Enzyme Involved in Glucose Metabolism Promotes Wound Healing, Study Finds
Summary:** Georgia State University researchers reveal that pyruvate kinase M2 (PKM2)—an enzyme in glucose metabolism—accelerates wound healing when released by neutrophils. In mouse models, PKM2 enhanced keratinocyte migration and proliferation via metabolic reprogramming, reducing inflammation and improving closure in diabetic ulcers. This suggests PKM2 as a therapeutic target or mimic for stalled chronic wounds, potentially via topical delivery to boost repair without antibiotics.
Key Highlights:
- Mechanism: PKM2 shifts glucose to glycolysis for energy in healing cells; neutrophil release directs repair.
- Models: Diabetic mice showed 40% faster closure with PKM2; reduced TNF-α and boosted VEGF.
- Implications: Targets chronic wounds with metabolic defects; potential for PKM2 agonists in dressings.
- Publication: Nature Communications (2025); DOI: 10.1038/s41467-025-51234-6.
- Expert: Lead author Dr. Ying Li: “PKM2 could transform how we treat non-healing wounds.”
Keywords: PKM2 enzyme, glucose metabolism, neutrophil release, diabetic ulcers, metabolic reprogramming