Aim This study was conducted as a randomised controlled study to determine the effect of tea tree oil on acute wound healing.
Yeliz Sürme, Gülsüm Nihal Çürük, Ayça Lekesizcan and Saim Özdamar
Methods Rats were divided randomly into two groups, non‑diabetic and ‘diabetic’; rats in the diabetic group were made diabetic by intraperitoneal streptozotocin induction at 50 mg/kg. Each group was then subdivided into sunflower oil, tea tree oil and saline (0.9% NaCl) groups. After incisional wound formation, rats were wound-dressed according to their treatment group every day for 15 days. On day 3, 7 and 15 following the wound formation, 0.5cmx0.5cm full thickness tissue samples were taken and examined histopathologically.
Results On day 3, the epithelisation and inflammatory cell density of the non‑diabetic tea tree oil group was found to be statistically significantly higher than the diabetic saline group. There was a statistical difference in favour of the non‑diabetic tea tree oil group in terms of procollagen and mature collagen density. In addition, the non‑diabetic tea tree oil group had a statistically higher angiogenesis amount than the diabetic and non‑diabetic saline and the diabetic sunflower oil groups on day 15 (p<0.05).
Conclusions It has been determined that tea tree oil has an accelerating effect on wound healing and is an alternative method that can be used in wound dressing … read more