Jingfang Granules Accelerate Diabetic Wound Healing via Multi‑Target Pathways
A recent manuscript in *Drug Design, Development and Therapy* reveals that Jingfang Granules (JFG), a traditional Chinese medicine blend of 11 herbs, significantly promotes healing of diabetic wounds in preclinical models. The study, using network pharmacology, molecular docking, and animal experiments, explores the mechanisms behind its efficacy.
Key Highlights:
- Multi-Mechanism Action: JFG alleviates oxidative stress, suppresses inflammation, promotes angiogenesis, and normalizes glucose and lipid metabolism—key processes impaired in diabetic wound healing.
- Strong Preclinical Results: In STZ-induced diabetic rats, JFG (1–2 g/kg) enhanced wound closure: day 8 closure improved from ~62% (untreated) to ~70–73%, and by day 14 reached ~95–96% vs 88% in controls.
- Phytochemical Targets Identified: Serum analysis found 56 active compounds. Network mapping highlighted six core protein targets—AKT1, EGFR, MAPK3, MAPK1, IL6, TNF—suggesting modulation of PI3K‑AKT and MAPK pathways.
- In Vitro Validation: JFG serum preparations protected endothelial (H₂O₂/glucose damage) and keratinocyte cultures; it reduced inflammatory cytokines and enhanced angiogenic behaviors.
By integrating computational and experimental data, this study provides compelling preclinical evidence that Jingfang Granules can effectively support diabetic wound healing through multi-dimensional molecular mechanisms.
Read the full study in Drug Design, Development and Therapy.
Keywords:
Jingfang Granules,
network pharmacology,
PI3K‑AKT pathway,
MAPK pathway,
diabetic wound healing