Insulin and Metformin Combo Aids Diabetic Foot Ulcer Healing, New Study Finds
A recent study by researchers at Michigan State University and South Shore Hospital has uncovered that combining insulin injections with oral metformin therapy can enhance healing in patients with diabetic foot ulcers (DFUs). The study found that this combination increases the concentration of metformin at the wound site, potentially accelerating the healing process.
Dr. Morteza Mahmoudi, an associate professor at MSU’s College of Human Medicine, noted that their analysis of wound exudates revealed the presence of metformin, suggesting that the combined therapy allows metformin to reach the wound area more effectively. This discovery indicates a synergistic effect between insulin and metformin in promoting wound healing.
Co-researcher Dr. Lisa Gould, a plastic surgeon and wound care clinician at South Shore Hospital and a clinical associate professor at Brown University, emphasized the clinical implications of these findings. The study suggests that clinicians could consider prescribing both insulin and metformin not only for glycemic control but also to enhance local wound healing processes in patients with chronic DFUs.
Read the full article on the Medical Xpress website.
Keywords:
Diabetic foot ulcers,
Insulin therapy,
Metformin,
Wound healing,
Combination therapy,
Michigan State University,
South Shore Hospital
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