AAN Updates Painful Diabetic Neuropathy Guidance

Four medication classes have been shown to help, plus topical and other treatments
Gabapentinoids, serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, and sodium channel blockers were more likely than placebo to improve diabetic neuropathy pain, according to a new practice guideline from the American Academy of Neurology (AAN).

Those classes typically had comparable effect sizes around the 0.5 standardized mean difference (SMD) cutoff for a medium effect size, reported Brian Callaghan, MD, MS, of University of Michigan in Ann Arbor, and co-authors … read more