Diabetic foot ulcerations—open sores or wounds that refuse to heal—are a devastating complication affecting more than 15 percent of people with diabetes and resulting in more than 70,000 lower extremity amputations per year in the United States alone. Notably, more than half of patients undergoing amputations due to diabetic foot ulcerations are expected to die within five years—a mortality rate higher than most cancers. Yet, the biological processes at work in diabetic foot ulcerations are poorly understood … read more