Pedro Salomão Piccinini, Mariana Rodrigues de Sousa Rebelato, Marwan Masri, Carlos Oscar Uebel, Rubem Lang Stümpfle, Milton Paulo de Oliveira
A diabetic foot ulcer (DFU) is a multifactorial complication affecting patients with diabetes mellitus (DM). These ulcers have a lifetime prevalence of 25% in this population and represent a major cause of hospitalization.1-4 Diabetic foot ulcers also generate an economic burden on the health care system and severely impact patient quality of life.5,6 Standard of care (SOC) consists of management of comorbidities, evaluation of vascular status and debridement, and provision of daily dressings, pressure offloading, and infection control. However, a majority of DFUs do not heal completely, and some lead to infection and amputation.3,7 Newer wound therapies have been shown to offer better alternatives by promoting angiogenesis to accelerate healing.4-6 In this context, the authors present the case of a patient with multiple comorbidities who presented with a chronic nonhealing plantar wound; while multiple prior treatments failed, the wound was successfully treated with nanofat grafting, negative pressure wound therapy … read more
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