Tag: Hypochlorous Acid

Bionix® Introduces AlphaCleanse™ to Wound Care Line

New AlphaCleanse™ Antimicrobial Wound Care System Offers a More Efficient and Convenient Approach to Wound Care Treatment

TOLEDO, Ohio, Oct. 18, 2021 /PRNewswire/ — Bionix® is pleased to announce their new, single-use product—AlphaCleanse™ Antimicrobial Wound Care System with NovaGran™ Hypochlorous Acid.
The all-in-one kit is designed to provide healthcare professionals with the tools for efficient, effective treatment of chronic wounds … Contained in the AlphaCleanse™ Antimicrobial kit are the Bionix® Igloo® Shield and Probe Applicator, NovaGran™ Hypochlorous Acid, and a highly absorbent LiquidLock™ pad. Having all of the components in one kit saves time and protects against the cross contamination that is possible if the user has to search through various boxes for the tools to treat the wound … read more

Adding a Hypochlorous Acid-Preserved Wound Cleanser to the Pressure Injury Management Toolbox: A Case Series

Pressure injuries (PIs) can impair quality of life, and the goal of management is to create an optimal local wound healing environment. PIs can be difficult to manage and are associated with significant morbidity and mortality. Wound cleansing is a routine part of managing these wounds and can aid in the removal of exudate, debris, and contaminants.3 PIs located on the sacrum or ischium are at high risk of infection due to exposure to urine and feces; for these wounds, regular cleansing is extremely important … read more

Hypochlorous Acid: an ideal wound care agent …



Chronic wounds and the infections associated with them are responsible for a considerable escalation in morbidity and the cost of health care. Infection and cellular activation and the relation between cells are 2 critical factors in wound healing. Since chronic wounds offer ideal conditions for infection and biofilm production, good wound care strategies are critical for wound healing. Topical antiseptics in chronic wounds remain in widespread use today. These antiseptics are successful in microbial eradication, but their cytotoxcity is a controversial issue in wound healing.


The aim of this study was to investigate the effect of stabilized hypochlorous acid solution (HOCl) on killing rate, biofilm formation, antimicrobial activity within biofilm against frequently isolated microorganisms and migration rate of wounded fibroblasts and keratinocytes.


Minimal bactericidal concentration of stabilized HOCl solution for all standard microorganisms was 1/64 dilution and for clinical isolates it ranged from 1/32 to 1/64 dilutions.


All microorganisms were killed within 0 minutes and accurate killing time was 12 seconds. The effective dose for biofilm impairment for standard microorganisms and clinical isolates ranged from 1/32 to 1/16. Microbicidal effects within the biofilm and antibiofilm concentration was the same for each microorganism.


The stabilized HOCl solution had dose-dependent favorable effects on fibroblast and keratinocyte migration compared to povidone iodine and media alone. These features lead to a stabilized HOCl solution as an ideal wound care agent.

Original article appeared in PubMed.gov

Flow-through Instillation of Hypochlorous Acid in the Treatment of Necrotizing Fasciitis

Abstract: Introduction. Necrotizing fasciitis (NF) is a rare and rapidly progressing bacterial infection of soft tissues. Bacterial toxins cause local tissue damage and necrosis, as well as blunt immune system responses. A self-propagating cycle of bacterial invasion, toxin release and tissue destruction can continue until substantial amounts of tissue become necrotic. Neutralization of bacterial toxins should improve the results.

Materials and Methods. Pure hypochlorous acid (HOCl) (0.01% w/v) with no sodium hypochlorite impurity in saline pH 4-5, which was recently shown to both eradicate bacteria and neutralize bacterial toxins in vitro, was administered via flow-through instillation to 6 patients with NF 4-6 times daily as needed. Utilizing a vacuum-assisted closure, 5-10 mL of pure 0.01% HOCl with no sodium hypochlorite impurity was instilled and removed frequently to irrigate the wounds. Results. Of the 6 patients, no deaths or limb amputations occurred. All infected areas healed completely without major complications. Conclusion. The toxicity and immune dysfunction caused by bacterial toxins and toxins released from damaged cells may be mitigated by flow-through instillation with saline containing pure 0.01% HOCl with no sodium hypochlorite impurity. Randomized controlled clinical trial research of this relatively simple and inexpensive instillation protocol is suggested for identified cases of NF.



Necrotizing fasciitis (NF), commonly referred to in nonmedical discourse as “flesh-eating” inflammation, is a rapidly progressing involvement of the fascia and subcutaneous tissues that can subsequently extend to the muscles and skin. Type I NF is classified as a polymicrobial infection, whereas type II NF is classified as a monomicrobial infection.1 Bacterial toxins released during the course of necrotic inflammations produce direct cytotoxic effects on surrounding tissues, while also causing immune system dysfunction and localized immunosuppression. The authors’ new therapy incorporates the use of an instillation vacuum-assisted closure procedure, also known as negative pressure wound therapy (NPWT), with pure 0.01% hypochlorous acid (HOCl) with no sodium hypochlorite—commonly known as bleach—impurity.2 As pure 0.01% HOCl (ie, > 97% relative molar distribution of active chlorine species as HOCl) in a 0.9% saline solution at pH 4-5 has been shown to both rapidly kill bacteria and neutralize bacterial toxins in vitro, clinical administration of pure HOCl with no sodium hypochlorite impurity was recently explored … read more