3D Acellular Collagen Matrix Shows Promise in Deep/Tunneling Diabetic Foot Ulcers
A retrospective case series published in *Journal of Wound Care* (Sept 2024) evaluated the use of a three-dimensional acellular collagen matrix (3D‑ACM) to treat deep, tunneling, or undermining diabetic foot ulcers (DFUs), which standard flat matrices cannot adequately fill.
Key Highlights:
- Patient Group: 11 patients with 13 deep or tunneling DFUs (average depth 1.6 cm); all wounds present ≥4 weeks.
- Rapid Early Response: 62% of wounds achieved ≥50% closure within 4 weeks.
- Healing Outcomes: 54% of wounds fully closed by 12 weeks; the remainder healed between 12–22 weeks. Overall mean therapy time was ~13 weeks.
- Matrix Benefits: The 3D structure enabled wound-wall apposition, creating a protective, biocompatible scaffold to facilitate cell migration and granulation in complex cavities.
This small series indicates that conforming 3D matrices may offer a valuable option for deep or irregular DFUs, though healing timelines vary with wound depth and volume. Further controlled research is needed to confirm efficacy and cost-effectiveness.
Based on Abdo RJ & Couch AL. “Use of three-dimensional acellular collagen matrix in deep or tunnelling diabetic foot ulcers: a retrospective case series,” *J Wound Care*, 2024.
Keywords: 3D acellular collagen matrix, diabetic foot ulcer, tunneling ulcer, deep ulcer, wound matrix
Read the full article on Journal of Wound Care
🔬 Spotlight: Commercial 3D/Collagen Matrix Products
Enhanced scaffolds offer targeted wound-bed filling with biocompatible structure—especially useful for deep, tunneling, or undermining wounds.
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Integra Bilayer Wound Matrix – A porous, cross‑linked bovine-tendon collagen–glycosaminoglycan dermal substitute topped with a silicone layer. Designed to fill irregular wound beds and support neodermis formation. Highly regarded in DFU management for its scaffold properties.
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Promogran Prisma Matrix (ORC‑Collagen) – A freeze-dried collagen and oxidized regenerated cellulose matrix that adapts to wound shape, absorbs excess fluid, and promotes granulation. Available in sheets and rope formats to accommodate deep tunnels.
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Oasis Fenestrated Wound Matrix – A 3D porcine SIS-derived acellular matrix with fenestrations for flexibility and drainage. Supports cellular ingrowth and structural integration in complex wound geometries.
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Smith & Nephew BIOSTEP Collagen Matrix – A conformable collagen matrix dressing that provides a moist, enzyme-modulating environment, ideal for covering wound beds and supporting epithelial migration.