Enhancing Wound Repair: Artificial Dermal Scaffolds with Recombinant Human Epidermal Growth Factor
Summary: This comparative study investigates the efficacy of artificial dermal (AD) scaffolds compounded with recombinant human epidermal growth factor (Rh-EGF) in promoting wound repair in a rat model. The composite scaffold demonstrates sustained Rh-EGF release, enhances cell proliferation and adhesion in vitro, and accelerates in vivo healing by stimulating epithelial regeneration, collagen production, angiogenesis, and cell proliferation, while showing potential to minimize scar formation through reduced fibrosis markers.
Key Highlights:
- AD/Rh-EGF scaffolds effectively absorb and release Rh-EGF, overcoming limitations like slow vascularization in standard AD materials.
- In vitro assays confirm improved L929 fibroblast proliferation and adhesion with the composite scaffold.
- In vivo, the composite promotes faster wound closure over 21 days compared to AD alone, Rh-EGF alone, or controls.
- Histological analysis reveals enhanced epithelial tissue regeneration, collagen deposition, and angiogenesis, with trends toward lower scar formation.
- Findings support clinical translation for advanced wound dressings in chronic wound management.
Keywords:
artificial dermal scaffolds,
Rh-EGF,
wound healing,
angiogenesis,
scar reduction