Time in Range Predicts Healing Time in Diabetic Foot Ulcers
A pilot prospective study conducted at Vall d’Hebron Hospital Campus (Barcelona) evaluated whether continuous glucose monitoring (CGM) metrics—specifically Time in Range (TIR), Time Above Range (TAR), and Glucose Management Indicator (GMI)—correlate with healing duration in outpatients with uncomplicated diabetic foot ulcers (DFUs, University of Texas Grades I–II Stage A–C).
Key Highlights:
- CGM Metrics Matter: Higher TIR was strongly associated with faster ulcer closure (p = 0.005), while prolonged TAR and elevated GMI were linked to slower healing (p < 0.05).
- Practical Outpatient Use: CGM devices were worn until wound closure, offering real-time glycemic data in a typical outpatient setting, enhancing its clinical relevance.
- Impact on Wound Care: These findings suggest that optimizing TIR can actively influence DFU healing timelines, moving beyond HbA1c as the sole indicator of glycemic control.
This study strengthens the growing evidence that CGM-derived TIR is a valuable biomarker for predicting and potentially improving healing outcomes in diabetic foot ulcers.
Read the full article in Wound Repair & Regeneration.
Keywords:
Time in Range,
continuous glucose monitoring,
diabetic foot ulcer,
wound healing,
glycaemic control