The shortage of donor sites for skin grafts is a significant problem for the treatment of severe burn injuries. In such cases, cultured epidermal autograft (CEA), which is a cultured keratinocyte sheet prepared from the patient’s skin, is a promising treatment option1. However, the clinical use of CEA is limited owing to its lower take rate, especially on an infected bed, mechanical fragility, and frequent spontaneous blistering, particularly in the early stages2. In addition, a delay of 3 to 4 weeks, required for the preparation of a CEA, creates a fundamental clinical problem, as it occurs during the life-threatening phase in patients with severe burns … read more