A recent systematic review and narrative synthesis has found several tools that demonstrate “acceptable-to-outstanding discrimination” for predicting key outcomes following major lower limb amputation. However, authors Ryan A Preece (Royal Gwent Hospital, Cardiff, UK) and colleagues note that “additional robust external validation” is needed to strengthen the clinical applicability of the prediction tools assessed. This research appeared online in the European Journal of Vascular and Endovascular Surgery (EJVES).