Application of Topical Sucralfate and Topical Platelet-Rich Plasma Improves Wound Healing in Diabetic Ulcer Rats Wound Model

One of the most devastating complications of diabetes mellitus is diabetic ulcers. Not only because these ulcers heal slowly, these ulcers may also cause disability and even results in limb loss.1 A diabetic ulcer is a chronic wound usually found in the soles of the diabetic patient’s feet. The occurrence of diabetic ulcers is mostly associated with neuropathy and vasculopathy in the form of the peripheral arterial disease which happens in the lower limb of the diabetic patient.2 Around 2% to 5% of all population in the world suffers from diabetic ulcers.3 The hyperglycemic state in diabetics causes molecular and physiological changes that cause diabetic ulcers to become difficult to heal, increasing its risk to secondary infection and potentially causing limb amputation if it is not treated properly.4 Diabetic ulcers account for nearly 90% of all lower limb amputation cases, with a reported mortality rate per year of 5.5% due to diabetic ulcers.

The main aim of diabetic ulcer therapy is to prevent extensive damage and secondary infection of diabetic ulcers, thereby minimizing the risk of further damage or even limb amputation. A thorough therapy for diabetic ulcers includes wound debridement, wound dressing, revascularization procedures, infection management, and ulcer off-loading … read more

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