Nitric oxide (NO) is a highly active gaseous signaling molecule that is synthesized by NO synthases and mediates many physiological processes, from vasodilation to signal transmission in neurons. In addition, NO has a bactericidal effect, the ability to activate cellular and humoral immunity, induces the proliferation and synthetic activity of fibroblasts, activates the proliferation of keratinocytes and the antioxidant system. The variety of these effects provides NO comprehensive effect in various stages of wound healing and accelerates regeneration. Currently, there are three distinct ways for increasing the concentration of NO in wound tissues: the application of inductors of NO synthesis, NO-containing gas flows, and donor molecules. Using NO donors is one of the most promising and actively developing areas because of the large variety of donor chemical compounds … read more