Unravelling the Cardio-Renal-Metabolic-Foot Connection in People with Diabetes-Related Foot Ulceration: A Narrative Review
A recent narrative review published in Cardiovascular Diabetology explores the interconnectedness of cardiovascular, renal, metabolic, and foot complications in individuals with diabetes-related foot ulceration (DFU). The authors propose a “cardio-renal-metabolic-foot” framework, highlighting shared pathophysiological mechanisms that link DFU with cardiovascular and renal diseases.
The review emphasizes that systemic inflammation and infection associated with DFU may contribute to the development and progression of cardiovascular and renal conditions. Conversely, existing cardiovascular and renal diseases can exacerbate the risk and severity of DFU, indicating a bidirectional relationship. The authors advocate for a holistic, multidisciplinary approach to managing DFU, incorporating early screening and management of cardiovascular and kidney diseases.
Emerging therapies, such as sodium-glucose co-transporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and non-steroidal mineralocorticoid receptor antagonists, have shown promise in improving cardiovascular and renal outcomes in people with type 2 diabetes. While dedicated research in DFU populations is needed, these therapies could potentially address multiple aspects of the cardio-renal-metabolic-foot connection.
Read the full article on the Cardiovascular Diabetology website.
Keywords:
Diabetes-related foot ulceration,
Cardio-renal-metabolic connection,
Systemic inflammation,
Multidisciplinary care,
SGLT2 inhibitors,
GLP-1 receptor agonists,
Mineralocorticoid receptor antagonists
Note: The above synopsis is based on the article’s abstract and available information. For a comprehensive understanding, please refer to the full article.