Frequency‑Specific Sound Enhances Tissue Regrowth
A review article published in *Dermatology Times* (May 2025) by Maddi Hebebrand highlights emerging research on how infrasound and low-frequency audible sound may enhance wound healing and tissue regeneration in non‑invasive and cost‑effective ways.
Key Insights:
- Infrasound & Bone Healing: Preclinical studies show that infrasound (1–20 Hz) improves bone mineral content and density via neuro‑osteogenic modulation and enhanced stem cell activity.
- Fibroblast Migration: Audible sound (~100 Hz) exposure promotes fibroblast movement in vitro, enabling faster tissue repair. Wave orientation (horizontal vs. vertical) significantly affects its effectiveness.
- Skin Barrier Recovery: Exposure to frequencies around 20 kHz accelerated keratinocyte activity and barrier restoration in animal models—suggesting potential for superficial wound applications.
- Clinical Potential and Caveats: Acoustic stimulation may offer new therapeutic avenues for chronic or complex wounds—but current evidence is limited by small studies and inconsistent protocols.
Conclusion: The review supports further investigation of acoustic therapies—like infrasound and audible sound—as adjunctive approaches to wound healing. Defining optimal sound parameters and conducting rigorous trials are essential next steps.
Keywords: Maddi Hebebrand, infrasound, low-frequency sound, fibroblast migration, keratinocyte activity, tissue regrowth, wound healing