As defective insulin secretion or impaired biological function, chronic hyperglycemia can cause damage to various tissues and systems, especially eyes, kidneys, blood vessels and nerves.1 Most diabetes patients can be divided into two types. Type 1 diabetes mellitus (T1DM), due to the absolute lack of insulin secretion, can usually be identified by serological evidence and genetic markers of islet autoimmunity. Abnormal inflammation and immune responses are associated with the development of T1DM. Recent study have shown that innate immunity and inflammatory mediators play an important and wide-ranging roles, possibly inhibiting β-cell function,2 promoting subsequent apoptotic processes, and leading to insulin resistance in surrounding tissues … read more
Tag: diabetic peripheral neuropathy
Decreased Physiological Serum Total Bile Acid Concentrations in Patients with Type 2 Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN), one of the most frequent diabetic microvascular complications, is characterized by symmetrical, bilateral distal motor and predominantly sensory abnormality, starting distally and gradually spreading proximally in a glove-and-stocking distribution. It is estimated that DPN would affect approximately 50% in those with over 10 years’ duration.1 DPN has been reported to lead to neuropathic pain, diabetic foot ulcers and lower-limb amputations, all of which contribute to a substantial effect on patient’s quality of life and a significant financial burden. However, other than improving glycemic control, there is no licensed pathogenetic treatment for DPN. Therefore, it would be of great importance if a simple, inexpensive, and reliable indicator is available for the early identification and management of individuals at high risk for DPN in clinical settings, and further effective strategies are formulated to prevent its development and progression … read more
Keys To Addressing Forefoot Plantar Ulcerations
The Centers for Disease Control and Prevention (CDC) estimates one in ten Americans have diabetes and one in three have prediabetes … Diabetes is also increasing among younger populations and can lead to sleep apnea, cardiovascular disease, pulmonary disease and risk of cancer … One major complication of diabetes is diabetic peripheral neuropathy (DPN), seen in 50 percent of the geriatric population with diabetes … continue