Bioengineered Autologous Skin Doubles Healing Speed in Preclinical Burn Model
Researchers from Tel Aviv University and Sheba Medical Center have developed a novel bioengineered skin graft using a patient’s own cells grown on a nanofiber scaffold. In preclinical full-thickness burn models, this graft enabled wound closure in just four days—half the time compared with standard treatments.
Key Highlights:
- Autologous Construction: Skin cells (fibroblasts and keratinocytes) were grown on a biodegradable PCL nanofiber scaffold enhanced with a bioactive peptide to support natural cell organization and adhesion.
- Structural Resilience: Unlike cultured epidermal autografts (CEAs), which can shrink over 50% and tear easily, this graft is flexible, durable, and easy to handle.
- Rapid Burn Healing: In animal models, 50% wound closure occurred within 4 days—compared to 8 days using standard care—while early regrowth of skin appendages like hair follicles was observed.
- Clinical Translation Potential: Made entirely from a patient’s own cells, using FDA-approved materials, and produced at scale via electrospinning, positioning it well for future human trials.
- Next Steps: The team plans additional preclinical testing, regulatory pathways, and eventual clinical trials to bring this technology closer to bedside application.
Read the full article on the MedicalXpress website.
Keywords:
bioengineered skin,
autologous graft,
nanofiber scaffold,
burn healing,
preclinical study