The impact of PANoptosis-related genes on immune profiles and subtype classification in ischemic stroke
Summary: This open-access computational study profiles PANoptosis-related genes (integrating pyroptosis, apoptosis, and necroptosis) in ischemic stroke blood datasets to define diagnostic gene signatures and immune-infiltration subtypes. While not a wound-care trial, the work offers mechanistic insights into inflammatory cell-death pathways that may inform future translational research across ischemia-driven tissue injury and chronic wound inflammation.
Key Highlights:
- Analyzed GEO datasets (e.g., GSE58294) to identify differentially expressed PANoptosis-related genes and build diagnostic models (ROC performance reported).
- Constructed interaction networks (genes–miRNAs–TFs–drugs) and a nomogram to visualize diagnostic potential.
- Single-cell re-analysis (GSE174574) mapped candidate genes to immune-cell subpopulations relevant to post-ischemic inflammation.
- Unsupervised clustering defined two immune subtypes with distinct infiltration patterns and functional pathways.
- Authors suggest these signatures could guide early diagnosis and targeted therapies in ischemic stroke; pathways overlap with inflammation and cell-death mechanisms studied in chronic wounds.
Keywords: PANoptosis, pyroptosis, apoptosis, necroptosis, ischemic stroke, bioinformatics, immune infiltration, biomarkers, Xinrui Cai, Yu Ren, Qin Yang