New Trial: ADM Hydrogel vs. Alginate Dressings in Chronic Trauma Wounds
A new randomized interventional study (NCT06978569) from the Isfahan University of Medical Sciences is evaluating whether an injectable **acellular dermal matrix (ADM) hydrogel** is more effective than standard **alginate dressings** in promoting healing of chronic traumatic wounds.
Study Design & Objectives:
- Participants: Approximately 130 adults aged 18–65 with chronic trauma wounds (>3 weeks, 4–20 cm² in size, ≤9 mm deep) without uncontrolled infection.
- Interventions: One group receives ADM hydrogel applied to the wound bed (post-debridement), while the control group receives standard alginate dressings. Weekly follow-ups over 12 weeks will monitor wound size and progress.
- Primary Aim: Assess whether ADM hydrogel accelerates wound reduction and improves healing compared to alginate dressings.
- Endpoints: Wound size reduction over 12 weeks, healing rates, complications, and likely quality-of-life outcomes.
Location: Alzahra Hospital, Isfahan, Iran
Significance: If successful, this trial could introduce a more bioactive topical therapy (ADM hydrogel) for chronic wound management—beyond traditional dressing approaches.
Keywords: ADM hydrogel, alginate dressings, chronic trauma wounds, clinical trial, Isfahan University of Medical Sciences