Royal Jelly for Diabetic Wound Healing: A Natural Approach (2025)
Summary:** Royal jelly (RJ), a bee secretion rich in antioxidants and growth factors, shows promise for diabetic wound healing through antimicrobial, anti-inflammatory, and regenerative properties. Topical RJ reduces oxidative stress, promotes collagen synthesis, and accelerates closure in DFU models by 30-50%, with low cytotoxicity. The review explores RJ-derived EVs for enhanced delivery, positioning it as a cost-effective adjunct to standard care for infection-prone ulcers.
Key Highlights:
- Composition: 10-HDA, proteins, flavonoids for antibacterial (vs E. coli/Staph) and antioxidant effects.
- DFU Benefits: Boosts fibroblast proliferation, VEGF for angiogenesis; 40% faster healing in rats.
- Delivery: Topical gels or EVs for sustained release; no allergies in diabetics.
- Evidence: Preclinical; human trials needed for dosing.
- Implications: Natural, affordable for global DFU management.
Keywords: royal jelly, diabetic wound, antimicrobial, collagen synthesis, natural therapy