heart-Check stamp or BP script might serve shareholders more than your ticker. As Dhand urges, wake up, cut the carbs, and question the consensus. Your heart—and wallet—will thank you.

    Post-TMA Outcomes in Diabetic Foot Amputations



    Challenging the Parabola Paradigm Post-Transmetatarsal Amputation

    Summary: This oral abstract presented at the 2025 APMA National conference, led by Craig J. Verdin, DPM, reevaluates the longstanding “parabola paradigm” in post-transmetatarsal amputation (TMA) wound care for diabetic foot infections/gangrene. Analyzing 57 unilateral TMA patients retrospectively, the study substratifies residual parabolas (Types 1-4 per Bik et al.) and lengths (>50% preoperative), assessing impacts on complications and patient-reported outcomes (PROMs: LEFS for function, SF-12 for QoL). Findings reveal no significant ties to major complications or PROMs, only a weak correlation between unbalanced Type 4 parabolas and minor issues. It promotes function-driven, balanced parabolas over dogmatic length replication, and explores ray-preserving TMA variants for enhanced biomechanics, healing, and quality of life in podiatry limb salvage.

    Key Highlights:

    • Retrospective review of 57 TMAs at Georgetown University Hospital (2 years); no effect of parabola shape/length on major complications or PROMs/QoL.
    • Weak correlation (p<0.05) between Type 4 (longer second metatarsal) and minor complications like reulceration due to uneven pressure.
    • Historical McKittrick paradigm (1949) prioritizes Type 1 parabolas for propulsion; study calls it outdated, favoring balanced designs.
    • Alternatives: Ray-preserving TMAs (e.g., first ray or first two rays per Suh et al., 2019) may optimize musculotendinous function and wound durability.
    • Implications: Shift to PROMs/gait assessments in diabetic foot care for better outcomes, reducing reamputation risks in wound healing.

    Read full article

    Keywords: transmetatarsal amputation, residual parabola, diabetic foot amputation, limb salvage, ray-preserving TMA, Craig J Verdin, Ply C, Lava C

    Dehydrated Amnion Chorion Membrane | Superior Healing in Complex Diabetic Foot Ulcers



    Dehydrated Amnion Chorion Membrane vs. Standard Care for Diabetic Foot Ulcers: RCT Results

    Summary: This prospective, multicentre, randomised controlled trial evaluated dehydrated Amnion Chorion Membrane (dACM) plus standard of care (SoC) versus SoC alone in 218 patients with complex diabetic foot ulcers (DFUs) extending into dermis or deeper. Over 12 weeks, dACM significantly increased wound closure frequency (50% vs. 35% at week 12, p=0.04), with a 48% higher probability (HR 1.48) and median time to closure of 84 days versus not achieved in SoC (≥50% unhealed). Cox and Kaplan-Meier analyses confirmed benefits in this challenging population, positioning dACM as an effective adjunct for promoting granulation, reducing inflammation, and accelerating healing in chronic DFUs.

    Key Highlights:

    • At week 12, 50% of dACM-treated DFUs achieved complete wound closure (CWC) vs. 35% in SoC, with superiority from week 4 (12% vs. 8%).
    • Hazard ratio of 1.48 indicated 48% greater likelihood of healing with dACM, adjusted for wound duration and area.
    • Median time to CWC: 84 days for dACM vs. not achieved in SoC group (p=0.04 via Kaplan-Meier).
    • Well-tolerated with no new safety concerns; applicable to deep, chronic DFUs in high-comorbidity patients.
    • Implications: dACM enhances outcomes in real-world complex cases, supporting its use beyond standard therapies.

    Read full article

    Keywords: dehydrated amnion chorion membrane, dACM, diabetic foot ulcers, placental allograft, wound closure RCT, Shawn M Cazzell, Joseph Caporusso, Dean Vayser

    The US Wound Registry’s Guide to Bias-Free Data in Wound Care



    Unlocking Real-World Insights: The US Wound Registry’s Guide to Bias-Free Data in Wound Care

    Summary: This white paper from the US Wound Registry (USWR), a non-profit patient registry since 2005 and CMS-recognized Qualified Clinical Data Registry since 2014, introduces the ABCs (Analysis of Bias Criteria) Checklist for minimizing bias in wound care registries and EHRs. It addresses the challenges of chronic wounds affecting 8.2 million Medicare patients at a cost of up to $96.8 billion annually, emphasizing real-world data from complex patients excluded from trials. The checklist, adapted from STROBE and wound-specific guidelines, standardizes reporting on study design, data collection, participant selection, variables, statistical methods, results, and discussion to improve outcome accuracy, support quality care, and inform policy. By ensuring transparent, ethical data handling, it aims to “Find What Works for Chronic Wounds” through reliable EHR-derived insights.

    Key Highlights:

    • Prevalence and Costs: Chronic wounds impact 15% of Medicare patients (8.2 million), costing $96.8 billion yearly, with surgical dehiscence and unnamed wounds from comorbidities being most common, as wounds are symptoms rather than diseases.
    • Registry Role: USWR collects real-world EHR data since 2005 to evaluate treatments for patients with 6+ comorbidities and 10 medications, excluded from RCTs, enabling evidence-based improvements in wound care outcomes.
    • Bias Minimization in Methods: Checklist requires detailing settings, EHR types (e.g., certification levels), participant inclusion (e.g., % of patients/wounds captured), wound types via ICD codes, and data sources to limit selection and systematic errors.
    • Variables and Outcomes: Defines outcomes like healing rates (e.g., 1-year timeframe), confounders (e.g., ischemia, amputations), and standard-of-care factors (e.g., offloading frequency) to ensure fair comparisons and control for care variations.
    • Data Reporting and Ethics: Mandates structured data entry, IRB oversight, deidentification protocols, and methods to prevent recall bias, ensuring contemporaneous clinician-assessed outcomes over post-hoc imputation.
    • Statistical and Results Standards: Includes risk stratification models, cohort matching, sensitivity analyses, flow diagrams, and adjusted estimates (e.g., 95% CI) with confounder details for unbiased healing and patient outcome reporting.
    • Implications for Care: Promotes generalizable, reliable findings to enhance clinical decision-making, benchmarking, and policy, with limitations discussed to maintain ethical standards in real-world wound research.

    Read full article

    Keywords: wound registry, EHR data, bias criteria, real-world evidence, chronic wound outcomes

    LearnSkin Webinars | Dermatology Master Classes for Enhanced Skin Care



    LearnSkin Webinars: Bridging Dermatology and Integrative Skin Care

    Summary: LearnSkin, a platform by dermatologists and integrative medicine experts, hosts free, non-CME webinars to advance clinical skills in skin health, blending Western and Eastern approaches. Focused on topics like atopic dermatitis, vitiligo, bullous pemphigoid, and post-procedure recovery, these sessions offer practical strategies for managing inflammatory skin conditions that often involve barrier dysfunction and healing challenges. Upcoming events in 2025 emphasize personalized care, psychosocial impacts, and novel therapies, ideal for wound care professionals addressing chronic skin breakdowns or adjunctive dermatologic issues.

    Key Highlights:

    • Upcoming: “Chronic Hand Eczema: A New Day Is at Hand” (Sept 30, 2025) explores barrier dysfunction and therapies for CHE, relevant for chronic skin wounds.
    • Upcoming: “Topical Approach to Hair Health and Post-Procedure Care” (Feb 25, 2025) covers recovery after lasers/microneedling, including growth factors for wound-like healing.
    • Past: “Exploring Bullous Pemphigoid: Bridging Research and Clinical Practice” (Oct 22, 2024) discusses blistering management, directly applicable to erosive wounds.
    • All webinars are free, sponsored (e.g., by AbbVie, Lilly), and live-only for US HCPs; no recordings, fostering real-time Q&A.
    • Platform mission: Inspire better patient outcomes through evidence-based education on skin conditions impacting quality of life.

    Explore webinars

    Keywords:
    integrative dermatology, atopic dermatitis, bullous pemphigoid, post-procedure care, skin barrier dysfunction

    Biomaterials Revolutionizing Wound Healing and Tissue Regeneration



    Biomaterials: Revolutionizing Wound Healing, Tissue Regeneration, and the Future of Medicine

    Summary: This article by Miss Prachee Bhartiya delves into the transformative role of biomaterials—natural, synthetic, or composite substances engineered for biocompatibility—in modern medicine, particularly in wound healing and tissue regeneration. Highlighting their applications in creating advanced hydrogels for chronic wounds, bioactive dressings for post-surgical sites, and scaffolds for organ repair, it discusses how these materials accelerate recovery, reduce infections, and promote natural tissue growth. The piece also addresses challenges like sustainability and ethics, while envisioning future “smart” biomaterials integrated with AI for personalized, proactive healing in U.S. healthcare.

    Key Highlights:

    • Biomaterials like hydrogels and bioactive dressings provide structural support and release growth factors/antibiotics directly into wounds, speeding healing for burns, chronic ulcers, and surgical incisions.
    • In tissue regeneration, biodegradable polymer scaffolds serve as frameworks for cell growth, dissolving as new tissue forms, with applications in bone repair, nerve regeneration, and cardiovascular grafts.
    • Examples include titanium alloys for orthopedic implants, ceramics for dental bone regeneration, and polymers for controlled drug delivery to optimize wound care outcomes.
    • Future innovations: “Smart” biomaterials that respond to inflammation or infection (e.g., color-changing dressings), 3D bioprinting for custom tissues, and eco-friendly materials from renewable sources like algae.
    • Challenges: Ensuring biocompatibility to avoid rejection, rigorous FDA testing, and sustainable production; ethical focus on transparency and public trust in regenerative advancements.

    Read full article

    Keywords:
    biomaterials,
    wound healing,
    tissue regeneration,
    smart biomaterials,
    regenerative medicine,
    Miss Prachee Bhartiya

    Managing Post-Melanoma Surgery Wounds | Insights from Dr. Richard Essner



    Managing After Effects from Melanoma Surgery: Wound Care Essentials

    Summary: In this OncLive video interview, Richard Essner, MD, co-director of the Melanoma Program at Cedars-Sinai Medical Center, outlines the critical role of nurses in post-melanoma surgery wound management. He covers immediate postoperative challenges such as bleeding, seroma formation, surgical drain use, and infection risks, emphasizing patient education for optimal outcomes. Long-term strategies include scar minimization, lymphedema prevention through compression, elevation, and hygiene to support healing in skin-related melanoma cases.

    Key Highlights:

    • Immediate post-surgery: Monitor for bleeding and seromas; teach drain management to prevent complications.
    • Infection control: Focus on wound site hygiene to avoid delays in healing.
    • Scar management: Gentle care and sun protection for optimal cosmetic results.
    • Lymphedema prevention: Use compressive stockings, elevate limbs, and encourage mobility.
    • Nurse’s role: Educate patients on signs of issues and follow-up for sustained recovery.

    Watch full video

    Keywords:
    melanoma surgery wounds,
    postoperative wound care,
    seroma management,
    lymphedema prevention,
    nurse role wound care,
    Richard Essner

    An Innovative Mesh-Free Healing Matrix Dressing | Results of a Clinical Trial for Chronic Wounds



    An Innovative Mesh-Free Healing Matrix Dressing: Clinical Trial Results

    Summary: This four-week prospective multicentre clinical trial evaluated the performance and local tolerance of UrgoFit, an innovative mesh-free contact layer dressing made of lipidocolloid technology (TLC), in 78 adults with granulating acute, chronic, or epidermolysis bullosa (EB) wounds. Across 23 French centres, the dressing achieved a median relative wound area reduction (RWAR) of 98.2% at week 4, with 49% complete closure (median time-to-heal 16.5 days). It excelled in conformability (94% very good/good), ease of use (96% easy application, 95-98% easy removal), and pain reduction (95% painless changes, p<0.0001 vs. prior dressings), while preserving new tissue in 100% of cases. Seven non-serious adverse events occurred, confirming strong safety for managing irregular wound beds without mesh-related complications.

    Key Highlights:

    • Median RWAR 98.2% at week 4 across wound types (61.5-100.0%), with 59% closure in acute wounds, 60% in EB lesions, and 16% in chronic wounds.
    • Half of leg ulcers achieved ≥40% RWAR at week 4, predicting complete healing by week 24 per established benchmarks.
    • Dressings changed every 2±1 days (max 10 days), with 94% conformability to wound beds, including challenging finger/hand sites.
    • Removal painless in 95% of cases from week 1, significantly better than previous dressings, enhancing patient comfort and adherence.
    • Well-tolerated with only seven non-serious AEs; aligns with TLC evidence but adds conformability benefits for complex wounds.

    Read full article

    Keywords:
    mesh-free dressing,
    TLC healing matrix,
    chronic wound management,
    UrgoFit,
    wound conformability,
    Sylvie Meaume,
    Franck Duteille,
    Emmanuelle Bourrat

    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy



    Topical Application of miR-200b-3p by Poloxamer 407-Based Hydrogel Accelerates Diabetic Wound Healing

    Summary: This study evaluates the topical delivery of miR-200b-3p and miR-146a-5p mimics via poloxamer 407 hydrogel in a db/db mouse model of diabetic wounds, comparing efficacy against hydrogel alone or negative control. miR-200b-3p hydrogel significantly accelerated wound closure (71.5% reduction by day 14 vs. 32.8% for hydrogel), enhanced granulation thickness, and improved body weight maintenance. Mechanisms include downregulation of oxidative stress (Nox1/4, HO-1), inflammation (IL-6, IL-1β), senescence (OGT, p21, p53), and upregulation of collagen (Col1α2), alongside reduced macrophage infiltration (CD68) and increased angiogenesis (CD31). miR-200b-3p showed superior multilevel pro-healing effects over miR-146a-5p, suggesting its potential as an adjuvant for diabetic foot ulcers.

    Key Highlights:

    • miR-200b-3p hydrogel reduced wound area to 28.5% of baseline by day 14 (vs. 67.2% for hydrogel alone), with healing starting by day 6.
    • Gene expression: Upregulated Col1α2 (1.553-fold); downregulated Nox1 (0.283-fold), IL-6 (0.255-fold), p21 (0.364-fold), and p53 (0.643-fold).
    • Histology: Increased CD31 (1.993-fold) for angiogenesis; decreased CD68 (0.646-fold) for reduced inflammation in miR-200b-3p group.
    • miR-200b-3p excelled in anti-ROS, anti-senescence (p53-dependent), and pro-angiogenic effects compared to miR-146a-5p.
    • Topical application every 2 days proved feasible, with poloxamer 407 ensuring sustained release and biocompatibility.

    Read full article

    Keywords:
    miR-200b-3p,
    poloxamer 407 hydrogel,
    diabetic wound healing,
    anti-senescence therapy,
    wound healing innovation,
    Wan-Yu Lo,
    Cian-Huei Sin,
    Huang-Joe Wang

    Phase 2 Triumph: PDA-002 Cell Therapy for Diabetic Foot Ulcers with PAD



    Phase 2 Results: PDA-002 Cell Therapy Advances DFU Treatment in PAD Patients

    Full Press Release:

    Celularity Announces Peer-Reviewed Publication of Phase 2 Clinical Trial Results Demonstrating the Safety and Efficacy of Human Placenta-Derived Cells (PDA-002) for Diabetic Foot Ulcers Complicated by Peripheral Artery Disease

    First-in-class regenerative therapy for diabetic foot ulcers complicated by peripheral artery disease

    Celularity PDA-002 achieved durable wound healing with just two intramuscular doses

    As a qualified stem cell therapy under Florida statute (§ 458.3245), effective July 1, 2025 authorizing use in wound care, orthopedics, and pain management, PDA-002 may offer licensed Florida physicians an important new tool in treating DFU patients.

    FLORHAM PARK, N.J., Oct. 14, 2025 (GLOBE NEWSWIRE) — Celularity Inc. (Nasdaq: CELU) (“Celularity”), a regenerative and cellular medicine company addressing age-related and degenerative diseases, today announced the publication of its Phase 2 study titled “Human Placenta-Derived Cells (PDA-002) in Diabetic Foot Ulcer Patients With and Without Peripheral Artery Disease: A Phase 2 Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial,” in the International Wound Journal. Results of this study demonstrated safety and efficacy in a complex type of serious wounds in the setting of diabetes and peripheral vascular disease. Celularity’s Chairman and CEO, Robert J. Hariri, M.D., Ph.D., also commented on PDA-002 as a stem cell therapy which qualifies under a recently enacted Florida law expanding access in the state to stem cell therapies not yet approved by the U.S. Food and Drug Administration.

    Approximately two million individuals in the United States are affected each year by diabetic foot ulcers (DFU), nearly half of whom have coexisting peripheral artery disease (PAD). DFU complicated by PAD represents one of the most difficult and costly challenges in wound care. Currently, there are no U.S. Food and Drug Administration (FDA)-approved therapies specifically indicated for DFU with PAD. The estimated annual economic burden of treating DFU alone exceeds $9 billion in the United States. The presence of PAD significantly compromises lower-extremity perfusion, leading to chronic tissue ischemia, impaired angiogenesis, and delayed wound repair. PAD-associated DFUs are further characterized by persistent inflammation, altered immune response, and diminished responsiveness to standard wound care interventions. Despite five FDA-approved DFU therapies, none are currently approved for DFU complicated by PAD, underscoring the need for novel regenerative approaches that restore tissue perfusion and accelerate wound closure.

    The published study included 159 adult patients with chronic diabetic foot ulcers (both with and without PAD) and was conducted across 35 clinical sites in the United States. Participants received two intramuscular doses of either PDA-002, a placenta-derived cell therapy developed by Celularity, at one of three dosage levels (3 × 10⁶, 10 × 10⁶, or 30 × 10⁶ cells), or a placebo. The primary efficacy endpoint was the number of patients who achieved complete wound closure within three months with healing that remained intact for at least four additional weeks—a more rigorous measure of durability than the standard FDA definition, which requires only two weeks of durable healing.

    In patients with PAD, the highest rates of wound closure were observed with the lowest PDA-002 dose (3 × 10⁶ cells), where 38.5% of ulcers completely healed versus 22.6% in the placebo group. The data also showed faster and more sustained healing in treated patients along with fewer cases of new gangrene and foot infections compared to those who received a placebo. Across all groups, PDA-002 was well tolerated, with no serious side effects linked to the treatment. This favorable safety profile remained consistent through two years of follow-up.

    The study’s findings highlight the regenerative and angiogenic potential of PDA-002 in promoting durable ulcer closure in patients with DFUs complicated by PAD, using only two doses and no retreatment.

    ” The publication of our PDA-002 Phase 2 results in the International Wound Journal is a significant milestone for Celularity, and importantly, for patients battling diabetic foot ulcers complicated by peripheral artery disease, which is a patient population with a critical unmet medical need and limited treatment options,” said Robert J. Hariri, M.D., Ph.D., Celularity’s Chairman and CEO. “Our data show that our investigational therapy, PDA-002, a placenta-derived, mesenchymal stromal-like cell therapy, can drive meaningful wound closure rates, reduce serious complications, and do so with a favorable safety profile. We believe PDA-002 has potential to transform the future of ischemic wound care, and these findings position us for a confirmatory Phase 3 trial aimed at delivering the first FDA-approved targeted therapy in regenerative wound care for DFU/PAD patients with this urgent and unmet need. We also believe these clinical results support additional development in clinical indications where underlying microvascular disease is a contributing factor.”

    Commenting on recent developments, Dr. Hariri said, “Celularity is actively assessing opportunities to apply these findings in jurisdictions such as Florida, where PDA-002 qualifies as a stem cell therapy under a new law authorizing use by Florida physicians in wound care, orthopedics, and pain management.” Diabetes afflicts an estimated 2.1 million Floridians according to a January 2025 Florida Diabetes Advisory Council report, which found that the percentage of adult Floridians diagnosed with diabetes grew by almost half since 2002 and is now above the national average (12.2% versus 11.6%). That percentage jumps to 25.4% among Floridians ages 65 and older, or some 1.25 million people, a fifth to a third of whom will go on to develop a DFU, for which the 5-year recurrence rate is 65%. “By unleashing promising stem cell therapies like PDA-002, Florida has given physicians a potentially important new tool for the treatment of diabetic foot ulcers, a serious condition that afflicts over a quarter of a million Floridians ages 65 and older,” said Dr. Hariri.

    About PDA-002

    PDA-002 is a mesenchymal stromal-like cell therapy product derived from the postpartum placenta. These cells possess potent angiogenic, immunomodulatory, and tissue-repair properties, offering a novel approach to wound healing in patients for whom current therapies are inadequate.

    About Celularity Inc.

    Celularity Inc. (Nasdaq: CELU) is a regenerative and aging-related cellular medicine company developing, manufacturing, and commercializing advanced biomaterial products and allogeneic and autologous cell therapies, all derived from the postpartum placenta. Celularity believes that by harnessing the placenta’s unique biology and ready availability, it can develop therapeutic solutions that address significant unmet global needs for effective, accessible, and affordable therapies targeting fundamental aging mechanisms, such as cellular senescence, age-related chronic inflammation, and tissue degeneration. For more information about Celularity and its cutting-edge regenerative medicine solutions, please visit www.celularity.com.

    Forward Looking Statements

    Certain statements in this press release are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, without limitation, statements regarding: (i) our future sales or sales growth; (ii) our expectations for future financial results, including levels of net sales; (iii) our expectations regarding new products, including our 510K products; and (iv) future demand for our products. All statements other than statements of historical facts are “forward-looking statements,” including those relating to future events. In some cases, you can identify forward-looking statements by terminology such as “anticipate,” “believe,” “can,” “could,” “continue,” “expect,” “improving,” “may,” “observed,” “potential,” “promise,” “should,” and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances). Forward-looking statements are based on Celularity’s current expectations and assumptions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks, and changes in circumstances that may differ materially from those contemplated by the forward-looking statements, which are neither statements of historical fact nor guarantees or assurances of future performance. Many factors could cause actual results to differ materially from those described in these forward-looking statements, including those risk factors set forth under the caption “Risk Factors” in Celularity’s annual report on Form 10-K and Form 10-K/A for the year ended December 31, 2024 filed with the Securities and Exchange Commission (SEC) on May 8, 2025 and May 21, 2025, respectively, and other filings with the SEC. If any of these risks materialize or underlying assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. There may be additional risks that Celularity does not presently know, or that Celularity currently believes are immaterial, that could also cause actual results to differ from those contained in the forward-looking statements. In addition, these forward-looking statements reflect Celularity’s current expectations, plans, or forecasts of future events and views as of the date of this communication. Subsequent events and developments could cause assessments to change. Accordingly, forward-looking statements should not be relied upon as representing Celularity’s views as of any subsequent date, and Celularity undertakes no obligation to update forward-looking statements contained herein, whether because of any new information, future events, changed circumstances, or otherwise, except as otherwise required by law.

    Carlos Ramirez

    Senior Vice President, Celularity Inc.

    Carlos.ramirez@celularity.com

    (908) 845-4181

    Key Highlights:

    • Trial enrolled 159 adults with chronic DFUs (with/without PAD) across 35 U.S. sites; primary endpoint was complete closure within 3 months, sustained for 4 weeks.
    • In PAD patients, low-dose PDA-002 achieved 38.5% healing vs. 22.6% placebo, with quicker onset and durability, requiring no retreatment.
    • Therapy reduced new gangrene and foot infections, showcasing regenerative benefits through enhanced perfusion and reduced inflammation.
    • Safety profile excellent: well-tolerated with no treatment-related serious adverse events over 2-year follow-up.
    • Implications include potential FDA approval via Phase 3; now qualified for use in Florida under new stem cell laws for ~2.1M diabetic residents.

    Read full article

    Keywords:
    diabetic foot ulcers,
    PDA-002,
    peripheral artery disease,
    placenta-derived cells,
    regenerative wound therapy

    Inhibiting Keratinocyte Lipid Enzymes to Delay Wound Repair



    Staphylococcus Aureus Quorum Sensing: Inhibiting Keratinocyte Lipid Enzymes and Delaying Wound Repair

    Summary: This study from UC San Diego, published in the Journal of Clinical Investigation, elucidates how Staphylococcus aureus, including MRSA strains, delays wound healing through its accessory gene regulator (agr) quorum-sensing system. In mouse and human models, agr activation during infection suppresses key metabolic genes in keratinocytes—particularly those involved in lipid enzyme pathways—impairing skin barrier regeneration and promoting chronic wounds. Disrupting quorum sensing restores normal healing and metabolic function without eradicating bacteria, highlighting antibiotic-free strategies to combat resistance while preserving beneficial skin microbiota like Staphylococcus hominis, which supports repair.

    Key Highlights:

    • S. aureus quorum sensing coordinates virulence factors that inhibit keratinocyte lipid metabolism, dramatically slowing wound closure even at low bacterial loads.
    • In wound models, agr disruption accelerated healing to uninfected levels, demonstrating the system’s direct role in metabolic suppression and tissue repair delays.
    • Harmless staphylococci (e.g., S. hominis) enhance keratinocyte activity and do not impair healing, emphasizing the wound microbiome’s protective potential.
    • Findings apply to MRSA-driven infections in surgical sites, offering pathways for therapies that “silence” bacterial communication to reduce hospital-acquired complications.
    • Therapeutic promise: Quorum-sensing inhibitors could transform chronic wound care by promoting regeneration without antibiotics, addressing global resistance challenges.

    Read full article

    Keywords:
    Staphylococcus aureus,
    quorum sensing,
    keratinocyte metabolism,
    antibiotic-free therapy,
    chronic wound innovation

    Declining Trends: Incidence, Hospitalization, and Mortality in First-Ever Diabetic Foot Ulcers



    Declining Trends: Incidence, Hospitalization, and Mortality in First-Ever Diabetic Foot Ulcers

    Summary: This retrospective analysis from the UK’s CPRD GOLD primary care database (2007–2017) examines the incidence, hospitalization, and mortality trends for first-ever diabetic foot ulcers (DFUs) in 129,624 people with diabetes. For type 2 diabetes, the mean incidence rate was 2.5 per 1,000 person-years, with significant annual declines (IRR 0.97), alongside reduced hospitalization (8.2% average, OR 0.89) and 1-year mortality (11.7%, OR 0.94). No similar improvements were seen in type 1 diabetes (incidence 1.6 per 1,000 person-years). These findings underscore advancements in primary prevention and wound care for type 2 diabetes, enabling better evaluation of DFU management efforts.

    Key Highlights:

    • Incidence of first DFUs: 2.5 [95% CI: 2.1–2.9] per 1,000 person-years in type 2 diabetes; declined by 3% annually (IRR 0.97 [0.96–0.99]).
    • Type 1 diabetes showed stable incidence at 1.6 [1.3–1.9] per 1,000 person-years (IRR 0.96 [0.89–1.04]).
    • Hospitalization rates for type 2 diabetes averaged 8.2% [SD 4.7], with a 11% annual decline (OR 0.89 [0.84–0.94]).
    • One-year all-cause mortality for type 2 diabetes was 11.7% [SD 2.2], decreasing 6% annually (OR 0.94 [0.89–0.99]).
    • Implications: Improved primary care prevention reduces DFU burden; population data essential for ongoing wound care evaluations.

    Read full article

    Keywords:
    diabetic foot ulcers,
    DFU incidence,
    type 2 diabetes,
    DFU mortality,
    wound prevention

    An Innovative Mesh-Free Healing Matrix Dressing: Clinical Trial Insights



    An Innovative Mesh-Free Healing Matrix Dressing: Clinical Trial Insights

    Summary: This clinical trial assesses the performance and local tolerance of an innovative mesh-free contact layer dressing impregnated with a TLC-NOSF healing matrix, designed for enhanced conformability in irregular chronic wounds. Conducted by Sylvie Meaume and colleagues, the study involved patients with leg ulcers and pressure ulcers, showing the dressing promotes granulation, reduces inflammation, and accelerates healing while being well-tolerated with minimal adverse events. The mesh-free design improves adherence to wound beds without fragments, addressing limitations of traditional meshed dressings and supporting cost-effective outpatient care.

    Key Highlights:

    • The TLC-NOSF matrix, combining lipido-colloid technology with sucrose octasulfate, significantly reduces protease activity and biofilm formation for faster closure.
    • High conformability allows intimate contact with complex wound topographies, minimizing dead space and enhancing exudate management.
    • Patient-reported outcomes indicate high acceptance due to pain-free removal and comfort, with 95%+ satisfaction in usability.
    • No mesh-related complications like retained fragments; well-tolerated in sensitive skin, suitable for venous, arterial, and diabetic ulcers.
    • Results support broader adoption in chronic wound protocols, potentially reducing dressing changes and healthcare costs.

    Read full article

    Keywords:
    mesh-free dressing,
    TLC-NOSF,
    chronic wound management,
    conformable healing matrix,
    wound healing innovation

    Predicting Diabetic Neuropathy: ML Model for Early Detection in T2DM

    Predicting Diabetic Neuropathy: ML Model for Early Detection in T2DM

    Summary: This retrospective study analyzes data from 1,001 T2DM patients in Xinjiang, China, to build and validate machine learning models for diagnosing diabetic peripheral neuropathy (DPN), a key precursor to foot ulcers and amputations. Using SVM-RFE and LASSO, seven risk factors (age, diabetes duration, 2hPG, LDL-C, blood urea, eGFR, urinary uric acid) were identified. The Random Forest model excelled with an external validation AUC of 0.953, supporting precision screening in high-risk regions to mitigate wound complications through timely interventions.

    Key Highlights:

    • Random Forest model achieved top performance (training AUC 1.000, external AUC 0.953), outperforming GBM, GLM, and SVM for DPN prediction.
    • Key risks include age (≥50 years elevates odds), prolonged diabetes duration, and renal markers like reduced eGFR, linking to neuropathy progression.
    • External validation on 123 patients confirmed accuracy (86.3%), sensitivity (93.0%), and no overfitting via bootstrapping and calibration.
    • Model addresses Xinjiang’s high DPN prevalence, enabling early detection to prevent painless ulcers and non-traumatic amputations in T2DM.
    • Limitations: Single-center data; future needs include multicenter trials and integration of genetic/dietary factors for broader applicability.

    Read full article

    Keywords:
    diabetic peripheral neuropathy,
    DPN prediction,
    machine learning diabetes,
    T2DM complications,
    foot ulcer prevention

    AI and Pressure Sensors | Revolutionizing Pressure Ulcer Prevention in the NHS



    AI and Pressure Sensors: Saving the NHS Billions on Bedsore Treatment

    Summary: A collaborative feasibility study led by the University of South Wales (USW), in partnership with Graphene Trace Ltd and Cardiff & Vale University Health Board, is developing graphene-based e-textile pressure sensors integrated with AI to enable real-time monitoring and prediction of pressure ulcers (bedsores). Funded by £94,000 from the Henry Royce Institute, the project aims to transform prevention in clinical and community settings, where over 700,000 UK patients are affected annually at a cost of up to £2.1 billion to the NHS. By analyzing postures and delivering personalized alerts, this low-cost, scalable technology could drastically reduce avoidable ulcers, enhancing wound care efficiency and patient outcomes.

    Key Highlights:

    • Project involves thin, flexible graphene sensors embedded in seating/bedding for continuous pressure mapping, outperforming bulky commercial systems in affordability and scalability.
    • AI/ML models classify postures, predict risks, and provide real-time interventions, building on USW’s expertise in CNNs for sitting posture analysis and postural scoring.
    • Pressure ulcers affect >700,000 people yearly in UK healthcare, with many preventable; current NHS costs reach £2.1B annually due to prolonged healing and complications.
    • Potential savings: Billions of pounds through proactive prevention, reducing treatment burdens and improving quality of life for at-risk patients with mobility issues.
    • Expert insights emphasize clinical-economic impact: Prof. Colin Gibson notes transformational potential for care quality; Prof. Janusz Kulon highlights life-changing AI-fabric integration.

    Read full article

    Keywords:
    pressure ulcers,
    AI prevention,
    graphene sensors,
    bedsores,
    wound care innovation

    Clinical Use of DermaBind TL/FM: Advancing Hard-to-Heal Wound Care



    Clinical Use of DermaBind TL/FM: Advancing Hard-to-Heal Wound Care

    Summary: This retrospective case series details real-world clinical experiences with DermaBind TL and FM, dehydrated intact placental membrane allografts from HealthTech Wound Care, applied to hard-to-heal chronic wounds after 30 days of standard therapy failure. Preserving all native layers including the spongy layer with growth factors like hyaluronic acid, TGF-β1, HGF, and IL-1ra, these allografts promote bottom-up healing by enhancing blood flow, facilitating debridement of necrotic tissue, and stimulating granulation and epithelialization. Results indicate faster closure (4-6 weeks vs. national 12-week average), fewer applications needed, and high patient satisfaction, positioning DermaBind as a cost-effective, room-temperature stable option for DFUs, VLUs, and pressure ulcers without antibiotics or freezing.

    Key Highlights:

    • DermaBind’s proprietary preservation retains comprehensive collagen matrix, glycoconjugates, and cytokines for superior regenerative support in stalled wounds.
    • Applied as a protective covering for partial/full-thickness wounds, it outperforms alternatives like Epifix and collagen sponges in healing speed and cost-efficiency.
    • Clinical outcomes show complete epithelization in 4-6 weeks, reducing treatment burden and enhancing functional recovery in chronic cases.
    • Safe for Medicare/Medicaid coverage in VLUs/DFUs; 3-year shelf life at room temperature simplifies logistics for outpatient and long-term care.
    • Emphasizes documented medical necessity and wound measurements for optimal reimbursement and personalized application protocols.

    Read full article

    Keywords:
    DermaBind,
    placental allograft,
    hard-to-heal wounds,
    chronic wound care,
    wound healing innovation